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| 1 | 上皮样炎性肌纤维母细胞肉瘤:一种炎性肌纤维母细胞瘤侵袭性腹腔内亚型伴有ALK核膜和核周表达显示文摘炎性肌纤维母细胞瘤(IMT)是一种在黏液到胶原间质背景中,由梭形的肌纤维母细胞组成的间叶性肿瘤,常伴有以浆细胞和淋巴细胞为主的慢性炎细胞浸润,偶尔可混有嗜酸性粒细胞和中性粒细胞。 | Marino-Enrìquez A Roy A 黄文斌(摘译) | 2011 | 临床与实验病理学杂志2011，27，2： | 63 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Role of the JNK signal transduction pathway in inflammatory bowel disease显示文摘The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD. | Praveen K Roy Farzana Rashid Jack Bragg Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 10 |
| 4 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 5 | Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis显示文摘Liposarcomas are rare soft tissue tumors, commonly affecting the lower limbs and less commonly the retroperitoneum. Although other organs can be affected,the pancreas is one of the rarest, and metastasis at presentation has never been reported. We describe the case of a 76-year-old gentleman presenting with abdominal pain and an abdominal mass. Imaging confirmed a primary tumor in the body and tail of the pancreas, with a metastatic deposit in the mesentery adjacent to the second part of the duodenum. Biopsy confirmed a liposarcoma, and subsequently a complete surgical excision was achieved. He then received adjuvant radiotherapy and has remained disease free for the next 26 mo. | IM Dodo JA Adamthwaite P Jain A Roy PJ Guillou KV Menon | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 6 | Challenges in managing hepatitis C virus infection in cancer patients显示文摘Cancer patients have unique problems associated with hepatitis C virus(HCV)infection and treatment not seen in the general population.HCV infection poses additional challenges and considerations for the management of cancer,and vice versa.HCV infection also can lead to the development of cancer,particularly hepatocellular carcinoma and non-Hodgkin lymphoma.In severely immunocompromised cancer patients,diagnosis of HCV infection requires increased reliance on RNA detection techniques.HCV infection can affect chemotherapy,and delay of HCV infection treatment until completion of chemotherapy and achievement of cancer remission may be required to decrease the potential for drug-drug interactions between antineoplastic agents and HCV therapeutics and potentiation of side effects of these agents.In addition,hematopoietic stem cell transplant(HSCT)recipients have an increased risk of early development of cirrhosis and fibrosis.Whether this increased risk applies to all patients regardless of cancer treatment is unknown.Furthermore,patients with cancer may have poorer sustained virological responses to HCV infection treatment than do those without cancer.Unfortunately,not all cancer patients are candidates for HCV infection therapy.In this article,we review the challenges in managing HCV infection in cancer patients and HSCT recipients. | Roy A Borchardt Harrys A Torres | 2014 | World Journal of Gastroenterology2014，20，11： | 4 |
| 7 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 8 | The use of psychotropic drugs in irritable bowel syndrome显示文摘 | Roy Dekel Douglas A Drossman Ami D Sperber | 2013 | Expert Opinion on Investigational Drugs2013，，3： | 4 |
| 9 | Infection After Spanning External Fixation for High-Energy Tibial Plateau Fractures: Is Pin Site–Plate Overlap a Problem?显示文摘 | Catherine Laible Emily Earl-Royal Roy Davidovitch Mike Walsh Kenneth A Egol | 2012 | Journal of Orthopaedic Trauma2012，，2： | 3 |
| 10 | The treatment of traumatic optic neuropathy显示文摘 | Leonard A Levin Roy W Beck Michael P Joseph Stuart Seiff Raymond Kraker | 1999 | Ophthalmology1999，，7： | 2 |
| 11 | Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat显示文摘Wheat(Triticum aestivum) seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 min treatment was provided 95%–100% germination rate.For the treatment duration of 3 and 9 min the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ~20% by 6 min treatment with H_2O/O_2 plasma with respect to control. | N C ROY M M HASAN A H KABIR M A REZA M R TALUKDER A N CHOWDHURY | 2018 | Plasma Science and Technology2018，20，11： | 2 |
| 12 | Mathematical modeling of localized melting around graphite nodules during laser surface hardening of austempered ductile iron显示文摘 | Roy A Manna I | 2000 | Optics and Laser Engineering2000，，34： | 2 |
| 13 | Cellular uptake of long-chain fatty acids: role of membrare-associated fatty-acid-binding/transport proteins 显示文摘 | Dutta Roy A K | 2000 | Cell Mol Life Sci2000，57，10： | 2 |
| 14 | Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics显示文摘 | Sarah K McGill Evangelos Evangelou John P A Ioannidis Roy M Soetikno Tonya Kaltenbach | 2013 | Gut2013，，12： | 2 |
| 15 | Properties of amorphous diamond films prepared by a filtered cathodic arc显示文摘 | Lossy R Pappas D L Roy R A | 1994 | J Appl Physics1994，75，： | 2 |
| 16 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 17 | A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative显示文摘 | Jack A DiPalma Peter H DeRidder Roy C Orlando Byron E Kolts Mark vB Cleveland | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 18 | 持续血糖监测用于检测危重症患儿高血糖的前瞻性研完显示文摘目的用组织间隙持续血糖监测仪评价PICU非糖尿病患儿血糖增高程度,并与实验室间断检测血糖的方法比较,评价监测效果。设计前瞻性、观察性研究。场所西马萨诸塞州一所医学中心拥有10张床位的PICU。对象20名非糖尿病患儿,年龄1~18岁,预计需要2d以上的重症监护。干预在患儿皮下放置持续血糖监测仪,征得患儿及家属同意后,另接探头进行72h连续血糖监测并与实验室所测血糖水平进行比较。测量指标和主要结果平均每位患儿持续监测685.2h,共有16337次探头读数,43.0%读数高于125mg/dl(6.9mmol/L),27.2%高于140mg/dl(7.8mmol/L),4%高于200mg/dl(11.1mmol/L)。实验室血糖值提示升高的频度不如持续监测,且易错过血糖升高的关键时段。结论PICU患儿可出现显著血糖升高,实验室间断检测血糖可能低估此现象。 | Allen HF Rake A Roy M | 2008 | 中国小儿急救医学2008，15，2： | 2 |
| 19 | Spectroelctrochemical study of the role played by carbon functionality in fuel cell electrodes显示文摘 | ROY S C HARDING A W RUSSELL A E | 1997 | J Electrochem Soc1997，144，7： | 2 |
| 20 | Testing bread slices in tension mode显示文摘 | Nussinovitch A Roy I | 1990 | Cereal Chem1990，67，： | 1 |
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