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| 1 | Cancer stem cell plasticity and tumor hierarchy显示文摘The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. | Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 2 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 3 | The role of IL-6 and STAT3 in inflammation and cancer显示文摘 | David R. Hodge Elaine M. Hurt William L. Farrar | 2005 | European Journal of Cancer2005，，16： | 3 |
| 4 | Diagnostic Evaluation of Mononucleosis-Like Illnesses显示文摘 | Christopher Hurt Dominick Tammaro | 2007 | The American Journal of Medicine2007，，10： | 2 |
| 5 | Lake Mead Intake No. 3显示文摘在美国西南部持续干旱的作用下,为了维持拉斯维加斯山谷既有水容量,南内华达水资源管理局在米德湖中新建了一个深水取水口(3号取水口)。本项目包括一口185 m深的竖井、十分困难的地质条件下4.7 km的隧道以及沉没式取水口海事工程。本文介绍设计和施工过程中积累的经验以及为解决隧道开挖过程中遇到的困难而采取的创新性解决方案,隧道开挖采用双模式泥浆隧道掘进机(TBM),压力高达15 bar(1 bar=10~5 Pa)。其中特别介绍了掘进机开挖过程中克服的主要挑战,包括作业模式、开挖面支撑压力、预注浆和维护;取水口的施工,涉及用锥形炸药爆破的水下竖井开挖;创造性地建设1200 t以上的混凝土-钢取水建筑物;取水建筑物在水下竖井中的就位;与混合式掘进机开挖的取水隧道的对接。 | Jon Hurt Claudio Cimiotti | 2017 | Engineering2017，3，6： | 2 |
| 6 | Polymerase chain reaction identification of human immunodefieiency virus-1 in preserved human sclera 显示文摘 | Seiff SR Chang JS Hurt MH | 1994 | Am J Ophthalmol1994，118，4： | 1 |
| 7 | Thresholds of Microwave-Evoked Warmth Sensations in Human Skin显示文摘 | BLICK D ADAIR E HURT W | 1997 | Bioelectromagnetics1997，18，： | 1 |
| 8 | Point attack tools : an evaluation of function and use for rock cutting 显示文摘 | Hurt KG Evans I | 1981 | The Mining Engineer1981，140，： | 1 |
| 9 | Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies显示文摘 | Hurt M Apte S Leher H Howard K Niederkorn J Alizadeh H | 2001 | Infect Immun2001，69，： | 1 |
| 10 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 11 | A generic strategy to analyze the spatial organization of multi-protein complexes by cross- linking and mass spectrometry显示文摘 | Rappsilber J Siniossoglou S Hurt E C | 2000 | Anal Chem2000，72，2： | 1 |
| 12 | Characteristics Of A Widespread Community Cluster of H275Y Oseltamivir-resistant A(H1N1)pdm09Influenza In Australia显示文摘 | Hurt A C Hardie K Wilson N J | 2012 | Journal of Infectious Diseases2012，206，2： | 1 |
| 13 | Cutaneous inflammatory pseudotumor :Lesions resembling 'inflammatory pseudotumors' or 'plasma cell granulomas' of extracutaneous sites显示文摘 | Hurt MA Santa CDJ | 1990 | Am J Sugr Pathol1990，14，： | 1 |
| 14 | Developments in the textural and rheological properties of UK Cheddar cheese during ripening 显示文摘 | Hurt J Le G G | 2001 | International Dairy Journal2001，11，7： | 1 |
| 15 | Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells:An integrated molecular profiling approach显示文摘 | Kawasaki BT Hurt EM Kalathur M | 2009 | Prostate2009，69，8： | 1 |
| 16 | Insulin resistance and adiposity correlate with acute phase reaction and soluble cell adhesion molecules with type 2 diabetes 显示文摘 | Leinonen E Hurt -Camejo E Wiklund O | 2003 | Atherosclerosis2003，166，： | 1 |
| 17 | Benign tumors of the bronchus and trachea, 1951-1981显示文摘 | Hurt R | 1984 | Ann R Coil Surg Engl1984，66，1： | 1 |
| 18 | In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1)Influenza Viruses显示文摘 | Hurt A C Holien J K Barr I G | 2009 | Antimicrob Agents Chem2009，53，10： | 1 |
| 19 | The role of IL-6 and STAT3 in in-flammation and cancer显示文摘 | Hodge DR Hurt EM Farrar WL | | 0，，： | 1 |
| 20 | The role of IL-6 and STAT3 in inflammation and cancer显示文摘 | Hodge DR Hurt EM Farrar WL | 2005 | European Journal of Cancer2005，41，16： | 1 |
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