|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo显示文摘Aim: To study the immunosuppressive activity of SM735 {[3-(12-β-artemisininoxy)] phenoxyl succinic acid}, a synthetic artemisinin derivative with nonsteroidal antiinflammatory drug structure, with the aim of finding potential immunosuppressive agents. Methods: Concanavalin A (ConA), lipopolysaccharide (LPS), and mixed lymphocyte reaction (MLR), were used to induce the proliferation of splenocytes, and [~3H]-thymidine incorporation was used to evaluate the proliferation of splenocytes. Cytokine production was promoted with ConA, LPS, or PMA plus ionomycin, and was detected with the enzyme-linked immunosorbent assay. Dinitrofluorobenzene (DNFB) and sheep red blood cells (SRBC) were used to induce delayed-type hypersensitivity and quantitative hemolysis of SRBC (QHS) mouse models, as criteria for the evaluation of in vivo immune activity. Results: SM735 strongly inhibited the proliferation of splenocytes induced by ConA, LPS, or MLR, withIC_(50)) values of 0.33 μmol/L, 0.27 μmol/L, and 0.51 μmol/L, respectively. When compared with a CC_(50) value of 53.1 μmol/L, SM735 had a favorable safety range. SM735 dose-dependently inhibited proinflammatory cytokine production [including interleukins (IL)-12, interferon (IFN)-γ and IL-6] induced by LPS or PMA plus ionomycin. Upon ConA stimulation, SM735 suppressed IFN-γ in a dose-dependent manner, but did not affect IL-2 secretion. SM735 also strongly suppressed both T-cell-mediated delayed-type hypersensitivity (DTH) and B-cell-mediated QHS reactions. Conclusion: SM735 had strong immunosuppressive activity in vitro and in vivo, suggesting a potential role for SM735 as an immunosuppressive agent, and established the groundwork for further research on SM735. | Wen-liang ZHOU Jin-ming WU Qing-li WU Jun-xia WANG Yu ZHOU Ru ZHOU Pei-lan HE Xiao-yu LI Yi-fu YANG Yu ZHANG Ying LI Jian-ping ZUO | 2005 | Acta Pharmacologica Sinica2005，26，11： | 25 |
| 2 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 3 | Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina显示文摘AIM: To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.METHODS: The streptozotocin(STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus(DM) group(saline, 3 μL/eye); RC28-E at low(0.33 μg/μL, 3 μL), medium(1 μg/μL, 3 μL), and high(3 μg/μL,3 μL) dose groups; vascular endothelial growth factor(VEGF) Trap group(1 μg/μL, 3 μL); fibroblast growth factor(FGF) Trap group(1 μg/μL, 3 μL). Normal control group was included. At week 1 and 4 following diabetic induction,the rats were intravitreally injected with the corresponding solutions. At week 6 following the induction, apoptosis in retinal vessels was detected by TUNEL staining.Glial fibrillary acidic protein(GFAP) expression was examined by immunofluorescence. Blood-retinal barrier(BRB) breakdown was assessed by Evans blue assay.Ultrastructural changes in choroidal and retinal vessels were analyzed by transmission electron microscopy(TEM).Content of VEGF and FGF proteins in retina was measured by enzyme linked immunosorbent assay(ELISA). The retinal expression of intercellular cell adhesion molecule-1(ICAM-1), tumor necrosis factor-α(TNF-α), VEGF and FGF genes was examined by quantitative polymerase chain reaction(qPCR).RESULTS: TUNEL staining showed that the aberrantly increased apoptotic cells death in diabetic retinal vascular network was significantly reduced by treatments of medium and high dose RC28-E, VEGF Trap, and FGF Trap(all P<0.05), the effects of medium and high dose RC28-E or FGF Trap were greater than VEGF Trap(P<0.01). GFAP staining suggested that reactive gliosis was substantially inhibited in all RC28-E and VEGF Trap groups, but the inhibition in FGF Trap group was not as prominent.Evans blue assay demonstrated that only high dose RC28-E could significantly reduce vascular leakage in early diabetic retina(P<0.01). TEM revealed that the ultrastructures in choroidal and retinal vessels were damaged in early diabetic retina, which was ameliorated to differential extents by each drug. The expression of VEGF and FGF2 proteins was significantly upregulated in early diabetic retina, and normalized by RC28-E at all dosages and by the corresponding Traps. The upregulation of ICAM-1 and TNF-α in diabetic retina was substantially suppressed by RC28-E and positive control drugs.CONCLUSION: Dual blockade of VEGF and FGF2 by RC28-E generates remarkable protective effects, including anti-apoptosis, anti-gliosis, anti-leakage, and improving ultrastructures and proinflammatory microenvironment,in early diabetic retina, thereby supporting further development of RC28-E into a novel and effective drug to diabetic retinopathy(DR). | Qian-Hui Yang Yan Zhang Jing Jiang Mian-Mian Wu Qian Han Qi-Yu Bo Guang-Wei Yu Yu-Sha Ru Xun Liu Min Huang Ling Wang Xiao-Min Zhang Jian-Min Fang Xiao-Rong Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 9 |
| 4 | Challenges of 22 nm and beyond CMOS technology显示文摘It is predicted that CMOS technology will probably enter into 22 nm node around 2012. Scaling of CMOS logic technology from 32 to 22 nm node meets more critical issues and needs some significant changes of the technology, as well as integration of the advanced processes. This paper will review the key processing technologies which can be potentially integrated into 22 nm and beyond technology nodes, including double patterning technology with high NA water immersion lithography and EUV lithography, new device architectures, high K/metal gate (HK/MG) stack and integration technology, mobility enhancement technologies, source/drain engineering and advanced copper interconnect technology with ultra-low-k process. | HUANG Ru WU HanMing KANG JinFeng XIAO DeYuan SHI XueLong AN Xia TIAN Yu WANG RunSheng ZHANG LiangLiang ZHANG Xing WANG YangYuan | 2009 | Science in China(Series F)2009，52，9： | 8 |
| 5 | DEK43 is a P-type pentatricopeptide repeat(PPR)protein responsible for the Cis-splicing of nad4 in maize mitochondria显示文摘Mitochondria, the main energy transducers in plant cells, require the proper assembly of respiratory chain complexes Ⅰ–Ⅴ for their function. The NADH dehydrogenase4(nad4) gene encodes mitochondrial respiratory chain complex Ⅰ subunit Ⅳ, but the mechanism underlying nad4 transcript splicing is unclear. Here, we report that the P-type pentatricopeptide repeat(PPR) protein DEFECTIVE KERNEL 43(DEK43) is responsible for cis-splicing of the nad4 transcript in maize. We demonstrate that DEK43 localizes to both the nucleus and mitochondria. The mutation of Dek43 resulted in embryo-lethal and light-colored defective kernels. Among the 22 mitochondrial group Ⅱ introns, the splicing efficiency of nad4 introns 1 and 3 was reduced by up to 50% compared to the wild type. The levels of complex Ⅰ and supercomplex Ⅰ+Ⅲ2 were also reduced in dek43. Furthermore, in-gel NADH dehydrogenase assays indicated that the activities of these complexes were significantly reduced in dek43. Further, the mitochondrial ultrastructure was altered in the mutant. Together, our findings indicate that DEK43, a dual-localized PPR protein,plays an important role in maintaining mitochondrial function and maize kernel development. | Ru Chang Ren Li Li Wang Lin Zhang Ya Jie Zhao Jia Wen Wu Yi Ming Wei Xian Sheng Zhang Xiang Yu Zhao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 6 |
| 6 | The Association of Socioeconomic Status with the Burden of Cataract-related Blindness and the Effect of Ultraviolet Radiation Exposure: An Ecological Study显示文摘Objective To assess the association of socioeconomic status with the burden of cataract blindness in terms of year lived with disability(YLD) rates and to determine whether ultraviolet radiation(UVR) levels modify the effect of socioeconomic status on this health burden.Methods National and subnational age-standardized YLD rates associated with cataract-related blindness were derived from the Global Burden of Disease(GBD) study 2017. The human development index(HDI) from the Human Development Report was used as a measure of socioeconomic status.Estimated ground-level UVR exposure was obtained from the Ozone Monitoring Instrument(OMI)dataset of the National Aeronautics and Space Administration(NASA).Results Across 185 countries, socioeconomic status was inversely associated with the burden of cataract blindness. Countries with a very high HDI had an 84% lower age-standardized YLD rate [95%confidence interval(CI): 60%–93%, P < 0.001] than countries with a low HDI;for high-HDI countries, the proportion was 76%(95% CI: 53%–88%, P < 0.001), and for medium-HDI countries, the proportion was48%(95% CI: 15%–68%, P = 0.010;P for trend < 0.001). The interaction analysis showed that UVR exposure played an interactive role in the association between socioeconomic status and cataract blindness burden(P value for interaction = 0.047).Conclusion Long-term high-UVR exposure amplifies the association of poor socioeconomic status with the burden of cataract-related blindness. The findings emphasize the need for strengthening UVR exposure protection interventions in developing countries with high-UVR exposure. | DENG Yan YANG Dan YU Jia Ming XU Jing Xian HUA Hui CHEN Ren Tong WANG Nan OU Feng Rong LIU Ru Xi WU Bo LIU Yang | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 7 | Effect of Chain Configuration on Thermal Conductivity of Polyethylene-A Molecular Dynamic Simulation Study显示文摘Stretched polyethylene(PE)fibers are found to have super high thermal conductivity,while the bulk of polyethylene is usually thermal insulating even for those with high crystalline degree.A molecular dynamic simulation is deliberately carried out to examine the relationship between chain configuration and thermal conductivity of polyethylene.In this simulation study,independent and interacting PE chains being stretched are compared with the aim to find out the effect of stretching on thermal conductivity of PE.Various crystallization conditions for PE bulk are considered.It is found that heat transports predominately along the covalent chain rather than across chains in PE crystals.Our simulation study helps to understand experimental findings on thermal conductivity of PE at different states.W e also predict that amorphous PE may be super thermally conductive if chains are strictly stretched along heat flux. | Xiang Zhang Yu Wang Ru Xi Bin Wu Peng Chen Jia Sheng Qian Hao-Jun Liang | 2020 | Chinese Journal of Polymer Science2020，38，12： | 6 |
| 8 | Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage显示文摘一个快速、绿、高度敏感的 excitationemission 矩阵(EEM ) 荧光方法在在秒顺序优点的帮助下包括 uncalibrated 干扰的人的血浆和尿样品的生物液体为 irinotecan (CPT-11 ) 的分析被建议。由于从生物矩阵,平行因素分析(PARAFAC ) 并且轮流出现的严肃的光谱的重叠正规化加权的错误(ANWE ) 被建议了直接执行刻度并且克服有麻烦做传统的 fluorospectrophotometer 的问题。令人满意的结果能被完成。而且,建议方法的性能基于优点和一些统计参数的数字被评估。两个算法的精确性被椭圆的联合信心区域(EJCR ) 验证测试。精确和重覆性被 intra 天的相对标准差(RSD ) 也调查并且内部天。 | Hai Yan Fu Hai Long Wu Jin Fang Nie Yong Jie Yu Hong Yan Zou Ru Qin Yu | 2010 | Chinese Chemical Letters2010，21，12： | 5 |
| 9 | Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration显示文摘A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper.The second-order calibration method based on APTLD(alternating penalty trilinear decomposition) algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time.The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples. | Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian Yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu | 2010 | Chinese Chemical Letters2010，21，10： | 4 |
| 10 | Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China: A Prospective, Multicenter, Noninterventional Study显示文摘 | Jian-Qiu WU Yong-Ping Song Li-Ping Su Ming-Zhi Zhang Wei Li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru Feng Wei Wang Jie-Wen Peng Xiao-Lin Li Xue-Nong Ouyang Chang-Ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang Yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng | 2018 | Chinese Medical Journal2018，，15： | 3 |
| 11 | Identification of Heterodera schachtii on sugar beet in Xinjiang Uygur Autonomous Region of China显示文摘The sugar beet cyst nematode,Heterodera schachtii,is a major parasite of sugar beet which has been recognized and listed as a quarantine nematode in China and more than 20 countries and regions worldwide.A survey for important nematodes was undertaken in the sugar beet planting area of China during 2015-2018,and numerous cysts were collected from sugar beet fields in Xinyuan County,Xinjiang Uygur Autonomous Region of China.The observations of morphological and morphometric characteristics revealed that cysts,vulval cones and second-stage juveniles of the Xinjiang population were in the same range of each other and within those of other reported H.schachtii populations.Molecular analysis of rDNA-ITS,28S-D2/D3 and mtDNA cytochrome c oxidase subunit 1(COI)gene sequences suggested that the Xinjiang population clustered in a branch with those foreign populations,and the sequence similarity was as high as 99.81-100%.Moreover,this result was confirmed by PCR assay with species-specific primer SHF6 and rDNA2 of H.schachtii,and the pathogenicity test confirmed successful Xinjiang population reproduction in both plant hosts.In conclusion,based on morphological and molecular characterization,this study confirmed that the cyst nematode population collected from sugar beet fields in Xinjiang is H.schachtii.As far as we know,this is the first report of H.schachtii on sugar beets in Xinjiang,China. | PENG Huan LIU Hui GAO Li JIANG Ru LI Guang-kuo GAO Hai-feng WU Wei WANG Jun ZHANG Yu HUANG Wen-kun KONG Ling-an PENG De-liang | 2022 | Journal of Integrative Agriculture2022，21，6： | 2 |
| 12 | Syntheses and Liquid Crystal Properties of New Rare Earth Sandwich Type Heteropoly Compounds显示文摘 | BI Li hua \{**\}, LIU Jing hua *** , WANG En bo **** , HUANG Ru dan YU Yong zhang and WU Ping song (Department of Chemistry, Northeast Normal University, Changchun 130024, P.R. China) (Received March 29, 1999) | 1999 | Chemical Research in Chinese Universities1999，15，4： | 2 |
| 13 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 14 | STUDY ON THE SYNTHESIS OF A NEW TYPE OF PHOSPHORUS HETEROCYCLIC COMPOUNDS-PYRAZOLO[3,4-d]-1,3,2-DIAZAPHOSPHORIN-6-ONE显示文摘1-substituted-5-benzoylamino-4-pyrazolecarboxamides(2)wereprepared by the reaction of 1-substituted pyrazolo[3,4-d]-oxazinone(1)with amines in benzene.The compound 2 was refluxed with excess LiAlH4in a mixture of THF and ether,one of the two carbamoyl groups in themolecule 2 was reduced selectively.As the results,1-substituted-5-benzylamino-4-pyrazolecarboxamides(3)were obtained.Compounds 3reacted with Cl2PPh-X,or P(NET2)3,producing the title compounds(4).The conditions of the reactions were studied. | Ru Yu CHEN Jian Wu WANG Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China | 1990 | Chinese Chemical Letters1990，1，1： | 2 |
| 15 | Comparison of Three Microwave/Chemical Pretreatment Processes for Enzymatic Hydrolysis of Rice Straw显示文摘 | Shengdong Zhu Yuanxin Wu Ziniu Yu Cunwen Wang Faquan Yu Siwei Jin Yigang Ding Ru’an Chi Jintao Liao Yan Zhang | 2005 | Biosystems Engineering2005，，3： | 1 |
| 16 | Frequency acqusition and tracking in high dynamic environments 显示文摘 | Su Yu T Wu Ru Chwen | 2000 | IEEE Transaction on Vehicular Technology2000，49，6： | 1 |
| 17 | Pitch as a UV Stabilizer for Polymers显示文摘 | Ru Yu Wu L D McCarthy V Christov | 1995 | Polymer Degradation and Stability1995，，47： | 1 |
| 18 | Pitch as a UV stabilizer for polymers显示文摘 | Ru Yu Wu | 1995 | PolymDegrad Stab1995，47，3： | 1 |
| 19 | Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages显示文摘 | Tzong-Shyuan Lee Chun-Yueh Lin Jin-Yi Tsai Yuh-Lin Wu Kuo-Hui Su Kuo-Yun Lu Sheng-Huang Hsiao Ching-Chian Pan Yu Ru Kou Yung-Pei Hsu Low-Tone Ho | 2008 | Life Sciences2008，，3： | 1 |
| 20 | Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice显示文摘 | Gau-Jun Tang Hsin-Yi Wang Jen-Ying Wang Chih-Chieh Lee Hsu-Wen Tseng Yuh-Lin Wu Song-Kun Shyue Tzong-Shyuan Lee Yu Ru Kou | 2011 | Free Radical Biology and Medicine2011，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员