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| 1 | Hypertension-Induced Cerebral Small Vessel Disease Leading to Cognitive Impairment显示文摘 | Yang Liu Yan-Hong Dong Pei-Yuan Lyu Wei-Hong Chen Rui Li | 2018 | Chinese Medical Journal2018，，5： | 56 |
| 2 | Status of glycosylated hemoglobin and prediction of glycemic control among patients with insulin-treated type 2 diabetes in North China:a multicenter observational study显示文摘Background:Blood glucose control is closely related to type 2 diabetes mellitus(T2DM)prognosis.This multicenter study aimed to investigate blood glucose control among patients with insulin-treated T2DM in North China and explore the application value of combining an elastic network(EN)with a machine-learning algorithm to predict glycemic control.Methods:Basic information,biochemical indices,and diabetes-related data were collected via questionnaire from 2787 consecutive participants recruited from 27 centers in six cities between January 2016 and December 2017.An EN regression was used to address variable collinearity.Then,three common machine learning algorithms(random forest[RF],support vector machine[SVM],and back propagation artificial neural network[BP-ANN])were used to simulate and predict blood glucose status.Additionally,a stepwise logistic regression was performed to compare the machine learning models.Results:The well-controlled blood glucose rate was 45.82%in North China.The multivariable analysis found that hypertension history,atherosclerotic cardiovascular disease history,exercise,and total cholesterol were protective factors in glycosylated hemoglobin(HbAlc)control,while central adiposity,family history,T2DM duration,complications,insulin dose,blood pressure,and hypertension were risk factors for elevated HbAlc.Before the dimensional reduction in the EN,the areas under the curve of RF,SVM,and BP were 0.73,0.61,and 0.70,respectively,while these figures increased to 0.75,0.72,and 0.72,respectively,after dimensional reduction.Moreover,the EN and machine learning models had higher sensitivity and accuracy than the logistic regression models(the sensitivity and accuracy of logistic were 0.52 and 0.56;RF:0.79,0.70;SVM:0.84,0.73;BP-ANN:0.78,0.73,respectively).Conclusions:More than half of T2DM patients in North China had poor glycemic control and were at a higher risk of developing diabetic complications.The EN and machine learning algorithms are alternative choices,in addition to the traditional logistic model,for building predictive models of blood glucose control in patients with T2DM. | Jiao Wang Meng-Yang Wang Hui Wang Hong-Wei Liu Rui Lu Tong-Qing Duan Chang-Ping Li Zhuang Cui Yuan-Yuan Liu Yuan-Jun Lyu Jun Ma | 2020 | Chinese Medical Journal2020，，1： | 19 |
| 3 | Carotid Atherosclerosis and Cognitive Impairment in Nonstroke Patients显示文摘 | Wei-Hong Chen Wei Jin Pei-Yuan Lyu Yang Liu Rui Li Ming Hu Xiang-Jian Xiao | 2017 | Chinese Medical Journal2017，，19： | 15 |
| 4 | Effects of Plasma Lipids and Statins on Cognitive Function显示文摘 | Rui Li Tian-Jun Wang Pei-Yuan Lyu Yang Liu Wei-Hong Chen Ming-Yue Fan Jing Xu | 2018 | Chinese Medical Journal2018，，4： | 14 |
| 5 | Benzene alkylation with methanol over phosphate modified hierarchical porous ZSM-5 with tailored acidity显示文摘The acidity and acid distribution of hierarchical porous ZSM-5 were tailored via phosphate modification. The catalytic results showed that both benzene conversion and selectivity of toluene and xylene increased with the presence of appropriate amount of phosphorus. Meanwhile, side reactions such as methanol to olefins related with the formation of by-product ethylbenzene formation and isomerization of xylene to meta-xylene were suppressed efficiently. The acid strength and sites amount of Br?nsted acid of the catalyst were crucial for improving benzene conversion and yield of xylene, whereas passivation of external surface acid sites played an important role in breaking thermodynamic equilibrium distribution of xylene isomers. | Jinghui Lyu Hualei Hu Carolyn Tait Jiayao Rui Caiyi Lou Qingtao Wang Wenwen Han Qunfeng Zhang Zhiyan Pan Xiaonian Li | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 11 |
| 6 | Effect of ozonated water on normal vaginal microecology and Lactobacillus显示文摘To the Editor:The female vagina is a complex microecology system.Generally,the vaginal microbiota of healthy women is dominated by H2O2-producing Lactobacillus,which decomposes glycogen in vaginal epithelial cells into lactic acid,maintaining the normal acidic environment of the vagina. | Qiong-Qiong Zhang Lei Zhang Ying Liu Ying Wang Rui Chen Zhen-Yu Huang Tao Lyu Qin-Ping Liao | 2019 | Chinese Medical Journal2019，，9： | 9 |
| 7 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 8 | Nitridation:A simple way to improve the catalytic performance of hierarchical porous ZSM-5 in benzene alkylation with methanol显示文摘Nitrided hierarchical porous ZSM-5 was synthesized by nitridation of hierarchical porous ZSM-5 with flowing ammonia at elevated temperature.The samples were characterized by XRD,SEM,Nitrogen sorption isotherms,NH3-TPD and Py-IR,and evaluated in alkylation of benzene and methanol.The result indicated that the high specific surface area of parent ZSM-5 was maintained,while the Bronsted acidity was effectively adjusted by nitridation.Moreover,the high suppression of ethylbenzene was observed on nitrided catalyst and this could be attributed to the decrease of Bronsted acidity which suppressed the methanol to olefins reactions. | Jing-Hui Lyu Hua-Lei Hu Jia-Yao Rui Qun-Feng Zhang Jie Cen Wen-Wen Han Qing-Tao Wang Xiao-Kun Chen Zhi-Yan Pan Xiao-Nian Li | 2017 | Chinese Chemical Letters2017，28，2： | 6 |
| 9 | Serum LDH level may predict outcome of chronic lymphocytic leukemia patients with a 17p deletion: a retrospective analysis of prognostic factors in China显示文摘Objective:This study aims to evaluate the natural history of patients with chronic lymphocytic leukemia(CLL)and a 17p deletion(17p-)and identify the predictive factors within this subgroup.Methods:The sample of patients with CLL were analyzed by fluorescence in situ hybridization for deletions in chromosome bands 11q22,13q14 and 17p13;trisomy of bands 12q13;and translocation involving band 14q32.The data from 456 patients with or without a 17p-were retrospectively collected and analyzed.Results:The overall response rate(ORR)in patients with a 17p-was 56.9%,and patients with a high percentage of 17p-(defined as more than 25%of cells harbouring a 17p-)had a lower ORR.The median overall survival(OS)in patients with a 17p-was 78.0 months,which was significantly shorter than the OS in patients without this genetic abnormality(median 162.0 months,P<0.001).Within the subgroup with a 17p-,the progression-free survival was significantly shorter in patients at Binet stage B-C and patients with elevated lactate dehydrogenase(LDH),B symptoms,unmutated IGHV and a high percentage of 17p-.Conclusions:These results indicated that patients with a 17p-CLL have a variable prognosis that might be predicted using simple clinical and laboratory characteristics. | Heng Li Wenjie Xiong Huimin Liu Shuhua Yi Zhen Yu Wei Liu Rui Lyu Tingyu Wang Dehui Zou Zengjun Li Lugui Qiu | 2017 | Chinese Journal of Cancer Research2017，29，2： | 6 |
| 10 | Facile synthesis of Au embedded CuOx-CeO2 core/shell nanospheres as highly reactive and sinter-resistant catalysts for catalytic hydrogenation of p-nitrophenol显示文摘Exploring cost-effective catalysts with high catalytic performance and long-term stability has always been a general concern for environment protection and energy conversion.Here,Au nanoparticles(NPs)embedded CuOx-CeO2 core/shell nanospheres(Au@CuOx-CeO2 CSNs)have been successfully prepared through a versatile one-pot method at ambient conditions.The spontaneous auto-redox reaction between HAuCl4 and Ce(OH)3 in aqueous solution triggered the self-assembly growth of micro-/nanostructural Au@CuOx-CeO2 CSNs.Meanwhile,the CuOx clusters in Au@CuOx-CeO2 CSNs are capable of improving the anti-sintering ability of Au NPs and providing synergistic catalysis benefits.As a result,the confined Au NPs exhibited extraordinary thermal stability even at a harsh thermal condition up to 700℃.In addition,before and after the severe calcination process,Au@CuOx-CeO2 CSNs can exhibit enhanced catalytic activity and excellent recyclability towards the hydrogenation of p-nitrophenol compared to previously reported nanocatalysts.The synergistic catalysis path between Au/CuOx/CeO2 triphasic interfaces was revealed by density functional theory(DFT)calculations.The CuOx clusters around the embedded Au NPs can provide moderate adsorption strength of p-nitrophenol,while the adjacent CeO2-supported Au NPs can facilitate the hydrogen dissociation to form H*species,which contributes to achieve the efficient reduction of p-nitrophenol.This study opens up new possibilities for developing high-efficient and sintering-resistant micro-/nanostructural nanocatalysts by exploiting multiphasic systems. | Ke Wu Xin-Yu Wang Ling-Ling Guo Yue-Jiao Xu Liang Zhou Ze-Yu Lyu Kang-Yu Liu Rui Si Ya-Wen Zhang Ling-Dong Sun Chun-Hua Yan | 2020 | Nano Research2020，13，8： | 6 |
| 11 | A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared显示文摘Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic designs.Herein,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction PD.Firstly,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,etc.The narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of PD.Secondly,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+PQDs.Thirdly,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+PQDs.In contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 cycles.This work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices. | Nan Ding Yanjie Wu Wen Xu Jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai Ji Zhou Hongwei Song | 2022 | Light(Science & Applications)2022，11，5： | 5 |
| 12 | Synthesized high-silica hierarchical porous ZSM-5 and optimization of its reaction conditions in benzene alkylation with methanol显示文摘In our present work, the high-silica hierarchical porous ZSM-5 with appropriate Br(o|¨)nsted acidity and hierarchical porous structure was synthesized by sol-gel method for continuously catalytic conversion of benzene alkylation with methanol to xylene. The effects of temperature, pressure, benzene/methanol molar ratio and weight hour space velocity(WHSV) on the catalytic performance of the catalyst were investigated as well. As a result, the high-silica hierarchical porous ZSM-5 showed great performance as the yield of xylene was up to 41.1% under the optimum reaction conditions(500 ℃,0.1 MPa,M_(benzene)/M_(methanol)= 1:1.5 and WHSV=4 h 1), while the selectivity to by-product, ethylbenzene, was well suppressed(below 0.1%). In addition, the catalyst structure and properties were characterized by the means of XRD, IR, TPD,SEM, TEM and N_2 physical adsorption technologies. | Jiayao Rui Jinghui Lyu Hualei Hu Qunfeng Zhang Qingtao Wang Xiaonian Li | 2019 | Chinese Chemical Letters2019，30，3： | 5 |
| 13 | A deterministic FE contact analysis of 3D rough surfaces with textures and comparison with classic statistical contact models显示文摘Accurate contact calculations of real rough surfaces are fundamental but complicated. The model-based methods are convenient and straightforward. But these methods ignore some factors and may lead to less accurate results. This is especially true when considering multi-scale topographic features of engineering rough surfaces. Based on artificially generated rough surfaces, the deterministic contact analysis of two 3D rough surfaces is conducted by the finite element method(FEM). The calculations show that when the separation between surfaces reduces, results of classic model-based methods are quite different from those of this study, especially when the roughness distribution and textures are considered. As friction pairs are working under increasing harsh conditions, the accurate contact calculation in this paper will be of great significance. | ZHANG Rui MENG XiangHui LYU BuGao SUN Kai | 2021 | Science China(Technological Sciences)2021，64，2： | 2 |
| 14 | A Simple, Low-cost Method to Fabricate Drag-reducing Coatings on a Macroscopic Model Ship显示文摘 | WANG Zhipeng ZHANG Songsong GAO Shan OUYANG Xiao LI Jie LI Rui WEI Hao SHUAI Zhijun LI Wanyou LYU Shanshan | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 15 | Chronic Lymphocytic Leukemia Prognostic Index: A New Inteorated Scorino System to Predict the Time to First Treatment in Chinese Patients with Chronic Lymphocytic Leukemia显示文摘 | Heng Li Shu-Hua Yi Wen-Jie Xiong Hui-Min Liu Rui Lyu Ting-Yu Wang Wei Liu Shi-Zhen Zhong Zhen Yu De-Hui Zou Yan Xu Gang An Zeng-Jun Li Lu-Gui Qiu | 2017 | Chinese Medical Journal2017，，2： | 2 |
| 16 | Inter-specific differences in survival and reproduction of cladocerants to nitrite gradient and the ecological implications显示文摘 | LYU Kai WANG Qianqian CHEN Rui | 2013 | Biochemical Systematics and Ecology2013，48，： | 1 |
| 17 | Analysis of the correlation between the longitudinal trajectory of SOFA scores and prognosis in patients with sepsis at 72 hour after admission based on group trajectory modeling显示文摘Background:To identify the distinct trajectories of the Sequential Organ Failure Assessment(SOFA)scores at 72 h for patients with sepsis in the Medical Information Mart for Intensive Care(MIMIC)-IV database and determine their effects on mortality and adverse clinical outcomes.Methods:A retrospective cohort study was carried out involving patients with sepsis from the MIMIC-IV database.Group-based trajectory modeling(GBTM)was used to identify the distinct trajectory groups for the SOFA scores in patients with sepsis in the intensive care unit(ICU).The Cox proportional hazards regression model was used to investigate the relationship between the longitudinal change trajectory of the SOFA score and mortality and adverse clinical outcomes.Results:A total of 16,743 patients with sepsis were included in the cohort.The median survival age was 66 years(interquartile range:54-76 years).The 7-day and 28-day in-hospital mortality were 6.0%and 17.6%,respectively.Five different trajectories of SOFA scores according to the model fitting standard were determined:group 1(32.8%),group 2(30.0%),group 3(17.6%),group 4(14.0%)and group 5(5.7%).Univariate and multivariate Cox regression analyses showed that,for different clinical outcomes,trajectory group 1 was used as the reference,while trajectory groups 2-5 were all risk factors associated with the outcome(P<0.001).Subgroup analysis revealed an interaction between the two covariates of age and mechanical ventilation and the different trajectory groups of patients’SOFA scores(P<0.05).Conclusion:This approach may help identify various groups of patients with sepsis,who may be at different levels of risk for adverse health outcomes,and provide subgroups with clinical importance. | Rui Yang Didi Han Luming Zhang Tao Huang Fengshuo Xu Shuai Zheng Haiyan Yin Jun Lyu | 2022 | Journal of Intensive Medicine2022，2，1： | 1 |
| 18 | High-Order Statistics of Temperature Fluctuations in an Unstable Atmospheric Surface Layer over Grassland显示文摘Skewness(S) and kurtosis(K) of temperature in the surface layer over a grassland are investigated under unstable thermal stratifications. We find that both skewness and kurtosis generally obey Monin–Obukhov similarity theory and tend to be constant values(1.5 and 5.3, respectively) when the stability parameter z/L <-2. Quantitative formulas of the similarity functions are proposed. The temperature probability density function(PDF) is close to Gaussian in near neutral stratification and non-Gaussian in unstable stratification. The influence of coherent motions on the PDF behavior is analyzed using the quadrant analysis technique. It shows that PDF behaviors are controlled by ejections and sweeps. The results also indicate that the PDF type of the ejections always follows a Gaussian distribution, while the PDF of the sweeps changes with stability. | Rui LYU Fei HU Lei LIU Jingjing XU Xueling CHENG | 2018 | Advances in Atmospheric Sciences2018，35，10： | 1 |
| 19 | Identification of Hypertension Subgroups through Topological Analysis of Symptom-Based Patient Similarity显示文摘Objective:To obtain the subtypes of the clinical hypertension population based on symptoms and to explore the relationship between hypertension and comorbidities.Methods:The data set was collected from the Chinese medicine(CM)electronic medical records of 33,458 hypertension inpatients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between July 2014 and May 2017.Then,a hypertension disease comorbidity network(HDCN)was built to investigate the complicated associations between hypertension and their comorbidities.Moreover,a hypertension patient similarity network(HPSN)was constructed with patients'shared symptoms,and 7 main hypertension patient subgroups were identified from HPSN with a community detection method to exhibit the characteristics of clinical phenotypes and molecular mechanisms.In addition,the significant symptoms,diseases,CM syndromes and pathways of each main patient subgroup were obtained by enrichment analysis.Results:The significant symptoms and diseases of these patient subgroups were associated with different damaged target organs of hypertension.Additionally,the specific phenotypic features(symptoms,diseases,and CM syndromes)were consistent with specific molecular features(pathways)in the same patient subgroup.Conclusion:The utility and comprehensiveness of disease classification based on community detection of patient networks using shared CM symptom phenotypes showed the importance of hypertension patient subgroups. | WANG Yi-fei WANG Jing-jing PENG Wei REN Yong-hao GAO Chao LI Yun-lun WANG Rui WANG Xiao-feng HAN Song-jun LYU Jia-yu HUAN Jia-ming CHEN Cui WANG Hai-yan SHU Zi-xin ZHOU Xue-zhong LI Wei | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 1 |
| 20 | Discharge rate consistency of each channel for UAV-based pneumatic granular fertilizer spreader显示文摘Unmanned aerial vehicles(UAVs)are widely being used to spread granular fertilizer in China.Granular fertilizer spreaders equipped with UAVs are mainly centrifugal disc-type and pneumatic.The multichannel pneumatic granular fertilizer spreaders(MPGFSs)have a banded fertilizer deposition distribution pattern,which are more suitable for variable rate fertilization with high precision requirement than the circular deposition distribution pattern of disc-type granular fertilizer spreaders(DGFSs).However,the existing MPGFS has the disadvantage of inconsistent discharge rate of each channel,which affects the uniformity of fertilization.In order to explore the causes of inconsistent discharge rate of each channel,the discrete element method(DEM)and bench test were performed to analysis the discharge process of the fluted roller fertilizing apparatus and distribution of fertilizer in axial direction of fluted roller.The computational fluid dynamics(CFD)was used to simulate the airflow field of pneumatic system to analyze the influence of airflow on the movement of fertilizer particles.The simulation results of the discharge process of the fluted roller fertilizing apparatus showed that the filling velocity at the axial ends of the fluted roller fertilizing apparatus was lower than that of the middle.The reason was that the filling capacity was weak near the wall.The simulated results of the airflow field without partitions showed that the airflow provided by the axial flow fan was rotational,and this caused the particles to move irregularly in the throat,resulting in inconsistency discharge rate of each channel.Based on the analysis of reasons of inconsistent discharge rate of each channel,a MPGFS with partitions in the throat was developed.The discharge rate bench tests were carried out to optimize the partition spacing parameters,and fertilization test was performed to test the performance of the improved MPGFS.The discharge rate test results showed better consistency with partition.The coefficient of variation(CV)of the discharge rate of each channel was 20.16%without the partition and 7.70%with the optimal partition.The fertilizer spreading uniformity bench test results shown that the CV of spreading uniformity of MPGFS without partitions was 15.32%,and that MPGFS with partitions was 8.69%.The partitions design was beneficial to improve the consistency of each channel discharge rate and the uniformity of fertilization.The finding can provide a strong reference to design the MPGFS. | Xunwei Wang Rui Jiang Zhiyan Zhou Cancan Song Xiwen Luo Ruifeng Bao Zichen Lyu Junhao Huang Jianqin Lin | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 1 |
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