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| 1 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 2 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 3 | Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study显示文摘Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem worldwide.Recent studies have reported that socioeconomic status(SES)is related to the incidence of COPD.This study aimed to investigate the association between SES and COPD among adults in Jiangsu province,China,and to determine the possible direct and indirect effects of SES on the morbidity of COPD.Methods:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2015 in Jiangsu province,China.Participants were selected using a multistage sampling approach.COPD,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk factors.Education,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory variable.Mixed-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different SES.Results:The mean age of the 2421 participants was 56.63±9.62 years.The prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample population.After adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience COPD.Such negative associations between all these three SES indicators and COPD were significant among men only.Education,FAI,and occupation had direct or indirect effects on pulmonary function including post-bronchodilator forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1,FVC,and FEV1 percentage of predicted.Education,FAI,and occupation had indirect effects on pulmonary function indices of all participants mainly through smoking status,indoor air pollution,and outdoor air pollution.We also found that occupation could affect post-bronchodilator FEV1/FVC through body mass index.Conclusions:Education,occupation,and FAI had an adverse relationship with COPD prevalence in Jiangsu province,China.SES has both direct and indirect associations with pulmonary function impairment.SES is of great significance for COPD morbidity.It is important that population-based COPD prevention strategies should be tailored for people with different SES. | Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu Xue-Qing Peng Gan Lu Jin-Yi Zhou Ran Tao Zhen Ding Fei Xu Linfu Zhou | 2021 | Chinese Medical Journal2021，，13： | 5 |
| 4 | A novel synthetic route for LiFePO_4/C cathode materials by addition of starch for lithium-ion batteries显示文摘LiFePO4/Carbon composite cathode material was prepared using starch as carbon source by spray-pelleting and subsequent pyrolysis in N2. The samples were characterized by XRD, SEM, Raman, and their electrochemical performance was investigated in terms of cycling behavior. There has a special micro-morphology via the process, which is favorable to electrochemical properties. The discharge capacity of the LiFePO4.C composite was 170 mAh g-1, equal to the theoretical specific capacity at 0.1 C rate. At 4 C current density, the specific capacity was about 80 mAh g-1, which can satisfy for transportation applications if having a more flat discharge flat. | Shao Hua Luo, Zi Long Tang, Jun Biao Lu, Zhong Tai Zhang State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2007 | Chinese Chemical Letters2007，18，2： | 5 |
| 5 | A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared显示文摘Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic designs.Herein,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction PD.Firstly,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,etc.The narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of PD.Secondly,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+PQDs.Thirdly,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+PQDs.In contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 cycles.This work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices. | Nan Ding Yanjie Wu Wen Xu Jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai Ji Zhou Hongwei Song | 2022 | Light(Science & Applications)2022，11，5： | 5 |
| 6 | Spatial-temporal Evolution Characteristics and Decoupling Analysis of Influencing Factors of China’s Aviation Carbon Emissions显示文摘The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent. | HAN Ruiling LI Lingling ZHANG Xiaoyan LU Zi ZHU Shaohua | 2022 | Chinese Geographical Science2022，32，2： | 5 |
| 7 | Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice显示文摘Objective Interferon-induced transmembrane protein 3(IFITM3)is an important member of the IFITM family.However,the molecular mechanisms underlying its antiviral action have not been completely elucidated.Recent studies on IFITM3,particularly those focused on innate antiviral defense mechanisms,have shown that IFITM3 affects the body’s adaptive immune response.The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection in vivo.Methods We performed proteomics,flow cytometry,and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer(NK)cell numbers,their activation,and their immune function in the lungs of Ifitm3-/-and wild-type mice.Results Ifitm3-/-mice developed more severe inflammation and apoptotic responses compared to wild-type mice.Moreover,the NK cell activation was higher in the lungs of Ifitm3-/-mice during acute influenza infection.Conclusions Based on our results,we speculate that the NK cells are more readily activated in the absence of IFITM3,increasing mortality in Ifitm3-/-mice. | SUN Qiang LEI Na LU Jian GAO Rong Bao LI Zi LIU Li Qi SUN Ying GUO Jun Feng WANG Da Yan SHU Yue Long | 2020 | Biomedical and Environmental Sciences2020，33，5： | 4 |
| 8 | A NOVEL STEROID FROM EICHHORNIA CRASSIPES显示文摘6(?)-Hydroxy-stigmasta-4,22-diene-3-one 1,a novel steroid,was isolated from the Eichhornia Crassipes.Its structure was deter-mined by 1H and 13C NMR spectroscopy and further confirmed by authen-tic sample,which was synthesized from stigmasterol 2. | Hou Ming WU Hui Qiang ZHOU Sheng yu HUANG Kan MA Xia Fei LAO State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry,Academia Sinica 345 LingLing Lu,Shanghai 200032Shu Wen YU Wen Hao SUN Zi Wen YU Shanghai Institute of Plant Physiology Academia Sinica,Shanghai 200032 | 1991 | Chinese Chemical Letters1991，2，7： | 3 |
| 9 | Circulating Neutrophil Counts Decrease in Response to Mitigated Air Quality in Stable COPD Patients显示文摘这三年的研究基于呼吸疾病(格子) 的广州研究所,长期的妨碍的肺的疾病(COPD ) Biobank,在 36 个 COPD 病人被进行估计在白血球,红血球,血红素,和血小板的层次的变化是否与在空气污染物质集中的变化有关。每天,没有 2 层次展出了基线年和 2010 亚洲比赛时期之间的重要差别。我们在白血球和 neutrophils 计数层次观察了重要减小,在 15.51% 和 23.01% ,从亚洲人前比赛到在期间 -- 亚洲运动会分别地。在亚洲人以后的比赛时期,大多数污染物质接近了亚洲人前比赛时期层次,和类似的效果在白血球和嗜中性的计数被表明。为两项条款,我们识别了重要增加源于没提高 2 在落后天 0-2/5-6。我们断定在污染物质的减小在 COPD 与 hematological 事件的 inactivation 在干预时期期间被联系。 | ZHANG Zi Li WANG Jian LIU Fen DING Ming Jing LIU Fei CHEN Si Fan LU Wen Ju | 2018 | Biomedical and Environmental Sciences2018，31，1： | 3 |
| 10 | A new nor-sesquiterpene lactone from Ainsliaea fulvioides显示文摘新 nor-sesquiterpene 内酯 ainsliatone A (1 ) 从 Ainsliaea fulvioides 的天线部分被孤立。它的结构被分光镜的方法和单个水晶的 X 光检查衍射分析的基础建立。 | Yan Wang Ming Lu Xu Hui Zi Jin Jian Jun Fu Xiao Jia Hu Jiang Jiang Qin Shi Kai Yan Yun Heng Shen Wei Dong Zhang | 2009 | Chinese Chemical Letters2009，20，5： | 2 |
| 11 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 12 | Inaccuracy of Self-reported Low Sodium Diet among Chinese: Findings from Baseline Survey for Shandong & Ministry of Health Action on Salt and Hypertension(SMASH) Project显示文摘This study was aimed to evaluate the agreement between the self-reported sodium intake level and 24-h urine sodium excretion level in Chinese.The 24-h urine collection was conducted among 2112 adults aged 18-69 years randomly selected in Shandong Province,China.The subjects were asked whether their sodium intake was low,moderate,or high.The weighted kappa statistics was calculated to assess the agreement | ZHANG Juan GUO Xiao Lei Dong Chul SEO XU Ai Qiang XUN Peng Cheng MA Ji Xiang SHI Xiao Ming Nicole LI YAN Liu Xia LI Yuan LU Zi Long ZHANG Ji Yu TANG Jun Li REN Jie ZHAO Wen Hua LIANG Xiao Feng | 2015 | Biomedical and Environmental Sciences2015，28，2： | 2 |
| 13 | Characterisation of a novel oral iron chelator: 1‐( N ‐ A cetyl‐6‐ A minohexyl)‐3‐ H ydroxy‐2‐ M ethylpyridin‐4‐one显示文摘 | Kanjana Pangjit Ratana Banjerdpongchai Chada Phisalaphong Suthat Fucharoen Yuan Yuan Xie Zi Dong Lu Robert C. Hider Somdet Srichairatanakool | 2015 | J Pharm Pharmacol2015，，5： | 2 |
| 14 | Alterations of ATPase activity and erythrocyte oxygen consumption in patients with liver-blood deficiency syndrome显示文摘AlterationsofATPaseactivityanderythrocyteoxygenconsumptioninpatientswithliverblooddeficiencysyndromeSHILinJie1,LIUJunFan2... | SHI Lin Jie 1, LIU Jun Fan 2, ZHANG Zi Qiang 1, LU Yi Qin 2, SHU Yi Gang 3, CHEN Guo Lin 1, XIN Zhi Hua 1 and XU Jin Yao 2 | 1997 | World Journal of Gastroenterology1997，3，3： | 1 |
| 15 | Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells 显示文摘 | Lu Y Zi X Pollak M | 2004 | Int J Cancer2004，108，3： | 1 |
| 16 | Insulin-like growth factor- Ⅰ receptor signaling and resistance to trastuzumab (Herceptin)显示文摘 | Zi XL Zhao YH | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
| 17 | Insulin-like growth factor- Ⅰ receptor signaling and resistance to trastuzumab ( Herceptin ) 显示文摘 | Lu Y Zi X Zhao Y | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
| 18 | Synthesis of silane monomer-modified styrene–acrylate microemulsion coatings by photopolymerization显示文摘 | Tao Wan Zi Wen Hu Xiao Ling Ma Jie Yao Kuai Lu | 2007 | Progress in Organic Coatings2007，，2： | 1 |
| 19 | Aerodynamic characteristics of morphing wing withflexible leading-edge显示文摘The morphing wing can improve the flight performance during different phases.However,research has been subject to limitations in aerodynamic characteristics of the morphing wing with a flexible leading-edge.The computational fluid dynamic method and dynamic mesh were used to simulate the continuous morphing of the flexible leading-edge.After comparing the steady aerodynamic characteristics of morphing and conventional wings,this study examined the unsteady aerodynamic characteristics of morphing wings with upward and downward deflections of the leading-edge at different frequencies.The numerical results show that for the steady aerodynamic,the leading-edge deflection mainly affects the stall characteristic.The downward deflection of the leading-edge increases the stall angle of attack and nose-down pitching moment.The results are opposite for the upward deflection.For the unsteady aerodynamic,at a small angle of attack,the transient lift coefficient of the upward deflection,growing with the increase of deflection frequency,is larger than that of the static case.The transient lift coefficient of the downward deflection,decreasing with the increase of deflection frequency,is smaller than that of the static case.However,at a large angle of attack,an opposite effect of deflection frequency on the transient lift coefficient was demonstrated.The transient lift coefficient is larger than that of the static case when the leading edge is in the nose-up stage,and lower than that of the static one in the nose-down stage. | Zi KAN Daochun LI Tong SHEN Jinwu XIANG Lu ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，10： | 1 |
| 20 | Induction of estrus in suckled female yaks (Bos grunniens) and synchronization of ovulation in the non-sucklers for timed artificial insemination using progesterone treatments and Co-Synch regimens显示文摘 | HE S M LU H | 2006 | Anim Reprod Sci2006，92，： | 1 |
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