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| 1 | Stochastic modeling the effect of wind gust on dust entrainment during sand storm显示文摘After the passage of a cold front,spring in northern China the outbreak of strong wind is often accompanied by dust emissions.Owing to the coherent structure of wind gust,dust particles can effectively overcome the systematic descending air motion and penetrate into the middle and upper levels of the atmospheric boundary layer,and then propagate further and diffuse into the troposphere where ascending air motion prevails.Here,we consider the coherent structure of wind gust in LS models,and construct a model suitable for the dust entrainment under the dust-storm canopy.With the parameter of gust,we simulate the dust entrainment during dust storms,and test that the coherent structures of wind gust make the sand particles to reach the upper of the boundary layer. | CHENG XueLing ZENG QingCun HU Fei | 2012 | Chinese Science Bulletin2012，57，27： | 10 |
| 2 | Fabrication and Characterization of Gecko-inspired Dry Adhesion, Superhydrophobicity and Wet Self-cleaning Surfaces显示文摘 | Yongchao Zhang Shuxin Qu Xiang Cheng Xueling Gao Xia Guo | 2016 | Journal of Bionic Engineering2016，13，1： | 8 |
| 3 | Simulation of wind gust structure in the atmospheric boundary layer with Lattice Boltzmann Method显示文摘Cold fronts occur in northern East Asia during winter and spring.After cold frontal passage,airflow is downward and accompa-nying strong winds fluctuate significantly;this is termed wind gusts.Analysis of observation data shows that wind gust structure has coherent characteristics.This is important for entrainment of spring dust storms into the upper boundary layer,where they are transported great distances.The Lattice Boltzmann Method(LBM) is a computational fluid technique based on the Boltzmann transport equation.The LBM has been used to study complex motion such as turbulence,because it describes motion at the micro level.In this paper,Large eddy simulation is introduced in the LBM,enabling simulation of turbulent flow in the atmospheric boundary layer.The formation and development of wind gusts are simulated,and a coherent structure with a combination of wave and vortex is obtained.This explains the mechanism of soil erosion and sand entrainment by the coherent structure of wind gusts. | CHENG XueLing HU Fei ZENG QingCun | 2012 | Chinese Science Bulletin2012，57，10： | 7 |
| 4 | Hard state of the urban canopy layer turbulence and its self-similar multiplicative cascade models显示文摘It is found by experiment that under the thermal convection condition, the temperature fluctuation in the urban canopy layer turbulence has the hard state character, and the temperature difference between two points has the exponential probability density function distribution. At the same time, the turbulent energy dissipation rate fits the log-normal distribution, and is in accord with the hypothesis proposed by Kolmogorov in 1962 and lots of reported experimental results. In this paper, the scaling law of hard state temperature n order structure function is educed by the self-similar multiplicative cascade models. The theory formula is Sn = n/3μ{n(n+6)/72+[2lnn!-nln2]/2ln6}, and μ Is intermittent exponent. The formula can fit the experimental results up to order 8 exponents, is superior to the predictions by the Kolmogorov theory, the β And log-normal model. | HU Fei CHENG Xueling ZHAO Songnian QUAN Lihong | 2005 | Science China Earth Sciences2005，48，z2： | 4 |
| 5 | Stochastic method to determine the scale and anomalous diffusion of gusts in a windy atmospheric boundary layer显示文摘In the atmospheric boundary layer, especially during strong wind period, the coherent structures are obvious and related to the direct interaction of the air masses with the ground. In this paper, we used the observation data during dust weather in Northwest Gansu to study the coherent structure and their ‘‘anomalous diffusion''. The structures in the atmospheric boundary layer included turbulent fluctuations and gusty wind disturbances, and could be denoted as ‘‘critical events' '. Their fractal dimensions were expressed by the complex index l of waiting times. Although the complex index can indicate the ability of the system to generate coherent structures, it has a strong dependence on the threshold marking the‘‘critical events' '. Hence, the continuous time random walk method was used to analyze the coherent structures. The scaling law of anomalous diffusion of coherent structures was obtained, and the diffusion scaling exponent H that indicated the ability of diffusion of different structures was analyzed. The exponents changed with structure scales which were affected by velocities and heights. At small scales, it was almost isotropic, and at large scales, the coherent structures were obvious and the diffusion was anomalous. | Xueling Cheng Fei Hu Qingcun Zeng | 2014 | Chinese Science Bulletin2014，59，34： | 3 |
| 6 | Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis显示文摘Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction.Studies on the therapeutic effect and mechanism of immunomodulatory drugs on the sepsis-induced hyperinflammatory or immunosuppression states of various immune cells remain limited.This study aimed to investigate the protective effects and underlying mechanism of artesunate(ART)on the splenic microenvironment of cecal ligation and puncture-induced sepsis model mice using single-cell RNA sequencing(scRNA-seq)and experimental validations.The scRNA-seq analysis revealed that ART inhibited the activation of pro-inflammatory macrophages recruited during sepsis.ART could restore neutrophils’chemotaxis and immune function in the septic spleen.It inhibited the activation of T regulatory cells but promoted the cytotoxic function of natural killer cells during sepsis.ART also promoted the differentiation and activity of splenic B cells in mice with sepsis.These results indicated that ART could alleviate the inflammatory and/or immunosuppressive states of various immune cells involved in sepsis to balance the immune homeostasis within the host.Overall,this study provided a comprehensive investigation of the regulatory effect of ART on the splenic microenvironment in sepsis,thus contributing to the application of ART as adjunctive therapy for the clinical treatment of sepsis. | Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 1 |
| 7 | High-Order Statistics of Temperature Fluctuations in an Unstable Atmospheric Surface Layer over Grassland显示文摘Skewness(S) and kurtosis(K) of temperature in the surface layer over a grassland are investigated under unstable thermal stratifications. We find that both skewness and kurtosis generally obey Monin–Obukhov similarity theory and tend to be constant values(1.5 and 5.3, respectively) when the stability parameter z/L <-2. Quantitative formulas of the similarity functions are proposed. The temperature probability density function(PDF) is close to Gaussian in near neutral stratification and non-Gaussian in unstable stratification. The influence of coherent motions on the PDF behavior is analyzed using the quadrant analysis technique. It shows that PDF behaviors are controlled by ejections and sweeps. The results also indicate that the PDF type of the ejections always follows a Gaussian distribution, while the PDF of the sweeps changes with stability. | Rui LYU Fei HU Lei LIU Jingjing XU Xueling CHENG | 2018 | Advances in Atmospheric Sciences2018，35，10： | 1 |
| 8 | The affect of a new surgical treatment to humoral immunity in preoperative period of the patients of hepatic echinococcosis 显示文摘 | Shijie Zhang Xueling Cheng Xiangwei Wu | 2004 | Immunology2004，4，20： | 1 |
| 9 | Response of Escherichia coli to hydrogen nanobubbles:an in vitro evaluation using synchrotron infrared spectroscopy显示文摘Hydrogen(H2)-rich water,an apparent source of molecular H2,is an emerging functional drink with many purported benefits for human health(Yang et al.,2020;Ostojic,2021).The preventive and therapeutic effects of H2 on various pathological processes have been intensively investigated in numerous clinical trials;it is commonly believed that the beneficial effects are mainly attributed to its selective antioxidant and antiinflammatory properties(Lee et al.,2015;Ohta,2015;LeBaron et al.,2019;Qiu et al.,2020).In recent years,a handful of rodent studies revealed that exogenous H2 can afifect the gut microbiota(Sha et al.,2018;Valdes et al.,2018). | Jinfang LU Jin ZHENG Yadi WANG Jie CHENG Xueling LI Jun HU Bin LI Junhong Lü | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 1 |
| 10 | Computer-aided detection and classification of microcalcifications in mammograms: a survey 显示文摘 | CHENG H D CAI Xiaopeng CHEN Xiaowei HU Liming LOU Xueling | 2003 | Pattern Recognition2003，36，： | 1 |
| 11 | Wind Gust and Turbulence Statistics of Typhoons in South China 显示文摘 | Wang Binglan Hu Fei Cheng Xueling | 2011 | ACTA METEOROLOGICA SINICA2011，25，： | 1 |
| 12 | Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes显示文摘Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields (up to 99%) and excellent stereoselectivities (up to 99:1 dr and 97% ee). | ZHANG Long XU Hui MI XueLing LUO SanZhong CHENG Jin-Pei | 2010 | Chinese Science Bulletin2010，55，17： | 1 |
| 13 | Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies显示文摘This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses. | Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong | 2021 | Frontiers of Medicine2021，15，1： | 0 |
| 14 | Advances in coastal ocean boundary layer detection technology and equipment in China显示文摘Accurate and comprehensive knowledge of the atmospheric environment and its evolution within the coastal ocean boundary layer are necessary for understanding the sources,chemical mechanisms,and transport processes of air pollution in land,sea,and atmosphere.We present an overview of coastal ocean boundary layer detection technology and equipment in China and summarize the progress and main achievements in recent years.China has developed a series of coastal ocean boundary layer detection technologies,including Light Detection and Ranging(LIDAR),turbulent exchange analyzer,air-sea flux analyzer,stereoscopic remote sensing of air pollutants,and oceanic aerosol detection equipment to address the technical bottleneck caused by harsh environmental conditions in coastal ocean regions.Advances in these technologies and equipment have provided scientific assistance for addressing air pollution issues and understanding land-sea-atmosphere interactions over coastal ocean regions in China.In the future,routine atmospheric observations should cover the coastal ocean boundary layer of China. | Haitao Zheng Youwen Sun Tao Luo Xueling Cheng Shiyong Shao Shouyin Zheng Bangyi Tao Bin Chen Qianguang Tu Kan Huang Bingbing Wang Mian Wang Xiaoquan Song Tianshu Zhang Yin Cheng Jianguo Liu | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 15 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 16 | LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins显示文摘Long noncoding RNAs(lncRNAs)have been widely proven to be involved in liver lipid homeostasis.Herein,we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in HepG2 cells.Knockdown of lncRP11-675F6.3 leads to a significant reduction in apolipoprotein 100(ApoB100),microsomal triglyceride transfer protein(MTTP),ApoE and ApoC3 with increased cellular triglyceride level and autophagy.Furthermore,we find that ApoB100 is obviously colocalized with GFP-LC3 in autophagosomes when lncRP11-675F6.3 is knocked down,indicating that elevated triglyceride accumulation likely related to autophagy induces the degradation of ApoB100 and impairs very low-density lipoprotein(VLDL)assembly.We then identify and validate that hexokinase 1(HK1)acts as the binding protein of lncRP11-675F6.3 and mediates triglyceride regulation and cell autophagy.More importantly,we find that lncRP11-675F6.3 and HK1 attenuate high fat diet induced nonalcoholic fatty liver disease(NAFLD)by regulating VLDL-related proteins and autophagy.In conclusion,this study reveals that lncRP11-675F6.3 is potentially involved in the downstream of mTOR signaling pathway and the regulatory network of hepatic triglyceride metabolism in cooperation with its interacting protein HK1,which may provide a new target for fatty liver disorder treatment. | Lingling Wang Xiaojuan Fang Ziyou Yang Xueling Li Mengdi Cheng Liang Cheng Ganglin Wang Wei Li Lin Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 17 | Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups显示文摘Understanding the micro-coevolution of the human gut microbiome with host genetics is challenging but essential in both evolutionary and medical studies.To gain insight into the interactions between host genetic variation and the gut microbiome,we analyzed both the human genome and gut microbiome collected from a cohort of 190 students in the same boarding college and representing 3 ethnic groups,Uyghur,Kazakh,and Han Chinese.We found that differences in gut microbiome were greater between genetically distinct ethnic groups than those genetically closely related ones in taxonomic composition,functional composition,enterotype stratification,and microbiome genetic differentiation.We also observed considerable correlations between host genetic variants and the abundance of a subset of gut microbial species.Notably,interactions between gut microbiome species and host genetic variants might have coordinated effects on specific human phenotypes.Bacteroides ovatus,previously reported to modulate intestinal immunity,is significantly correlated with the host genetic variant rs12899811(meta-P=5.55×10^(-5)),which regulates the VPS33B expression in the colon,acting as a tumor suppressor of colorectal cancer.These results advance our understanding of the micro-coevolution of the human gut microbiome and their interactive effects with host genetic variation on phenotypic diversity. | Mingyue Cheng Xueling Ge Chaofang Zhong Ruiqing Fu Kang Ning Shuhua Xu | 2021 | Journal of Genetics and Genomics2021，48，11： | 0 |
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