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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Study of latch-up immunization in bulk CMOS integrated circuits exposed to transient ionizing radiation显示文摘This paper presents experimental results of transient gamma irradiation effects on two kinds of circuits.One is a two-stage circuit consisting of a bipolar power device L7805CV and a bulk complementary metal-oxide-semiconductor(CMOS) device IDT6116,the other is a two-stage circuit consisting of a bipolar power device L7805CV and the equivalent circuit of the parasitic P-N-P-N structure in bulk CMOS devices.The results show that the L7805CV's output interruption after transient irradiation can prevent latch-up from occurring on the second stage circuit.The demanded minimum interruption duration to avoid latch-up varies with dose rate,and this is confirmed by the experimental results. | LI RuiBin CHEN Wei LIN DongSheng YANG ShanChao BAI XiaoYan WANG GuiZhen LIU Yan QI Chao MA Qiang | 2012 | Science China(Technological Sciences)2012，55，11： | 5 |
| 3 | Highly luminescent and stable lead-free cesium copper halide perovskite powders for UV-pumped phosphor-converted light-emitting diodes显示文摘Lead halide perovskites have drawn extensive attention over recent decades owing to their outstanding photo-electric performances.However,their toxicity and instability are big issues that need to be solved for further commercialization.Herein,we adopt a facile dry ball milling method to synthesize lead-free Cs3Cu2X5(X=I,CI)perovskites with photoluminescence(PL)quantum yield up to 60%.The optical features including broad emission spectrum,large Stokes shift,and long PL lifetime can be attributed to self-trapped exciton recombination.The as-synthesized blue emissive Cs3Cu2I5 and green emissive Cs3Cu2Cl5 lead-free perovskite powders have good thermal stability and photostability.Furthermore,UV-pumped phosphor-converted light-emitting diodes were obtained by using Cs3Cu2I5 and Cs3Cu2Cl5 as phosphors. | LINGLING XIE BINGKUN CHEN FA ZHANG ZHENG ZHAO XINXIN WANG LIJIE SHI YUE LIU LINGLING HUANG RUIBIN LIU BINGSUO ZOU YONGTIAN WANG | 2020 | Photonics Research2020，8，6： | 5 |
| 4 | On the Response of Subduction in the South Pacific to an Intensification of Westerlies and Heat Flux in an Eddy Permitting Ocean Model显示文摘Based on an eddy permitting ocean general circulation model, the response of water masses to two distinct climate scenarios in the South Pacific is assessed in this paper. Under annually repeating atmospheric forcing that is characterized by different westerlies and associated heat flux, the response of Subantarctic Mode Water(SAMW) and Antarctic Intermediate Water(AAIW) is quantitatively estimated. Both SAMW and AAIW are found to be warmer, saltier and denser under intensified westerlies and increased heat loss. The increase in the subduction volume of SAMW and AAIW is about 19.8 Sv(1 Sv =10~6m^3s^(-1)). The lateral induction term plays a dominant role in the changes in the subduction volume due to the deepening of the mixed layer depth(MLD). Furthermore, analysis of the buoyancy budget is used to quantitatively diagnose the reason for the changes in the MLD. The deepening of the MLD is found to be primarily caused by the strengthening of heat loss from the ocean to the atmosphere in the formation region of SAMW and AAIW. | Chengyan LIU Zhaomin WANG Bingrui LI Chen CHENG Ruibin XIA | 2017 | Advances in Atmospheric Sciences2017，34，4： | 5 |
| 5 | On the subtropical Northeast Pacific mixed layer depth and its influence on the subduction显示文摘The present climate simulations of the mixed layer depth(MLD) and the subduction rate in the subtropical Northeast Pacific are investigated based on nine of the CMIP5 models. Compared with the observation data,spatial patterns of the MLD and the subduction rate are well simulated in these models. The spatial pattern of the MLD is nonuniform, with a local maximum MLD(>140 m) region centered at(28°N, 135°W) in late winter. The nonuniform MLD pattern causes a strong MLD front on the south of the MLD maximum region, controls the lateral induction rate pattern, and then decides the nonuniform distribution of the subduction rate. Due to the inter-regional difference of the MLD, we divide this area into two regions. The relatively uniform Ekman pumping has little effect on the nonuniform subduction spatial pattern, though it is nearly equal to the lateral induction in values. In the south region, the northward warm Ekman advection(–1.75×10^(–7) K/s) controls the ocean horizontal temperature advection(–0.85×10^(–7) K/s), and prevents the deepening of the MLD. In the ensemble mean, the contribution of the ocean advection to the MLD is about –29.0 m/month, offsetting the sea surface net heat flux contribution(33.9 m/month). While in the north region, the southward cold advection deepens the MLD(21.4 m/month) as similar as the heat flux(30.4 m/month). In conclusion, the nonuniform MLD pattern is dominated by the nonuniform ocean horizontal temperature advection. This new finding indicates that the upper ocean current play an important role in the variability of the winter MLD and the subduction rate. | XIA Ruibin LIU Chengyan CHENG Chen | 2018 | Acta Oceanologica Sinica2018，37，3： | 4 |
| 6 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 7 | Closed form algorithm of double-satellite TDOA+AOA localization based on WGS-84 model显示文摘In this paper,we consider the double-satellite localization under the earth ellipsoid model of the Wideband Geodetic System(WGS-84)using the Time Difference of Arrival(TDOA)and the Angle-of-Arrival(AOA).Several closed-form solution algorithms via the pseudolinearization of the measurement equations are presented to efficiently estimate the location.These algorithms include the Weighted Least Squares(WLS),the Constrained Total Least Squares(CTLS),and the Taylor-Series Iteration(TSI).Performance comparison of the proposed methods with the Cramér-Rao Lower Bound(CRLB)in the simulation is shown to demonstrate that the proposed algorithms are feasible and have stable performance. | Wanchun LI Ruibin CHEN Yuning GUO Caixia FU | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 8 | Response of the mixed layer depth and subduction rate in the subtropical Northeast Pacific to global warming显示文摘The response of the mixed layer depth(MLD)and subduction rate in the subtropical Northeast Pacific to global warming is investigated based on 9 CMIP5 models.Compared with the present climate in the 9 models,the response of the MLD in the subtropical Northeast Pacific to the increased radiation forcing is spatially nonuniform,with the maximum shoaling about 50 m in the ensemble mean result.The inter-model differences of MLD change are non-negligible,which depend on the various dominated mechanisms.On the north of the MLD front,MLD shallows largely and is influenced by Ekman pumping,heat flux,and upper-ocean cold advection changes.On the south of the MLD front,MLD changes a little in the warmer climate,which is mainly due to the upper-ocean warm advection change.As a result,the MLD front intensity weakens obviously from 0.24 m/km to0.15 m/km(about 33.9%)in the ensemble mean,not only due to the maximum of MLD shoaling but also dependent on the MLD non-uniform spatial variability.The spatially non-uniform decrease of the subduction rate is primarily dominated by the lateral induction reduction(about 85%in ensemble mean)due to the significant weakening of the MLD front.This research indicates that the ocean advection change impacts the MLD spatially non-uniform change greatly,and then plays an important role in the response of the MLD front and the subduction process to global warming. | Ruibin Xia Bingrui Li Chen Cheng | 2021 | Acta Oceanologica Sinica2021，40，4： | 2 |
| 9 | Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells显示文摘Dear Editor,Newly engineered tissues often fail to function due to insufficient blood vessels formation.Autologous vascular endothelial cells are ideal sources for tissue engineering but are often of limited availability.We first identified that transcriptional factor Etv2(ets variant 2,initially named as Etsrp)was specifically expressed in the zebrafish vascular endothelial cells and was required for vascular development in zebrafish(Sumanas and Lin,2006). | Guanrong Yan Ruibin Yan Cheng Chen Yanqiu Zhao Wei Qin Matthew B.Veldman Song Li Shuo Lin | 2019 | Protein & Cell2019，10，3： | 2 |
| 10 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 11 | Transcatheter Closure of Perimembranous Ventricular Septal Defect Using a Modified Double-Disk Occluder显示文摘 | Yongwen Qin Jinming Chen Xianxian Zhao Dening Liao Ruibin Mu Shengqiang Wang Hong Wu Haoxue Guo | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 12 | Transcatheter Closure of Perimembranous Ventricular Septal Defect Using a Modified Double-Disk Occluder显示文摘 | Yongwen Qin Jinming Chen Xianxian Zhao Dening Liao Ruibin Mu Shengqiang Wang Hong Wu Haoxue Guo | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 13 | Clubroot resistance introgression in interspecific hybrids between Raphanus sativus and Brassica napus显示文摘Clubroot is a prevailing soil-borne disease affecting rapeseed production worldwide.However,few clubroot resistant rapeseed accessions were available for breeding.Identification and introgression of new clubroot resistant genes from closely related species by distant hybridization is an effective strategy.In the present study,9 radish(Raphanus sativus L.,2n=18,RR)lines resistant to Plasmodiophora brassicae pathotype 4 were used as donors to transfer clubroot resistance into a susceptible rapeseed(Brassica napus L.,2n=38,AACC)line by distant hybridization combined with embryo rescue.Nine intergeneric crosses were made but only 1(411×93039)produced F1 plants both from embryo rescue and natural seed-setting.Authenticity of triploid F1 hybrids(2n=28,ACR)were verified by flower color,cytological observation and molecular marker analysis,and 2 genuine F1 hybrids were identified.After chromosome doubling,these synthetic allohexaploid plants(2n=56,AACCRR)became partially fertile(pollen viability rate=35%)and were backcrossed with rapeseed parent to generate a BC1 population(2n=47,AACCR).Totally 178 BC1 plants were obtained,of which the majority(96.1%)were resistant to clubroot.These backcrossing progenies could be used for the breeding of new rapeseed varieties resistant to clubroot. | Xiuzhen Wang Lingyi Zeng Li Xu Wang Chen Fan Liu Huan Yang Peng Chi Li Ren Ruibin Yan Guangyuan Lu Xiaoping Fang | 2019 | Oil Crop Science2019，4，3： | 0 |
| 14 | Approaches to Nanoparticle Labeling:A Review of Fluorescent,Radiological,and Metallic Techniques显示文摘Nanomaterials are widely used in commercial products,resulting in the release of nanoscale particles into the environment.This raises concerns about their potential exposure risks in complex biological matrices.Most attempts use engineered nanomaterials(ENMs)to mimic the biological behavior of nanoparticles in the environment,and labeling of ENMs by sensors is a commonly used approach for sensitive detection and tracking of ENMs in organisms.However,due to the distinct physicochemical properties of nanoparticles,different labeling approaches have been developed,each with varying applicability.In this Review,we summarize the three main types of labeling methods used for nanoparticles:fluorescent,radiological,and metallic labeling.We discuss their labeling mechanisms,efficiency,stability,target nanoparticles,and applicability in different organism models.Finally,we propose a labeling scheme for specific nanoparticles.Overall,this Review provides a comprehensive overview of the advances in nanoparticle labeling techniques and their potential applications in environmental and health studies. | Huilin Chen Qingyuan Hu Wenjie Li Xiaoming Cai Liang Mao Ruibin Li | 2023 | Environment & Health2023，1，2： | 0 |
| 15 | Positional cloning and characterization reveal the role of a miRNA precursor gene ZmLRT in the regulation of lateral root number and drought tolerance in maize显示文摘Lateral roots play essential roles in drought tolerance in maize(Zea mays L.). However, the genetic basis for the variation in the number of lateral roots in maize remains elusive. Here, we identified a major quantitative trait locus(QTL),q LRT5-1, controlling lateral root number using a recombinant inbred population from a cross between the maize lines Zong3(with many lateral roots) and 87-1(with few lateral roots).Fine-mapping and functional analysis determined that the candidate gene for qLRT5-1,ZmLRT, expresses the primary transcript for the microRNA miR166a. ZmLRT was highly expressed in root tips and lateral root primordia,and knockout and overexpression of ZmLRT increased and decreased lateral root number,respectively. Compared with 87-1, the ZmLRT gene model of Zong3 lacked the second and third exons and contained a 14 bp deletion at the junction between the first exon and intron,which altered the splicing site. In addition,ZmLRT expression was significantly lower in Zong3 than in 87-1, which might be attributed to the insertions of a transposon and over large DNA fragments in the Zong3 ZmLRT promoter region. These mutations decreased the abundance of mature miR166a in Zong3, resulting in increased lateral roots at the seedling stage.Furthermore, miR166a post-transcriptionally repressed five development-related class-Ⅲ homeodomain-leucine zipper genes. Moreover,knockout of ZmLRT enhanced drought tolerance of maize seedlings. Our study furthers our understanding of the genetic basis of lateral root number variation in maize and highlights ZmLRT as a target for improving drought tolerance in maize. | Ming Zhang Yanhong Chen Hongyan Xing Wensheng Ke Yunlu Shi Zhipeng Sui Ruibin Xu Lulu Gao Ganggang Guo Jiansheng Li Jiewen Xing Yirong Zhang | 2023 | Journal of Integrative Plant Biology2023，65，3： | 0 |
| 16 | Cipherchain:A Secure and Efficient Ciphertext Blockchain via mPECK显示文摘Most existing blockchain schemes are based on the design concept“openness and transparency”to realize data security,which usually require transaction data to be presented in the form of plaintext.However,it inevitably brings the issues with respect to data privacy and operating performance.In this paper,we proposed a novel blockchain scheme called Cipherchain,which can process and maintain transaction data in the form of ciphertext while the characteristics of immutability and auditability are guaranteed.Specifically in our scheme,transactions can be encrypted locally based on a searchable encryption scheme called multi-user public key encryption with conjunctive keyword search(mPECK),and can be accessed by multiple specific participants after appended to the globally consistent distributed ledger.By introducing execution-consensus-update paradigm of transaction flow,Cipherchain cannot only make it possible for transaction data to exist in the form of ciphertext,but also guarantee the overall system performance not greatly affected by cryptographic operations and other local execution work.In addition,Cipherchain is a promising scheme to realize the technology combination of“blockchain+cloud computing”and“permissioned blockchain+public blockchain”. | Hailin Chen Gang Xu Yuling Chen Xiubo Chen Yixian Yang Ruibin Fan Kaixiang Zhang Huizhong Li | 2020 | Journal of Quantum Computing2020，2，1： | 0 |
| 17 | A Gel-Based Solidification Technology for Large Fracture Plugging显示文摘Fault fractures usually have large openings and considerable extension. Accordingly, cross-linked gel materials aregenerally considered more suitable plugging agents than water-based gels because the latter often undergo contaminationvia formation water, which prevents them from being effective over long times. Hence, in this study, aset of oil-based composite gels based on waste grease and epoxy resin has been developed. These materials havebeen observed to possess high compressive strength and resistance to the aforementioned contamination, therebyleading to notable increase in plugging success rate. The compressive strength, thickening time, and resistance toformation water pollution of these gels have been evaluated indoors. The results show that the compressivestrength of the gel can reach 11 MPa;additionally, the related gelation time can be controlled to be more than3 h, thereby providing a safe construction time;Invasion of formation water has a small effect on the gel strengthand does not shorten the thickening time. All considered performance indicators of the oil-based gel confirm itssuitability as a plugging agent for fault fractures. | Kunjian Wang Ruibin He Qianhua Liao Kun Xu Wen Wang Kan Chen | 2024 | Fluid Dynamics & Materials Processing2024，20，3： | 0 |
| 18 | COMPOSITIVE EMISSION CONTROL SYSTEM OF GASOLINE VEHICLE显示文摘一种综合排放控制系统的工作原则被调查,它包括用尽加热器,第二等的空气补充,用尽煤气的再通行(EGR ) ,热反应器和触媒转化器,等等。汽油火花的公司, HC 和 NO_xemission 的纯化效果点火(S.I ) 引擎被学习。基于国家排放标准驾驶周期测试的全部车辆并且一系列包括完整的负担特征实验,负担特征实验和闲散速度的汽油发动机严峻凳子测试试验被做。结果证明系统有很好的排放控制效果到汽油引擎的公司, HC 和 NO_x。系统的构造很简单并且能是装的在没有车辆使用汽油引擎的任何改变,方便地用尽管子。 | CAI Ruibin CHEN Zijian | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 0 |
| 19 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfs96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
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