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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Improvement of Heating Method for Measuring the Wetness of Flowing Wet Steam显示文摘In this paper, an improvement of heating method for measuring wetness of the flowing wet steam is developed, the basic principle of the heating method is presented and the mathematical model has been built for analyzing the thermodynamics problezns during the process of heating. Moreover, an instru-ment for measuring wetness of wet steam flow was designed and made out. This instrument has been used for measuring wetness of the wet steam flow at the outlet of the nozzle rig in Thermal TUrbine Laboratory Xi’an Jiaotong University. By analyzing the relative error of the result, it was found that this instrument has fairly high accuracy it can be used as the prototype of practical instrument and has an important applicable value in engineering. | Li YanFeng Wang XinJun Xu TingXiang(School of Energy and Power Engineering, Xi’an Jiaotong University Xi’an, Shed, 710049, China) | 1998 | Journal of Thermal Science1998，7，3： | 3 |
| 3 | Factors affecting the superconductivity in the process of depositing Nd_(1.85)Ce_(0.15)CuO_(4-δ)by the pulsed electron deposition technique显示文摘On SrTiO3 single crystal substrate,by using the pulsed electron deposition tech-nique,the high-quality electron doped Nd1.85Ce0.15CuO4?δ superconducting film was successfully fabricated. After careful study on the R-T curves of the obtained sam-ples deposited with different substrate temperatures,thicknesses,annealing methods and pulse frequencies,the effects of them on the superconductivity of the films were found,and the reasons were also analyzed. Additionally,by using the same model of the pulsed laser deposition technique,the relation between the target-to-substrate distance and the deposition pressure was drawn out as a quantitative one. | GUO YanFeng CHEN LeiMing GUO Xi LI PeiGang LEI Ming TANG WeiHua | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，6： | 1 |
| 4 | Dual non-diffractive terahertz beam generators based on all-dielectric metasurface显示文摘The applications of terahertz(THz)technology can be greatly extended using non-diffractive beams with unique field distributions and non-diffiactive transmission characteristics.Here,we design and experimentally demonstrate a set of dual non-diffractive THz beam generators based on an all-dielectric metasurface.Two kinds of non-diffractive beams with dramatically opposite focusing properties,Bessel beam and abruptly autofocus-ing(AAF)beam,are considered.A Bessel beam with longdistance non-diffractive characteristics and an AAF beam with low energy during transmission and abruptly increased energy near the focus are generated for x-and^-polarized incident waves,respectively.These two kinds of beams are characterized and the results agree well with simulations.In addition,we show numerically that these two kinds of beams can also carry orbital angular momentum by further imposing proper angular phases in the design.We believe that these metasurface-based beam generators have great potential use in THz imaging,communications,non-destructive evaluation,and many other fields. | Chunyu LIU Yanfeng LI Xi FENG Xixiang ZHANG Jiaguang HAN Weili ZHANG | 2021 | Frontiers of Optoelectronics2021，14，2： | 1 |
| 5 | 优子时尚狂本月的主题:假睫毛让双眸变得更迷人显示文摘一直走在时尚前沿的优子,
这次亲身体验假睫毛!
让我们随优子一起,
看看还有哪些好玩的东西! | Yuji Okura(摄影) Xi Yanfeng(翻译) | 2006 | 国际服装技术2006，，4： | 0 |
| 6 | 知性又兼具可爱!千吉良惠子的风格 平衡彩妆显示文摘这个秋季化妆的趋势有着略微的变化 ,可爱与酷感并存的化妆,富有平衡感的新妆容受到欢迎,如此让人注目的秋季妆容,千吉良惠子小姐将一一公开! | Mie Kawamura Xi Yanfeng(翻译) | 2007 | 国际服装技术2007，，9： | 0 |
| 7 | 拥有了它就能变得“靓丽可爱”——绝妙的流行单品大公开!!显示文摘时髦睿智“靓丽可爱女孩”会选择适合自身的流行款式。快来看看经过改良的今年特别流行的6种主打单品! | Tatsuo Moriyama(摄影) Tatsuhisa Yogi(摄影) Ayako Yonaga Xi YanFeng(翻译) | 2006 | 国际服装技术2006，，6： | 0 |
| 8 | Benefit-based cost allocation for residentially distributed photovoltaic systems in China:A cooperative game theory approach显示文摘Distributed photovoltaic(PV)systems have constantly been the key to achieve a low-carbon economy in China.However,the development of Chinese distributed PV systems has failed to meet expectations because of their irrational profit and cost allocations.In this study,the methodology for calculating the levelized cost of energy(LCOE)for PV is thoroughly discussed to address this issue.A mixed-integer linear programming model is built to determine the optimal system operation strategy with a benefit analysis.An externality-corrected mathematical model based on Shapley value is established to allocate the cost of distributed PV systems in 15 Chinese cities between the government,utility grid and residents.Results show that(i)an inverse relationship exists between the LCOEs and solar radiation levels;(ii)the government and residents gain extra benefits from the utility grid through net metering policies,and the utility grid should be the highly subsidized participant;(iii)the percentage of cost assigned to the utility grid and government should increase with the expansion of battery bank to weaken the impact of demand response on increasing theoretical subsidies;and(iv)apart from the LCOE,the local residential electricity prices remarkably impact the subsidy calculation results. | Xi LUO Xiaojun LIU Yanfeng LIU Jiaping LIU Yaxing WANG | 2021 | Frontiers of Engineering Management2021，8，2： | 0 |
| 9 | 3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing显示文摘Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted drugs.To address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of cells.The GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 model.Immunofluorescence analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the model.Compared with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and genes.Moreover,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three models.In addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude mice.Immunohistochemical evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was higher.This research therefore acts as a foundation for the application of 3DP-7721 models in drug development research. | Xiaoyuan Wang Zixian Liu Qianqian Duan Boye Zhang Yanyan Cao Zhizhong Shen Meng Li Yanfeng Xi Jianming Wang Shengbo Sang | 2024 | Bio-Design and Manufacturing2024，7，2： | 0 |
| 10 | Lynch syndrome pre-screening and comprehensive characterization in a multi-center large cohort of Chinese patients with colorectal cancer显示文摘Objective:Lynch syndrome(LS)pre-screening methods remain under-investigated in colorectal cancers(CRCs)in Asia.Here,we aimed to systematically investigate LS pre-screening and comprehensively characterize LS CRCs.Methods:Microsatellite instability(MSI)and germline variants of DNA mismatch repair(MMR)genes were examined in 406 deficient MMR(dMMR)and 250 proficient MMR CRCs.The genetic differences between LS and sporadic CRCs were studied with whole exome sequencing analysis.Results:The incidence of dMMR in Chinese patients with CRCs was 13.8%.Consistency analysis between MMR immunohistochemistry(IHC)and MSI testing showed the kappa value was 0.758.With next-generation sequencing(NGS),germline variants were detected in 154 CRCs.Finally,88 patients with CRC were identified as having LS by Sanger sequencing.Among them,we discovered 21 previously unreported pathogenic germline variants of MMR genes.Chinese patients with LS,compared with sporadic CRCs,tended to be early-onset,right-sided,early-stage and mucinous.Overall,the performance of MMR IHC and MSI testing for LS pre-screening was comparable:the area under the ROC curve for dMMR,MSI-H,and MSI-H/L was 0.725,0.750,and 0.745,respectively.dMMR_MSI-H LS and sporadic CRCs showed substantial differences in somatic genetic characteristics,including different variant frequencies of APC,CREBBP,and KRAS,as well as different enriched pathways of VEGF,Notch,TGFβR,mTOR,ErbB,and Rac protein signal transduction.Conclusions:MMR IHC and MSI testing were effective methods for LS pre-screening.The revealed clinical and somatic genetic characteristics in LS CRCs may have the potential to improve the performance of LS pre-screening in combination with dMMR/MSI. | Yan Li Lihong Fan Jianming Zheng Xiu Nie Yu Sun Qin Feng Shenyi Lian Wenqi Bai Weijing Cai Yanan Yang Bo Su Yanfeng Xi Dongmei Lin | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 11 | 人见人爱GIRL高雅配色新法则显示文摘在办公室提升个人好感度、人见人爱的颜色组合是本次的主题SHIHO十分中意今冬流行的绿色和粉色相互搭配。办公室造型还是以协调的颜色为根本,以打造可爱风格为目标。运用优雅浓郁的颜色,让心情也变得暧和起来。 | Kaz Ogawa(model)(摄影) Yoshihito Ishizawa(still)(摄影) Ayako Yonaga Xi Yanfeng(翻译) | 2006 | 国际服装技术2006，，2： | 0 |
| 12 | FIND UPI显示文摘奢华的CELINE购物包让人过目不忘,流行的颜色加上新颖的设计塑料女鞋受人瞩目,今年夏天的LALTRAMODA刮起紫色旋风,顶级的高中蕾丝为手腕处带来华贵的性感, Van Cillf & Arpels 诞生100周年最新作品闪亮登场,穿上沙滩鞋一起感受世界杯的热浪,LOEWE的新作清新自然&惹人喜爱, | Tsuyoshi Ogawa(摄影) Miasako kondo Xi Yanfeng(翻译) | 2006 | 国际服装技术2006，，7： | 0 |
| 13 | “小玩意的璀璨华彩”最新流行饰品让你绽放时髦光芒显示文摘终于到了可以尽情享受夏日风情的季节了!如能拥有令人向往的闪耀饰品或是那些极受人喜爱的流行饰品,那么任何装扮都能呈现出高雅魅力!赶快跟着LUCi,一起去CHECK吧! | John Chan(摄影) Shoko Shibusawa Xi Yanfeng(翻译) | 2006 | 国际服装技术2006，，7： | 0 |
| 14 | Conceptualizing and Measuring Global Justice:Theories,Concepts,Principles and Indicators显示文摘The paper focuses on the conceptualization and measurement of global justice and discusses theories,concepts,evaluative principles,and methodologies related to the study of global justice.In this paper,we seek to clarify how to conceptualize global justice,how conceptual indicators can be selected and justified by theories,and how those indicators can be conceptually consistent with the concept of global justice.Global justice is a broad concept that is composed of multi-level and multidimensional aspects belonging to both normative and empirical realities.A coherent and integrated theoretical framework that covers the normative basis and various empirical dimensions is therefore much needed in order to address some of the basic and important questions under study.The paper seeks to synthesize the multiple theories and conceptions of global justice that exist in the academic discourse and literature into three main theoretical approaches to global justice-rights based,good based,and virtue based.These three approaches are a good sample of and reflect well the strengths of the different theoretical,intellectual and cultural traditions at play in the study of global justice.From this perspective,the synthesis of the three approaches is meant to provide us with a coherent theoretical framework that serves as the normative basis and justifies the selection of indicators for measurement. | Sujian Guo Xi Lin Jean-Marc Coicaud Su Gu Yanfeng Gu Qingping Liu Xuan Qin Guodong Sun Zhongyuan Wang Chunman Zhang | 2019 | Fudan Journal of the Humanities and Social Sciences2019，12，4： | 0 |
| 15 | Timetabling optimization of classrooms and self-study rooms in university teaching buildings based on the building controls virtual test bed platform considering energy efficiency显示文摘The energy consumption of a teaching building can be effectively reduced by timetable optimization.However,in most studies that explore methods to reduce building energy consumption by course timetable optimization,self-study activities are not considered.In this study,an MATLAB-EnergyPlus joint simulation model was constructed based on the Building Controls Virtual Test Bed platform to reduce building energy consumption by optimizing the course schedule and opening strategy of self-study rooms in a holistic way.The following results were obtained by taking a university in Xi’an as an example:(1)The energy saving percentages obtained by timetabling optimization during the heating season examination week,heating season non-examination week,cooling season examination week,and cooling season non-examination week are 35%,29.4%,13.4%,and 13.4%,respectively.(2)Regarding the temporal arrangement,most courses are scheduled in the morning during the cooling season and afternoon during the heating season.Regarding the spatial arrangement,most courses are arranged in the central section of the middle floors of the building.(3)During the heating season,the additional building energy consumption incurred by the opening of self-study rooms decreases when duty heating temperature increases. | Yanfeng Liu Hui Ming Xi Luo Liang Hu Yongkai Sun | 2023 | Building Simulation2023，16，2： | 0 |
| 16 | Multi-objective optimization of equipment capacity and heating network design for a centralized solar district heating system显示文摘Northwest China has abundant solar energy resources and a large demand for winter heating.Using solar energy for centralized heating is a clean and effective way to solve local heating problems.While present studies usually decoupled solar heating stations and the heating network in the optimization design of centralized solar heating systems,this study developed a joint multi-objective optimization model for the equipment capacity and the diameters of the heating network pipes of a centralized solar district heating system,using minimum total life cycle cost and CO_(2)emission of the system as the optimization objectives.Three typical cities in northwest China with different solar resource conditions(Lhasa,Xining,and Xi'an)were selected as cases for analysis.According to the results,the solar heating system designed using the method proposed in this study presents lower economic cost and higher environmental protection in comparison to separately optimizing the design of the solar heating station and the heating network.Furthermore,the solar fraction of the optimal systems are 90%,70%,and 31%for Lhasa,Xining,and Xi'an,and the minimum water supply temperatures are 55℃,50℃,and 65℃for an optimal economy and 55℃,45℃,and 45℃for optimal environmental protection,respectively.It was also established that the solar collector price has a greater impact on the equipment capacity of the solar heating station than the gas boiler price. | Yanfeng Liu Ting Mu Xi Luo | 2023 | Building Simulation2023，16，1： | 0 |
| 17 | Halogen-doped phosphorescent carbon dots for grayscale patterning显示文摘Flexible organic materials that exhibit dynamic ultralong room temperature phosphorescence(DURTP)via photoactivation have attracted increasing research interest for their fascinating functions of reversibly writing-reading-erasing graphic information in the form of a long afterglow.However,due to the existence of a nonnegligible activation threshold for the initial exposure dose,the display mode of these materials has thus far been limited to binary patterns.By resorting to halogen element doping of carbon dots(CDs)to enhance intersystem crossing and reduce the activation threshold,we were able to produce,for the first time,a transparent,flexible,and fully programmable DURTP composite film with a reliable grayscale display capacity.Examples of promising applications in UV photography and highly confidential steganography were constructed,partially demonstrating the broad future applications of this material as a programmable platform with a high optical information density. | Yanfeng Liu Mahmoud Al-salihi Yong Guo Roman Ziniuk Songtao Cai Luwei Wang Yuan Li Zhigang Yang Dengfeng Peng Kai Xi Zhongfu An Xudong Jia Liwei Liu Wei Yan Junle Qu | 2022 | Light(Science & Applications)2022，11，7： | 0 |
| 18 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsu5wk959pv5xx6qn6.ffgz.tsg.suse.edu.cn/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
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