| 1 | Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer显示文摘Claudin 18.2(CLDN18.2)is a tight-junction protein.CLDN18.2-targeting strategy has cut a striking figure in CLDN18.2 positive patients with advanced gastric cancer.Zolbetuximab,the CLDN18.2 antibody,obtained a better clinical benefit in patients compared with the controlled.In phase II trials,combination treatment of epirubicin,oxaliplatin and capecitabine(EOX)+zolbetuximab achieved the optimal effects of overall survival which extended to 13.2 months with tolerable safety events,indicating its greater potential playing the second promising target in gastric cancer.This review will reveal the definitive clinical benefit CLDN18.2-targeting therapies have achieved and update the highlighting development(like chimeric antigen receptor T-cell immunotherapy)to CLDN18.2 positive patients.We then focus on 10 questions arisen from recent progress and anticipate to provide a future perspective for novel cancer treatment. | Jianwei Zhang Ruilan Dong Lin Shen | 2020 | Chinese Journal of Cancer Research2020，32，2： | 13 |
| 2 | LONG-TERM EFFECTS OF THE GEZHOUBA PROJECT ON FLOOD PROPAGATION IN THE YANGTZE RIVER显示文摘Based on hydrographs of '81.7'flood and topographies of 1980 and 1993, a 1-D mathematical model of flood is developed to study the effects of the Gezhouba Project on flood propagation along the Yichang-Jianli river reaches in the Yangtze River. Calculations and analysis show that, after 13 years’ operation of the Gezhouba Project, the flood peak stages have been lowered, the flood curves of stage-discharge relationship have been moved, however, the effects on the flood discharges and storages can be neglected relatively. | Yaohua DONG 1and Ruilan YIN2 1 Senior engineer ,Yangtze River Scientific Research Institute (YRSRD, Wuhan 430010, P.R.China. 2 Professor-senior engineer, Yangtze River Scientific Research Institute (YRSRI). | 2001 | International Journal of Sediment Research2001，16，2： | 1 |
| 3 | Correlation between clinical course and radiographic development on CT scan in patients with COVID-19显示文摘Background:To analyze the correlation between clinical course and radiographic development on computed tomography(CT)in patients with confirmed coronavirus disease 2019(COVID-19)and to provide more evidence for treatment.Methods:This retrospective,observational,cohort study enrolled 49 patients with Reverse transcription-polymerase chain reaction(RT-PCR)-confirmed COVID-19,which included 30 patients admitted to the intensive care unit(ICU)of Wuhan Third Hospital and 19 patients either admitted to or receiving telemedicine consultation from Shanghai General Hospital,Shanghai Xuhui Dahua Hospital,and hospitals in other provinces.CT scans were performed in all enrolled patients and the radiographic features including simple ground-glass opacities(GGOs),GGO with interlobular septal thickening,consolidations with GGO,and consolidations only were monitored by repeating the CT.The progression of these radiographic features was analyzed in combination with their clinical staging and the time interval between onset of symptoms to CT.Results:Based on illness severity,the 49 patients were classified into four stages:mild(n=6),moderate(n=12),severe(n=16),and critically ill(n=15).The CT findings were classified into three phases:early(n=5),progres-sion(n=39),and recovery(n=5).Among the 49 patients,9 had bilateral diffuse GGO or diffuse consolidations(white lungs)and were counted as 18 lesions.Three patients had no abnormal findings on initial CT,but their repeat CT showed new lesions.In all,we identified 892 lesions including simple GGO,GGO with interlobular septal thickening,consolidations with GGO,and consolidations only.Conclusions:Most patients had pulmonary lesions on the posterior,inferior,and peripheral lung fields on CT.The development of GGO with interlobular septal thickening,GGO with consolidations,and consolidations only happened mainly between day 8 and 14.The emergence of consolidations may suggest the progression to the severe phase of the illness,whereas simple consolidations or“white lung”may suggest a critically ill phase. | Yun Xie Luyu Yang Hui Dong Song Cao Wenkai Zhang Qiong Chen Baoliang Jin Zhiguo Zhou Jun Liu Zhiyan He Ruilan Wang | 2021 | Journal of Intensive Medicine2021，1，1： | 0 |
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