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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 3 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 4 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 5 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 6 | Inducible nitric oxide synthase,nitrotyrosine,and apoptosis in Helicobacter pylori gastritis:effect of antibiotics and antioxidants 显示文摘 | Mannick EE Bravo LE Zarama G Realpe JL Zhang XJ Ruiz B Eonthan ETH Mera R Miller MJL Correa P | 1996 | Cancer Res1996，56，： | 1 |
| 7 | Rate effect on the mechanical properties of eight types of high strength concrete and comparison with FIB MC2010 显示文摘 | ZHANG X RUIZ G YU R C POVEDA E PORRAS R | 2012 | Construction and Building Materials2012，30，： | 1 |
| 8 | Connective tissue growth factor is a biomarker and mediator ofkidney allograft fibrosis显示文摘 | Cheng O Thuillier R Sampson E Schultz G Ruiz P Zhang X etal | 2006 | Am J Transplant2006，406，： | 1 |
| 9 | Comparison of Inoue single-ballon versus double-balloon technique for peroutaneous mitral valvotomy显示文摘 | Zhang HP Macaya C | 1992 | Am Heart J1992，123，： | 1 |
| 10 | Late clinical and echocardiographic follow up after percutaneous balloon dilatation of the mitral valve显示文摘 | Ruiz CE Zhang HP Gamra H | 1994 | Br Heart J1994，71，5： | 1 |
| 11 | Sa1721 Conventional Narrow Band Imaging for the Improved Detection of Gastritis显示文摘 | Kunal Dalal Xuefeng Zhang Mariano Gonzalez-Haba Ruiz Maria Westerhoff K.G. Reddy John Hart Vani J. Konda | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 12 | Resistive-type superconducting faultcurrent limiters : concepts,mterials,and nmerical mdeling 显示文摘 | Ruiz H S Zhang X Coombs T A | 2015 | IEEETransactions on Applied Superconductivity2015，25，3： | 1 |
| 13 | Resistive-Type Superconducting Fault Current Limiters:Concepts,Materials,and Numerical Modeling显示文摘 | RUIZ H S ZHANG X COOMBS T A | 2015 | IEEE Transactions on Applied Superconductivity2015，25，3： | 1 |
| 14 | Ultra-wideband LTCC ridge waveguide filters 显示文摘 | RUIZ C ZHANG J ZAKI Y | 2007 | IEEE Microwave and Wireless Compo- nents Letters2007，17，2： | 1 |
| 15 | A novel method for treatment of abdominal aortic aneurysms using percutaneous implantation of a newly designed endovascular device显示文摘 | RUIZ C E ZHANG H P DOUGLAS J T | 1995 | Circulation1995，91，9： | 1 |
| 16 | Percutaneous treatment of abdominal aortic aneurysm in a swine model:understanding the behavior of aortic ane urysm closure through a serial histopathological analysis显示文摘 | RUIZ C E ZHANG H P BUTT A I | | Circulation0，96，7： | 1 |
| 17 | Late clinical and echocardiographic follow up after percutaneous balloon dilatation of the mitral valve 显示文摘 | Ruiz CE Zhang HP Gamera H | 1994 | Br Heart J1994，71，： | 1 |
| 18 | Percutancous treatment of ab-dominal aortic aneurysm in a swine model: understanding the behav-ior of aortic aneurysm closure through a serial histopathological anal-ysis显示文摘 | Ruiz CE Zhang HP Butt AI | 1997 | Circulation1997，96，： | 1 |
| 19 | Oxidative stress in cyanobac- teria 显示文摘 | Latifi A Ruiz M Zhang C C | 2009 | FEMS Microbiology Reviews2009，33，2： | 1 |
| 20 | Influence of the loading rate on the measurement of the fracture energy of a high strength concrete显示文摘 | RUIZ G ZHANG Xiao-xin DEL VISO J R | 2008 | Anales de Mecdnica de la Fractura2008，25，： | 1 |
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