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| 1 | Silver nanocrystals sensitize magnetic-nanoparticle-mediated thermo-induced killing of cancer cells显示文摘磁性的 nanoparticles (MNP ) 能加热肿瘤纸巾起来并且导致在外部交流磁场下面癌症房间杀死。然而,磁性的 nanoparticles 过高热(MNPH ) 要求被注入肿瘤以便因为复杂的热转移,在 vivo 和 MNP 的有限的热质量获得临床上需要的热剂量的 MNP 的高集中。为了切,击倒 MNP 的剂量并且提高这 Nanotherapy 的效果,我们与不同尺寸准备了银 nanoparticles (AgNPs ) 并且在 MNPH 治疗在癌症房间上调查了这些 AgNPs 的效果。AgNPs 能提高 glioma 房间的 thermo 敏感,这效果是尺寸依赖者,这被发现。AgNPs 能导致在 G2/M 阶段逮捕并且在过高热以后提高了癌症房间的 apoptosis 率的房间周期。在适用的老鼠建模的 glioma,与 AgNPs 相结合的 MNPH 能在癌症房间提高 Bax 表示。我们的结果建议 AgNPs 能是潜在的 thermo 敏化并且能进一步为 MNPH 治疗为 Ag 基于 nanostructure 的热种子的设计被开发。 | Lianke Liu Fang Ni Jianchao Zhang Xiaoli Jiang Xiang Lu Zhirui Guo Ruizhi Xu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 4 |
| 2 | Reducing maize yield gap by matching plant density and solar radiation显示文摘Yield gap exists because the current attained actual grain yield cannot yet achieve the estimated yield potential. Chinese high yield maize belt has a wide span from east to west which results in different solar radiations between different regions and thus different grain yields. We used multi-site experimental data, surveyed farmer yield data, the highest recorded yield data in the literatures, and simulations with Hybrid-Maize Model to assess the yield gap and tried to reduce the yield gap by matching the solar radiation and plant density. The maize belt was divided into five regions from east to west according to distribution of accumulated solar radiation. The results showed that there were more than 5.8 Mg ha^(–1) yield gaps between surveyed farmer yield and the yield potential in different regions of China from east to west, which just achieved less than 65% of the yield potential. By analyzing the multi-site density experimental data, we found that the accumulated solar radiation was significantly correlated to optimum plant density which is the density with the highest yield in the multi-site density experiment(y=0.09895 x–32.49, P<0.01), according to which the optimum plant densities in different regions from east to west were calculated. It showed that the optimum plant density could be increased by 60.0, 55.2, 47.3, 84.8, and 59.6% compared to the actual density, the grain yield could be increased by 20.2, 18.3, 10.9, 18.1, and 15.3% through increasing plant density, which could reduce the yield gaps of 33.7, 23.0, 13.4, 17.3, and 10.4% in R(region)-1, R-2, R-3, R-4, and R-5, respectively. This study indicates that matching maize plant density and solar radiation is an effective approach to reduce yield gaps in different regions of China. | LIU Guang-zhou LIU Wan-mao HOU Peng MING Bo YANG Yun-shan GUO Xiao-xia XIE Ruizhi WANG Ke-ru LI Shao-kun | 2021 | Journal of Integrative Agriculture2021，20，2： | 2 |
| 3 | Kernel position effects of grain morphological characteristics by X-ray micro-computed tomography (μCT)显示文摘Grain size and shape are important factors for yield and quality.The difference in grain phenotypic characteristics in the same maize hybrid is related to its position in the ear.This study aimed to clarify the distribution characteristics of grain morphological characteristics in the ear and to provide guidance for research of grain phenotype and kernel position effects.Three maize hybrids were used in the experiment,namely,Denghai 618(DH618),KX3564,and Xianyu 335(XY335),and the kernel number per row were 40,40,and 36,respectively.The X-rayμCT was applied to obtain five kernel morphological indicators,including grain length,width,thickness,volume,surface area.Grain sphericity,length-width ratio,specific surface area,and volume coefficient were further calculated.The results showed that there were three types of maize ear morphological indicators trends:grain length,width,volume,and surface area were parabolic;thickness and sphericity were inverted parabolic;length-to-width ratio and specific surface area were irregular.The volume coefficient of grain at different parts of the ear,namely the relation coefficient between grain volume and grain length,width,and thickness,was determined.The average value of the middle grains morphological indicators of the ear was taken to select kernels representing stable characteristics of the variety.Within the range of 5%deviation from the morphological mean value of the middle grains of the ear,the grains in the middle part accounted for 26.39%of the total ear,about 10 grains extending from the 14th grain at the base of the ear to the top.Within the range of 10%deviation,the middle accounted for 47.22%,about 18 grains extending from the 12th grain at the base of the ear to the top.This study found that grain morphological indicators were greatly different at different positions of the maize ear,and showed different change rules as extend from the base to the top of the ear.Therefore,there were different grain volume coefficients at different positions of maize ear.And the representative sampling range on maize ear was determined based on the comprehensive analysis of different morphological indexes variation of grain. | Xuebo Yin Junfeng Hou Bo Ming Ying Zhang Xinyu Guo Shang Gao Keru Wang Peng Hou Shaokun Li Ruizhi Xie | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 2 |
| 4 | Hypoglycemic effects of aqueous extract of Rhizoma Polygonati Odorati in mice and rats显示文摘 | Hong bin Chen Ruizhi Feng Yi Guo | 2001 | Journal of Ethnopharmacology2001，74，： | 1 |
| 5 | VNLSTM-PoseNet: A novel deep ConvNet for real-time 6-DOF camera relocalization in urban streets显示文摘Image-based relocalization is a renewed interest in outdoor environments,because it is an important problem with many applications.PoseNet introduces Convolutional Neural Network(CNN)for the first time to realize the real-time camera pose solution based on a single image.In order to solve the problem of precision and robustness of PoseNet and its improved algorithms in complex environment,this paper proposes and implements a new visual relocation method based on deep convolutional neural networks(VNLSTM-PoseNet).Firstly,this method directly resizes the input image without cropping to increase the receptive field of the training image.Then,the image and the corresponding pose labels are put into the improved Long Short-Term Memory based(LSTM-based)PoseNet network for training and the network is optimized by the Nadam optimizer.Finally,the trained network is used for image localization to obtain the camera pose.Experimental results on outdoor public datasets show our VNLSTM-PoseNet can lead to drastic improvements in relocalization performance compared to existing state-of-theart CNN-based methods. | Ming Li Jiangying Qin Deren Li Ruizhi Chen Xuan Liao Bingxuan Guo | 2021 | Geo-Spatial Information Science2021，24，3： | 1 |
| 6 | Evaluation of grain breakage sensitivity of maize varieties mechanically-harvested by combine harvester显示文摘A high grain breakage rate is the main problem that occurs during mechanical maize harvest in China.The breakage sensitivity of different varieties was significantly different,and the breakage resistance is heritable.Therefore,breakage resistant variety screening can help improve the field production efficiency and provide references for breeding work.In this study,42 varieties of maize were harvested with the same mechanical parameters and the same manipulator on a range of harvest dates at experimental stations in Xinxiang,Henan Province,in 2017 and Changji,Xinjiang Province,in 2018 to determine the sensitivity of grain moisture content on grain breakage rate during machine harvest for different varieties.The integral value of the grain breakage rate curve corresponding to the range of 15%to 30%grain moisture content was used as an index that expressed the sensitivity of maize grains to breakage depending on grain moisture content(BSW).Forty-two varieties were categorized as having weak,intermediate,or strong BSW.Among the same four varieties in the two stations,Lianchuang 825 and Lianchuang 808 were classified as sensitive and fragile varieties,Shandan 650 was classified as an intermediate variety,Zeyu 8911 was divided into weak sensitive and breakage-resistance varieties in Xinxiang and intermediate varieties in Changji.The BSW classification results at the two experimental sites were generally consistent,indicating that breakage sensitivity due to moisture content may be a relatively stable genetic characteristic.This study suggested that the integral method for determining BSW can be used to assess the resistance of different maize varieties to grain breakage during mechanical harvesting.The integral method was used to identify twelve breakage-resistant varieties in Xinxiang Station,and six breakage-resistant varieties in Changji Station.This study provides a method for screening maize varieties that are suited to mechanical grain harvesting and for studying the mechanisms of grain breakage resistance. | Yizhou Wang Lulu Li Shang Gao Yanan Guo Guoqiang Zhang Bo Ming Ruizhi Xie Jun Xue Peng Hou Keru Wang Shaokun Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
| 7 | Toxicity studies of Rhizoma Polygonati odorati 显示文摘 | Cheu Hongbin Feng Ruizhi Guo Yi | 2001 | JEt hnopharmacol2001，74，3： | 1 |
| 8 | Hypoglycemic effects of aqueous extract of Rhizoma Polygonati Odorati in mice and rats显示文摘 | Hongbin Chen Ruizhi Feng Yi Guo | 2001 | Journal of Ethnopharmacology2001，74，： | 1 |
| 9 | An optimal design of the broadcast ephemeris for LEO navigation augmentation systems显示文摘As the deployment of large Low Earth Orbiters(LEO)communication constellations,navigation from the LEO satellites becomes an emerging opportunity to enhance the existing satellite navigation systems.The LEO navigation augmentation(LEO-NA)systems require a centimeter to decimeter accuracy broadcast ephemeris to support high accuracy positioning applications.Thus,how to design the broadcast ephemeris becomes the key issue for the LEO-NA systems.In this paper,the temporal variation characteristics of the LEO orbit elements were analyzed via a spectrum analysis.A non-singular element set for orbit fitting was introduced to overcome the potential singularity problem of the LEO orbits.Based on the orbit characteristics,a few new parameters were introduced into the classical 16 parameter ephemeris set to improve the LEO orbit fitting accuracy.In order to identify the optimal parameter set,different parameter sets were tested and compared and the 21 parameters data set was recommended to make an optimal balance between the orbit accuracy and the bandwidth requirements.Considering the real-time broadcast ephemeris generation procedure,the performance of the LEO ephemeris based on the predicted orbit is also investigated.The performance of the proposed ephemeris set was evaluated with four in-orbit LEO satellites and the results indicate the proposed 21 parameter schemes improve the fitting accuracy by 87.4%subject to the 16 parameters scheme.The accuracy for the predicted LEO ephemeris is strongly dependent on the orbit altitude.For these LEO satellites operating higher than 500 km,10 cm signal-in-space ranging error(SISRE)is achievable for over 20 min prediction. | Xueli Guo Lei Wang Wenju Fu Yingbo Suo Ruizhi Chen Hongxing Sun | 2022 | Geo-Spatial Information Science2022，25，1： | 1 |
| 10 | Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats显示文摘The present study was aimed to investigate the effects of minocycline (MC) on the expression of nerve growth factor (NGF) and heat shock protein 70 (HSP70) following intracerebral hemorrhage (ICH) in rats,and explore the neuroprotective function of MC.Seventy-eight male SD rats were randomly assigned to three groups:the ICH control group (n=36),ICH intervention group (n=36) and sham operation group (n=6).The ICH control group and ICH intervention group were subdivided into 6 subgroups at 1,2,4,5,7 and 14 d after ICH with 6 rats in each subgroup.Type IV collagenase was injected into the basal nuclei to establish the ICH model.All rats showed symptoms of the nervous system after the model was established,and the sympotsm in the ICH control group were more serious than the ICH intervention group.The number of NGF-positive cells and HSP70-positive cells in the ICH intervention group was higher than that of the ICH control group.MC administration by intraperitoneal injection can increase the expression of NGF and HSP70.MC may inhibit the activation of microglia,the inflammatory reaction and factors,matrix metalloproteinases and apoptosis,thus protecting neurons.The change of the expression of NGF and HSP70 may be involved in the pathway of neuroprotection by MC. | Jingnan Pu Wei Shi Zizhang Wang Ruizhi Wang Zhenyu Guo Chongxiao Liu Jianjun Sun Ligui Gao Ren Zhou | 2011 | The Journal of Biomedical Research2011，25，4： | 0 |
| 11 | Changes in blood-brain barrier permeability and expression of related factors in a rat model of intracerebral hemorrhage following minocycline treatment显示文摘Inflammatory factor aggregation and blood-brain barrier (BBB) damage occur around hematoma foci following intracerebral hemorrhage. Minocycline is lipophilic, can pass through the BBB, and shows anti-inflammatory effects in models of central nervous system disease. We found that minocycline application at 6 hours after intracerebral hemorrhage reduced BBB permeability, decreased vascular endothelial growth factor expression, and increased nerve growth factor and heat shock protein 70 expression, primarily in neurons and microglia. Early intraperitoneal injection of minocycline attenuated BBB damage possibly by reducing vascular endothelial growth factor expression and enhancing nerve growth factor and heat shock protein 70 expression. | Wei Shi Zizhang Wang Jingnan Pu Ruizhi Wang Zhenyu Guo Chongxiao Liu Jianjun Sun Ligui Gao Ren Zhou | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 12 | Macro Meso Response and Stress Wave Propagation Characteristics of MCT High-Voltage Switch Under Shock load显示文摘In order to study the dynamic and electrical coupling response characteristics of Metal Oxide Semiconductor Controlled Thyristor(MCT)high-voltage switch under the synergic action of mechanical load and high voltage,the separated Hopkinson pressure bar(SHPB)test system was used to simulate different impact load environments,and combined with the multi-layer high-voltage ceramic capacitor charging and discharging system,the instantaneous electrical signals of MCT high-voltage switch were collected.Combined with numerical simulation and theoretical analysis,the failure mode and stress wave propagation characteristics of MCT high voltage switch were determined.The mechanical and electrical coupling response characteristics and failure mechanism of MCT high voltage switch under dynamic load were revealed from macroscopic and microscopic levels.The results show that the damage modes of MCT high-voltage switches can be divided into non-functional damage,recoverable functional damage,non-recoverable damage and structural damage.Due to the gap between the metal gate and the oxide layer,the insulating oxide layer was charged.After placing for a period of time,the elastic deformation of the metal gate partially recovered and the accumulated charge disappeared,which induced the recoverable functional damage failure of the device.In addition,obvious cracks appeared on both sides of the monocrystalline silicon inside the MCT high-voltage switch,leading to unrecoverable damage of the device. | Yuyang Guo Chuang Chen Ruizhi Wang Enling Tang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 13 | Blue light-promoted cyclopropenizations of N-tosylhydrazones in water显示文摘Carbene transfer reactions play an important role in the field of organic synthesis because of their ability to construct a variety of molecules. Herein, we reported on blue light-induced cyclopropenizations of N-tosylhydrazones in water, which avoids the use of expensive metal-based catalysts and toxic organic solvents. This metal-free and operationally simple methodology enable highly efficient cyclopropenizations, X-H insertion reactions, and cyclopropanation under mild reaction conditions. | Kaichuan Yan Hua He Jianglian Li Yi Luo Ruizhi Lai Li Guo Yong Wu | 2021 | Chinese Chemical Letters2021，32，12： | 0 |
| 14 | Freeman,Joshua B.Behemoth:A History of the Factory and the Making of the Modern World显示文摘Joshua B.Freeman is a distinguished Professor of History at Queens College and the Graduate Center of City University of New York.His main research interest is labor history,and his major books include American Empire,1945-2000:The Rise of a Global Power,the Democratic Revolution at Home(2012);Working-Class New York:Life and Labor since World WarⅡ(2000);and In Transit:The Transport Workers Union in New York,1933--1966(2001),which have made him a well-known labor historian. | Guo Ruizhi | 2021 | Frontiers of History in China2021，16，1： | 0 |
| 15 | An infant monitoring system with the support of accurate real-time indoor positioning显示文摘This article presents an indoor infant monitoring system based on Android system which employs a low-cost Bluetooth Low Energy(BLE)pseudolite to accurately locate the infants in the activity indoors and timely remind the parents.It can achieve a positioning accuracy better than 2 m and effectively reduce the risk of injury to infants and young children.The performance of the proposed system,using false negative rate,false alarm rate,and alarm response time as indicators,is compared with that of the system using Quuppa as a positioning source.The experiment results show that both BLE pseudolite and Quuppa as a positioning source can basically meet the positioning accuracy for the infant monitoring system,but the BLE-pseudolite-based system provides a more cost-efficient solution. | Zhipeng Cao Yifan Cheng Ruizhi Chen Guangyi Guo Feng Ye Liang Chen Yuanjin Pan | 2019 | Geo-Spatial Information Science2019，22，4： | 0 |
| 16 | Efficient Synthesis of P-Chirogenic Compounds Enabled by Chiral Selenide-Catalyzed Enantioselective Electrophilic Aromatic Halogenation显示文摘P-chirogenic compounds have been applied in different fields,especially in asymmetric catalysis as ligands and organocatalysts.However,broader applicability has been severely restricted by the lack of efficient synthetic methods.Consequently,developing efficient methods to access these compounds is of high synthetic value.Herein,we report a convenient,efficient,and unprecedented pathway to construct valuable P-chirogenic compounds via chiral selenide-catalyzed enantioselective electrophilic aromatic halogenation.Using a new chiral bifunctional selenide as the catalyst,a variety of bis(2-hydroxyaryl)aryl phosphine oxides were efficiently converted to the corresponding chlorinated and brominated P-chirogenic compounds with good to excellent enantioselectivities.By slightly adjusting the catalyst and solvent,this method is also able to prepare chiral alkyl diaryl phosphine oxides and diaryl phosphinates.Furthermore,control experiments revealed the decomposition pathways of catalysts and the possible reasons why chiral selenide catalyst was more effective than chiral sulfide catalyst.The effect of hydrogen bonding was studied,and the reason why the chlorination took place on the various aromatic rings was elucidated when the substrates were switched from triaryl phosphine oxides to alkyl diaryl phosphine oxides and diaryl phosphinates. | Ruizhi Guo Ziqi Liu Xiaodan Zhao | 2021 | CCS Chemistry2021，3，11： | 0 |
| 17 | Laboratory and numerical modelling of irrigation infiltration and nitrogen leaching in homogeneous soils显示文摘Nitrogen (N) plays a key role in crop growth and production;however,data are lacking especially regarding the interaction of biochar,grass cover,and irrigation on N leaching in saturated soil profiles.Eighteen soil columns with 20-cm diameter and 60-cm height were designed to characterize the effects of different grass cover and biochar combinations,i.e.,bare soil+0%biochar (control,CK),perennial ryegrass+0%biochar (C1),Festuca arundinacea+0%biochar (C2),perennial ryegrass+1%biochar (C3),perennial ryegrass+2%biochar (C4),perennial ryegrass+3%biochar (C5),F.arundinacea+1%biochar (C6),F.arundinacea+2% biochar (C7),and F.arundinacea+3%biochar (C8),on periodic irrigation infiltration and N leaching in homogeneous loess soils from July to December 2020.Leachates in CK were 10.2%–35.3%higher than those in C1 and C2.Both perennial ryegrass and F.arundinacea decreased the volumes of leachates and delayed the leaching process in the 1%,2%,and 3%biochar treatments,and the vertical leaching rate decreased with biochar addition.The N leaching losses were concentrated in the first few leaching tests,and both total N (TN) and nitrate (NO_(3)^(-))-N concentrations in CK and C1–C8 decreased with increasing leaching test times.Biochar addition (1%,2%,and 3%) could further reduce the leaching risk of NO_(3)^(-)-N and the NO_(3)^(-)-N loss decreased with biochar addition.However,compared to 1%biochar,2% biochar promoted the leaching of TN under both grass cover types.The N leaching losses in CK,C1,C2,C3,C4,C6,and C7 were primarily in the form of NO_(3)^(-)-N.Among these treatments,CK,C1,and C2had the highest cumulative leaching fractions NO_(3)^(-)-N (>90%),followed by those in C3,C4,C6,and C7 (>80%).The cumulative leaching fraction of NO_(3)^(-)-N decreased with increasing leaching test times and biochar addition,and 3%biochar addition (i.e.,C5 and C8) reduced it to approximately 50%.The one-dimensional advective-dispersive-reactive transport equation can be used as an effective numerical approach to simulate and predict NO_(3)^(-)-N leaching in saturated homogeneous soils.Understanding the effects of different biochar and grass combinations on N leaching can help us design environmentally friendly interventions to manage irrigated farming ecosystems and reduce N leaching into groundwater. | Lei WU Ruizhi LI Yan WANG Zongjun GUO Jiaheng LI Hang YANG Xiaoyi MA | 2024 | Pedosphere2024，34，1： | 0 |
| 18 | PAID study design on the role of PKC activation in immune/inflammation-related depression:a randomised placebo-controlled trial protocol显示文摘Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression.Microglia activation can lead to an increase in the levels of proinflammatory cytokines,including TNF-α,which leads to neuronal apoptosis in the specific neural circuits of some brain regions,abnormal cognition and treatment-resistant depression(TRD).Protein kinase C(PKC)is a key regulator of the microglia activation process.We assume that the abnormality in PKC might result in abnormal microglia activation,neuronal apoptosis,significant changes in emotional and cognitive neural circuits,and TRD.In the current study,we plan to target at the PKC signal pathway to improve the TRD treatment outcome.Methods and analysis This is a 12-week,ongoing,randomised,placebo-controlled trial.Patients with TRD(N=180)were recruited from Shanghai Mental Health Center,Shanghai Jiao Tong University.Healthy control volunteers(N=60)were recruited by advertisement.Patients with TRD were randomly assigned to‘escitalopram+golimumab(TNF-αinhibitor)’,‘escitalopram+calcium tablet+vitamin D(PKC activator)’or‘escitalopram+placebo’groups.We define the primary outcome as changes in the 17-item Hamilton Depression Rating Scale(HAMD-17).The secondary outcome is defined as changes in anti-inflammatory effects,cognitive function and quality of life.Discussion This study might be the first randomised,placebo-controlled trial to target at the PKC signal pathway in patients with TRD.Our study might help to propose individualised treatment strategies for depression.Trial registration number The trial protocol is registered with ClinicalTrials.gov under protocol ID 81930033 and ClinicalTrials.gov ID NCT04156425. | Xiaoyun Guo Ruizhi Mao Lvchun Cui Fan Wang Rubai Zhou Yun Wang Jia Huang Yuncheng Zhu Yamin Yao Guoqing Zhao Zezhi Li Jun Chen Jinhui Wang Yiru Fang | 2021 | General Psychiatry2021，34，2： | 0 |
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