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| 1 | Germafluorene conjugated copolymer——synthesis and applications in blue-light-emitting diodes and host materials显示文摘A germafluorene-fluorene copolymer was successfully obtained via Suzuki polymerization.The ger-manium containing copolymer has an efficient blue light emission under the ultraviolet irradiation and its single layer EL device showed the highest brightness of 2630 cd/m2 at 7.8 V and the highest effi-ciency of 0.301 lm/W at 6.2 V.The copolymer can also serve as the host material for phosphorescent metal complexes with the maximum brightness of 15600 cd/m2 and the quantum efficiency of 8.5%.The results are quite promising and promise that as its analogs of fluorene and silafluorene,germafluorene is an excellent building block for blue light-emitting polymers and host materials. | CHEN RunFeng ZHU Rui ZHENG Chao LIU ShuJuan FAN QuLi HUANG Wei | 2009 | Science China Chemistry2009，52，2： | 12 |
| 2 | Dynamic Analysis and Optimal Design of a Novel Small 2-D planar Ultrasonic Motor显示文摘 | Chaodong Li Shi Xu Runfeng Liu | 2006 | IEEE Ultrasonics Sympoisum2006，，： | 1 |
| 3 | Conju- gated chelating polymers with charged iridium complexes in the backbones: Synthesis, characterization, energy trans fer, and electrochemical properties显示文摘 | Liu Shuiuan Zhao Qiang Chen Runfeng | 2006 | Chemistry A Euro- pean Journal2006，12，16： | 1 |
| 4 | Research on optimization of virtual machine memory access based on NUMA architecture显示文摘With the rapid development of big data and artificial intelligence(AI),the cloud platform architecture system is constantly developing,optimizing,and improving.As such,new applications,like deep computing and high-performance computing,require enhanced computing power.To meet this requirement,a non-uniform memory access(NUMA)configuration method is proposed for the cloud computing system according to the affinity,adaptability,and availability of the NUMA architecture processor platform.The proposed method is verified based on the test environment of a domestic central processing unit(CPU). | 何牧君 Zheng Linjiang Yang Kai Liu Runfeng Liu Weining | 2021 | High Technology Letters2021，27，4： | 1 |
| 5 | Silafluorene moieties as promising building blocks for constructing wide-energy-gap host materials of blue phosphorescent organic light-emitting devices显示文摘In this article, we reported the synthesis and characterization of a novel silafluorene-based host material, 1,3-bis(5-methyl-5Hdibenzo[b,d]silol-5-yl)benzene(Me-DBSi B), for blue phosphorescent organic light-emitting devices(PHOLEDs). The MeDBSi B was constructed by linking 9-methyl-9-silafluorene units to the phenyl framework through the sp3-hybridized silica atom to maintain high singlet and triplet energy, as well as to enhance thermal and photo-stability. The calculated result shows that the phenyl core does not contribute to both the highest occupied molecular orbital and lowest unoccupied molecular orbital. Wide optical energy gap of 4.1 e V was achieved. When the Me-DBSi B was used as the host and iridium(III) bis[(4,6-difluorophenyl)pyridinato-N,C2′]picolate(Firpic) as the guest, a maximum current efficiency was 14.8 cd/A, lower than the counterpart of 1,3-bis(9-carbazolyl)benzene(28 cd/A). The unbalanced barrier for electron and hole injection to host layer may be responsible for low efficiency. Even so, our results show that silafluorene moieties are promising building blocks for constructing wide-energy-gap host materials. | Dongdong Wang Qingqing Liu Yue Yu Yong Wu Xinwen Zhang Hua Dong Lin Ma Guijiang Zhou Bo Jiao Zhaoxin Wu Runfeng Chen | 2015 | Science China Chemistry2015，58，6： | 0 |
| 6 | Early-Life Gut Microbiota Governs Susceptibility to Colitis via Microbial-Derived Ether Lipids显示文摘Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to increases in the aerobic bacteria population and reduction in the anaerobic bacteria population by changing the intestinal environment.However,the mechanisms involved and the associated functions of intestinal anaerobes in gut health still remain unclear.Here,we found that early-life depletion of gut microbiota exacerbated later colitis,while mid-life microbiota depletion showed partially reduced colitis.Notably,we observed that early-life gut microbiota depletion confers susceptibility to ferroptosis in colitis.In contrast,restitution of early-life microbiota conferred protection against colitis and inhibited ferroptosis triggered by gut microbiota dysbiosis.Similarly,colonization with anaerobic microbiota from young mice suppressed colitis.These results may attribute to high abundance of plasmalogen-positive(plasmalogen synthase[PlsA/R]-positive)anaerobes and plasmalogens(one of the common ether lipids)in young mice but reduced abundance in the development of inflammatory bowel disease.Early-life anaerobic bacteria elimination also resulted in the aggravation of colitis,while this aggravation phenotype was reverted by plasmalogen administration.Interestingly,plasmalogens inhibited ferroptosis triggered by microbiota dysbiosis.We further find that the alkenyl-ether group of plasmalogens was critical to colitis prevention and ferroptosis inhibition.These data point to one of the mechanisms by which the gut microbiota controls susceptibility to colitis and ferroptosis early in life via microbial-derived ether lipids. | Yanjun Liu Chunhua Jiao Tao Zhang Xue Li Panpan Li Meishan Lu Zhan Ye Yanpeng Du Runfeng Du Wenlong Zhang Jie Xu Zhaojun Zheng Yongjiang Xu Changhu Xue Yi Zhang Yuanfa Liu | 2023 | Research2023，，3： | 0 |
| 7 | Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis显示文摘Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001. | Nazi Song Hongjiao Xu Jiahua Liu Qian Zhao Hui Chen Zhibin Yan Runling Yang Zhiteng Luo Qi Liu Jianmei Ouyang Shuohan Wu Suijia Luo Shuyin Ye Runfeng Lin Xi Sun Junqiu Xie Tian Lan Zhongdao Wu Rui Wang Xianxing Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
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