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| 1 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 2 | A cyberphysical-based approach to leader-following consensus for distributed multi-agent systems显示文摘This paper considers a leader-following consensus problem for first-order linear multi-agent systems with constant input and communication time-delays. Based on the idea of cyber physical systems, the use of control states of neighboring agents, a new distributed control protocol is presented. Furthermore, in terms of linear matrix inequalities, sufficient conditions of leader-following consensus for multi-agent systems with constant input, communication and input time-delays are presented respectively. Numerical simulations on multi-agent systems are presented to demonstrate the efficiency of the proposed criteria. | 何牧君 Zheng Linjiang Liu Hui | 2019 | High Technology Letters2019，25，2： | 1 |
| 3 | Typical Microstructural Characteristics of Ti–5Al–5Mo–5V–3Cr–1Fe Metastable β Ti Alloy Forged in α + β Region显示文摘In this study,typical microstructural characteristics of a metastableβTi alloy(Ti–5Al–5Mo–5V–3Cr–1Fe)forged in a dual-phase region(strain of 54%at 820℃)were investigated in detail by the combined use of X-ray diff raction,energy dispersive spectroscopy,electron channeling contrast imaging and electron backscatter diff raction techniques.Results show that the microstructure of the forged alloy is composed of bulkαgrains,αplates andβmatrix.The bulkαgrains correspond to retained primaryαphase(αp,average grain size^2.4μm),while theαplates are secondaryαphase(αs,width^70 nm)precipitated from theβmatrix during air cooling.During forging,theβmatrix experiences dynamic recovery with many subgrains and signifi cant orientation gradients formed.Analyses of the orientation relationship between theαandβphases show that the Burgers orientation relationship is not maintained between someα_p andβphases,which should be related to thermal deformation-induced changes of their orientations.In contrast,all of theαs plates are found to maintain well the Burgers orientation relationship with theβphase. | Zhiying Zheng Linjiang Chai Kang Xiang Weijiu Huang Yongfeng Wang Liangliang Liu Lin Tian | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，12： | 1 |
| 4 | Research on optimization of virtual machine memory access based on NUMA architecture显示文摘With the rapid development of big data and artificial intelligence(AI),the cloud platform architecture system is constantly developing,optimizing,and improving.As such,new applications,like deep computing and high-performance computing,require enhanced computing power.To meet this requirement,a non-uniform memory access(NUMA)configuration method is proposed for the cloud computing system according to the affinity,adaptability,and availability of the NUMA architecture processor platform.The proposed method is verified based on the test environment of a domestic central processing unit(CPU). | 何牧君 Zheng Linjiang Yang Kai Liu Runfeng Liu Weining | 2021 | High Technology Letters2021，27，4： | 1 |
| 5 | Perceptual stimulus——A Bayesian-based integration of multi-visual-cue approach and its application显示文摘With the view that visual cue could be taken as a kind of stimulus, the study of the mechanism in the visual perception process by using visual cues in their probabilistic representation eventually leads to a class of statistical integration of multiple visual cues (IMVC) methods which have been applied widely in perceptual grouping, video analysis, and other basic problems in computer vision. In this paper, a survey on the basic ideas and recent advances of IMVC methods is presented, and much focus is on the models and algorithms of IMVC for video analysis within the framework of Bayesian estimation. Furthermore, two typical problems in video analysis, robust visual tracking and 'switching problem' in multi-target tracking (MTT) are taken as test beds to verify a series of Bayesian-based IMVC methods proposed by the authors. Furthermore, the relations between the statistical IMVC and the visual per- ception process, as well as potential future research work for IMVC, are discussed. | XUE JianRu ZHENG NanNing ZHONG XiaoPin PING LinJiang | 2008 | Chinese Science Bulletin2008，53，18： | 0 |
| 6 | Misorientation characteristics and textural changes induced by dense twins in high-purity Ti sheet after small strain rolling显示文摘A high-purity Ti(HP-Ti)sheet was subjected to small strain rolling(10%reduction)with microstructural and textural characteristics examined by electron channeling contrast imaging and electron backscatter diffraction techniques.Particular attentions were paid to misorientation and textural changes aroused by twins in the rolled HP-Ti sheet.Results show that after the 10%rolling,almost all the prior equiaxed grains in the initial specimen are twinned,leading to remarkable grain refinement.The presence of two major misorientation angle peaks around 65°and 85°is ascribed to{11-22}<11-23>and{10-12}<10-11>twinning,respectively,and two minor peaks around 47°and 77°are due mainly to impingement of various variants of such twins.Distinct from earlier work,the small strain rolling is confirmed to be able to induce drastic textural changes in pure Ti sheets:largely reduced texture intensity and appearance of new textural components.This can essentially be attributed to enhanced twinning activity due to much lower impurity contents of the present material.Primary{11?22}twins are mainly responsible for the new textural component of c-axes aligned near the rolling direction with spread,while the component of caxes parallel to the normal direction is due to reorientation of secondary{10-12}twins.This study clearly demonstrates the capability of small strain rolling to effectively modify both microstructures and textures of the HP?Ti sheet and may shed some light on exploring feasible processings for such materials. | DAI JiaHong ZENG LingGuo LI ZhiJun CHAI LinJiang ZHENG ZhiYing WU Hao MURTY KL GUO Ning | 2019 | Science China(Technological Sciences)2019，62，11： | 0 |
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