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14篇 您的检索式：作者名="Runkuan"

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		题名	作者	年代	出处	被引量
	1	HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice显示文摘	Penny L. Sappington Runkuan Yang Huan Yang Kevin J. Tracey Russell L. Delude Mitchell P. Fink	2002	Gastroenterology2002，，3：	1
	2	IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice 显示文摘	Yang Runkuan Hart Xiaonan Uchiyama T	2003	Gastrointest Liver Physiol2003，285，：	1
	3	Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism 显示文摘	Runkuan YANG Harada Tomoyuki Jinyou LI	2005	Intensive Care Medicine2005，31，5：	1
	4	Ischemia/reperfusion injury in porcine intestine-Viability assessment显示文摘AIM To investigate viability assessment of segmental small bowel ischemia/reperfusion in a porcine model.METHODS In 15 pigs, five or six 30-cm segments of jejunum were simultaneously made ischemic by clamping the mesenteric arteries and veins for 1 to 16 h. Reperfusion was initiated after different intervals of ischemia(1-8 h) and subsequently monitored for 5-15 h. The intestinal segments were regularly photographed and assessed visually and by palpation. Intraluminal lactate and glycerol concentrations were measured by microdialysis, and samples were collected for light microscopy and transmission electron microscopy. The histological changes were described and graded.RESULTS Using light microscopy, the jejunum was considered as viable until 6 h of ischemia, while with transmission electron microscopy the ischemic muscularis propria was considered viable until 5 h of ischemia. However, following ≥ 1 h of reperfusion, only segments that had been ischemic for ≤ 3 h appeared viable, suggesting a possible upper limit for viability in the porcine mesenteric occlusion model. Although intraluminal microdialysis allowed us to closely monitor the onset and duration of ischemia and the onset of reperfusion, we were unable to find sufficient level of association between tissue viability and metabolic markers to conclude that microdialysis is clinically relevant for viability assessment. Evaluation of color and motility appears to be poor indicators of intestinal viability.CONCLUSION Three hours of total ischemia of the small bowel followed by reperfusion appears to be the upper limit for viability in this porcine mesenteric ischemia model.	Runar J Strand-Amundsen Henrik M Reims Finn P Reinholt Tom E Ruud Runkuan Yang Jan O Hogetveit Tor I Tonnessen	2018	World Journal of Gastroenterology2018，24，18：	1
	5	IL -6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice 显示文摘	Yang Runkuan Han Xiaonan Uchiyama T	2003	Gastrointest Liver Physio2003，285，：	1
	6	HMGB1 B box increases the permeability of Caco - 2 enterocytic monolayers and impairs intesti- nal barrier function in mice 显示文摘	Penny L Sappington Runkuan Yang	2002	Gastroenterology2002，123，3：	1
	7	SuPAR and PAI- l in critically ill, mechanically ventilated patients 显示文摘	VILLE J RUNKUAN Y RITA L	2013	Intensive Care Med2013，39，3：	1
	8	Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis显示文摘	Runkuan Yang Angel L. Shaufl Meaghan E. Killeen Mitchell P. Fink	2009	Journal of Surgical Research2009，，2：	1
	9	MEthyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis显示文摘	Runkuan Y Takashi U Sean A	2004	Critical Care Medicine2004，32，7：	1
	10	Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis显示文摘	Runkuan Yang Angel L. Shaufl Meaghan E. Killeen Mitchell P. Fink	2009	Journal of Surgical Research2009，，2：	1
	11	Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism显示文摘	Runkuan Yang Tomoyuki Harada Jinyou Li Takashi Uchiyama Yusheng Han Joshua A. Englert Mitchell P. Fink	2005	Intensive Care Medicine2005，，5：	1
	12	HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice显示文摘	Penny L. Sappington Runkuan Yang Huan Yang Kevin J. Tracey Russell L. Delude Mitchell P. Fink	2002	Gastroenterology2002，，3：	1
	13	Bilemodulates intestinalepithelial barrier function via an extracellular signal related kinase1/2 dependent mech-anism显示文摘	Runkuan Yang Tomoyuki Harada Jinyou Li	2005	Intensive Care Med2005，31，5：	1
	14	Toll-Like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock显示文摘	Jose M. Prince Ryan M. Levy Runkuan Yang Kevin P. Mollen Mitchell P. Fink Yoram Vodovotz Timothy R. Billiar	2006	Journal of the American College of Surgeons2006，，3：	1

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