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| 1 | Risk factors associated with 90-day recurrent stroke in patients on dual antiplatelet therapy for minor stroke or high-risk TIA:a subgroup analysis of the CHANCE trial显示文摘Objective Many patients receiving dual antiplatelet therapy still had recurrent strokes.We aimed to identify factors associated with recurrent stroke at 90 days in patients receiving dual antiplatelet therapy in Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Methods Patients with transient ischaemic attack or minor stroke receiving clopidogrel and aspirin in the trial were analysed in the study.The primary outcome was recurrent stroke within 90 days after the index event.Cox proportional hazard model with backward selection was used to identify factors associated with stroke.results Among 2584 patients,212(8.2%)had a recurrent stroke,216(8.4%)had a composite of stroke,myocardial infarction,or vascular death and 204(7.9%)had ischaemic stroke within 90 days.Multivariate analysis identified the following factors associated with stroke:history of hypertension with poor blood pressure control(HR,1.92;95%CI 1.22 to 3.03),the high baseline National Institute of Health Stroke Scale(NIHSS)score of 2 and 3(2.12(1.07 to 4.21)and 4.11(2.05 to 8.22),respectively),time from onset to randomisation of<12 hours(1.47(1.12 to 1.94)),the lipid-lowering therapy(0.61(0.47 to 0.83)),the open-label aspirin dose at day 1 of≥300 mg(1.98(1.45 to 2.69)).Intracranial arterial stenosis(ICAS)was significantly associated with stroke in the sensitivity analysis(2.17(1.16 to 4.04)).conclusions The high baseline NIHSS score,hypertension with poor blood pressure control,ICAS,time from onset to randomisation of less than 12 hours and no lipid-lowering therapy were associated with stroke,suggesting that patients with identified predictors still remain to be at high risk of recurrent stroke although being under the dual antiplatelet therapy. | Runqi Wangqin Xianwei Wang Yilong Wang Ying Xian Xingquan Zhao Liping Liu Hao Li Xia Meng Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，4： | 6 |
| 2 | Turbidity maximum formation and its seasonal variations in the Zhujiang(Pearl River)Estuary,southern China显示文摘Real-time observations in the field and numerical simulations(with Delft3D) were combined to study the formation, distribution and the relevant influencing factors of turbidity maximum(TM) in the Zhujiang(Pearl River) Estuary(ZE). The spatial distribution pattern of the TM varies with the longitudinal distributions of salinity and suspended sediment concentration(SSC). The SSC is enhanced and the TM is intensified during dry seasons,whereas the center of the TM moves upstream by a distance of 10 km during wet seasons. The formation of the TM is influenced by a complex combination of numerous factors, including tides, river discharges and topography, wherein sediment resuspension and vertical circulation dominate the formations and variability of the TM. | LIU Runqi WANG Yaping GAO Jianhua WU Ziyin GUAN Weibing | 2016 | Acta Oceanologica Sinica2016，35，8： | 5 |
| 3 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 4 | TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat显示文摘Grain development is a crucial determinant of yield and quality in bread wheat(Triticum aestivum L.).However,the regulatory mechanisms underlying wheat grain development remain elusive.Here we report how Ta MADS29 interacts with Ta NF-YB1 to synergistically regulate early grain development in bread wheat.The tamads29 mutants generated by CRISPR/Cas9 exhibited severe grain filling deficiency,coupled with excessive accumulation of reactive oxygen species(ROS)and abnormal programmed cell death that occurred in early developing grains,while overexpression of Ta MADS29 increased grain width and1,000-kernel weight.Further analysis revealed that Ta MADS29 interacted directly with Ta NF-YB1;null mutation in Ta NF-YB1caused grain developmental deficiency similar to tamads29 mutants.The regulatory complex composed of Ta MADS29 and Ta NF-YB1 exercises its possible function that inhibits the excessive accumulation of ROS by regulating the genes involved in chloroplast development and photosynthesis in early developing wheat grains and prevents nucellar projection degradation and endosperm cell death,facilitating transportation of nutrients into the endosperm and wholly filling of developing grains.Collectively,our work not only discloses the molecular mechanism of MADS-box and NF-Y TFs in facilitating bread wheat grain development,but also indicates that caryopsis chloroplast might be a central regulator of grain development rather than merely a photosynthesis organelle.More importantly,our work offers an innovative way to breed high-yield wheat cultivars by controlling the ROS level in developing grains. | Guoyu Liu Runqi Zhang Sen Li Rehmat Ullah Fengping Yang Zihao Wang Weilong Guo Mingshan You Baoyun Li Chaojie Xie Liangsheng Wang Jie Liu Zhongfu Ni Qixin Sun Rongqi Liang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 5 | Temperature dependence simulation and characterization for InP/InGaAs avalanche photodiodes显示文摘Based on the newly proposed temperature dependent dead space model,the breakdown voltage and bandwidth of InP/InGaAs avalanche photodiode (APD) have been investigated in the temperature range from -50℃ to 100℃.It was demonstrated that our proposed model is consistent with the experimental results.Our work may provide a guidance to the design of APDs with controllably low temperature coefficient. | Yanli ZHAO Junjie TU Jingjing XIANG Ke WEN Jing XU Yang TIAN Qiang LI Yuchong TIAN Runqi WANG Wenyang LI Mingwei GUO Zhifeng LIU Qi TANG | 2018 | Frontiers of Optoelectronics2018，11，4： | 0 |
| 6 | Relative roll control of satellite docking using electromagnetic coils显示文摘An electromagnetic coil topology and its control strategy,which can be incorporated into the electromagnetic docking device,have been proposed for the relative roll control of two satellites in space.The target satellite and the chaser satellite are respectively embarked with four and six coils evenly arranged around the docking axis.All the coils on the target satellite are Direct Current(DC)energized,while the currents in the coils of the chaser satellite are regulated to achieve the relative roll control.The electromagnetic force/torque model is built by utilizing the frequentlyused far field model.Based on the fundamental components extracted from that model,this paper proposes a real-time magnetic moment vector distribution formula that simply generates a constant roll torque.This paper not only presents an equation for calculating the relative roll angle through the Euler angles of two satellites,but also an equation that converts the roll torque setpoint to the setpoints of the coil currents.A 3-closed-loop positioning controller composed of angle,angular velocity,and current loop is developed.The proposed topology is verified by finite element simulation,and the control strategy is validated by dynamics simulation and ground-based tests. | Lijian WU Guangzheng RUAN Runqi HAN Bo WANG Yaobing WANG | 2023 | Chinese Journal of Aeronautics2023，36，12： | 0 |
| 7 | Visual exploration of latent space for traditional Chinese music显示文摘Generating compact and effective numerical representations of data is a fundamental step for many machine learning tasks.Traditionally,handcrafted features are used but as deep learning starts to show its potential,using deep learning models to extract compact representations becomes a new trend.Among them,adopting vectors from the model’s latent space is the most popular.There are several studies focused on visual analysis of latent space in NLP and computer vision.However,relatively little work has been done for music information retrieval(MIR)especially incorporating visualization.To bridge this gap,we propose a visual analysis system utilizing Autoencoders to facilitate analysis and exploration of traditional Chinese music.Due to the lack of proper traditional Chinese music data,we construct a labeled dataset from a collection of pre-recorded audios and then convert them into spectrograms.Our system takes music features learned from two deep learning models(a fully-connected Autoencoder and a Long Short-Term Memory(LSTM)Autoencoder)as input.Through interactive selection,similarity calculation,clustering and listening,we show that the latent representations of the encoded data allow our system to identify essential music elements,which lay the foundation for further analysis and retrieval of Chinese music in the future. | Jingyi Shen Runqi Wang Han-Wei Shen | 2020 | Visual Informatics2020，4，2： | 0 |
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