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| 1 | Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks显示文摘Meiotic recombination is initiated by the formation of double-strand breaks(DSBs),which are repaired as either crossovers(COs)or noncrossovers(NCOs).In most mammals,PRDM9-mediated H3K4me3 controls the nonrandom distribution of DSBs;however,both the timing and mechanism of DSB fate control remain largely undetermined.Here,we generated comprehensive epigenomic profiles of synchronized mouse spermatogenic cells during meiotic prophase I,revealing spatiotemporal and functional relationships between epigenetic factors and meiotic recombination.We find that PRDM9-mediated H3K4me3 at DSB hotspots,coinciding with H3K27ac and H3K36me3,is intimately connected with the fate of the DSB.Our data suggest that the fate decision is likely made at the time of DSB formation:earlier formed DSBs occupy more open chromatins and are much more competent to proceed to a CO fate.Our work highlights an intrinsic connection between PRDM9-mediated H3K4me3 and the fate decision of DSBs,and provides new insight into the control of CO homeostasis. | Yao Chen Ruitu Lyu Bowen Rong Yuxuan Zheng Zhen Lin Ruofei Dai Xi Zhang Nannan Xie Siqing Wang Fuchou Tang Fei Lan Ming-Han Tong | 2020 | Cell Research2020，30，3： | 3 |
| 2 | H3K14me3 genomic distributions and its regulation by KDM4 family demethylases显示文摘 | Bin Zhao Wenqi Xu Bowen Rong Guoyu Chen Xuanjia Ye Ruofei Dai Wenjinq Li Jiajia Chen Jiajun Cai Lei Song Zhao-Qing Luo Rong Zeng Yang Shi Jing-Dong J. Han Fei Lan | 2018 | Cell Research2018，28，11： | 1 |
| 3 | A nanoforest-based humidity sensor for respiration monitoring显示文摘Traditional humidity sensors for respiration monitoring applications have faced technical challenges,including low sensitivity,long recovery times,high parasitic capacitance and uncalibrated temperature drift.To overcome these problems,we present a triple-layer humidity sensor that comprises a nanoforest-based sensing capacitor,a thermistor,a microheater and a reference capacitor.When compared with traditional polyimide-based humidity sensors,this novel device has a sensitivity that is improved significantly by 8 times within a relative humidity range of 40-90%.Additionally,the integration of the microheater into the sensor can help to reduce its recovery time to 5 s.The use of the reference capacitor helps to eliminate parasitic capacitance,and the thermistor helps the sensor obtain a higher accuracy.These unique design aspects cause the sensor to have an excellent humidity sensing performance in respiration monitoring applications.Furthermore,through the adoption of machine learning algorithms,the sensor can distinguish different respiration states with an accuracy of 94%.Therefore,this humidity sensor design is expected to be used widely in both consumer electronics and intelligent medical instrument applications. | Guidong Chen Ruofei Guan Meng Shi Xin Dai Hongbo Li Na Zhou Dapeng Chen Haiyang Mao | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
| 4 | DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘Dear Editor,DNA methylation at the 5-position of cytosine(5mC)is a crucial epigenetic mark in regulating biological processes including gene silencing,gene imprinting,and X chromo-some inactivation(Jaenisch and Bird,2003;Smith and Meissner,2013).Human genome encodes three DNA methyltransferases,DNMT1,DNMT3A and DNMT3B to catalyze 5mC.Although not tightly restricted,DNMT1 is thought to maintain the established pattern of 5mC throughout DNA replication,while DNMT3A and DNMT3B are largely responsible for the de novo establishment of 5mC.It has long been questioned how de novo DNA 5mC patterns are established in different genomic regions and whether histone modifications crosstalk to the process.Until recently,it was reported that through recognition of histone H3K36me3 mark,DNMT3B plays a dominant role in medi-ating DNA 5mC in the genic region undergoing active tran-scription(Baubec et al.,2015;Neri et al,2017).However,5mC occurs at both intergenic and genic regions,while H3K36me3 is largely absent in the intergenic regions,indi-cating that the intergenic 5mC may be mediated through diferent mechanisms. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，2： | 0 |
| 5 | Correction to:DNMT3A reads and connects histone H3K36me2 to DNA methylation显示文摘The author would like to add the below information in this correction.A similar study from Chao Lu group was published online on 5 September 2019 in Nature,entitled“The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape”(Weinberg et al.,2019).Although both studies reported the preferential recognition of H3K36me2 by DNMT3A PWWP,ours in addition uncovered a stimulation function by such interaction on the activity of DNMT3A.On the disease connections,we used a NSD2 gain-of-function model which led to the discovery of potential therapeutic implication of DNA inhibitors in the related cancers,while the other study only used NSD1 and DNMT3A loss-of-function models. | Wenqi Xu Jiahui Li Bowen Rong Bin Zhao Mei Wang Ruofei Dai Qilong Chen Hang Liu Zhongkai Gu Shuxian Liu Rui Guo Hongjie Shen Feizhen Wu Fei Lan | 2020 | Protein & Cell2020，11，3： | 0 |
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