| 1 | An injectable self-adaptive polymer as a drug carrier for the treatment of nontraumatic early-stage osteonecrosis of the femoral head显示文摘Core decompression(CD)with the elimination of osteonecrotic bone is the most common strategy for treating early-stage nontraumatic osteonecrosis of the femoral head(ONFH).Adjuvant treatments are widely used in combination with CD as suitable methods of therapy.Existing augmentations have to be fabricated in advance.Here,we report a novel injectable glycerin-modified polycaprolactone(GPCL)that can adapt to the shape of the CD cavity.GPCL shows great flowability at 52.6℃.After solidification,its compressive modulus was 120 kPa at body temperature(37℃).This excellent characteristic enables the polymer to provide mechanical support in vivo.In addition,GPCL acts as a carrier of the therapeutic agent zoledronic acid(ZA),demonstrating sustained release into the CD region.ZA-loaded GPCL was injected into ONFH lesions to treat early-stage nontraumatic cases.Compared to that in the CD group,CD+ZA-loaded GPCL injection preserved bone density and increased the collagen level in the femoral head.At the interface between the GPCL and CD tunnel wall,osteogenesis was significantly promoted.In addition,morphological evaluations revealed that the femoral heads in the CD+ZA-GPCL group exhibited improved pressure resistance.These results suggest a strategy effective to preserve the bone density of the femoral head,thus decreasing the possibility of femoral head collapse.This novel injectable polymer has,therefore,considerable potential in clinical applications. | Ning Kong Hang Yang Run Tian Guanzhi Liu Yiyang Li Huanshuai Guan Qilu Wei Xueshan Du Yutian Lei Zhe Li Ruomu Cao Yiwei Zhao Xiaohui Wang Kunzheng Wang Pei Yang | 2022 | Bone Research2022，10，3： | 1 |
| 2 | Soft and transient magnesium plasmonics for environmental and biomedical sensing显示文摘由于它有水和 biofluids 的控制反应, Mg 作为一个可分解的售票员启用了许多短暂电子设备的发展。另外, Mg 是有高扑灭效率的新奇 plasmonic 材料,但是它的 transientoptical 性质没彻底地被探索。在这研究,第一次,我们在环境、生物医学的传感器应用利用 Mg 的短暂、悦耳的 plasmonic 性质。我们使用了软 nanoimprint 平版印刷术制作能在人的皮肤上被使用的灵活、大区域的 Mg plasmonic 结构。他们的回声(或颜色) 能被渐渐的 Mg 溶解在水液体或充满蒸汽的环境在可见范围调节;没有对复杂电子电路或电源供应的需要,这些结构能容易作为被动光传感器被实现。我们在在锻练期间的在人的皮肤上的环境湿度和汗损失的生理的察觉的精确监视演示我们的光传感器的应用程序。我们的设备能被用作光传感器和罐头帮助最小化与消费者设备废物联系的长期的健康效果和环境风险的 decomposable/resorbable,它将在短暂 photonic 设备应用导致许多新可能性。 | Ruomu Li Suxia Xie Labao Zhang Liqiang Li Deying Kong QiangWang Run Xin Xing Sheng Lan Yin Cunjiang Yu Xinran Wang Li Gao | 2018 | Nano Research2018，11，8： | 0 |
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