|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects显示文摘Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP‐1) or plasma cell membrane glycoprotein 1 (PC‐1) gene single nucleotide polymorphism (K121Q, rs1044498) and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case‐control studies in European adult populations. Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio (OR) with 95% confidence intervals (CIs). Results Ten case‐control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta‐analysis results showed a statistically significant association of K121Q with obesity [OR (95%CI): 1.25 (1.04‐1.52) P=0.021] under a recessive model of inheritance (QQ vs. KK+KQ) without heterogeneity or publication bias. Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well‐designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes. | WANG RuoQi ZHOU DongHao XI Bo GE XiuShan ZHU Ping WANG Bo ZHOU MingAi HUANG YuBei LIU JunTing YU Yang WANG ChunYu | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 2 | Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration显示文摘Varieties of pathological conditions,including diabetes,are closely related to oxidative stress(OS),but the osseointegration or bioadaptation of implants to OS and the related mechanism remain poorly explored.In this study,the antioxidation and osteoimmune regeneration of titanium implants with micro/nanotopographies were evaluated under H2O2-,lipopolysaccharide(LPS)-and hyperglycemia-mediated cellular OS models and in diabetic rats as a representative animal model of OS.TiO2 nanotube(TNT)coating on titanium implants directly induced superior osteogenic differentiation of bone mesenchymal stem cells(MSCs)and osseointegration compared with microscale sand blasted-acid etched topography(SLA)under OS,attributed to higher superoxide dismutase 2 activity,the neutralization of intracellular reactive oxygen species(ROS),and less apoptosis.Mechanistically,the oxidation resistance on TNT is driven by upregulated forkhead box transcription factor O1(FoxO1),which is abolished after knockdown of FoxO1 via shRNA in MSCs.Indirectly,TNT also alleviates OS in macrophages,therefore inducing a higher portion of the M2 phenotype under OS with increased secretion of the anti-inflammatory cytokine IL-10,further promoting the osseoimmunity capacity compared with SLA.The current study not only suggests the potential application of TiO2 nanotube-coated titanium implants in compromised conditions but also provides a systematic evaluation strategy for the future development of bone biomaterials. | Jingyan Huang Ruoqi Li Jinghong Yang Min Cai Yichen Lee Anxun Wang Bin Cheng Yan Wang | 2021 | Bioactive Materials2021，6，10： | 1 |
| 3 | Protein crystallization with DNA templates显示文摘Protein crystallization plays a significant role in three-dimensional structural analysis and protein pu-rification.It is important to increase the crystallization efficiency,which is possible by adding hetero-geneous templates in crystallization systems.DNA is biologically compatible and artificially designable polymer,which is easy to extract.In this study,single-and double-stranded DNA of precise sequences were designed and used as templates to promote protein crystallization of lysozyme and catalase.In-fluence of DNA,single-stranded DNA with 10,20,40 bases and double-stranded DNA with 10,20,40 base pairs,were investigated.The success rate of obtaining crystals of lysozyme and catalase in equal period was significantly improved with the addition of DNA comparing without templates added.Double-stranded DNA led to higher nucleation rate than that with single-stranded DNA.The promotion of nucleation was more obvious at low concentration of protein solution and with longer chain DNA templates.Crystal number and crystallization rate was enhanced with addition of long double-stranded DNA templates.All the results confirm that DNA is an effective polymer additive to enhance protein crystallization,especially for the application of the scarce protein crystallization. | Bo Zhang Jia Yu Zhe Pu Wenhui Guo Ruoqi Yang Yu Wen Zhijiang Rong Hui Wang Xiaoli Wu Bo Wang Hongyan Sun | 2024 | Particuology2024，86，3： | 0 |
| 4 | Material,design,and fabrication of custom prosthetic liners for lower-extremity amputees:A review显示文摘As a physical interface,a prosthetic liner is commonly used as a transition material between the residual limb and the stiff socket.Typically made from a compliant material such as silicone,the main function of a prosthetic liner is to protect the residual limb from injuries induced by load-bearing normal and shear stresses.Compared to conventional liners,custom prosthetic lower-extremity(LE)liners have been shown to better relieve stress concentrations in painful and sensitive regions of the residual limb.Although custom LE liners have been shown to offer clinical benefits,no review article on their design and efficacy has yet been written.To address this shortcoming in the literature,this paper provides a comprehensive survey of custom LE liner materials,design,and fabrication methods.First,custom LE liner materials and components are summarized,including a description of commercial liners and their efficacy.Subsequently,digital methods used to design and fabricate custom LE liners are addressed,including residual limb biomechanical modeling,finite element-based design methods,and 3-D printing techniques.Finally,current evaluation methods of custom/commercial LE liners are presented and discussed.We hope that this review article will inspire further research and development into the design and manufacture of custom LE liners. | Xingbang Yang Ruoqi Zhao Dana Solav Xuan Yang Duncan R.C.Lee Bjorn Sparrman Yubo Fan Hugh Herr | 2023 | Medicine in Novel Technology and Devices2023，，1： | 0 |
| 5 | The application of artificial intelligence in the management of sepsis显示文摘Sepsis is a complex and heterogeneous syndrome that remains a serious challenge to healthcare worldwide.Patients afflicted by severe sepsis or septic shock are customarily placed under intensive care unit(ICU)supervision,where a multitude of apparatus is poised to produce high-granularity data.This reservoir of high-quality data forms the cornerstone for the integration of AI into clinical practice.However,existing reviews currently lack the inclusion of the latest advancements.This review examines the evolving integration of artificial intelligence(AI)in sepsis management.Applications of artificial intelligence include early detection,subtyping analysis,precise treatment and prognosis assessment.AI-driven early warning systems provide enhanced recognition and intervention capabilities,while profiling analyzes elucidate distinct sepsis manifestations for targeted therapy.Precision medicine harnesses the potential of artificial intelligence for pathogen identification,antibiotic selection,and fluid optimization.In conclusion,the seamless amalgamation of artificial intelligence into the domain of sepsis management heralds a transformative shift,ushering in novel prospects to elevate diagnostic precision,therapeutic efficacy,and prognostic acumen.As AI technologies develop,their impact on shaping the future of sepsis care warrants ongoing research and thoughtful implementation. | Jie Yang Sicheng Hao Jiajie Huang Tianqi Chen Ruoqi Liu Ping Zhang Mengling Feng Yang He Wei Xiao Yucai Hong Zhongheng Zhang | 2023 | Medical Review2023，3，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员