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| 1 | Chemical composition,antioxidant and antibacterial activities of essential oil and methanol extract of Artemisia vulgaris and Gaultheria fragrantissima collected from Nepal显示文摘Objective: To identify the chemical constituents and biological activities of essential oil and crude methanol extract of Artemisia vulgaris(A.vulgaris) and Gaultheria fragrantissima(G.fragrantissima).Methods: Phytochemical screening, total phenolic and flavonoid content, antibacterial activities, anti-oxidant assay of the crude extract were carried out to identify the biological activities and phytonutrients present in the extract.Furthermore, the chemical constituents present in the essential oil and crude methanol extract were analyzed using gas chromatography mass spectroscopy and high performance liquid chromatography(HPLC) analysis.Results: Gas chromatography mass spectroscopy analysis of essential oil from the aerial part of A.vulgaris revealed 24 different compounds in it.Sabinene(11.29%), b-thujone(19.19%), chrysanthenone(4.48%), camphor(11.89%), borneol(4.44%) and germacrene D(8.42%) were the major compounds.Similarly, leaves of G.fragrantissima contained methyl salicylate(95%) and asarone(4.64%).Furthermore, methanol extract of leaves of A.vulgaris and G.fragrantissima were found rich in the total flavonoids and phenolic content.HPLC analysis of the methanol extract of leaves A.vulgaris revealed the presence of morin and luteolin, whereas rutin was found as a major flavonoids compound in the leaves of G.fragrantissima.Further, methanol extract of the A.vulgaris and G.fragrantissima showed the highest antioxidant and antibacterial properties compared to the essential oil.Conclusions: The HPLC analysis of the methanol extract of A.vulgaris shows the presence of luteolin and morin, whereas G.fragrantissima reveals the presence of rutin and a glycosylated flavonoids.Results reveal that A.vulgaris oil is the rich source of monoterpene and sesquiterpene compounds.Furthermore, A.vulgaris and G.fragrantissima are the rich source of the phenolic and flavonoids compounds and show good antioxidant and antibacterial activity. | Bishnu Prasad Pandey Rupak Thapa Anil Upreti | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，10： | 8 |
| 2 | Combined functional and anatomical diagnostic endpoints for assessing arteriovenous fistula dysfunction显示文摘Failure of arteriovenous fistulas(AVF) to mature and thrombosis in matured fistulas have been the major causes of morbidity and mortality in hemodialysis patients. Stenosis, which occurs due to adverse remodeling in AVFs, is one of the major underlying factors under both scenarios. Early diagnosis of a stenosis in an AVF can provide an opportunity to intervene in a timelymanner for either assisting the maturation process or avoiding the thrombosis. The goal of surveillance strategies was to supplement the clinical evaluation(i.e., physical examination) of the AVF for better and earlier diagnosis of a developing stenosis. Surveillance strategies were mainly based on measurement of functional hemodynamic endpoints, including blood flow(Q a) to the vascular access and venous access pressure(VAP). As the changes in arterial pressure(MAP) affects the level of VAP, the ratio of VAP to MAP(VAPR = VAP/MAP) was used for diagnosis. A Q a < 400-500 m L/min or a VAPR > 0.55 is considered sign of significant stenosis, which requires immediate intervention. However, due to the complex nature of AVFs, the surveillance strategies have failed to consistently detect stenosis under different scenarios. VAPR has been primarily developed to detect outflow stenosis in arteriovenous grafts, and it hasn't been successful in accurate diagnosis of outflow lesions in AVFs. Similarly, AVFs can maintain relatively high blood flow despite the presence of a significant outflow stenosis and thus, Q a has been found to be a better predictor of only inflow lesions. Similar shortcomings have been reported in the detection of functional severity of coronary stenosis using diagnostic endpoints that were based on either flow or pressure. This limitation has been associated with the fact that both pressure and flow change in the presence of a stenosis and thus, hemodynamic diagnostic endpoints that employ only one of these parameters are inherently prone to inaccuracies. Recent attempts have resulted in development of new diagnostic endpoints that can combine the effects of pressure and flow. These new hemodynamic diagnostic endpoints have shown to be better predictors of functional severity of lesions as compared to either flow or pressure based counterparts. In this review article, we discussed the advantages and limitations of current functional and anatomical diagnostic endpoints in AVFs. | Ehsan Rajabi-Jaghargh Rupak K Banerjee | 2015 | World Journal of Nephrology2015，4，1： | 6 |
| 3 | Observed changes in surface air temperature and precipitation in the Hindu Kush Himalayan region over the last 100-plus years显示文摘In this paper, we analyzed the long-term changes in temperature and precipitation in the Hindu Kush Himalayan (HKH) region based on climate datasets LSAT-V1.1 and CGP1.0 recently developed by the China Meteorological Administration. The analysis results show that during 1901e2014 the annual mean surface air temperature over the whole HKH has undergone a significant increasing trend. We determined the change rates in the mean temperature, mean maximum temperature, and mean minimum temperature to be 0.104 C per decade, 0.077 C per decade, and 0.176 C per decade, respectively. Most parts of the HKH have experienced a warming trend, with the largest increase occurring on the Tibetan Plateau (TP) and south of Pakistan. The trend of precipitation for the whole HKH is characterized by a slight decrease during 1901e2014. During 1961e2013, however, the trend of the annual precipitation shows a statistically significant increase, with a rate of 5.28% per decade and has a more rapid increase since the mid-1980s. Most parts of northern India and the northern TP have experienced a strong increase in the number of precipitation days (daily rainfall 1 mm), whereas Southwest China and Myanmar have experienced a declining trend in precipitation days. Compared to the trends in precipitation days, the spatial pattern of trends in the precipitation intensity seems to be more closely related to the terrain, and the higher altitude areas have shown more significant upward trends in precipitation intensity during 1961e2013. | REN Yu-Yu REN Guo-Yu SUN Xiu-Bao Arun Bhakta SHRESTHA YOU Qing-Long ZHAN Yun-Jian Rupak RAJBHANDARI ZHANG Pan-Feng WEN Kang-Min | 2017 | Advances in Climate Change Research2017，8，3： | 6 |
| 4 | Changes in extreme temperature events over the Hindu Kush Himalaya during 1961e2015显示文摘This study uses the CMA (China Meteorological Administration) global land-surface daily air temperature dataset V1.0 (GLSATD V1.0) to analyze long-term changes in extreme temperature events over the Hindu Kush Himalaya (HKH) during 1961e2015. Results show there was a significant decrease in the number of extreme cold events (cold nights, cold days, and frost days) but a significant increase in the number of extreme warm events (warm nights, warm days, and summer days) over the entire HKH during 1961e2015. For percentile-based indices, trends of extreme events related to minimum temperature (Tmin) were greater in magnitude than those related to maximum temperature (Tmax). For absolute-value based indices, maximum Tmax, minimum Tmin, and summer days all show increasing trends, while frost days and the diurnal temperature range (DTR) show significant decreasing trends. In addition, there was a decrease in extreme cold events in most parts of east HKH, particularly in Southwest China and the Tibetan Plateau, while there was a general increase in extreme warm events over the entire HKH. Finally, the change in extreme cold events in the HKH appears to be more sensitive to elevation (with cold nights and cold days decreasing with elevation), whereas the change in warm extremes (warm nights, warm days, and maximum Tmax) shows no detectable relationship with elevation. Frost days and minimum Tmin also have a good relationship with elevation, and the trend in frost days decreases with an increase in elevation while the trend in minimum Tmin increases with an increase in elevation. | SUN Xiu-Bao REN Guo-Yu Arun Bhaka SHRESTHA REN Yu-Yu YOU Qing-Long ZHAN Yun-Jian XU Yan Rupak RAJBHANDARI | 2017 | Advances in Climate Change Research2017，8，3： | 5 |
| 5 | Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance显示文摘Antibiotics are the chemotherapeutic agents that kill or inhibit the pathogenic microorganisms.Resistance of microorganism to antibiotics is a growing problem around the world due to indiscriminate and irrational use of antibiotics.In order to overcome the resistance problem and to safely use antibiotics,the correct measurement of potency and bioactivity of antibiotics is essential.Microbiological assay and high performance liquid chromatography(HPLC) method are used to quantify the potency of antibiotics.HPLC method is commonly used for the quantification of potency of antibiotics,but unable to determine the bioactivity;whereas microbiological assay estimates both potency and bioactivity of antibiotics.Additionally,bioassay is used to estimate the effective dose against antibiotic resistant microbes.Simultaneously,microbiological assay addresses the several parameters such as minimal inhibitory concentration(MIC),minimum bactericidal concentration(MBC),mutation prevention concentration(MPC) and critical concentration(Ccr) which are used to describe the potency in a more informative way.Microbiological assay is a simple,sensitive,precise and cost effective method which gives reproducible results similar to HPLC.However,the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results. | Nishant A.Dafale Uttam P.Semwal Rupak K.Rajput G.N.Singh | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 5 |
| 6 | Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample显示文摘BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and goutrelated hospitalizations, relevant comorbidities, revascularization and postrevascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACSgout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17- 1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, postoperative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of postrevascularization in-hospital mortality in ACS, it did increase postrevascularization complications. | Rupak Desai Tarang Parekh Hemant Goyal Hee Kong Fong Dipen Zalavadia Nanush Damarlapally Rajkumar Doshi Sejal Savani Gautam Kumar Rajesh Sachdeva | 2019 | World Journal of Cardiology2019，11，5： | 4 |
| 7 | Changes in extreme precipitation events over the Hindu Kush Himalayan region during 1961e2012显示文摘Based on a new multi-source dataset (GLDP-V1.0) recently developed in China Meteorological Administration, we employed precipitation indices including percentile-based indices of light (below the 50th percentile), moderate (between the 50th and 90th percentile), and intense (above the 90th percentile) precipitation, maximum 1-day, 3-day, and 5-day precipitation amounts (RX1DAY, RX3DAY, and RX5DAY, respectively), and consecutive wet and dry days (CWDs and CDDs) to analyze variations in extreme precipitation events in the Hindu Kush Himalayan (HKH) during 1961e2012. The main results are presented as follows. Firstly, there was a significant increase in the amount of light and moderate precipitation and number of associated days over various parts of India and northern Tibetan Plateau during 1961e2012; but the intensity of light precipitation decreased significantly in the Hindu Kush and central India, and the regional average intensity also decreased. Secondly, the amount and frequency of intense precipitation mostly increased significantly on the Tibetan Plateau, but there was a heterogeneous change over the remainder of the HKH, and regional average annual intense precipitation amount and frequency significantly increased over the HKH during 1961e2012. Thirdly, regional average RX1DAY, RX3DAY, and RX5DAYall showed significant upward trends during 1961e2012, and there was a significant increased tendency of consecutive wet-days in most parts of the study region; however, trends of consecutive dry-days were mostly opposite to those of consecutive wet-days, with regional averaged consecutive dry-days showing no noticeable trend. | ZHAN Yun-Jian REN Guo-Yu Arun Bhaka SHRESTHA Rupak RAJBHANDARI REN Yu-Yu Jayanarayanan SANJAY XU Yan SUN Xiu-Bao YOU Qing-Long WANG Shu | 2017 | Advances in Climate Change Research2017，8，3： | 3 |
| 8 | Downscaled climate change projections for the Hindu Kush Himalayan region using CORDEX South Asia regional climate models显示文摘This study assessed the regional climate models (RCMs) employed in the Coordinated Regional climate Downscaling Experiment (CORDEX) South Asia framework to investigate the qualitative aspects of future change in seasonal mean near surface air temperature and precipitation over the Hindu Kush Himalayan (HKH) region. These RCMs downscaled a subset of atmosphere ocean coupled global climate models (AOGCMs) in the Coupled Model Intercomparison Project phase 5 (CMIP5) to higher 50 km spatial resolution over a large domain covering South Asia for two representation concentration pathways (RCP4.5 and RCP8.5) future scenarios. The analysis specifically examined and evaluated multi-model and multi-scenario climate change projections over the hilly sub-regions within HKH for the near-future (2036e2065) and far-future (2066e2095) periods. The downscaled multi-RCMs provide relatively better confidence than their driving AOGCMs in projecting the magnitude of seasonal warming for the hilly sub-region within the Karakoram and northwestern Himalaya, with higher projected change of 5.4 C during winter than of 4.9 C during summer monsoon season by the end of 21st century under the high-end emissions (RCP8.5) scenario. There is less agreement among these RCMs on the magnitude of the projected warming over the other sub-regions within HKH for both seasons, particularly associated with higher RCM uncertainty for the hilly sub-region within the central Himalaya. The downscaled multi-RCMs show good consensus and low RCM uncertainty in projecting that the summer monsoon precipitation will intensify by about 22% in the hilly subregion within the southeastern Himalaya and Tibetan Plateau for the far-future period under the RCP8.5 scenario. There is low confidence in the projected changes in the summer monsoon and winter season precipitation over the central Himalaya and in the Karakoram and northwestern Himalaya due to poor consensus and moderate to high RCM uncertainty among the downscaled multi-RCMs. Finally, the RCM related uncertainty is found to be large for the projected changes in seasonal temperature and precipitation over the hilly sub-regions within HKH by the end of this century, suggesting that improving the regional processes and feedbacks in RCMs are essential for narrowing the uncertainty, and for providing more reliable regional climate change projections suitable for impact assessments in HKH region. | Jayanarayanan SANJAY Raghavan KRISHNAN Arun Bhakta SHRESTHA Rupak RAJBHANDARI REN Guo-Yu | 2017 | Advances in Climate Change Research2017，8，3： | 3 |
| 9 | Clinical outcomes of combined flow-pressure drop measurements using newly developed diagnostic endpoint:Pressure drop coefficient in patients with coronary artery dysfunction显示文摘AIM:To combine pressure and flow parameter, pressure drop coefficient(CDP) will result in better clinical outcomes in comparison to the fractional flow reserve(FFR) group. METHODS:To test this hypothesis, a comparison was made between the FFR < 0.75 and CDP > 27.9 groups in this study, for the major adverse cardiac events [major adverse cardiac events(MACE): Primary outcome] and patients’ quality of life(secondary outcome). Further, a comparison was also made between the survival curves for the FFR < 0.75 and CDP > 27.9 groups. Two-tailed χ~2 test proportions were performed for the comparison of primary and secondary outcomes. Kaplan-Meier survival analysis was performed to compare the survival curves of FFR < 0.75 and CDP > 27.9 groups(MedcalcV10.2, Mariakerke, Belgium). Results were considered statistically significant for P < 0.05. RESULTS: The primary outcomes(%MACE) in the FFR < 0.75 group(20%, 4 out of 20) was not statistically different(P = 0.24) from the %MACE occurring in CDP > 27.9 group(8.57%, 2 out of 35). Noteworthy is the reduction in the %MACE in the CDP > 27.9 group, in comparison to the FFR < 0.75 group. Further, the secondary outcomes were not statistically significant between the FFR < 0.75 and CDP > 27.9 groups. Survival analysis results suggest that the survival time for the CDP > 27.9 group(n = 35) is significantly higher(P = 0.048) in comparison to the survival time for the FFR < 0.75 group(n = 20). The results remained similar for a FFR = 0.80 cut-off. CONCLUSION: Based on the above, CDP could prove to be a better diagnostic end-point for clinical revascularization decision-making in the cardiac catheterization laboratories. | Mohamed A Effat Srikara Viswanath Peelukhana Rupak K Banerjee | 2016 | World Journal of Cardiology2016，8，3： | 2 |
| 10 | Bilateral traumatic proximal humerus fractures managed by open reduction and internal fixation with locked plates显示文摘近似肱骨的破裂在年轻病人是不平常的。尽管近似肱骨本身的双边的骨折是稀罕的,有癫痫和电刑的协会是经常的。仅仅创伤的双边的近似肱骨骨折的一个案例在文学被报导了。我们在 40 岁男性病人报导双边的创伤的代替的近似肱骨破裂的一个稀罕案例,它与近似肱骨借助于开的减小和内部固定被对待在双方上锁了头并且获得了好功能的结果。 | Atin Jaiswal Naiman Deepak Kachchhapt Rupak Chaterjee Yashwant Singh Tanwar Masood Habib Satya Prakash Singh | 2013 | Chinese Journal of Traumatology2013，16，6： | 2 |
| 11 | Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient:A pilot outcome study显示文摘AIM To investigate the patient-outcomes of newly developed pressure drop coefficient(CDP) in diagnosing epicardial stenosis(ES) in the presence of concomitant microvascular disease(MVD).METHODS Patients from our clinical trial were divided into two subgroups with:(1) cut-off of coronary flow reserve(CFR) < 2.0;and(2) diabetes.First,correlations were performed for both subgroups between CDP and hyperemic microvascular resistance(HMR),a diagnostic parameter for assessing the severity of MVD.Linear regression analysis was used for these correlations.Further,in each of the subgroups,comparisons were made between fractional flow reserve(FFR) < 0.75 and CDP > 27.9 groups for assessing major adverse cardiac events(MACE:Primary outcome).Comparisons were also made between the survival curves for FFR < 0.75 and CDP > 27.9 groups.Two tailed chi-squared and Fischer's exact tests were performed for comparison of the primary outcomes,and the log-rank test was used to compare the Kaplan-Meier survival curves.P < 0.05 for all tests was considered statistically significant.RESULTS Significant linear correlations were observed between CDP and HMR for both CFR < 2.0(r = 0.58,P < 0.001) and diabetic(r = 0.61,P < 0.001) patients.In the CFR < 2.0 subgroup,the %MACE(primary outcomes) for CDP > 27.9 group(7.7%,2/26) was lower than FFR < 0.75 group(3/14,21.4%);P = 0.21.Similarly,in the diabetic subgroup,the %MACE for CDP > 27.9 group(12.5%,2/16) was lower than FFR < 0.75 group(18.2%,2/11);P = 0.69.Survival analysis for CFR < 2.0 subgroup indicated better event-free survival for CDP > 27.9 group(n = 26) when compared with FFR < 0.75 group(n = 14);P = 0.10.Similarly,for the diabetic subgroup,CDP > 27.9 group(n = 16) showed higher survival times compared to FFR group(n = 11);P = 0.58.CONCLUSION CDP correlated significantly with HMR and resulted in better %MACE as well as survival rates in comparison to FFR.These positive trends demonstrate that CDP could be a potential diagnostic endpoint for delineating MVD with or without ES. | Ullhas Udaya Hebbar Mohamed A Effat Srikara V Peelukhana Imran Arif Rupak K Banerjee | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 12 | Functional and Anatomical Diagnosis of Coronary Artery Stenoses显示文摘 | Abhijit Sinha Roy Martin R. Back Saeb F. Khoury Eric W. Schneeberger Lloyd H. Back Vijaya V. Velury Ronald W. Millard Rupak K. Banerjee | 2008 | Journal of Surgical Research2008，，： | 2 |
| 13 | Influence of coronary collateral flow on coronary diagnostic parameters: An in vitro study显示文摘 | Srikara Viswanath Peelukhana Lloyd H. Back Rupak K. Banerjee | 2009 | Journal of Biomechanics2009，，： | 1 |
| 14 | Microbial transformation of baccatin VI and 1β-Hydroxy baccatin I by aspergillus niger显示文摘 | Ya-Ching Shen Kuang-Liang Lo Chun-Ling Lin Rupak Chakraborty | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，24： | 1 |
| 15 | Spectroscopic studies of the ionic liquid during the eleetrodeposition of A1-Ti alloy in 1-ethyl-3-methylimidazolium chloride melt显示文摘 | Abhishek Lahiri Rupak Das | 2012 | Mate- rials Chemistry and Physics2012，132，： | 1 |
| 16 | Spectroscopic studies of the ionic liquid during the electrodeposition of Al–Ti alloy in 1-ethyl-3-methylimidazolium chloride melt显示文摘 | Abhishek Lahiri Rupak Das | 2011 | Materials Chemistry and Physics2011，，1： | 1 |
| 17 | Software Model Checking显示文摘 | Ranjit Jhala Rupak Majumdar | 2009 | ACM Computing Surveys (CSUR)2009，，： | 1 |
| 18 | Mechanical properties of talc filled i-PP/CSM rubber composites显示文摘 | Maiti S N Rupak D | 2005 | International Journal of Polymeric Materials2005，54，： | 1 |
| 19 | Selective Induction of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Atrial and Ventricular Myocardium in Patients With Atvial Fibrillation显示文摘 | Amanda R Hemon BS Abigails | 2006 | Am/Cardiol2006，97，： | 1 |
| 20 | Characterizing momentum change and viscous loss of a hemodynamic endpoint in assessment of coronary lesions显示文摘 | Rupak K. Banerjee Abhijit Sinha Roy Lloyd H. Back Martin R. Back Saeb F. Khoury Ronald W. Millard | 2006 | Journal of Biomechanics2006，，： | 1 |
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