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| 1 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 2 | A competitive microcystin-LR immunosensor based on Au NPs@metal-organic framework(MIL-101)显示文摘An electrochemical immunosensor was developed for ultrasensitive detection of microcystin-LR in water. MIL-101, a porous metal-organic frameworks(MOFs) material based on trivalent chromium skeleton were synthesized by hydrothermal synthesis method, and loaded with Au nanoparticles(Au NPs) to prepare Au NPs@MIL-101 composite materials which were used as a marker to label anti microcystin-LR(Anti-MC-LR). The composite materials have strong catalytic properties to the oxidation of ascorbic acid. Anti-MC-LR was immobilized on glassy carbon electrode surface using electrodeposition graphene oxide(GO) as an immobilization matrix to construct a competitive microcystin-LR immunosensor. The electrochemical immunosensor display linear relationship in the range of 0.05 ng/mL-75 μg/mL with linear correlation coefficient of 0.9951 and detection limit of 0.02 ng/mL(S/N = 3). This sensor was used to detect microcystin-LR in the water sample. The recovery was 102.43%,which is satisfied. The good testing results indicate the sensor has a great prospect in practical application. | Kunlei Zhang Kun Dai Ruyan Bai Yuchan Ma Yan Deng Delei Li Xi Zhang Rong Hu Yunhui Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 3 | Scalable privacy-preserving big data aggregation mechanism显示文摘 | Dapeng Wu Boran Yang Ruyan Wang | 2016 | Digital Communications and Networks2016，2，3： | 2 |
| 4 | UTM:A trajectory privacy evaluating model for online health monitoring显示文摘A huge amount of sensitive personal data is being collected by various online health monitoring applications.Although the data is anonymous,the personal trajectories(e.g.,the chronological access records of small cells)could become the anchor of linkage attacks to re-identify the users.Focusing on trajectory privacy in online health monitoring,we propose the User Trajectory Model(UTM),a generic trajectory re-identification risk predicting model to reveal the underlying relationship between trajectory uniqueness and aggregated data(e.g.,number of individuals covered by each small cell),and using the parameter combination of aggregated data to further mathematically derive the statistical characteristics of uniqueness(i.e.,the expectation and the variance).Eventually,exhaustive simulations validate the effectiveness of the UTM in privacy risk evaluation,confirm our theoretical deductions and present counter-intuitive insights. | Zhigang Yang Ruyan Wang Dapeng Wu Daizhong Luo | 2021 | Digital Communications and Networks2021，7，3： | 0 |
| 5 | A novel data channel fault detection mechanism in optical burst switching networks显示文摘 | 常交法 Wang Ruyan Long Keping Yang Xiaolong Lv Kewei Duan Zhenying | 2007 | High Technology Letters2007，13，3： | 0 |
| 6 | Current Status and Future Trends for Mooring Systems of Floating Offshore Wind Turbines显示文摘With the increasing demand of energy and the limitation of bottom-fixed wind turbines in moderate and deep waters,floating offshore wind turbines are doomed to be the right technical choice and they are bound to enter a new era of rapid development.The mooring system is a vital system of a floating wind turbine for station-keeping under harsh environmental conditions.In terms of existing floating wind turbine projects,this paper is devoted to discussing the current status of mooring systems and mooring equipment.This paper also presents the mooring analysis methods and points out the technical difficulties and challenges in mooring design,installation,operation and maintenance stages.Finally,the developing trends of the mooring system are summarized,aiming to provide a reference for future mooring research. | Ruyan Yang Xiangyuan Zheng Jinlu Chen Yufei Wu | 2022 | Sustainable Marine Structures2022，4，2： | 0 |
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