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| 1 | Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene显示文摘Dipentaerythritol(DPER),4,40-diphenylmethanediisocyanate(MDI)and melamine(MEL)are used as raw materials to microencapsulate ammonium polyphosphate(MAPP)in situ polymerization.The MAPP is characterized by Fourier transform infrared(FT-IR),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and thermal gravimetric analysis(TGA).The results show that the coating operation can effectively improve water resistance of ammonium polyphosphate(APP),and MAPP has higher residual rate than that of APP after combustion.The flame retardant action of MAPP and APP in polypropylene(PP)is investigated by the limited oxygen index(LOI),vertical burning test(UL-94),TGA,SEM,and cone calorimeter test(CCT).The LOI value of the PP/MAPP composite at the same loading is higher than that of PP/APP composite.UL 94 ratings of PP/MAPP composites are raised to V-0 at 20 wt%loading.The results of CCT also show that MAPP is more efficient than APP.The morphological structures observed by digital photos and SEM demonstrated that MAPP could be promoted to form the continuous and compact intumescent char layer.The flame retardant mechanism of PP/MAPP is also discussed. | Shouwu Yu Shujuan Xiao Zewen Zhao Xiaowen Huo Junfu Wei | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 6 |
| 2 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 3 | Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip显示文摘EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells,which may be covered by the noises from majority of unmutated cells, is currently becoming an urgent clinical requirement. Here we present the validation of a microfluidic-chip-based method for detecting EGFR multimutations at single-cell level. By trapping and immunofluorescently imaging single cells in specifically designed silicon microwells, the EGFR-expressed cellswere easily identified. By in situ lysing single cells, the cell lysates of EGFR-expressed cells were retrieved without cross-contamination. Benefited from excluding the noise from cells without EGFR expression, the simple and cost-effective Sanger's sequencing, but not the expensive deep sequencing of the whole cell population, was used to discover multi-mutations. We verified the new method with precisely discovering three most important EGFR drugrelated mutations from a sample in which EGFR-mutated cells only account for a small percentage of whole cell population. The microfluidic chip is capable of discovering not only the existence of specific EGFR multi-mutations,but also other valuable single-cell-level information: on which specific cells the mutations occurred, or whether different mutations coexist on the same cells. This microfluidic chip constitutes a promising method to promote simple and cost-effective Sanger's sequencing to be a routine test before performing targeted cancer therapy. | Ren Li Mingxing Zhou Jine Li Zihua Wang Weikai Zhang Chunyan Yue Yan Ma Hailin Peng Zewen Wei Zhiyuan Hu | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 4 | An Efficient and High-Throughput Electroporation Microehip Applicable for siRNA Delivery 显示文摘 | Huang Huang Zewen Wei Yuanyu Huang | 2011 | Lab on a Chip2011，11，： | 1 |
| 5 | Toward carbon neutrality:Uncovering constraints on critical minerals in the Chinese power system显示文摘China has set up its ambitious carbon neutrality target,which mainly relies on significant energy-related carbon emissions reduction.As the largest important contributing sector,power sector must achieve energy transition,in which critical minerals will play an essential role.However,the potential supply and demand for these minerals are uncertain.This study aims to predict the cumulative demand for critical minerals in the power sector under different scenarios via dynamic material flow analysis(DMFA),including total demands,supplies and production capacities of different minerals.Then,these critical minerals are categorized into superior and scarce resources for further analysis so that more detailed results can be obtained.Results present that the total minerals supply will not meet the total minerals demand(74260 kt)in 2060.Serious resource shortages will occur for several key minerals,such as Cr,Cu,Mn,Ag,Te,Ga,and Co.In addition,the demand for renewable energy will be nearly fifty times higher than that of fossil fuels energy,implying more diversified demands for various minerals.Finally,several policy recommendations are proposed to help improve the overall resource efficiency,such as strategic reserves,material substitutions,and circular economy. | Wendong Wei Zewen Ge Yong Geng Mingkun Jiang Zhujun Chen Wei Wu | 2022 | Fundamental Research2022，2，3： | 1 |
| 6 | A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss显示文摘Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone.Presently,no effective countermeasure exists,and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity.The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy.Our studies revealed that P7C3 repressed ionizing radiation(IR)-induced osteoclastic activity,inhibited adipogenesis,and promoted osteoblastogenesis and mineral deposition in vitro.We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened,osteoporotic bone.However,the administration of P7C3 significantly inhibited osteoclastic activity,lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area,architecture,and mechanical strength.Our findings revealed significant enhancement of cellular macromolecule metabolic processes,myeloid cell differentiation,and the proteins LRP-4,TAGLN,ILK,and Tollip,with downregulation of GDF-3,SH2B1,and CD200.These proteins are key in favoring osteoblast over adipogenic progenitor differentiation,cell matrix interactions,and shape and motility,facilitating inflammatory resolution,and suppressing osteoclastogenesis,potentially via Wnt/β-catenin signaling.A concern was whether P7C3 afforded similar protection to cancer cells.Preliminarily,and remarkably,at the same protective P7C3 dose,a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro.Together,these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy,leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications.Our data uncover a new approach for the prevention of radiation-induced bone damage,and further work is needed to investigate its ability to selectively drive cancer cell death. | Fei Wei Zewen Kelvin Tuong Mahmoud Omer Christopher Ngo Jackson Asiatico Michael Kinzel Abinaya Sindu Pugazhendhi Annette R.Khaled Ranajay Ghosh Melanie Coathup | 2023 | Bone Research2023，11，3： | 0 |
| 7 | Enhanced galloping energy harvester with cooperative mode of vibration and collision显示文摘The low power and narrow speed range remain bottlenecks that constrain the application of small-scale wind energy harvesting.This paper proposes a simple,lowcost,and reliable method to address these critical issues.A galloping energy harvester with the cooperative mode of vibration and collision(GEH-VC)is presented.A pair of curved boundaries attached with functional materials are introduced,which not only improve the performance of the vibration energy harvesting system,but also convert more mechanical energy into electrical energy during collision.The beam deforms and the piezoelectric energy harvester(PEH)generates electricity during the flow-induced vibration.In addition,the beam contacts and separates from the boundaries,and the triboelectric nanogenerator(TENG)generates electricity during the collision.In order to reduce the influence of the boundaries on the aerodynamic performance and the feasibility of increasing the working area of the TENG,a vertical structure is designed.When the wind speed is high,the curved boundaries maintain a stable amplitude of the vibration system and increase the frequency of the vibration system,thereby avoiding damage to the piezoelectric sheet and improving the electromechanical conversion efficiency,and the TENG works with the PEH to generate electricity.Since the boundaries can protect the PEH at high wind speeds,its stiffness can be designed to be low to start working at low wind speeds.The electromechanical coupling dynamic model is established according to the GEH-VC operating principle and is verified experimentally.The results show that the GEH-VC has a wide range of operating wind speeds,and the average power can be increased by 180%compared with the traditional galloping PEH.The GEH-VC prototype is demonstrated to power a commercial temperature sensor.This study provides a novel perspective on the design of hybrid electromechanical conversion mechanisms,that is,to combine and collaborate based on their respective characteristics. | Qiong WANG Zewen CHEN Linchuan ZHAO Meng LI Hongxiang ZOU Kexiang WEI Xizheng ZHANG Wenming ZHANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，7： | 0 |
| 8 | 40 Hz light flickering promotes sleep through cortical adenosine signaling显示文摘Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders.However,the lack of a neurochemical underpinning has hampered its therapeutic development.Here,we demonstrate that light flickering triggered an immediate and sustained increase(up to 3 h after flickering)in extracellular adenosine levels in the primary visual cortex(V1)and other brain regions,as a function of light frequency and intensity,with maximal effects observed at 40 Hz frequency and 4000 lux.We uncovered cortical(glutamatergic and GABAergic)neurons,rather than astrocytes,as the cellular source,the intracellular adenosine generation from AMPK-associated energy metabolism pathways(but not SAM-transmethylation or salvage purine pathways),and adenosine efflux mediated by equilibrative nucleoside transporter-2(ENT2)as the molecular pathway responsible for extracellular adenosine generation.Importantly,40 Hz(but not 20 and 80 Hz)light flickering for 30 min enhanced non-rapid eye movement(non-REM)and REM sleep for 2–3 h in mice.This somnogenic effect was abolished by ablation of V1(but not superior colliculus)neurons and by genetic deletion of the gene encoding ENT2(but not ENT1),but recaptured by chemogenetic inhibition of V1 neurons and by focal infusion of adenosine into V1 in a dose-dependent manner.Lastly,40 Hz light flickering for 30 min also promoted sleep in children with insomnia by decreasing sleep onset latency,increasing total sleep time,and reducing waking after sleep onset.Collectively,our findings establish the ENT2-mediated adenosine signaling in V1 as the neurochemical basis for 40 Hz flickering-induced sleep and unravel a novel and non-invasive treatment for insomnia,a condition that affects 20%of the world population. | Xuzhao Zhou Yan He Tao Xu Zhaofa Wu Wei Guo Xi Xu Yuntao Liu Yi Zhang Huiping Shang Libin Huang Zhimo Yao Zewen Li Lingya Su Zhihui Li Tao Feng Shaomin Zhang Olivia Monteiro Rodrigo A.Cunha Zhi-Li Huang Kang Zhang Yulong Li Xiahong Cai Jia Qu Jiang-Fan Chen | 2024 | Cell Research2024，34，3： | 0 |
| 9 | Study on the controllability of the fabrication of single-crystal silicon nanopores/nanoslits with a fast-stop ionic current-monitored TSWE method显示文摘The application of single-crystal silicon(SCS)nanopore structures in single-molecule-based analytical devices is an emerging approach for the separation and analysis of nanoparticles.The key challenge is to fabricate individual SCS nanopores with precise sizes in a controllable and reproducible way.This paper introduces a fast-stop ionic current-monitored three-step wet etching(TSWE)method for the controllable fabrication of SCS nanopores.Since the nanopore size has a quantitative relationship with the corresponding ionic current,it can be regulated by controlling the ionic current.Thanks to the precise current-monitored and self-stop system,an array of nanoslits with a feature size of only 3 nm was obtained,which is the smallest size ever reported using the TSWE method.Furthermore,by selecting different current jump ratios,individual nanopores of specific sizes were controllably prepared,and the smallest deviation from the theoretical value was 1.4 nm.DNA translocation measurement results revealed that the prepared SCS nanopores possessed the excellent potential to be applied in biosensing. | Hao Hong Jiangtao Wei Xin Lei Haiyun Chen Pasqualina M.Sarro Guoqi Zhang Zewen Liu | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
| 10 | Hierarchical structural complexity in atomically precise nanocluster frameworks显示文摘The supramolecular chemistry of nanoclusters is a flourishing area of nano-research;however,the controllable assembly of cluster nano-building blocks in different arrays remains challenging.In this work,we report the hierarchical structural complexity of atomically precise nanoclusters in micrometric linear chains(1 D array),grid networks(2 D array) and superstructures(3 D array).In the crystal lattice,the Ag_(29)(SSR)_(12)(PPh3)4 nanoclusters can be viewed as unassembled cluster dots(Ag_(29)-OD).In the presence of Cs^(+) cations,the Ag_(29)(SSR)_(12) nano-building blocks are selectively assembled into distinct arrays with different oxygen-carrying solvent molecules—Cs@Ag_(29)(SSR)_(12)(DMF)x as 1 D linear chains(Ag_(29)-1 D),Cs@Ag_(29)(SSR)_(12)(NMP)x as 2 D grid networks(Ag_(29)-2 D),and Cs@Ag_(29)(SSR)_(12)(TMS)_(x) as 3 D superstructures(Ag_(29)-3 D).Such self-assemblies of these Ag_(29)(SSR)_(12) units have not only been observed in their crystalline state,but also in their amorphous state.Due to the diverse surface structures and crystalline packing modes,these Ag_(29)-based assemblies manifest distinguishable optical absorptions and emissions in both solutions and crystallized films.Furthermore,the surface areas of the nanocluster crystals are evaluated,the maximum value of which occurs when the cluster nano-building blocks are assembled into 2 D arrays(i.e.Ag_(29)-2 D).Overall,this work presents an exciting example of the hierarchical assembly of atomically precise nanoclusters by simply controlling the adsorbed molecules on the cluster surface. | Xiao Wei Xi Kang Zewen Zuo Fengqi Song Shuxin Wang Manzhou Zhu | 2021 | National Science Review2021，8，3： | 0 |
| 11 | Textured Asymmetric Membrane Electrode Assemblies of Piezoelectric Phosphorene and Ti_(3)C_(2)T_(x)MXene Heterostructures for Enhanced Electrochemical Stability and Kinetics in LIBs显示文摘Black phosphorus with a superior theoretical capacity(2596 mAh g^(-1))and high conductivity is regarded as one of the powerful candidates for lithium-ion battery(LIB)anode materials,whereas the severe volume expansion and sluggish kinetics still impede its applications in LIBs.By contrast,the exfoliated two-dimensional phosphorene owns negligible volume variation,and its intrinsic piezoelectricity is considered to be beneficial to the Li-ion transfer kinetics,while its positive influence has not been discussed yet.Herein,a phosphorene/MXene heterostructure-textured nanopiezocomposite is proposed with even phosphorene distribution and enhanced piezo-electrochemical coupling as an applicable free-standing asymmetric membrane electrode beyond the skin effect for enhanced Li-ion storage.The experimental and simulation analysis reveals that the embedded phosphorene nanosheets not only provide abundant active sites for Li-ions,but also endow the nanocomposite with favorable piezoelectricity,thus promoting the Li-ion transfer kinetics by generating the piezoelectric field serving as an extra accelerator.By waltzing with the MXene framework,the optimized electrode exhibits enhanced kinetics and stability,achieving stable cycling performances for 1,000 cycles at 2 A g^(-1),and delivering a high reversible capacity of 524 m Ah g^(-1)at-20℃,indicating the positive influence of the structural merits of self-assembled nanopiezocomposites on promoting stability and kinetics. | Yihui Li Juan Xie Ruofei Wang Shugang Min Zewen Xu Yangjian Ding Pengcheng Su Xingmin Zhang Liyu Wei Jing‑Feng Li Zhaoqiang Chu Jingyu Sun Cheng Huang | 2024 | Nano-Micro Letters2024，16，4： | 0 |
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