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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 4 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 5 | Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats 显示文摘 | Keith I M Tjen-A-Looi S Kraiczi H | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 2 |
| 6 | SCIENCE OF WINNING SOCCER:EMERGENT PATTERN-FORMING DYNAMICS IN ASSOCIATION FOOTBALL显示文摘Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social systems.Here,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team sports.The authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes location.The authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive opportunity.The authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own goal.This is consistent with a predominantly defensive strategy intended to prevent yielding even a single goal.The authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive opportunity.That team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would indicate.The proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player capability.It supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching strategy.By applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play. | VILAR Luís ARAUJO Duarte DAVIDS Keith BAR-YAM Yaneer | 2013 | Journal of Systems Science & Complexity2013，26，1： | 2 |
| 7 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 8 | Analytical methods for detection of selected estrogenic compounds in aqueous mixtures 显示文摘 | Snyder S A Keith T L Verbrugge D A | 1999 | Environ Sci Technol1999，33，16： | 2 |
| 9 | Nanofabrication with proximal probes显示文摘 | Campbell Paul M Perkins F Keith | 1997 | Proceedings of the IEEE1997，85，4： | 1 |
| 10 | On the role of Mn (IV) vacancies in the photoreductive dissolution of hexagonal birnessite显示文摘 | KIDEOK D K KEITH R GARRISON S | 2009 | Geochimica et Cosmochimica Acta2009，73，： | 1 |
| 11 | The sequence of the rice phytochrome gene显示文摘 | Kay S A Keith B Shinozaki K | | 0，，： | 1 |
| 12 | Human Neuroblastonm( SH- SY5Y) Cell Culture and Differentiation in 3-D Collagen Hydrogels for Cell-Based Biosensing 显示文摘 | Desai A Kisaalita W S Keith C | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
| 13 | Generalizing the partial global planning algorithm 显示文摘 | Decker Keith S Lesser Victor R | 1992 | International Journal of Intelligent and Cooperative Information System1992，1，2： | 1 |
| 14 | Characterization of inclusion complexes of betamethasone - related steroids with cy- clodextrins using high- performance liquid chromatography显示文摘 | Keith G F Eugene R R Nicholas H S | 2000 | Chromatography A2000，903，12： | 1 |
| 15 | Effects of simulated acidic rain on yields of field-grown crops显示文摘 | LNACE S E KEITH F L ELIZABETH A C | 1982 | New Phytol1982，91，： | 1 |
| 16 | Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors显示文摘 | LY K S LETAVIC M A KEITH J M | 2008 | Bioorg Med Chem Lett2008，18，1： | 1 |
| 17 | PIK-Related Kinases: DNA repair, recombination, and cell cycle checkpoint显示文摘 | Keith C T Schreiber S L | 1995 | Science1995，270，1： | 1 |
| 18 | The epidemiology and diagnosis of penetrating eye injuries显示文摘 | David S Keith W Lawrence SB | 2002 | Accad Emerge Med2002，9，3： | 1 |
| 19 | Bioconcentration of nonyiphenol in fathead minnows ( pimephales promelas) 显示文摘 | SNYDER S A KEITH T L PIERENS S L | 2001 | Chemosphere2001，44，8： | 1 |
| 20 | Factors controlling prolific gas production from low-permeability sandstone reservoirs= Implica- tions for resource assessment, prospect development, and risk analysis显示文摘 | Keith W S Robert M C John W R | 2004 | AAPG Bulletin2004，88，10： | 1 |
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