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| 1 | 老年复杂糖尿病患者的潜在过度治疗显示文摘价值对于存在多种严重合并症及功能受限的老年人来说,强化血糖控制所带来的伤害很可能超过其所带来的益处。目的通过健康状况检测老年糖尿病患者的血糖控制水平,并评估糖尿病潜在过度治疗的发生率。设计、设定及参与者对国家健康与营养调查研究中2001—2010年进行了糖化血红蛋白(HbA_(1c))测定的1 288例老年(≥65岁)糖尿病患者的资料进行横断面分析。所有分析具备复杂的调查设计以生成国家代表性评估。表现健康状况分类:非常复杂/差,至少有两项日常活动做起来困难,或者依赖透析;复杂/一般,至少有两项日常工具的使用困难,或存在至少3种慢性疾病;相对健康,不具备以上几点。主要结果及措施严格的血糖控制(HbA_(1c)<7.0%)以及糖尿病药物的使用很可能导致低血糖(胰岛素或磺酰脲类药物)。结果在1 288例老年糖尿病患者中,50.7%〔95%CI(46.6%,54.8%)〕的患者代表310万人〔95%CI(270,350)万人〕为相对健康状况,28.1%〔95%CI(24.8%,31.5%)〕的患者代表170万人〔95%CI(140,200)万人〕为复杂/一般的健康状况,21.2%〔95%CI(18.3%,24.4%)〕的患者代表130万人〔95%CI(110,150)万人〕为非常复杂/差的健康状况。总体来说,61.5%〔95%CI(57.5%,65.3%)〕的患者代表380万人〔95%CI(340,420)万人〕其HbA_(1c)<7.0%;这个比例在3种健康状况中无差别{62.8%〔95%CI(56.9%,68.3%)〕为相对健康状况,63.0%〔95%CI(57.0%,68.6%)〕为复杂/一般健康状况,56.4%〔95%CI(49.7%,62.9%)〕为非常复杂/差的健康状况(P=0.26)}。在HbA_(1c)<7.0%的老年患者中,54.9%〔95%CI(50.4%,59.3%)〕接受了胰岛素或磺酰脲类药物治疗;这个比例在各类健康状况糖尿病患者中近似。在研究涵盖的10年间,HbA_(1c)<7.0%的老年患者比例(P=0.34)、HbA_(1c)<7.0%且健康状况为复杂/一般或非常复杂/差的患者比例(P=0.27)、HbA_(1c)<7.0%健康状况为复杂/一般或非常复杂/差但接受胰岛素或磺酰脲类药物治疗的患者比例(P=0.65)均无明显变化。结论及意义尽管对于健康状况为复杂/一般或非常复杂/差的老年糖尿病患者来说,强化治疗所带来的伤害很可能超过其带来的益处,但是大多数患者2001—2010年已经达到了严格的血糖目标。大部分患者接受了胰岛素或磺酰脲类药物治疗,这可能导致严重的低血糖。本研究发现,有相当大比例的老年糖尿病患者接受了潜在过度治疗。 | elbert s.huang 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 2 |
| 2 | Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning显示文摘 | P.Rondard S.Huang C.Monnier | | 0，，： | 1 |
| 3 | Adaptive blind calibration of timing offset and gain mismatch for two-channel time-interleaved ADCs显示文摘 | S.Huang B.C.Levy | | 0，，： | 1 |
| 4 | Response of oxidative stress defense systems in rice(Oryza sativa) leaves with supplemental UV-B radiation显示文摘 | Q.Dai B.Yan S.Huang | | 0，，： | 1 |
| 5 | Micropropagation of self‐rooting juvenile clones by secondary somatic embryogenesis in Hevea brasiliensis显示文摘 | Y. W.Hua T. D.Huang H. S.Huang | 2010 | Plant Breeding2010，，2： | 1 |
| 6 | Using empirical mode decomposition for iris recognition显示文摘 | Chien-Ping Chang Jen-Chun Lee Yu Su Ping S.Huang Te-Ming Tu | | 0，，： | 1 |
| 7 | Demonstration of a Low VL Modulator with GHz Bandwidth Based on Electro-Optic Polymer-Clad Silicon Slot Waveguides显示文摘 | R. Ding T. Baehr-Jones Y. Liu R.Bojko J.Witzens S.Huang J.Luo S.Benight P.Sullivan J-M Fedeli M.Fournier L.Dalton A.Jen and M.Hochberg | | 0，，： | 1 |
| 8 | Predicting Changes in Staff Morale and Burnout at Community Health Centers Participating in the Health Disparities Collaboratives显示文摘 | Jessica E.Graber Elbert S.Huang Melinda L.Drum Marshall H.Chin Amy E.Walters LorettaHeuer HuiTang Cynthia T.Schaefer Michael T.Quinn | 2008 | Health Services Research2008，，4： | 1 |
| 9 | 荔枝采后贮藏期的酶变和色变显示文摘亨特色度评分与荔枝采后贮于4℃时红色的消退和褐变有关。贮藏期间荔枝内果皮的过氧化物酶活性下降,而多酚氧化酶活性上升。在贮藏至29天时外果皮过氧化物酶增加到36.93u/min,随后则下降。在头29天里未规察到外果皮多酚氧化酶活性的变化,随后增加了近10倍,达0.55u/min。 | S.Huang 韩涛 | 1992 | 世界热带农业信息1992，，6： | 0 |
| 10 | Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics显示文摘Targeting peripheral CB1R is desirable for the treatment of metabolic syndromes without adverse neuropsychiatric effects.We previously reported a human hCB1b isoform that is selectively enriched in pancreatic beta-cells and hepatocytes,providing a potential peripheral therapeutic hCB1R target.It is unknown whether there are peripherally enriched mouse and rat CB1R(mCB1 and rCB1,respectively)isoforms.In this study,we found no evidence of peripherally enriched rodent CB1 isoforms;however,some mCB1R isoforms are absent in peripheral tissues.We show that the mouse Cnr1 gene contains six exons that are transcribed from a single promoter.We found that mCB1A is a spliced variant of extended exon 1 and protein-coding exon 6;mCB1B is a novel spliced variant containing unspliced exon 1,intron 1,and exon 2,which is then spliced to exon 6;and mCB1C is a spliced variant including all 6 exons.Using RNAscope in situ hybridization,we show that the isoforms mCB1A and mCB1B are expressed at a cellular level and colocalized in GABAergic neurons in the hippocampus and cortex.RT-qPCR reveals that mCB1A and mCB1B are enriched in the brain,while mCB1B is not expressed in the pancreas or the liver.Rat rCB1R isoforms are differentially expressed in primary cultured neurons,astrocytes,and microglia.We also investigated modulation of Cnr1 expression by insulin in vivo and carried out in silico modeling of CB1R with JD5037,a peripherally restricted CB1R inverse agonist,using the published crystal structure of hCB1R.The results provide models for future CB1R peripheral targeting. | Qing-Rong Liu Nicholas S.Huang Hong Qu Jennifer F.O′Connell Isabel Gonzalez-Mariscal Sara Santa-Cruz-Calvo Maire E.Doyle Zheng-Xiong.Xi Yun Wang Emmanuel.S.Onaivi Josephine M.Egan | 2019 | Acta Pharmacologica Sinica2019，40，3： | 0 |
| 11 | 夏威夷玄武岩中同位素亏损的组分来自于地幔柱内部显示文摘洋岛文式岩(OIB)和洋中脊玄武岩(MORB)的组成能够用来了解地球的内部演化。亏损强不相容元素的M0RB被认为起源于上地幔。而一些来自地做柱的0IB被认为起源于下地慢,这为我宿了解地球长期的地球化学分异以及下地幔的组成提供了难得的机会。 | C.Defelice S.Mallick A.E.Saal S.Huang 夏群科 | 2019 | 矿物岩石地球化学通报2019，38，4： | 0 |
| 12 | Retinal microvasculature is a potential biomarker for acute mountain sickness显示文摘Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMS).However,studies on cerebral blood flow in AMS have been mostly restricted to gross cerebrovascular endpoints as opposed to the microvasculature.This study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNS),during early-stage AMS using a hypobaric chamber.This study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)enlarged.Optical coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the nerve.The AMSpositive group had the largest increases in RPC flow density in the nasal sector(AMS-positive,?3.21±2.37;AMS-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMS symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMS outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage AMS.RPC OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNS microvascular changes and AMS development during risk assessment of individuals at high altitudes. | Yuan Xie Diya Yang Alex S.Huang Yiquan Yang Ying Han Yunxiao Sun Kai Cao Huaizhou Wang Shizheng Wu Qiang Zhu Guozhong Wang Tianyi Wu Ningli Wang | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 13 | Central endoscopy reads in inflammatory bowel disease clinical trials:The role of the imaging core lab显示文摘Clinical trials in inflammatory bowel disease(IBD)are evolving at a rapid pace by employing central reading for endoscopic mucosal assessment in a field that was,historically,largely based on assessments by local physicians.This transition from local to central reading carries with it numerous technical,operational,and scientific challenges,many of which can be resolved by imaging core laboratories(ICLs),a concept that has a longer history in clinical trials in a number of diseases outside the realm of gastroenterology.For IBD trials,ICLs have the dual goals of providing objective,consistent assessments of endoscopic findings using central-reading paradigms whilst providing important expertise with regard to operational issues and regulatory expectations.This review focuses on current approaches to using ICLs for central endoscopic reading in IBD trials. | Harris Ahmad Tyler M.Berzin Hui Jing Yu Christopher S.Huang Daniel S.Mishkin | 2014 | Gastroenterology Report2014，2，3： | 0 |
| 14 | 基于二维关节型人体模型和EM算法的人体跟踪(英文)显示文摘提出一种跟踪单眼图像序列中的行人 ,并恢复其运动参数的新方法 .在跟踪中采用了基于SPM (ScaledPrismatModel)扩展的二维纸板人模型取代三维人体模型 ,以获取更快的计算速度 .作者使用EM算法在概率框架下进行运动估计 ,同时 ,算法也考虑了混合的运动模型和运动约束 ,以减小解的搜索空间 . | Thomas S.Huang | 2003 | 自动化学报2003，29，3： | 0 |
| 15 | TiO_2 nanosheets synthesized by atomic layer deposition for photocatalysis显示文摘Two-dimensional TiO_2 nanosheets were synthesized by atomic layer deposition(ALD) on dissolvable sacrificial polymer layer. The photocatalytic performance of free-standing TiO_2 nanosheets prepared with different numbers of ALD cycles(100, 300, 500, and 1000) were investigated by evaluating the degradation rates of methyl orange solutions. It is shown that the photocatalytic activity increases due to Ti^(3+) defect and the locally ordered structures in amorphous TiO_2 nanosheets. The difference in the surface areas of nanosheets may also play a crucial role in the photocatalytic activity. The results obtained in this work can have potential applications in fields like water splitting and dye-sensitized solar cells. | Riyanto Edy Yuting Zhao Gaoshan S.Huang Jianjun J.Shi Jing Zhang Alexander A.Solovev Yongfeng Mei | 2016 | Progress in Natural Science:Materials International2016，26，5： | 0 |
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