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| 1 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 2 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 3 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 4 | Chemical factors for chemical-mechanical and electrochemical mechanical planarization of silver examined using potentiodynamic and impedance measurements 显示文摘 | SAMUEL B E JENNIFER L H MARIA A D | 2005 | Materials Chemistry and Physics2005，89，23： | 1 |
| 5 | Binding of shiga toxin 2e to porcine erythrocytes in vivo and in vitro 显示文摘 | Matise I Cornick N A Samuel J E | 2003 | Infect Immun2003，71，： | 1 |
| 6 | Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1,a putative component of the exocyst complex显示文摘 | Samuel M A Chong Y T Haasen K E Aldea-Brydges M G Stone S L Goring D R | | 0，，09： | 1 |
| 7 | Biosynthesis of reovirus-specified polypeptides:identification of regions of the bicistronic reovirs S1 mRNA that affect the efficiency of translation in animal cells显示文摘 | Belli B A Samuel C E | 1993 | Virology1993，193，： | 1 |
| 8 | Subduction components and the generation of arc-like melts in the Zambales ophiolite,Philippines:Pb,Sr and Nd isotopic constraints显示文摘 | John E Samuel B M Cynthia A E | | 0，，： | 1 |
| 9 | population study of urinaryin- contimence and noctufia among women aged 20 - 59 years, p reva- lence, well2 being and wish for treatmentl显示文摘 | Samuels on E Victor A Tibblin GIA | 1997 | Acta Obstet Oynceob Scand1997，76，： | 1 |
| 10 | Precipitation-hardening in cast Al-Si-Cu-Mg alloys显示文摘 | TAVITAS M F J MOHAMED A M A GRUZLESKI J E SAMUEL F H DOTY H W | 2010 | Journal of Material Science2010，45，3： | 1 |
| 11 | 黄粉虫替代蛋白质饲料对太平洋白虾(凡纳滨对虾)消化性能的影响显示文摘试验旨在评估黄粉虫粉(MM)作为凡纳滨对虾养殖中蛋白质来源的可行性。饲料分为正常饲料和试验饲粮,试验饲料中包含正常饲料85%和MM 15%,两种饲料中均含有氧化铬0.5%作为惰性标记,试验采用表观消化率系数(ADC)对两种饲料进行检测。为评估MM消化价值,对虾饲料中采用鱼粉替代MM,替代比例分别为0%、25%、50%、75%和100%,在清水中饲养6周后,对生长参数和整个虾体成分进行评估。干物质ADC为45.9%,能量ADC为66.5%,粗蛋白质ADC为76.1%,必须氨基酸ADC为72%~86%。MM中蛋氨酸为第一限制性氨基酸。饲料中添加MM后,各组间对虾的体增重、特定生长率、采食量、饲料转化率、存活率和蛋白质合成率均无显著变化(P>0.05),虾体蛋白质含量无显著差异(P>0.05)。而随着鱼粉替代比例上升,虾体脂含量从1.13%升至1.88%。结果表明,黄粉虫粉可作为凡纳滨对虾饲料中的替代蛋白质饲料,但添加时应注意补充蛋氨酸。 | Panini R L Freitas L E L Guimarǎes A M Rios C da Silva M F O Vieira F N Fracalossi D M Samuels R I | 2017 | 饲料博览2017，0，7： | 1 |
| 12 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 13 | Semantic divergence and creative story generation: An FMRI investigation显示文摘 | HOWARD-JONES P A BLAKEMOREB S J SAMUEL E A | 2005 | Cognitive Brain Res2005，25，1： | 1 |
| 14 | Metallurgical parameters controlling the microstructure and hardness of AI-Si-Cu-Mg base alloys 显示文摘 | lbrahim M Samuel E Samuel A | 2011 | Materials and Design2011，，32： | 1 |
| 15 | A Combined Particle/Kalman Filter for Improved Tracking of Beam Aspect Targets显示文摘 | Zaugg D A Samuel A A Waagen D E | 2003 | IEEE Workshop on Statistical Signal Processing2003，，： | 1 |
| 16 | Laboratory con-firmation of new emulsion stability model显示文摘 | FARUK C LUDY J A SAMUEL E C | 2004 | Pet SciEng2004，43，： | 1 |
| 17 | Cancer Statistics, 2003 显示文摘 | Jemal A Murray T Samuels A Ghafoor A Ward E Thun MJ | 2003 | CA Cancer J Clin2003，53，1： | 1 |
| 18 | Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex显示文摘 | Samuel M A Chong Y T Haasen K E | 2009 | Plant Ce112009，21，9： | 1 |
| 19 | Phylogenetic diversty of the Rickettsiae 显示文摘 | Dobson M E Samuel J E Dasch G A Mallavia L P | 1989 | J Bacteriol1989，，： | 1 |
| 20 | Light out-coupling efficiencies of organic light-emitting diode structures and the effect of photoluminescence quantum yield显示文摘 | Smith L H Wasey J A E Samuel D W | 2005 | Advanced Functional Material2005，15，11： | 1 |
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