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| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | Operating experience with modulation of the pacific HVDC inter-tie显示文摘 | Cresap R L Scott D N | 1978 | IEEE Trans on Power Apparatus andSystems1978，97，4： | 2 |
| 3 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 4 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 5 | Mechanism of film growth during anodizing of A1-alloy-8090/SiC metal composites显示文摘 | Coleman S L Scott V D Mcenaney B | 1994 | J Mater Sci1994，29，： | 2 |
| 6 | Rationale of the Knee Society clinical rating system显示文摘 | INSALL J N DORR L D SCOTT R D | 1989 | Clin Or- thop Relat Res1989，，248： | 1 |
| 7 | A behavioral approach to occupational safety:Pinpointing and reinforcing safe performance in a food manufacturing plant显示文摘 | Komaki J Barwick K D Scott L R | | 0，，04： | 1 |
| 8 | Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies显示文摘 | Skol A D Scott L J Abecasis G R | 2006 | Nat Genet2006，38，2： | 1 |
| 9 | Ferroelectric thin films in integrated microelectronic devices 显示文摘 | Scott J F Paz de Araujo C A McMillan L D | 1992 | Ferroelectrics1992，133，： | 1 |
| 10 | Development of coarsegrained facies in lacustrine rift basins, example from East of America 显示文摘 | Scholz C A Rosendahl B R Scott D L | 1990 | Geology1990，18，2： | 1 |
| 11 | Place attachment and context:comparing a park and a trail within 显示文摘 | Moore R L Scott D | 2003 | Forest Science2003，49，6： | 1 |
| 12 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 13 | Ferro-electrically induced ferromagnetism 显示文摘 | Fox D L Scott J F | 1977 | Journal of Physics C-Solid State Physics1977，，10： | 1 |
| 14 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 15 | A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults显示文摘 | Scott D Blizzard L Fell J et a2 | 2010 | C1inEndocrinol (Oxf)2010，73，： | 1 |
| 16 | Fatigue-free ferroelectric capacitors with platinum electrodes 显示文摘 | ARAUJO C A CUCHIARO J D MCMILLAN L D SCOTT M C SCOTT J F | 1995 | Nature (London)1995，374，： | 1 |
| 17 | The links be- tween joint damage and disability in rheumatoid arthritis 显示文摘 | SCOTT D L PUGNER K KAARELA K | 2000 | Rheumatology (Oxford)2000，39，2： | 1 |
| 18 | Rationale of the Knee Societyclinical rating system显示文摘 | Insall J N Dorr L D Scott R D | 1989 | Clin Orthop Relat Res1989，248，： | 1 |
| 19 | Place attachment and context com- paring a park and a trail within 显示文摘 | Moore R L Scott D | 2003 | Forest Science2003，49，6： | 1 |
| 20 | Dual-action penems and carbapenems显示文摘 | Alfred J C Scott L D Norma K D | 1992 | J Med Chem1992，35，10： | 1 |
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