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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Superficial foveal avascular zone area changes before and after idiopathic epiretinal membrane surgery显示文摘To investigate the foveal morphological changes and foveal avascular zone(FAZ)area before and after epiretinal membrane(ERM)surgery.Twenty-two eyes with treatmentnaive ERM were included in this retrospective study.The central foveal thickness(CFT)and FAZ area were measured via swept-source optical coherence tomography(SS-OCT)and OCT angiography pre-and postoperatively.The unaffected fellow eyes were used as controls.The preoperative superficial FAZ area was significantly smaller in patients(0.08±0.04 mm~)than in controls(0.33±0.09 mm^2;P<0.001).The postoperative superficial FAZ(0.12±0.06 mm^2)area was significantly greater than the preoperative area(P<0.001).The preoperative superficial FAZ area was strongly negatively correlated with CFT(P<0.001,rho=-0.763).ERM induced significant foveal morphological changes and reduction of the superficial FAZ area.Foveal thickness was restored and FAZ area increased postoperatively.However,the process is rather slow and the recovery is incomplete. | Yo Sep Yoon Je Moon Woo Jong Eun Woo Jung Kee Min | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 3 |
| 3 | Heart rate variability in athletes显示文摘 | Aubert A Seps B Beckers F | 2003 | SportsMed2003，33，12： | 1 |
| 4 | The map-based sequence of the rice genome 显示文摘 | Enome I Roject SEP | 2005 | Nature2005，436，7052： | 1 |
| 5 | Heart rate variability in athletes显示文摘 | AUBERT A E SEPS B BECKERS F | 2003 | Sports Med2003，33，12： | 1 |
| 6 | Dimples shape and distribution effect on characteristics of Stribeck curve显示文摘 | Galda L Pawlus P Sep J | 2009 | Tribology International2009，42，10： | 1 |
| 7 | Glycodelin in ovarian serous carcinoma:association with differentiation and survival显示文摘 | Lassus H Sep pala M | 2003 | Cancer Res2003，63，19： | 1 |
| 8 | Cross-linking chitosan into UV-irradiated cellulose fibers for the preparation of antimicrobial-finished textiles显示文摘 | Diana Alonso Miquel D Sepúlveda-Sánchez Keiko Shirai | 2009 | Carbohydrate Polymers2009，，3： | 1 |
| 9 | Metabolic syndrome as a risk factor for hypertension after preeclampsia 显示文摘 | Spaan JJ Sep SJ van Balen VL | 2012 | Obstet Gynecol2012，120，21： | 1 |
| 10 | An alternative explanation of the price puzzle 显示文摘 | GIORDANIA PAOLO SEP | 2004 | Journal of Monetary Economics2004，51，6： | 1 |
| 11 | Experimental testing of journal bearing with two- component surface layer in the present of an oil abrasive conminant显示文摘 | Sep J Kucaba-Pietal A | 2001 | Wear2001，249，： | 1 |
| 12 | Screening and determination of pesticides in soil using continuous subcritical water extraction and gas chromatography-mass spectrometry显示文摘 | RICHTER P SEP U'LVEDA B OLIVA R | 2003 | J Chromatogr:A2003，994，12： | 1 |
| 13 | Maternal immuneactivation alters fetal brain development throughinterleukin-6显示文摘 | Smith SEP Li J Garbett K | 2007 | J Neuroscience2007，27，10： | 1 |
| 14 | Is there a role for cervical assessment and uterine artery Doppler in the first trimester of pregnancy as a screening test for spontaneous preterm delivery?显示文摘 | M. Parra‐Cordero A. Sepúlveda‐Martínez G. Rencoret E. Valdés D. Pedraza H. Mu?oz | 2014 | Ultrasound Obstet Gynecol2014，，3： | 1 |
| 15 | Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons显示文摘 | Avila ME Sepúlveda FJ Burgos CF | 2010 | J Bid Chem2010，285，18： | 1 |
| 16 | Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2 显示文摘 | Vasquez-Martinez Y Ohri RV Kenyon V Holman TR Sep(dveda-Boza S | 2007 | Bioorg Med Chem2007，15，23： | 1 |
| 17 | X-ray microtornogra-phy , nondestructive three dimensional imaging for in vitro endodontic studies显示文摘 | Dowker SEP Davis GR ElliottJC | 1997 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1997，83，： | 1 |
| 18 | Reevaluation of the time course of the effect of propofol described with the Schnider pharmacokinetic model显示文摘 | Sepúlveda PO Mora X | 2012 | Rev Esp Anestesiol Reanim2012，59，10： | 1 |
| 19 | A review of the environmental fate and effects of hazardous substances released from electrical and electronic equipments during recycling:Examples from China and India显示文摘 | Sepúlveda A Schluep M Renaud F G | 2010 | Environmental Impact Assessment Review2010，30，1： | 1 |
| 20 | Hydroisomerization-cracking of n -octane on heteropolyacid H 3 PW 12 O 40 supported on ZrO 2 , SiO 2 and carbon显示文摘 | Juan C. Yori Javier M. Grau Viviana M. Benítez Jorge Sepúlveda | 2005 | Applied Catalysis A, General2005，，1： | 1 |
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