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| 1 | C4 Rice-an Ideal Arena for Systems Biology Research显示文摘Engineering the C4 photosynthetic pathway into C3 crops has the potential to dramatically increase the yields of major C3 crops. The genetic control of features involved in C4 photosynthesis are still far from being understood; which partially explains why we have gained little success in C4 engineering thus far. Next generation sequencing techniques and other high throughput technologies are offering an unprecedented opportunity to elucidate the developmental and evolutionary processes of C4 photosynthesis. Two contrasting hypotheses about the evolution of C4 photosynthesis exist, i.e. the master switch hypothesis and the incremental gain hypothesis. These two hypotheses demand two different research strategies to proceed in parallel to maximize the success of C4 engineering. In either case, systems biology research will play pivotal roles in identifying key regulatory elements controlling development of C4 features, identifying essential biochemical and anatomical features required to achieve high photosynthetic efficiency, elucidating genetic mechanisms underlining C4 differentiation and ultimately identifying viable routes to engineer C4 rice. As a highly interdisciplinary project, the C4 rice project will have far-reaching impacts on both basic and applied research related to agriculture in the 21st century. | Xin-Guang Zhu Lanlan Shan Yu Wang William Paul Quick | 2010 | Journal of Integrative Plant Biology2010，52，8： | 2 |
| 2 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | Chong Cai ChangJie Xu LanLan Shan Xian Li ChunHua Zhou WangShu Zhang Ian Ferguson KunSong Chen | 2006 | Postharvest Biology and Technology2006，，3： | 2 |
| 3 | Hyper-crosslinked Porous Polymer Based on Bulk Rigid Monomer for Gas and Dye Absorptions显示文摘 | SHAN Liang WANG Li FAN Yong SHEN Lanlan WANG Shengyan XU Jianing | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 4 | LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral显示文摘Background:Oral squamous cell carcinoma(OSCC)is a common malignant tumor.Recently,Laminin Gamma 2(LAMC2)has been shown to be abnormally expressed in OSCC;however,how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored.This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC.Methods:To explore the mechanism by which LAMC2 is highly expressed in OSCC,we used small interfering RNA(siRNA)to knock down LAMC2 to further observe the changes in the signaling pathway.Furthermore,we used cell proliferation assays,Transwell invasion assays,and wound-healing assays to observe the changes in OSCC proliferation,invasion,and metastasis.RFP-LC3 was used to detect the level of autophagy intensity.A cell line-derived xenograft(CDX)model was used to detect the effect of LAMC2 on tumor growth in vivo.Results:This study found that the level of autophagy was correlated with the biological behavior of OSCC.The downregulation of LAMC2 activated autophagy and inhibited OSCC proliferation,invasion,and metastasis via inhibiting the PI3K/AKT/mTOR pathway.Moreover,autophagy has a dual effect on OSCC,and the synergistic downregulation of LAMC2 and autophagy can inhibit OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR pathway.Conclusions:LAMC2 interacts with autophagy to regulate OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR pathway.LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration,invasion,and proliferation. | FAYU SHAN LANLAN LIANG CHONG FENG HONGBAO XU ZIROU WANG WEILI LIU LINGLING PU ZHAOLI CHEN GANG CHEN XINXING WANG | 2023 | Oncology Research2023，31，4： | 1 |
| 5 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | Cai Chong Xu Changjie Shan Lanlan | 2006 | Postharvest Biology and Technology2006，41，3： | 1 |
| 6 | Gold nanoparticles modified ZnO nanorods with improved photocatalytic activity显示文摘 | Lanlan Sun Dongxu Zhao Zhiming Song Chongxin Shan Zhenzhong Zhang Binghui Li Dezhen Shen | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 7 | Low temperature conditioning reduces postharvest chilling injury in loquat fruit显示文摘 | CAI Chong XU Changjie SHAN Lanlan | 2006 | Postharvest Biology and Technology2006，41，： | 1 |
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