|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aqueous extract of Taxus Chinensis (Pilger) Rehd inhibits lung carcinoma A549 cells through the epidermal growth factor receptor/mitogen-activated protein kinase pathway in vitro and in vivo显示文摘OBJECTIVE:To explore the anticancer mechanismof aqueous extract of Taxus Chinensis (Pilger) Rehd (AETC).METHODS: The serum pharmacological method was used to avoid interference from administration of the crude medicinal herbs. Eight purebred New Zealand rabbits were used for preparation of serum containing various concentrations of AETC. Forty-eightBalb/c-nu mice were used for in vivo experiments. The effects of serum containing AETC on the proliferation of A549 cells and expression levels of the epidermal growth factor receptor/mitogen-activated protein kinase(EGFR/MAPK) pathway-related proteins in vitro were investigated. Additionally, the effects on the growth of A549 xenografts in nudemice,and expression levels of the EGFR/MAPK pathway-related proteins in the xenografts,were investigated.RESULTS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay revealed that the serum containing AETC significantly decreased the viability of A549 cells in a dose-dependent manner.Western blot showed that the serum containing various concentrations of AETC strongly reduced the levels of phospho-Jun N-terminal kinase(p-JNK) and phospho-extracellular signal-regulated kinase1/2(ERK1/2) while it increased the level of p-p38. However, no significant effects on the expression levels of JNK, ERK1/2, and p38 MAPK were found. In addition, an anticancer effect from AETC was observed invivo in the Balb/c-nu mice bearing A549xenografts.CONCLUSION: AETC has significant effects on the growth of A549 xenografts and on the activity of the EGFR/MAPK pathway. Therefore, AETC may be beneficial in lung carcinoma treatment. | Qijin Shu Minhe Shen Binbin Wang Qingli Cui Xiaoying Zhou Luming Zhu | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 10 |
| 2 | Tunable and switchable harmonic h-shaped pulse generation in a 3.03 km ultralong mode-locked thulium-doped fiber laser显示文摘We experimentally demonstrated a type of tunable and switchable harmonic h-shaped pulse generation in a thulium-doped fiber(TDF) laser passively mode locked by using an ultralong nonlinear optical loop mirror.The total cavity length was ~3.03 km, the longest ever built for a TDF laser to our best knowledge, which resulted in an ultralarge anomalous dispersion over -200 ps^2 around the emission wavelength. The produced h-shaped pulse can operate either in a fundamental or in a high-order harmonic mode-locking(HML) state depending on pump power and intra-cavity polarization state(PS). The pulse duration, no matter of the operation state, was tunable with pump power. However, pulse breaking and self-organizing occurred, resulting in high-order HML,when the pump power increased above a threshold. At a fixed pump power, the order of HML was switchable from one to another by manipulating the PS. Switching from the 8 th up to the 48 th order of HML was achieved with a fixed pump power of ~4.15 W. Our results revealed the detailed evolution and switching characteristics of the HML and individual pulse envelope with respect to both the pump power and PS. We have also discussed in detail the mechanisms of both the h-shaped pulse generation and the switching of its HML. This contribution would be helpful for further in-depth study on the underlying dynamics of long-duration particular-envelope pulses with ultralarge anomalous dispersion and ultralong roundtrip time. | JUNQING ZHAO LEI LI LUMING ZHAO DINGYUAN TANG DEYUAN SHEN LEI SU | 2019 | Photonics Research2019，7，3： | 4 |
| 3 | Damage assessment for seismic response of recycled concrete filled steel tube columns显示文摘A model for evaluating structural damage of recycled aggregate concrete filled steel tube(RCFST) columns under seismic effects is proposed in this paper. The proposed model takes the lateral deformation and the effect of repeated cyclic loading into account. Available test results were collected and utilized to calibrate the parameters of the proposed model. A seismic test for six RCFST columns was also performed to validate the proposed damage assessment model. The main test parameters were the recycled coarse aggregate(RCA) replacement percentage and the bond-slip property. The test results indicated that the seismic performance of the RCFST member depends on the RCA contents and their damage index increases as the RCA replacement percentage increases. It is also indicated that the damage degree of RCFST changes with the variation of the RCA replacement percentage. Finally, comparisons between the RCA contents, lateral deformation ratio and damage degree were implemented. It is suggested that an improvement procedure should be implemented in order to compensate for the performance difference between the RCFST and normal concrete filled steel tubes(CFST). | Huang Yijie Xiao Jianzhuang Shen Luming | 2016 | Earthquake Engineering and Engineering Vibration2016，15，3： | 4 |
| 4 | Shrinking target problems for beta-dynamical system显示文摘For any β>1,let([0,1],Tβ) be the beta dynamical system.For a positive function ψ:N→R+ and a real number x0 ∈[0,1],we define D(Tβ,ψ,x0) the set of ψ-well approximable points by x0as {x∈[0,1]:|Tβnx-x0|<ψ(n) for infinitely many n∈N}.In this note,by proving a structure lemma that any ball B(x,r) contains a regular cylinder of comparable length with r,we determine the Hausdorff dimension of the set D(Tβ,ψ,x0) completely for any β>1 and any positive function ψ. | SHEN LuMing WANG BaoWei | 2013 | Science China Mathematics2013，56，1： | 2 |
| 5 | Five- phase composite sphere model for chloride diffusivity predic- tion of recycled aggregate concrete显示文摘 | Ying Jingwei Xiao Jianzhuang Shen Luming | 2013 | Magazine of Concrete Research2013，65，9： | 1 |
| 6 | Exclusively selective oxi- dation of toluene to benzaldehyde on ceria nanocubes by molecular oxygen 显示文摘 | Lv Jiangang Shen Yi Peng Luming | 2010 | Chemical Communications2010，46，32： | 1 |
| 7 | Infrared spectroscopic analysis of urinary stones (including stones induced by melamine-contaminated milk powder) in 189 Chinese children显示文摘 | Sun Xizhao Shen Luming Cong Xiaoming | 2011 | Journal of Pediatric Surgery2011，46，4： | 1 |
| 8 | Seismicbehavior of semi-precast column with recycled aggregateconcrete 显示文摘 | Xiao Jianzhuang Huang Xiao Shen Luming | 2012 | Construction and Building Materials2012，35，： | 1 |
| 9 | Seismic Behavior of Semi-Precastcolumn with Recycled Aggregate Concrete 显示文摘 | Xiao Jianzhuang Huang Xiao Shen Luming | 2012 | Construction and Building Materials2012，35，： | 1 |
| 10 | Comparison of re- nal function and metabolic abnormalities of cystine stone patients and Calcium oxalate stone patients in China显示文摘 | SHEN Luming SUN Xizhao ZHU Huaijun | 2013 | World Journal of Urology2013，31，5： | 1 |
| 11 | Modified smoothed particle hydrodynamics approach for modelling dynamic contact angle hysteresis显示文摘Dynamic wetting plays an important role in the physics of multiphase flow, and has a significant influence on many industrial and geotechnical applications. In this work, a modified smoothed particle hydrodynamics (SPH) model is employed to simulate surface tension, contact angle and dynamic wetting effects at meso-scale. The wetting and dewetting phenomena are simulated in a capillary tube, where the liquid particles are raised or withdrawn by a shifting substrate. The SPH model is modified by introducing a newly developed viscous force formulation at the liquid-solid interface to reproduce the rate-dependent behaviour of the moving contact line. Dynamic contact angle simulations with the interfacial viscous force are conducted to verify the effectiveness and accuracy of this new formulation. In addition, the influence of interfacial viscous forces with different magnitude on the contact angle dynamics is examined by empirical power-law correlations;the derived constants suggest that the dynamic contact angle changes monotonically with the interfacial viscous force. The simulation results are consistent with experimental observations and theoretical predictions, implying that the interfacial viscous force can be associated with the slip length of flow and the microscopic surface roughness. This work demonstrates that the modified SPH model can successfully account for the rate-dependent effects of a moving contact line, and can be used for realistic multiphase flow simulations under dynamic conditions. | Yanyao Bao Ling Li Luming Shen Chengwang Lei Yixiang Gan | 2019 | Acta Mechanica Sinica2019，35，3： | 1 |
| 12 | ON THE ERROR-SUM FUNCTION OF ALTERNATING LüROTH SERIES显示文摘The error-sum function of alternating Luroth series is introduced, which, to some extent, discerns the superior or not of an expansion comparing to other expansions. Some elementary properties of this function are studied. Also, the Hausdorff dimension of graph of such function is determined. | Luming Shen Chao Ma Jihong Zhang | 2006 | Analysis in Theory and Applications2006，22，3： | 0 |
| 13 | A Possible 250s X-Ray Quasi-periodicity in the Fast Blue Optical Transient AT2018cow显示文摘The fast blue optical transients(FBOTs)are a new population of extragalactic transients of unclear physical origin.A variety of mechanisms has been proposed including failed supernova explosion,shock interaction with a dense medium,young magnetar,accretion onto a compact object and stellar tidal disruption event,but none is conclusive.Here we report the discovery of a possible X-ray quasi-periodicity signal with a period of~250 s(at a significance level of 99.76%)in the brightest FBOT AT2018cow through the analysis of XMM-Newton/PN data.The signal is independently detected at the same frequency in the average power density spectrum from data taken from the Swift telescope,with observations covering from 6 to 37 days after the optical discovery,though the significance level is lower(94.26%).This suggests that the quasi-periodic oscillation(QPO)frequency may be stable over at least 1.1×10^(4)cycles.Assuming the~250 s QPO to be a scaled-down analog of that typically seen in stellar mass black holes,a black hole mass of~103–10^(5)solar masses could be inferred.The overall X-ray luminosity evolution could be modeled with a stellar tidal disruption by a black hole of~10^(4)solar masses,providing a viable mechanism to produce AT2018cow.Our findings suggest that other bright FBOTs may also harbor intermediate-mass black holes. | Wenjie Zhang Xinwen Shu Jin-Hong Chen Luming Sun Rong-Feng Shen Lian Tao Chun Chen Ning Jiang Liming Dou Ying Qin Xue-Guang Zhang Liang Zhang Jinlu Qu Tinggui Wang | 2022 | Research in Astronomy and Astrophysics2022，22，12： | 0 |
| 14 | HAUSDORFF DIMENSION OF SOME KIND OF ALTERNATING OPPENHEIM SERIES EXPANSION显示文摘为奥本海姆系列 epansions,作者[7 ] 讨论了非凡的集合 B_m ={ x ∈(0, 1 ] :1 <
(d_j (x))/(h_(j-1 )(d_(j-1 )(x))) 为任何 j ≥的≤ m 2 } 。在这篇论文,我们调查发生在 alternatingOppenheim 系列扩大的一种非凡的集合的 Hausdorff 尺寸。作为应用,我们得到集合 inLueroth 系列扩大的准确 Hausdorff 尺寸,也,我们给如此的维的数字的估计。 | Luming Shen Chao Ma Yuehua Liu | 2007 | Analysis in Theory and Applications2007，23，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员