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1Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR.Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa 2005World Journal of Gastroenterology2005,11,46:25
2Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy.Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine 2004World Journal of Gastroenterology2004,10,11:10
3Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage显示文摘Subarachnoid hemorrhage by a ruptured cerebral aneurysmremains the most devastating cerebrovascular disorderswith high morbidity and mortality (Suzuki et al.,2017), which are mainly caused by early brain injury anddelayed cerebral ischemia. Despite many experimentaland clinical research efforts, the mechanisms of earlybrain injury as well as delayed cerebral ischemia remainunclarified. However, recent works have suggested thattenascin-C, which is a special type of secreted extracellularmatrix proteins, is promising as a novel therapeutictarget against post-subarachnoid hemorrhage early braininjury and delayed cerebral ischemia.Masato Shiba Hidenori Suzuki 2019Neural Regeneration Research2019,14,2:7
4Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients显示文摘AIM:To clarify the gender differences about the clini-cal features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatmentduring the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk fac-tor, and the time to diagnosis as having LDA-associat-ed peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050). CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-asso-ciated peptic ulcer. Special attention should be paid to aged female patients taking LDA.Kazuhisa Okada Masahiko Inamori Kento Imajyo Hideyuki Chiba Takashi Nonaka Tadahiko Shiba Takashi Sakaguchi Kazuhiko Atsukawa Hisao Takahashi Etsuo Hoshino Atsushi Nakajima 2010World Journal of Gastroenterology2010,16,15:4
5Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells显示文摘Sakata M Shiba H Komatsuzawa H 1999J Bone Miner Res1999,14,9:2
6A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding显示文摘Natsuhiko Kameda Kazuhide Higuchi Masatsugu Shiba Hirohisa Machida Hirotoshi Okazaki Hirokazu Yamagami Tetsuya Tanigawa Kenji Watanabe Toshio Watanabe Kazunari Tominaga Yasuhiro Fujiwara Nobuhide Oshitani Tetsuo Arakawa 2008Journal of Gastroenterology2008,,6:2
7Seismic proof test of a reinforced concrete containment vessel (RCCV)显示文摘Toshihiko Hirama Masashi Goto Keiji Shiba Toshio Kobayashi Ryozo Tanaka Shizuo Tsurumaki Katsuki Takiguchi Hiroshi Akiyama 2005Nuclear Engineering and Design2005,,13:2
8Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case显示文摘We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved.Hirotoshi Okazaki Kazuhide Higuchi Masatsugu Shiba Shirou Nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga Toshio Watanabe Yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa 2006World Journal of Gastroenterology2006,12,33:2
9First principles calculation of stable structure and adhesive strength of plated Ni/Fe(100) or Cu/Fe(100) interfaces显示文摘A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was performed.Ni or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) substrate.Other calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square lattices.The orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) interfaces.This structure was supported by TEM analysis of plated Ni layer on Fe(100) surfaces.The adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) interface.The experimental results of Hull cell iron plated with Ni or Cu supported the results of the calculation.These results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces.Ryota NAKANISHI Koji SUEOKA Seiji SHIBA M akoto HINO Koji MURAKAMI Ken MURAOKA 2009中国有色金属学会会刊:英文版2009,19,4:2
10Mechanism underlying specificity of proteins targeting inorganic materials显示文摘Hayashi T Sano K Shiba K 2006Nano Letters2006,6,:1
11An experimental study on transpedicular screw fixation in relation to ostcoporosis of the lumbar spine显示文摘Soshi S Shiba R Knodo H 1991Spine1991,16,11:1
12Clinical and angiographic analysis of congenital coronary artery fistulae in adulthood 显示文摘Nawa S Miyaehi Y Shiba T el al 1996Jpn Heart J1996,37,1:1
13A pollen coat protein,SP11/SCR,determines the pollen S-specificity in the self-incompatibility of Brassica species显示文摘Shiba H Takayama S Iwano M 2001Plant Physiology2001,125,:1
14Stereotactic vacuum-assisted breast biopsy (Mammotome biopsy) for non-palpable microcalcification on mammography显示文摘Matsuzaki S Shiba E Kobayashi Y 2005Nippon Igaku Hoshasen Gakkai Zasshi2005,65,1:1
15Proliferative abilityand alkaline phosphatase activity with in vivo cellularaging in human pulpcell显示文摘Shiba H Nakanishi K Rashid F 2003J Endod2003,29,1:1
16A neutrophil elastase inhibitor (ONO -5046) reduces neurologic damage after spinal cord injury in rats 显示文摘Tonai T Shiba K Taketani Y 2001J Neurochem2001,78,5:1
17Acute elevation of free fatty acids impairs hepatic glucose uptake in conscious rats显示文摘Nakahara I Matsuhisa M Shiba Y 2004Diabetes Res Clin Pract2004,66,2:1
18Adult neurogenesis is regulated by endogenous factors produced during neurodegeneration 显示文摘Yoneyama M Shiba T Hasebe S 2011J Pharmacol Sci2011,115,:1
19Differential effects of various growth factors and cytokines on the syntheses of DNA,typeⅠcollagen,laminin,fibronectin,osteonectin/secreted protein,acidic and rich in cysteine( SPARC),and alkaline phosphatase by human pulp cells in culture显示文摘Shiba H Fujita T Doi N 1998Cell Physiol1998,174,2:1
20Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids显示文摘Shiba Y 2007Metab Eng2007,9,:1
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