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| 1 | A case of invasive hemolymphangioma of the pancreas显示文摘Hemolymphangioma of the pancreas is a very rare benign tumor. There were only five reports of this disease until March 2008. Herein, we report a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to duodenal invasion. A 53-year-old man had been admitted a referral hospital because of severe anemia due to gastrointestinal bleeding in December 2005. He was then transferred to our institute with a diagnosis of a tumor of the head of the pancreas with duodenal invasion in January 2006. No abnormalities were revealed except for anemia in laboratory data including CEA and CA19-9. Gastrointestinal endoscopy revealed bleeding at the duodenum. Computed tomography also demonstrated a heterogenous mass at the pancreatic head and suspected invasion to the duodenal wall. Ultrasonography showed a huge mass at the pancreatic head with a mixture of high and low echoic areas. Pylorous-preserving pancreatoduodenectomy was performed. The pancreatic tumor was soft and had invaded to the duodenum. The pathological diagnosis was a hemolymphangioma of the pancreas invaded to the duodenum. His postoperative course was uneventful and he was discharged on the 26th d after surgery. Hemolymphangioma of the pancreas is a very rare benign tumor. In a literature review until March 2008, we found five case reports. Major symptoms are abdominal pain and distension due to the enlarged tumor. However, we experienced a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to invasion to the duodenum. This disease is a very rare entity, but should be considered when patients have gastrointestinal bleeding. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Daisuke Kudoh Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，18： | 26 |
| 2 | 为胃的癌症的内视镜的 submucosal 解剖的支持的技术和设备显示文摘 The indications for endoscopic treatment have expanded in recent years,and relatively intestinal-type mucosal stomach carcinomas with a low potential for metastasis are now often resected en bloc by endoscopic submucosal dissection(ESD),even if they measure over 20 mm in size.However,ESD requires complex maneuvers,which entails a long operation time,and is often accompanied by complications such as bleeding and perforation.Many technical developments have been implemented to overcome these complications.The scope,cutting device,hemostasis device,and other supportive devices have been improved.However,even with these innovations,ESD remains a potentially complex procedure.One of the major difficulties is poor visualization of the submucosal layer resulting from the poor countertraction afforded during submucosal dissection.Recently,countertraction devices have been developed.In this paper,we introduce countertraction techniques and devices mainly for gastric cancer. | Nobuyuki Sakurazawa Shunji Kato Itsuo Fujita Yoshikazu Kanazawa Hiroyuki Onodera Eiji Uchida | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 18 |
| 3 | An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture显示文摘AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic texture.METHODS: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa anastomosis.RESULTS: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely seen.CONCLUSION: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido Takuya Miura Norihito Kubo Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，7： | 9 |
| 4 | Progress in elucidating the relationship between Helicobacter pylori infection and intestinal diseases显示文摘Helicobacter pylori(H.pylori)infection causes changes to the intestinal flora,such as small intestinal bacterial overgrowth,and increases gastric acid secretionstimulating gastrointestinal hormones,mainly gastrin,due to a decrease in gastric acid caused by atrophic gastritis.In addition,the cellular components of H.pylori travel through the intestinal tract,so the bacterial infection affects the immune system.Therefore,the effects of H.pylori infection are observed not only in the stomach and the proximal duodenum but also in the small and large intestines.In particular,meta-analyses reported that H.pylori-infected individuals had an increased risk of colorectal adenoma and colorectal cancer.Moreover,a recent study reported that the risk of developing colorectal cancer was increased in subjects carrying H.pylori vacuolating cytotoxin A antibody.In addition,it has been reported that H.pylori infection exacerbates the symptoms of Fabry’s disease and familial Mediterranean fever attack and is involved in irritable bowel syndrome and small intestinal ulcers.On the other hand,some studies have reported that the frequency of ulcerative colitis,Crohn’s disease,and celiac disease is low in H.pylori-infected individuals.Thus,H.pylori infection is considered to have various effects on the small and large intestines.However,few studies have reported on these issues,and the details of their effects have not been well elucidated.Therefore,additional studies are needed. | Shunji Fujimori | 2021 | World Journal of Gastroenterology2021，27，47： | 9 |
| 5 | A COMPARISON OF SOME ELECTRONIC COUNTERMEASURES ON INVERSE SYNTHETIC APERTURE RADAR (ISAR)显示文摘Inverse Synthetic Aperture Radar (ISAR) is an important means for target classification, recognition, identification and many other military applications. A simulation model of ISAR system is established after analyzing the principle of ISAR imaging, and then several ECM (Electronic Counter Measurement) techniques are studied. Simulation experiments are done on the basis of such research. The experimental result of the research can be used for ECM equipment. | Fan Luhong Pi Yiming Huang Shunji Hou Yinming | 2006 | Journal of Electronics(China)2006，23，1： | 9 |
| 6 | Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer显示文摘AIM:To study gastric mucosal interleukine-8(IL-8) mRNA expression,the cytotoxin-associated gene A(cagA) mutation,and serum pepsinogen(PG)Ⅰ/Ⅱ ratio related risk in Thai gastric cancer.METHODS:There were consent 134 Thai non-cancer volunteers who underwent endoscopic narrow band imaging examination,and 86 Thais advance gastric cancer patients who underwent endoscopic mucosal biopsies and gastric surgery.Tissue samples were taken by endoscopy with 3 points biopsies.The serum PG Ⅰ,Ⅱ,and Helicobacter pylori(H.pylori) immunoglobulin G(IgG) antibody for H.pylori were tested by enzyme-linked immunosorbent assay technique.The histopathology description of gastric cancer and non-cancer with H.pylori detection was defined with modified Sydney Score System.Gastric mucosal tissue H.pylori DNA was extracted and genotyped for cagA mutation.Tissue IL-8 and cyclooxygenase-2(COX-2) mRNA expression were conducted by real time relative quantitation polymerase chain reaction.From 17 Japanese advance gastric cancer and 12 benign gastric tissue samples,all were tested for genetic expression with same methods as well as Thai gastric mucosal tissue samples.The multivariate analysis was used for the risk study.Correlation and standardized t-test were done for quantitative data,P value < 0.05 was considered as a statistically significant.RESULTS:There is a high non cagA gene of 86.8 per cent in Thai gastric cancer although there are high yields of the East Asian type in the positive cagA.The H.pylori infection prevalence in this study is reported by combined histopathology and H.pylori IgG antibody test with 77.1% and 97.4% of sensitivity and specificity,respectively.The serum PG Ⅰ/Ⅱ ratio in gastric cancer is significantly lower than in the non-cancer group,P = 0.045.The serum PG Ⅰ/Ⅱ ratio of less than 3.0 and IL-8 mRNA expression ≥ 100 or log 10 ≥ 2 are significant cut off risk differences between Thai cancer and non-cancer,P = 0.03 and P < 0.001,respectively.There is a significantly lower PGI/II ratio in Japanese than that in Thai gastric cancer,P = 0.026.Serum PG Ⅰ/Ⅱ ratio at cut off less than 3.0 and IL-8 mRNA expression Raw RQ > 100 or log 10 > 2 are significantly difference between Thai cancer group when compared to non-cancer group,P = 0.013 and P < 0.001,respectively.In the correlation study,low PG Ⅰ/Ⅱ ratio does not associate with chronic atrophic gastritis severity score in Thais non-cancer cases.However,there is a trend,but not significant convert correlation between IL-8 mRNA expression level and low PG Ⅰ/Ⅱ ratio in Thai positive H.pylori infection.The high expression of IL-8 gene demonstrates a poorer prognosis by stage and histology.CONCLUSION:Predominant gastric mucosal IL-8 mRNA expression level,H.pylori infection,and low PG Ⅰ/Ⅱ ratio are relative risks for Thai gastric cancer without correlation with cagA mutation. | Sirikan Yamada Shunji Kato Takeshi Matsuhisa Luksana Makonkawkeyoon Masaru Yoshida Thiraphat Chakrabandhu Nirush Lertprasertsuk Pawit Suttharat Bandhuphat Chakrabandhu Shin Nishiumi Wilaiwan Chongraksut Takeshi Azuma | 2013 | World Journal of Gastroenterology2013，19，19： | 8 |
| 7 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 7 |
| 8 | What are the effects of proton pump inhibitors on the small intestine?显示文摘Generally, proton-pump inhibitors(PPIs) have great benefit for patients with acid related disease with less frequently occurring side effects. According to a recent report, PPIs provoke dysbiosis of the small intestinal bacterial flora, exacerbating nonsteroidal anti-inflammatory drug-induced small intestinal injury.Several meta-analyses and systematic reviews have reported that patients treated with PPIs, as well as post-gastrectomy patients, have a higher frequency of small intestinal bacterial overgrowth(SIBO) compared to patients who lack the aforementioned conditions.Furthermore, there is insufficient evidence that these conditions induce Clostridium difficile infection. At this time, PPI-induced dysbiosis is considered a type of SIBO. It now seems likely that intestinal bacterial flora influence many diseases, such as inflammatory bowel disease, diabetes mellitus, obesity, nonalcoholic fatty liver disease, and autoimmune diseases.When attempting to control intestinal bacterial flora with probiotics, prebiotics, and fecal microbiota transplantation, etc., the influence of acid suppression therapy, especially PPIs, should not be overlooked. | Shunji Fujimori | 2015 | World Journal of Gastroenterology2015，21，22： | 7 |
| 9 | Survival of pathogenic bacteria in compost with special reference to Escherichia coli显示文摘Application of compost in agricultural practice could potentially cause contamination of foodstuffs with pathogenic bacteria such as Escherichia coli O157: H7 ( E. Coli O157). We investigated pathogenic bacteria in compost collected from the compost facilities, and evaluated the survival of E. coli K12 and O157 in laboratory experiments. Out of 19 compost product samples, coliform bacteria and salmonella were detected in 7 and 3 samples respectively. The number of coliform bacteria was 1.8 × 102 to 2.5 × 106 CFU/g dw and that of salmonella was 4.2 × 101 to 6.0 × 103 CFU/g dw. Moreover, coliform bacteria, fecal coliform, E. coli and salmonella were detected during composting at 54℃ to 67℃. The results indicated that moisture content was a very important factor to the heat sensitivity of pathogenic bacteria in compost, E. coli in compost of high moisture content was more sensitive than that in compost of low moisture content, cells harvested in logarithmic phase was more sensitive than these in stationary phase, and E. coli K12 was more sensitive than E. coli O157. Based on the D values, the lethal time of E. coli K12 and O157 from 108 to 100 CFU/g dw were 16.3 and 28.8 min, respectively, at 60℃ in compost with 40% moisture content. However, some E. coli cells survived in composting process at 54℃ to 67℃. Water potential (low moisture content) and physiological aspects of bacteria (stationary phase) could explain only in part of the prolonged survival of E. coli in compost, and there should be some other factors that are conducive to bacterial survival in compost. | GONG Chun-ming Koichi Inoue Shunji Inanaga Takashi Someya | 2005 | Journal of Environmental Sciences2005，17，5： | 7 |
| 10 | Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous VX2 cancer显示文摘 | Li Peijing Zhu Mei Xu Yali Zhao Yang Gao Shunji Liu Zheng Gao Yun-hua | 2014 | Chinese Medical Journal2014，，14： | 6 |
| 11 | Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma显示文摘AIM:To study the relationship between adverse events(AEs),efficacy,and nursing intervention for sorafenibtherapy in patients with hepatocellular carcinoma(HCC).METHODS:We enrolled 37 consecutive patients withadvanced HCC who received sorafenib therapy.Relationships among baseline characteristics as well as AEoccurrence and tumor response,overall survival(OS),and treatment duration were analyzed.The nursingintervention program consisted of education regardingself-monitoring and AEs management,and telephoneRESULTS:A total of 37 patients were enrolled in the study,comprising 30 males(81%) with a median age of 71 years.The disease control rate at 3 mo was 41%,and the median OS and treatment duration were 259 and 108 d,respectively.Nursing intervention was given to 24 patients(65%).Every patient exhibited some kinds of AEs,but no patients experienced G4 AEs.Frequently observed AEs > G2 included anorexia(57%),skin toxicity(57%),and fatigue(54%).Factors significantly associated with longer OS in multivariate analysis demonstrated that age ≤ 70 years,presence of > G2 skin toxicity,and absence of > G2 hypoalbuminemia.The disease control rate in patients with > G2 skin toxicity was 13/20(65%),which was significantly higher compared with that in patients with no or G1 skin toxicity.Multivariate analysis revealed that nursing intervention and > G2 skin toxicity were independent significant predictors for longer treatment duration.CONCLUSION:Skin toxicity was associated with favorable outcomes with sorafenib therapy for advanced HCC.Nursing intervention contributed to better adher-ence,which may improve the efficacy of sorafenib. | Masako Shomura Tatehiro Kagawa Koichi Shiraishi Shunji Hirose Yoshitaka Arase Tetsuya Mine Jun Koizumi | 2014 | World Journal of Hepatology2014，6，9： | 6 |
| 12 | Intraoperative ultrasound as an educational guide for laparoscopic biliary surgery显示文摘AIM: To analyze the efficacy of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary tract anatomy, to avoid bile duct injury (BDI) after laparoscopic cholecystectomy (LC), as well as any burden during the learning period. METHODS: A retrospective analysis was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly feasible even in patients with high-grade cholecystitis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by inexperienced surgeons. Incidences of other morbidity, mortality, and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly extended after the educational program began (P < 0.001), and the grade of laparoscopic cholecystitis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly feasible modality, which provided accurate, real- time information about the biliary structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially when performed by less-skilled surgeons. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Motonari Oohashi Takuya Miura Hiroyuki Jin Syuichi Yoshihara Michihiro Sugai Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，15： | 6 |
| 13 | Higher-Ordered Actin Structures Remodeled by Arabidopsis ACTIN-DEPOLYMERIZING FACTOR5 Are Important for Pollen Germination and Pollen Tube Growth显示文摘肌动朊细胞骨架的动力学为花粉萌芽和花粉试管生长是必要的。使解聚肌动朊的因素(ADF ) 典型地由切断 / 使解聚肌动朊细丝贡献肌动朊周转。最近,我们证明 Arabidopsis 亚纲 III ADF (ADF5 和 ADF9 ) 从保存 F-actin-depolymerizing 功能发展了 F-actin-bundling 功能。然而,很少对生理的功能,进化意义,和这些 neofunctionalized ADF 的肌动朊捆绑机制被知道。这里,我们报导 ? 引起的 ADF5 功能的那损失推迟了花粉萌芽,延迟的花粉试管生长,并且增加对由影响肌动朊捆的产生和维护的 latrunculin B (LatB ) 处理敏感。在生活房间的肌动朊细丝动力学的检查表明捆绑频率显著地在 adf5 花粉试管被减少,与它的生物化学的功能一致。进一步生物化学、基因的互补分析 ? 两个都表明了那 N-? 并且 ADF5 的 C 终端肌动朊绑定域为它的生理、生物化学的函数被要求。有趣地,当两个是不正常的肌动朊捆绑 ADF, ADF5,然而并非 ADF9 时,在成熟花粉起一个重要作用生理的活动。一起拿,我们的结果建议 ADF5 发展了捆绑肌动朊细丝的功能并且在花粉萌芽和花粉试管生长期间在肌动朊捆的形成,组织,和维护起一个重要作用。 | Jingen Zhu Qiong Nan Tao Qin Dong Qian Tonglin Mao Shunjie Yuan Xiaorong Wu Yue Niu Qifeng Bai Lizhe An Yun Xiang | 2017 | Molecular Plant2017，10，8： | 6 |
| 14 | Annexin5 Is Essential for Pollen Development in Arabidopsis显示文摘 | Jingen Zhu Shunjie Yuan Guo Wei Dong Qian Xiaorong Wu Honglei Jia Mengyuan Gui Wenzhe Liu Lizhe An Yun Xiang | 2014 | Molecular Plant2014，7，4： | 6 |
| 15 | Thrombocytopenia after liver transplantation:should we care?显示文摘Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver transplantation(LT), platelet count decreases and reaches a nadir on postoperative days 3-5, with an average reduction in platelet counts of 60%; platelet count recovers to preoperative levels approximately two weeks after LT. The putative mechanisms include haemodilution, decreased platelet production, increased sequestration, medications, infections, thrombosis, or combination of these processes. However, the precise mechanisms remain unclear. The role of platelets in liver transplantation has been highlighted in recent years, and particular attention has been given to their effects beyond hemostasis and thrombosis. Previous studies have demonstrated that perioperative thrombocytopenia causes poor graft regeneration, increases the incidence of postoperative morbidity, and deteriorates the graft and decreases patient survival in both the short and long term after liver transplantation. Platelet therapies to increase perioperative platelet counts, such as thrombopoietin, thrombopoietin receptor agonist, platelet transfusion, splenectomy, and intravenous immunoglobulin treatment might have a potential for improving graft survival, however clinical trials are lacking. Further studies are warranted to detect direct evidence on whether thrombocytopenia is the cause or result of poor-graft function and postoperative complications, and to determine who needs platelet therapies in order to prevent postoperative complications and thus improve post-transplant outcomes. | Kazuhiro Takahashi Shunji Nagai Mohamed Safwan Chen Liang Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，13： | 5 |
| 16 | Pulmonary embolism after arterial chemoembolization for hepatocellular carcinoma: An autopsy case report显示文摘We report an extremely rare case of pulmonary lipiodol embolism with acute respiratory distress syndrome(ARDS) after transcatheter arterial chemoembolization(TACE) for hepatocellular carcinoma(HCC). A 77-yearold man who was diagnosed with a huge HCC wasadmitted for TACE. Immediately after the procedure, this patient experienced severe dyspnea. We suspected that his symptoms were associated with a pulmonary lipiodol embolism after TACE, and we began intensive treatment. However, his condition did not improve, and he died on the following day. A subsequent autopsy revealed that the cause of death was ARDS due to pulmonary lipiodol embolism. No cases have been previously reported for which an autopsy was performed to explain the most probable mechanism of pulmonary lipiodol embolism; thus, ours is the first report for such a rare case. | Keiichi Hatamaru Shunjiro Azuma Takuji Akamatsu Takeshi Seta Shunji Urai Yoshito Uenoyama Yukitaka Yamashita Kazuo Ono | 2015 | World Journal of Gastroenterology2015，21，4： | 5 |
| 17 | Asymptomatic small intestinal ulcerative lesions:Obesity and Helicobacter pylori are likely to be risk factors显示文摘It is often difficult to explain why ulcerative lesions are found in the small intestine because there are no obvious aggressors such as gastric acid.In particular,the treatment of small intestinal ulcerative lesions in asymptomatic patients with no symptoms,normal physical examinations,and normal blood test findings is not well documented.According to a summary of capsule endoscopy studies in healthy subjects,approximately 10%of subjects have small intestinal mucosal breaks.The number of mucosal breaks in these instances is approximately 1-3.We examined small intestinal mucosal breaks in healthy subjects recruited from our past two studies.Mucosal breaks were observed in approximately 10%of subjects,and the average number was 0.24±1.21.The number of mucosal breaks in the small intestine was correlated with body mass index and was significantly higher in Helicobacter pylori-infected subjects and higher in males.These results indicate that 1-2 small ulcerative lesions,such as erosions in the small intestine,can be considered to be in the normal range,and close examination is not required.It is assumed that a follow-up medical examination is required for such asymptomatic persons.The presence of many small ulcerative lesions or an unequivocal ulcer indicates an abnormality for which close examination is desired.However,in many cases,it is sufficient to scrutinize after detecting anemia,but it is difficult to make a judgment due to insufficient reports,and future studies are required. | Shunji Fujimori | 2021 | World Journal of Gastroenterology2021，27，28： | 5 |
| 18 | Hemosuccus pancreaticus: Problems and pitfalls in diagnosis and treatment显示文摘Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneurysm of the splenic artery and bleeding from the wall of pancreatic pseudocyst. Interventional radiology is the first modality for early diagnosis and possible treatment of hemosuccus pancreaticus. When angiography shows no abnormal findings or interventional radiological therapy can not be successful, surgery should be considered without delay. Our patients herein underwent surgery without recurrence or sequelae. Intraoperative ultrasonography and pancreatoscopy were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially in patients with chronic pancreatitis, which would lead to a prompt and proper treatment. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，17： | 5 |
| 19 | Effects of anti-hypertensive drugs on esophageal body contraction显示文摘AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine. | Koichi Yoshida Kenji Furuta Kyoichi Adachi Shunji Ohara Terumi Morita Takashi Tanimura Shuji Nakata Masaharu Miki Kenji Koshino Yoshikazu Kinoshita | 2010 | World Journal of Gastroenterology2010，16，8： | 4 |
| 20 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet . 2008 (9636)2008，，： | 4 |
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