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| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Animal model of depression:Tests of three structurally and pharmacologically novel antidepressant comdpouns显示文摘 | Kate RJ Sibel M | 1982 | Pharmacol Biochem Behav1982，16，6： | 1 |
| 3 | The effects of intratracheal dexamethasone on acute lung injury in rabbits-experimental study显示文摘 | Funda A Guniz M Sibel E | 2005 | Middle East J Anesthesiol2005，18，1： | 1 |
| 4 | Effect of paclobutrazoI on flowering,leaf and flower colour of Consolid orientalis显示文摘 | Sibel M Osman K Veli O | 2009 | Pak J Bot2009，41，23： | 1 |
| 5 | Human Pathogens Abundant in the Bacterial Metagenome of Cigarettes显示文摘 | Sapkota Amy R Berger Sibel Vogel Timothy M | 2010 | Environmental Health Perspectives2010，，3： | 1 |
| 6 | The evaluation of antimicrobial susceptibility of urine enterococci with the Vitek 2 automated system in eastern Turkey显示文摘 | Sibel AK Koroglu M Muharrem AK | 2012 | Southeast Asian J Trop Med Public Health2012，43，4： | 1 |
| 7 | Further analysis of the specificity of a novel animalmodel of depression: effects of an antihistaminic, antip sychotic and anxiolytie compound显示文摘 | KATZ RJ SIBEL M | 1982 | Pharmaeol Biochem Behav1982，16，6： | 1 |
| 8 | Palladium and Mo-lybdenum Mono and Bimetallic Catalysts on Modernitefor Direct NO Decomposition Reaction显示文摘 | Rodrigo S Andréa M Sibele B etc | 2009 | Catalysis Let-ters2009，129，34： | 1 |
| 9 | Effects of sodium fluoride exposure on some biochemical parameters inmice:Evaluation of the ameliorative effect of royal jelly applications onthese parameters显示文摘 | Murat Kanbur Gkhan Eraslan Sibel Silici Mürsel Karabacak | 2009 | Food and Chemical Toxicology2009，47，： | 1 |
| 10 | Animal model of depression:tests of three structurally and pharmacologically novel antidepressant compounds显示文摘 | Katz Rj Sibel M | 1982 | Pharmacol Biochem Behav1982，16，6： | 1 |
| 11 | Formaldehyde in the indoor environment 显示文摘 | TUNGA S SIBEL M RAINER M | 2010 | Chemical Reviews2010，110，4： | 1 |
| 12 | Reversal of haemorrhagic shock in rats by tetrahydroaminoacridine显示文摘 | Vahide S Sinan C Sibel M | 2001 | Pharmacology2001，62，： | 1 |
| 13 | Comparison of the treatment methods efficiency for decolorization and mineralization of Reactive Black 5 azo dye 显示文摘 | Eral Kusvuran Sibel Irmak Ibrahim M | 2005 | Hazardous Materials2005，，119： | 1 |
| 14 | The association of anti-CCP antibodies with disease activity in rheumatoid arthritis显示文摘 | Münevver Serdaro?lu Ha?im ?ak?rbay Orhan De?er Sevil Cengiz Sibel Kul | 2008 | Rheumatology International2008，，10： | 1 |
| 15 | Reversal of haemorrhagic shock in rats by tetrahydroaminoacridine显示文摘 | Vahide S Sinan C Sibel M | 2001 | Pharmacology2001，62，： | 1 |
| 16 | The association of anti-CCP antibodies with disease activity in rheumatoid arthritis显示文摘 | Münevver Serdaro?lu Ha?im ?ak?rbay Orhan De?er Sevil Cengiz Sibel Kul | 2008 | Rheumatology International2008，，10： | 1 |
| 17 | Animal model of depression:tests of three structurally and pharmacologically novel antidepressant compounds显示文摘 | Katz RJ Sibel M | 1982 | Pharmacol Biochem Behav1982，16，6： | 1 |
| 18 | Palladium and molybdenum mono and bimetallic catalysts on modernite for direct NO decomposition reaction显示文摘 | Andréa M Rodrigo S Sibele B | 2009 | Catalysis Let-ters2009，129，34： | 1 |
| 19 | Geochronology of the Karaderebasement (NW Turkey) and implications for the geologicalevolution of the Istanbul zone显示文摘 | Chen F K Sibel W Satir M | 2002 | Earth Science2002，91，： | 1 |
| 20 | On dynamical behavior for optical solitons sustained by the perturbed Chen–Lee–Liu model显示文摘This study investigates the perturbed Chen–Lee–Liu model that represents the propagation of an optical pulse in plasma and optical fiber.The generalized exponential rational function method is used for this purpose.As a result,we obtain some non-trivial solutions such as the optical singular,periodic,hyperbolic,exponential,trigonometric soliton solutions.We aim to express the pulse propagation of the generated solutions,by taking specific values for the free parameters existed in the obtained solutions.The obtained results show that the generalized exponential rational function technique is applicable,simple and effective to get the solutions of nonlinear engineering and physical problems.Moreover,the acquired solutions display rich dynamical evolutions that are important in practical applications. | Sibel Tarla Karmina K Ali Resat Yilmazer M S Osman | 2022 | Communications in Theoretical Physics2022，74，7： | 0 |
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