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| 1 | Classification of anemia for gastroenterologists显示文摘Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time. | Jose Antonio Moreno Chulilla Maria Soledad Romero Colás Martín Gutiérrez Martín | 2009 | World Journal of Gastroenterology2009，15，37： | 6 |
| 2 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 3 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 2 |
| 4 | Effects of Heavy Fuel Oil on the Bacterial Community Structure of a ristine Microbial Mat 显示文摘 | Bordenave S Soledad M Caumette P | 2007 | Applied and Environmental Microbiology2007，73，： | 1 |
| 5 | Rapid determination of volatile compounds in grapes by HS-SPME coupled with GC-MS显示文摘 | Consuelo D M Soledad P C | 2005 | Talanta2005，66，5： | 1 |
| 6 | Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin α1 and thymutin concentrations: observations in rats and humans显示文摘 | Patrocinio M Mohamed S Soledad B | 2000 | J Neuroimmunol2000，103，： | 1 |
| 7 | Health-related quali- ty of life in coronary heart disease compared to norms in Spanish population显示文摘 | Maria S T Soledad M C Ignacio R D | 2004 | Quality of Life Research2004，13，8： | 1 |
| 8 | Identification of metol degra- dation products under Fenton reagent treatment using liquid chro- matography-mass spectrometry显示文摘 | Loreto L Dolores S Soledad R | 2000 | Water Research2000，34，13： | 1 |
| 9 | Frequency of cognitive im-pairment without dementia in patients with stroke a two -year fol - low - up study 显示文摘 | Soledad S Julio D Elena R G | 2007 | J Stroke2007，38，： | 1 |
| 10 | Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms显示文摘 | Roberto Rosal Ismael Rodea-Palomares Karina Boltes Francisca Fernández-Pi?as Francisco Leganés Soledad Gonzalo Alice Petre | 2010 | Environmental Science and Pollution Research2010，，1： | 1 |
| 11 | Rapid determination of volatile compounds in grapes by HS-SPME coupled with GC-MS显示文摘 | Eva S P Consuelo D M Soledad P C | 2005 | Talanta2005，66，5： | 1 |
| 12 | Emerging bisphenol a replacements(colour developers)in indoor dust from Spain显示文摘Bisphenol A(BPA)and replacements,such as bisphenol S(BPS)and F(BPF)and other substitutes(BPSMAE,D-8 and TGSA)have been recently reported in thermal paper.In this study,BPA,BPS,BPF;BPS-MAE,D-8 and TGSA were analysed in indoor dust collected in Spain from different microenvironments(living rooms,bedrooms,cars and offices).Levels were compared with those reported in our previous study(shops and other public microenvironments,where frequent use of thermal paper is expected).We investigated the differences between microenvironments,possible correlations between compounds and estimated the ingestion rates.BPS-MAE,D-8 and TGSA were present at levels up to 529,128 and 356 ng g^-1,respectively,in all the microenvironments.The highest levels were measured in cars. | María Jesús Duenas-Mas Ana Ballesteros-Gomez Soledad Rubio | 2019 | Emerging Contaminants2019，5，1： | 1 |
| 13 | Rapid determination of volatile compounds in grapes by HS-SPME coupled with GC–MS显示文摘 | Eva Sánchez-Palomo M. Consuelo Díaz-Maroto M. Soledad Pérez-Coello | 2005 | Talanta2005，，5： | 1 |
| 14 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 15 | Effect of the modification of natural clay minerals withhexadecylpyridinium cation on the adsorption-desorption offungicides显示文摘 | SOLEDAD A M SONIA R C M JESUS S M M MARIA S C | 2004 | International Journal of Environmental AnalyticalChemistry2004，84，13： | 1 |
| 16 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 1 |
| 17 | Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children显示文摘 | Corsino Rey Marta Los?Arcos Andrés Concha Alberto Medina Soledad Prieto Pablo Martinez Belen Prieto | 2007 | Intensive Care Medicine2007，，3： | 1 |
| 18 | Do MSIL sporadic colorectal tumors develop through “mild mutator pathway”显示文摘 | Soledad O Cristina M S Mariano M A | 2006 | Clin Oncol2006，29，4： | 1 |
| 19 | Rapid determination of volatile compounds in grapes by HS-SPME coupled with GC-MS显示文摘 | Eva S P Consuelo D M Soledad P C | 2005 | Talanta2005，66，5： | 1 |
| 20 | Primary malignant melanoma of the biliary tract: A case report and literature review显示文摘BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location.This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case.The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy.This patient remains disease-free 36 mo after the treatment of metastatic lung lesions.CASE SUMMARY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical course.Magnetic resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic duct.Given the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of complications.Anatomo-pathological diagnosis was melanoma.After intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and eyes.This confirmed diagnosis of primary biliary tract melanoma.Computed tomography was performed 12 mo after the procedure revealed several subcentimetric lung nodules.Wedge resection was performed.After confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with nivolumab.Tolerance to treatment was excellent.The patient remains disease-free 36 mo after the treatment of metastatic lung lesions.CONCLUSION The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy. | Soledad Cameselle-García José Luis Fírvida Pérez María C Areses Jesús Daniel Fernández de Castro Juan Mosquera-Reboredo Jesús García-Mata | 2019 | World Journal of Clinical Cases2019，7，16： | 1 |
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