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| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | Effects of dietary Clostridium butyricum supplementation on growth performance,intestinal development,and immune response of weaned piglets challenged with lipopolysaccharide显示文摘Background: Weanling pigs, with immature immune system and physiological function, usually experience postweaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, and immunity of weaned pigs challenged with lipopolysaccharide(LPS).Methods: In Experiment(Exp.) 1,144 weaned piglets were weaned at 21 d and randomly assigned to six groups,with six replicates per group and four pigs per replicate, receiving a control diet(CON) or diet supplemented with antibiotics(AB) or C. butyricum(CB)(0.1%, 0.2%, 0.4%, or 0.8%), respectively. All diets in Exp. 1 were a highly digestible basal diet, with 3,000 mg/kg zinc oxide supplied in the first 2 wk only. In Exp. 2, 180 piglets were weaned at 21 d and randomly assigned to five groups, with six replicates per group and six pigs per replicate, receiving CON, AB, or CB(0.2%, 0.4%, or 0.6%) diets. The digestibility of diets was lower than those in Exp. 1, and did not include zinc oxide. At 36 d of Exp. 2, 12 piglets were selected from each of the CON and 0.4% CB groups, six piglets were intraperitoneally injected with LPS(50 μg/kg body weight) and the other six piglets with normal saline;animals were killed at 4 h after injection to collect blood, intestine, and digesta samples for biochemical analysis.Results: In Exp. 1, CB and AB diets had no effect on growth performance of piglets. In Exp. 2, 0.4% CB decreased feed-gain ratio(P < 0.1), diarrhea score(P < 0.05), and increased duodenal, jejunal, and ileal villus height and jejunal villus height/crypt depth(P < 0.05). The 0.4% CB decreased the plasma tumor necrosis factor(TNF) α(P < 0.05) but increased ileal mucosa IL-10 and TLR2 mRNA expression(P < 0.05). Furthermore, 0.4% CB altered the microbial profile, with Bacillus and Ruminococcaceae UGG-003 at genus level and Lactobacillus casei and Parasutterella secunda at species level were higher than CON in colonic content(P < 0.05).Conclusions: Dietary C. butyricum supplementation had positive effects on growth of weaned piglets with less digestible diets. There was a tendency to reduce the feed-gain ratio, which could reduce feed costs in pig production. Moreover, C. butyricum decreased post-weaning diarrhea by improving the intestinal morphology,intestinal microflora profile, and immune function. | Ling Chen Shuang Li Jie Zheng Wentao Li Xuemei Jiang Xilun Zhao Jian Li Lianqiang Che Yan Lin Shengyu Xu Bin Feng Zhengfeng Fang De Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 26 |
| 3 | Geochemical Signatures of Early Paleogene Source Rocks in the Sanshui Basin, South China显示文摘The Honggang member of the early Paleogene Buxin Formation is the main source rock in the Sanshui Basin, characterized by organic-rich black shales with the cyclic recurrence of organic- poor sediments. The geochemical characteristics of the Honggang member have been documented to determine the organic matter types and depositional environments in this paper. The organic matter of the black shales mainly consists of a mixture of land plant-derived and phytoplankton-derived organic matter. Total organic carbon content (TOC)–sulfur–iron (Fe) relationships suggest that the organic- rich black shales were deposited under dysoxic-to-euxinic water conditions. The time that iron minerals remained in contact with H2S in anoxic waters possibly influenced the formation of syngenetic pyrite, and organic carbon controlled the formation of diagenetic pyrite. Organic-poor intervals usually show pyrite sulfur enrichment and higher degree of pyritization values relative to low organic carbon contents. This resulted from HS– diffusing downward from overlying organic-rich sediments and formed Fe sulfides through reactions with sufficient Fe. Trace elements generally exhibit low concentrations and little TOC dependence, suggesting some degree of depletion in these elements in the early Paleogene sediments of the Sanshui Basin. This probably resulted from cyclic recurrences of oxic benthic conditions, which promoted the remobilization of trace elements and caused the low concentration of trace elements. | LIU Chunlian Franz T. FURSICH CHEN Ling CHE Xiaoguang WU Jie | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 10 |
| 4 | Body mass index does not affect the survival of pancreatic cancer patients显示文摘AIM to evaluate the association of body mass index(b MI) with the overall survival of pancreatic ductal adenocarcinoma(PDAC) patients.METHODS A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. these patients were categorized into four b MI groups(< 18.5, 18.5-22.9, 23-27.4 and ≥ 27.5 kg/m2). χ2 tests for comparison of the proportions of categorical variables, and Student's t-test or Mann-Whitney test for continuous variables were employed. Survival analysis was performed with the Kaplan-Meyer method. their HRs of mortality and 95%CIs were estimated using the Cox proportional hazards model.RESULTS With a median age of 59.6 years(range: 22.5-84.6 years), in total 1783 PDAC patients were enrolled in this study. their mean usual b MI was 24.19 ± 3.53 for the whole cohort. More than half of the patients(59.3%) experienced weight loss during the disease onset and progression. Compared with healthy-weight individuals, newly diagnosed patients who were overweight or obese had more severe weight loss during their disease onset and progression(P < 0.001). Individuals who were overweight or obese were associated with positive smoking history(P < 0.001). A significant difference in comorbidity of diabetes(P = 0.044) and coronary artery disease(P < 0.001) was identified between high b MI and normal-weight patients. After a median follow-up of 8 mo, the survival analysis showed no association between b MI and the overall survival(P = 0.90, n = 1783). When we stratified the whole cohort by pancreatic cancer stage, no statistically significant association between b MI and overall survival was found for resectable(P = 0.99, n = 217), unresectable locally advanced(P = 0.90, n = 316) and metastatic patients(P = 0.88, n = 1250), respectively. the results did not change when we used the b MI at diagnosis.CONCLUSION Our results showed no significance of b MI for the overall survival of PDAC patients. | Qing-long Jiang Cheng-feng Wang Yan-tao tian Huang Huang Shui-Sheng Zhang Dong-bing Zhao Jie Ma Wei Yuan Yue-Min Sun Xu Che Jian-Wei Zhang Yun-Mian Chu Ya-Wei Zhang Ying-tai Chen | 2017 | World Journal of Gastroenterology2017，23，34： | 7 |
| 5 | MOF-Derived Ni1-xCox@Carbon with Tunable Nano-Microstructure as Lightweight and Highly Efficient Electromagnetic Wave Absorber显示文摘Intrinsic electric-magnetic property and special nano-micro architecture of functional materials have a significant effect on its electromagnetic wave energy conversion,especially in the microwave absorption(MA) field.Herein,porous Ni1-xCox@Carbon composites derived from metal-organic framework(MOF)were successfully synthesized via solvothermal reaction and subsequent annealing treatments.Benefiting from the coordination,carbonized bimetallic Ni-Co-MOF maintained its initial skeleton and transformed into magnetic-carbon composites with tunable nano-micro structure.During the thermal decomposition,generated magnetic particles/clusters acted as a catalyst to promote the carbon sp^2 arrangement,forming special core-shell architecture.Therefore,pure Ni@C microspheres displayed strong MA behaviors than other Ni1-xCox@Carbon composites.Surprisingly,magnetic-dielectric Ni@C composites possessed the strongest reflection loss value-59.5 dB and the effective absorption frequency covered as wide as 4.7 GHz.Meanwhile,the MA capacity also can be boosted by adjusting the absorber content from 25% to 40%.Magnetic-dielectric synergy effect of MOF-derived Ni1-xCox@Carbon microspheres was confirmed by the off-axis electron holography technology making a thorough inquiry in the MA mechanism. | Lei Wang Mengqiu Huang Xuefeng Yu Wenbin You Jie Zhang Xianhu Liu Min Wang Renchao Che | 2020 | Nano-Micro Letters2020，12，11： | 7 |
| 6 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 7 | A direct H2O2 production based on hollow porous carbon sphere-sulfur nanocrystal composites by confinement effect as oxygen reduction electrocatalysts显示文摘Carbon-sulfur composites have draw n in creasing interest in various fields including electrocatalysis because of their unique structures.However,carb on-sulfur composite with tiny sulfur nano crystals has still received little attention.Herein,hollow porous carb on sphere-sulfur composite(HPCS-S)which possesses excellent electrochemical performance towards H2O2 has been prepared for the first time via a simple silica template method.The 2-5 nm sulfur nan ocrystals being restricted in the cha nnel of the hollow porous carb on spheres are un der a strong compressive stress,which was further con firmed by high-resoluti on tran smissi on electr on microscopy(HRTEM)and GPA.The HPCS-S nano crystals show better con ductivity tha n amorphous sulfur clusters because of the reducti on of the steric hindrance which efficie ntly promotes the electron transportation.Consequently,the higher activity and selectivity towards the 2e^oxygen reduction reaction(ORR)to H2O2 in alkaline solution was obtained.The H2O2 selectivity rises from 20%to over 70%after the sulfur addition and the H2O2 production rate achieves 183.99 mmol-gcataiyst-1 with the Faradaic efficiency of 70%.Furthermore,performance enhancement mechanism was also investigated using the den sity functional theory(DFT)calculatio ns.After the in troduci ng of sulfur nano crystals,the appeara nee of S-S bond greatly decreases the overpotential compared with S-doping,which results in significant enhancement of the electrocatalytic property.Consequently,the HPCS-S can be an efficient H2O2 production electrocatalyst in alkaline solution. | Guanyu Chen Jiwei Liu Qingqing Li Pengfei Guan Xuefeng Yu Linshen Xing Jie Zhang Renchao Che | 2019 | Nano Research2019，12，10： | 6 |
| 8 | Suitability projection for Chinese ski areas under future natural andsocioeconomic scenarios显示文摘Ski tourism is extremely sensitive to climate change and is also heavily affected by socioeconomic conditions.Although some ski areas arestill profitable under current climate and socioeconomic conditions,they will become difficult to operate in the face of rising winter temper-atures,which will result in further economic losses,resource waste and environmental damage.This study projects variability in the suitability ofski area development across China in the coming decades.Natural suitability under three representative concentration pathway emission sce-narios(RCP2.6,RCP4.5 and RCP8.5),socioeconomic suitability under four shared socioeconomic pathways(SSP1,SSP2,SSP3,and SSP5)andintegrated suitability under four climatic-socioeconomic scenarios(RCP2.6-SSP1,RCP4.5-SSP2,RCP8.5-SSP3,and RCP8.5-SSP5)are re-ported.Furthermore,the suitability of 731 existing ski areas in China is assessed.The results show a substantial decline in integrated suitabilityfor most regions of China except for some very cold areas,where higher air temperatures will make visitors feel more comfortable and therelatively poor socioeconomic conditions will improve in the 2030s,2050s and 2090s.The average higher integrated suitability area(integratedsuitability values greater than 0.5)under four climatic-socioeconomic scenarios decreases from the current 29.9%e14.4%,5.0%and 4.5%bythe 2030s,2050s and 2090s,respectively.Under RCP2.6-SSP1,the higher integrated suitability area is projected to decrease from the current28.0%e5.2%by the 2050s and then increase to 5.3%by the 2090s.Under RCP4.5-SSP2,RCP8.5-SSP3,and RCP8.5-SSP5,the higher inte-grated suitability area is projected to continuously decrease from 30.3%,30.6%and 30.6%in the 2010s to 4.1%,4.4%and 4.4%in the 2090s,respectively.By the 2090s,41,138 and 277 existing ski areas are projected to be closed under RCP2.6-SSP1,RCP4.5-SSP2,and RCP8.5-SSP3/RCP8.5-SSP5,respectively.It is clear that emission pathways and climate change adaptation and mitigation strategies will greatly shape thedevelopment of China's regional ski tourism. | DENG Jie CHE Tao JIANG Tong DAI Li-Yun | 2021 | Advances in Climate Change Research2021，12，2： | 5 |
| 9 | Direct conversion of fructose-based carbohydrates to 5-ethoxymethylfurfural catalyzed by AlCl_3·6H_2O/BF_3·(Et)_2O in ethanol显示文摘Direct conversion of fructose-based carbohydrates to 5-ethoxymethylfurfural (EMF) catalyzed by Lewis acid in ethanol was investigated. It was found that BF3(Et)2O was favorable for 5-hydroxymethylfurfural (HMF) etherification to EMF. BF3(Et)2O combination with AlCl3 6H2O with the molar ratio of 1 was an effective catalyst system for synthesis of EMF from fructose-based carbohydrates. 55.0%, 45.4% and 23.9% of EMF yields were obtained from fructose, inulin and sucrose under optimized conditions, respectively. | Xiuquan Jia Jiping Ma Penghua Che Fang Lu Hong Miao Jin Gao Jie Xu | 2013 | Journal of Energy Chemistry2013，22，1： | 5 |
| 10 | Expression of S100B during the innate immune of corneal epithelium against fungi invasion显示文摘AIM: To explore the expression of S100 B in corneal epithelial cells under Aspergillus stimulation both in vivo and in vitro.·METHODS: Immortalized human corneal epithelial cells(HCECs) were exposed to inactive Aspergillus fumigatus(A. fumigatus) conidia at 0, 4, 8, 12, 16, and 24 h respectively. The corneas of Wistar rats were exposed to active A. fumigatus at 0, 12, 24, 48 h and the normal rat corneas were used for normal control. The m RNA level of S100 B was evaluated by real time quantitative reverse transcription-polymerase chain reaction(q RT-PCR).S100 B protein expression in cornea epithelium was detected by immunohistochemical/immunocytochemical staining(IHC/ICC).· RESULTS: Histopathology revealed a significant inflammatory cell infiltration in fungal keratitis human and rat cornea. Corneal epithelial cells didn't express or rarely express S100 B at baseline. A. fumigatus significantly induced S100 B m RNA expression in cultured corneal epithelial cells in a time depended manner in vitro, the m RNA began to rise significantly at8 h in vitro(P <0.05) and continue to rise as time prolonged(P <0.01). In vivo, S100 B m RNA level was low in the normal corneas. However, it was increased in keratitis corneas from 12 h after infection(P <0.05) and reached to a peak at 24h(P <0.001). Immunochemistryrevealed an obvious staining in fungal keratitis corneas as well as immortalized HCECs compared to the normal ones respectively, indicating an increased expression of S100 B protein.·CONCLUSION: S100 B exists in corneal epithelial cells and is over-expressed under A. fumigatus stimulation.S100 B may play an important role in the innate immune response of the corneal epithelium during A. fumigatus infection. | Jie Zhang Gui-Qiu Zhao Jing Qu Cheng-Ye Che Jing Lin Nan Jiang Han Zhao Xue-Jun wang | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 5 |
| 11 | Phosphate recovery with granular acid-activated neutralized red mud:Fixed-bed column performance and breakthrough curve modelling显示文摘Granular acid-activated neutralized red mud(AaN-RM)has been successfully prepared with good chemical stability and physical strength.However,its potential for industrial application remains unknown.Therefore,the performance of granular AaN-RM for phosphate recovery in a fixed-bed column was investigated.The results demonstrated that the phosphate adsorption performance of granular AaN-RM in a fixed-bed column was affected by various operational parameters,such as the bed depth,flow rate,initial solution pH and initial phosphate concentration.With the optimal empty-bed contact time(EBCT)of 24.27 min,the number of processed bed volumes and the phosphate adsorption capacity reached 496.95 and 84.80 mg/g,respectively.Then,the saturated fixed-bed column could be effectively regenerated with a0.5 mol/L HCl solution.The desorption efficiency remained as high as 83.45%with a low weight loss of 3.57%in the fifth regeneration cycle.In addition,breakthrough curve modelling showed that a 5-9-1 feed-forward artificial neural network(ANN)could be effectively applied for the optimization of the fixed-bed adsorption system;the coefficient of determination(R^2)and the root mean square error(RMSE)evaluated on the validation-testing data were 0.9987 and 0.0183,respectively.Therefore,granular AaN-RM fixed-bed adsorption exhibits promising potential for phosphate removal and recovery from polluted water. | Andong Hu Guoping Ren Jiangang Che Yulin Guo Jie Ye Shungui Zhou | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 12 | Self-transforming ultrathin α-Co(OH)2 nanosheet arrays from metal-organic framework modified graphene oxide with sandwichlike structure for efficient electrocatalytic oxygen evolution显示文摘Developing efficient and low-cost electrocatalysts for oxygen evolution reaction(OER)with high electrochemical activity and durability for diverse renewable and sustainable energy technologies remains challenging.Herein,an ultrasonic-assisted and coordination modulation strategy is developed to construct sandwich-like metal-organic framework(MOF)derived hydroxide nanosheet(NS)arrays/graphene oxide(GO)composite via one-step self-transformation route.Inducing from unsteady state,the dodecahedral ZIF-67 with Co^2+in tetrahedral coordination auto-converts into defect-rich ultrathin layered hydroxides with the interlayered ion NO3-.The self-transforming a-Co(OH)2/GO nanosheet arrays from ZIF-67(Co(OH)2-GNS)change the coordination mode of Co^2+and bring about the exposure of more metal active sites,thereby enhancing the spatial utilization ratio within the framework.As monometal-based electrocatalyst,the optimized Co(OH)2-GNS exhibits remarkable OER catalytic performance evidenced by a low overpotential of 259 mV to achieve a current density of 10 mA·cm-2 in alkaline medium,even exceeding commercial RuO2.During the oxygen evolution process,electron migration can be accelerated by the interfacial/in-plane charge polarization and local electric field,corroborated by the off-axis electron holography.Density functional theory(DFT)calculations further studied the collaboration between ultrathin Co(OH)2 NS and GO,which leads to lower energy barriers of intermediate products and greatly promotes electrocatalytic property. | Mengqiu Huang Weiwei Liu Lei Wang Jiwei Liu Guanyu Chen Wenbin You Jie Zhang Lijun Yuan Xuefeng Zhang Renchao Che | 2020 | Nano Research2020，13，3： | 4 |
| 13 | Expression of indoleamine 2,3-dioxygenase in a murine model of Aspergillus fumigatus keratitis显示文摘AIM: To observe the presence and expression of indoleamine 2,3-dioxygenase(IDO) during the corneal immunity to Aspergillus fumigatus(A. fumigatus) in the murine models.·METHODS: The murine model of fungal keratitis was established by smearing with colonies of A. fumigatus after scraping central epithelium of cornea and covering with contact lenses in C57BL/6 mice. The mice were randomly divided into control group, sham group and A.fumigatus keratitis group. The cornea was monitored daily using a slit lamp and recorded disease score after infection. Corneal lesion was detected by immunofluorescence staining. IDO m RNA and protein were also detected by quantitative reverse transcription-polymerase chain reaction(q RT-PCR) and Western blot.· RESULTS: The disease score and slit lamp photography indicated that disease severity was consistent with corneal inflammation in the murine models, and the disease scores in A. fumigatus keratitis group were obviously higher than those in the sham group. By immunofluorescence staining, IDO was mainly localized in corneal epithelium and stroma in the murine corneal tissues with A. fumigatus keratitis. Compared with the sham group, IDO m RNA expression was significantly enhanced in corneal epithelium infected by A. fumigatus. Furthermore, IDO protein expression detected by Western blot was in accord with transcript levels of IDO m RNA measured by q RT-PCR. IDO protein expression was enhanced after A. fumigatus infection compared with the sham group.·CONCLUSION: IDO is detected in corneal epithelium and stroma locally, which indicates IDO takes part in the pathogenesis of A. fumigatus keratitis and plays a key role in immune regulation at the early stage. | Nan Jiang Gui-Qiu Zhao Jing Lin Li-Ting Hu Cheng-Ye Che Cui Li Qian Wang Qiang Xu Jie Zhang Xu-Dong Peng | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 4 |
| 14 | Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients显示文摘评估外部血的动员的有效性和安全的目的由把 docetaxel 与 granulocyte 相结合的造血的干细胞在乳癌病人的刺激殖民地的因素(G-CSF ) 。57 个乳癌病人全部的方法 A 与 docetaxel 被对待 120 mg/m2。白血房间(白血球) 计数什么时候减少了到 1.0 猠浡汰獥映潲 ? 楳杮敬攠摮栭汯摥渠敥汤 ? 湡 ? 桴獯 ? 牦浯洠汵楴汰 ? 楳敤栭汯? 敮摥敬灡?? | Jing Yu Jun Ren Li-jun Di Guo-hong Song Yu-lin Zhu Jie Zhang Xu Liang Li Che Han-fang Jiang Jun Jia Chun-rong Zhang | 2011 | Chinese Journal of Cancer Research2011，23，1： | 4 |
| 15 | Hierarchical coupling effect in hollow Ni/NiFe2O4-CNTs microsphere via spray-drying for enhanced oxygen evolution electrocatalysis显示文摘Design and fabrication of cost-effective transition metal and their oxides-based nanocomposites are of paramount significance for metal-air batteries and water-splitting.However,the traditional optimized designs for nanostructure are complicated,low-efficient and underperform for wide-scale applications.Herein,a novel hierarchical framework of hollow Ni/NiFe2O4-CNTs compositemicrosphere forcibly-assembled by zero-dimensional(OD)Ni/NiFo204 nanoparticle(<16 nm)and one-dimensional(1D)self-supporting CNTs was fabricated successfully.Benefitted from the unique nanostructure,such monohybrids can achieve remarkable oxygen evolution reaction(OER)performance in alkaline media with a low overpotential and superior durability,which exceeds most of the commercial catalysts based on IrO/RuO2 or other non-noble metal nanomaterials.The enhanced OER performance of Ni/NiFe2OA-CNTs composite is mainly ascribed to the increased catalytic activity and the optimized conductivity induced by the effects of strong hierarchical coupling and charge transfers between CNTs and Ni/NiFe204 nanoparticles.These effects are greatly boosted by the polarized heterojunction interfaces confirmed by electron holography.The density functional theory(DFT)calculation indicates the epitaxial Ni further enriches the intrinsic electrons contents of NiFe204 and thus accelerates absorption/desorption kinetics of OER intermediates.This work hereby paves a facile route to construct the hollow composite microsphere with excellent OER electrocatalytic activity based on non-noble metal oxide/CNTs. | Xuefeng Yu Guanyu Chen Yizhe Wang Jiwei Liu Ke Pei Yunhao Zhao Wenbin You Lei Wang Jie Zhang Linshen Xing Jingjun Ding Guangzhou Ding Min Wang Renchao Che | 2020 | Nano Research2020，13，2： | 3 |
| 16 | G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation显示文摘目的: G226 是有有势力的 epipolythiodioxopiperazines 的新奇衍生物对癌症房间的禁止的活动。这里,我们寻求了识别涉及 G226 的反癌症活动的潜在的目标。 | Peng-xing HE Jie ZHANG Yong-sheng CHE Qiao-jun HE Yi CHEN Jian DING | 2014 | Acta Pharmacologica Sinica2014，35，12： | 3 |
| 17 | ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma显示文摘Apoptosis and autophagy are distinct cellular processes that can be highly interconnected. The cross talk between the two processes is indispensable in determining the overall cell fate. Although the apoptosis-promoting effect of caspases has been demonstrated, the roles of autophagy-related proteins and even autophagy itself in regulating apoptosis remain poorly understood. In our present study, we found that downregulation of ubiquitin E3 ligase ASB3 led to enhanced mitochondrial apoptosis as well as autophagy, which synergistically promoted cell death in hepatocellular carcinoma(HCC). We observed the activation of caspase-8 and decrease of autophagy protein Beclin1 in apoptotic cells that were depleted of ASB3. Beclin1 was mainly cleaved by activated caspase-8 and active Beclin1 initiated mitochondrial apoptosis via locating its C-terminal fragment to mitochondria. In addition, knocking down of Beclin1 markedly blocked the apoptosis, indicating its essential role in the process.Notably, our study indicated that enhanced autophagy level might be involved in the activation of caspase-8 and promote the apoptosis. Taken together, our results demonstrated that ASB3 can regulate mitochondrial pathway of apoptosis by controlling caspase-8 mediated cleavage of Beclin1 in HCC. Therefore, ASB3 may potentially serve as a novel target for HCC therapy,especially when combined with autophagy agonist. | Wenli Zhang Fuchen Liu Zhihui Che Mengmeng Wu Zihui Tang Jie Liu Dongqin Yang | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 18 | Mincle in the innate immune response of mice fungal keratitis显示文摘AIM: To investigate how macrophage inducible C-type lectin(Mincle) influences inflammation in mice fungal keratitis induced by Aspergillus fumigatus(A. fumigatus).METHODS: C57 BL/6 mice were infected with A. fumigatus after pretreated with Mincle agonist TDB or Mincle neutralizing antibody(MincleAb), taking DMSO or IgG as control group respectively. The cornea lesions were monitored with slit-lamp microscope and evaluated by clinical score. Mincle expression was assessed using reverse transcriptionploymerase chain reaction(RT-PCR) and immunostaining. The expression of cytokines(IL-1β, TNF-α and IL-6) chemokines(CXCL-1 and MIP-2) was determined by RTPCR and ELISA. Neutrophil infiltration was observed by immunostaining. The levels of nitric oxide(NO) generated by corneas were tested by Griess reaction. RESULTS: Mincle mRNA and protein levels were higher in infected corneas than normal corneas of C57 BL/6 mice, saving clinical scores revealed differences. When pretreated with Mincle agonist TDB, the mRNA and protein levels of IL-1β, TNF-α and IL-6 in infected corneas were significantly increased compared with the control group(P<0.01). Results of the counterpart in corneas pretreated with Mincle neutralizing antibody was decreased consistently(P<0.01). Expression of CXCL1 and MIP-2 mRNA levels were upregulated in TDB group and down-regulated in Mincle Ab group(P<0.01), coincide with neutrophil aggregation degree in corneas showed by immunostaining. As for the concentration of NO, it was promoted in TDB group compared with DMSO control group, and decreased in Mincle Ab group compared with Ig G control group.CONCLUSION: Mincle plays a dual role in mice fungal keratitis. It participates in the innate immune system by enhancing inflammation. What's more, Mincle can mediate cytotoxic effects by regulating the formation of NO. | Guo-Rong Yu Jing Lin Jie Zhang Cheng-Ye Che Xu-Dong Peng Cui Li Li-Ting Hu Guo-Qiang Zhu Kun He Gui-Qiu Zhao | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 3 |
| 19 | Strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome显示文摘Background:There is growing evidence indicating that the microbial communities that dwell on the human ocular surface are crucially important for ocular surface health and disease.Little is known about interspecies interactions,functional profiles,and strain heterogeneity across individuals in healthy ocular surface microbiomes.Methods:To comprehensively characterize the strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome,we performed shotgun metagenomics sequencing on ocular surface mucosal membrane swabs of 17 healthy volunteers.Results:The healthy ocular surface microbiome was classified into 12 phyla,70 genera,and 140 species.The number of species in each healthy ocular surface microbiome ranged from 6 to 47,indicating differences in microbial diversity among individuals.The species with high relative abundances and high positivity rates were Streptococcus pyogenes,Staphylococcus epidermidis,Propionibacterium acnes,Corynebacterium accolens,and Enhydrobacter aerosaccus.A correlation network analysis revealed a competitive interaction of Staphylococcus epidermidis with Streptococcus pyogenes in ocular surface microbial ecosystems.Staphylococcus epidermidis and Streptococcus pyogenes revealed phylogenetic diversity among different individuals.At the functional level,the pathways related to transcription were the most abundant.We also found that there were abundant lipid and amino acid metabolism pathways in the healthy ocular surface microbiome.Conclusion:This study explored the strain heterogeneity,cooccurrence network,taxonomic composition,and functional profile of the healthy ocular surface microbiome.These findings have important significance for the future development of probiotic-based eye therapeutic drugs. | Yutong Kang Shudan Lin Xueli Ma Yanlin Che Yiju Chen Tian Wan Die Zhang Jiao Shao Jie Xu Yi Xu Yongliang Lou Meiqin Zheng | 2021 | Eye and Vision2021，8，1： | 3 |
| 20 | Potential recoverable natural gas resources in China显示文摘在中国的天然气资源是丰富的。在中国的未被发现的可重获的天然气资源被估计是 19.27 敳瀠獯瑩吗? | Liu Chenglin Zhu Jie Che Changbo Liu Guangd | 2008 | Petroleum Science2008，5，1： | 3 |
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