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| 1 | Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites显示文摘AIM: To determine intestinal permeability,the serum tumor necrosis factor (TNF)-α level and urine nitric oxide (NO) metabolites are altered in liver cirrhosis (LC) with or without ascites. METHODS: Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol (PEG) 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay (ELISA) and Greiss reaction method,respectively. RESULTS: The intestinal permeability index wassignif icantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites (0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03,P < 0.05) and correlated with urine nitrite excretion (r = 0.98). Interestingly,the serum TNF-α concentra-tion was significantly higher in LC without ascites than in control subjects or in LC with ascites (198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL,P < 0.05). Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites (1170.9 ± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L,P < 0.05). CONCLUSION: Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites,but the serum TNF-α concentration was not related to LC with ascites. | Soong Lee Seung-Cheol Son Moon-Jong Han Woo-Jin Kim Soo-Hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun Shin | 2008 | World Journal of Gastroenterology2008，14，24： | 16 |
| 2 | MMP-2和TIMP-2基因多态性与胃癌发病风险的研究显示文摘目的探讨西南汉族人群中基质金属蛋白酶-2(matrix metallopmteinase-2,MMP-2)和金属蛋白酶组织抑制剂-2(tissue inhibitor of metalloproteinase-2,TIMP-2)基因启动子区域单核苷酸多态性与胃癌发病风险的关系。方法在美国Sequenom MassARRAY系统上利用基质辅助激光解吸电离飞行时间质谱法(MALDI-TOF MS)针对308对胃癌病例和对照分析MMP-2-1306C/T和TIMP-2-418G/C基因多态特征。同时利用自行设计的问卷收集研究对象的人口学特征和日常生活习惯。结果 MMP-2-1306C/T的CC、CT和TT基因型在病例组和对照组中的频率分别为:79.5%、19.8%、0.6%和79.8%、19.2%、1%;TIMP-2-418G/C的GG、GC和CC基因型在病例组和对照组中的频率分别为:71.4%、26.6%、2.0%和70.5%、27.8%、1.7%;MMP-2-1306C/T(P=0.936和0.984)和TIMP-2-418G/C(P=0.817和0.898)的基因型和等位基因频率分布在胃癌组与对照组间均无统计学差异(P>0.05)。同时未发现基因-基因联合作用(OR=1.004;95%CI:0.460~2.191)和基因-环境之间的交互作用。结论本研究未发现MMP-2-1306C/T和TIMP-2-418G/C多态性与胃癌发病风险有关,且两单核苷酸多态之间无基因-基因联合作用,也未发现基因与环境的交互作用。 | 陈凤 杨淑娟 田智 温圆圆 谢瑶 潘雄飞 Marie Loh 黄荷 兰慧 温莹 赵志梅 Richie Soong 杨春霞 | 2014 | 现代预防医学2014，41，1： | 9 |
| 3 | Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor ubiquitously associated with the Epstein-Barr virus(EBV),which is highly prevalent in South China,Southeast Asia,and North Africa.Despite being a highly radio-sensitive and treatable cancer,a majority of NPC patients are diagnosed in their advanced stage,and locoregional and distant relapses following definitive treatment contribute largely to cancer-specific mortality among these patients.Given that EBV-driven NPC is the predominant variant seen in endemic regions,various EBV detection methods have been developed and are utilized in screening,prognostication,and post-treatment surveillance of NPC patients.While the Immunoglobulin A(IgA)serology assay is the most extensively studied EBV detection method,the detection of plasma EBV DNA released during replication or cellular apoptosis has shown superior outcomes in endemic population screening,prognostication,and detection of distant relapse.Furthermore,there is emerging evidence on the use of circulating tumor cells,microRNAs,DNA hypermethylation,and combination assays in various clinical scenarios.Herein,this paper provides a comprehensive overview of the relevant studies using various EBV detection techniques in the management of NPC.Specifically,the recent advances,clinical evidence,and challenges associated with the clinical application of EBV liquid biopsies in population screening,prognostication,and surveillance of NPC are presented. | Rong Tan Sean Kean Ann Phua Yoke Lim Soong Lynette Lin Ean Oon Kian Sing Chan Sasidharan Swarnalatha Lucky Jamie Mong Min Han Tan Chwee Ming Lim | 2020 | Cancer Communications2020，40，11： | 8 |
| 4 | IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis显示文摘Viral hepatitis is still a public health problem affecting several million people around the world.Neutrophils are polymorphonuclear cells that have a critical role in antibacterial infection.However,the role of neutrophils in viral infection is not fully understood.By using a mouse model of lymphocytic choriomeningitis virus infection-induced viral hepatitis,we observed increased neutrophil recruitment in the liver accompanied by enhanced CD8+T-cell responses.Liver neutrophils expressed high levels of immunomodulatory cytokines,such as C-X-C chemokine ligand 2,arginase-1,inducible nitric oxide synthase and interleukin(IL)-10,demonstrating immunosuppressive properties.Depletion of neutrophils in vivo by a neutralizing antibody resulted in the exacerbation of liver injury and the promotion of T-cell responses at the immune contraction stage.IL-33 significantly induced neutrophil recruitment in the liver and attenuated liver injury by limiting effector T-cell accumulation.Mechanistically,we found that IL-33 promoted the expression of arginase-1 in neutrophils through the type 2 innate lymphoid cell(ILC2)-derived IL-13.Additionally,IL-13 increased the inhibitory effect of neutrophils on CD8+T-cell proliferation in vitro,partially through arginase-1.Finally,we found that IL-13 induced arginase-1 expression,depending on signal transducer and activator of transcription factor 6(STAT6)signaling.Therefore,IL-33 induced immunosuppressive neutrophils via an ILC2/IL-13/STAT6 axis.Collectively,our findings shed new light on the mechanisms associated with IL-33-triggered neutrophils in the liver and suggest potential targets for therapeutic investigation in viral hepatitis. | Yuejin Liang Panpan Yi Denley Ming Kee Yuan Zuliang Jie Zakari Kwota Lynn Soong Yingzi Cong Jiaren Sun | 2019 | Cellular & Molecular Immunology2019，16，2： | 7 |
| 5 | Coal-gas interaction: implications of changes in texture and porosity显示文摘 | Vyacheslav N. Romanov Lauren C. Graeser Sinisha A. Jikich Yee Soong Gino A. Irdi | 2016 | International Journal of Coal Science & Technology2016，3，1： | 4 |
| 6 | Tumor response assessment by the single-lesion measurement per organ in small cell lung cancer显示文摘Background: The criterion of two target lesions per organ in the Response Evaluation Criteria in Solid Tumors(RECIST) version 1.1 is an arbitrary one, being supported by no objective evidence. The optimal number of target lesions per organ still needs to be investigated. We compared tumor responses using the RECIST 1.1(measuring two target lesions per organ) and modified RECIST 1.1(measuring the single largest lesion in each organ) in patients with small cell lung cancer(SCLC).Methods: We reviewed medical records of patients with SCLC who received first-line treatment between January 2004 and December 2014 and compared tumor responses according to the two criteria using computed tomography.Results: There were a total of 34 patients who had at least two target lesions in any organ according to the RECIST 1.1 during the study period. The differences in the percentage changes of the sum of tumor measurements between RECIST 1.1 and modified RECIST 1.1 were all within 13%. Seven patients showed complete response and fourteen showed partial response according to the RECIST 1.1. The overall response rate was 61.8%. When assessing with the modified RECIST 1.1 instead of the RECIST 1.1, tumor responses showed perfect concordance between the two criteria(k=1.0).Conclusions: The modified RECIST 1.1 showed perfect agreement with the original RECIST 1.1 in the assessment of tumor response of SCLC. Our result suggests that it may be enough to measure the single largest target lesion per organ for evaluating tumor response. | Soong Goo Jung Jung Han Kim Hyeong Su Kim Kyoung Ju Kim Ik Yang | 2016 | Chinese Journal of Cancer Research2016，28，2： | 4 |
| 7 | CMA和ALDH2基因多态性与胃癌发病风险的研究显示文摘目的探讨西南地区汉族人群CMA-1903G/A(rs1800875)和ALDH2-rs671多态性与胃癌发病风险的关系。方法采用1∶1配对病例对照研究,纳入经组织病理确诊的胃癌病人及健康对照各308例,使用自行设计的问卷收集研究对象的人口学特征和胃癌危险因素信息,并对rs1800875和rs671基因多态特征进行检测。结果 rs1800875GG、AG和AA基因型在病例组和对照组中的分布频率分别为:64.4%、32.7%、2.9%和61.7%、33.7%、4.6%;rs671GG、GA和AA基因型在两组中的分布频率分别为:63.0%、34.4%、2.6%和63.0%、32.5%、4.5%;上述两基因型频率分布在两组间差异均无统计学意义(P>0.05)。吸烟和饮酒两类人群中rs671 GA+AA基因型携带者患胃癌的风险高于GG基因型携带者(P=0.01,P=0.025),rs1800875基因多态性与胃癌的患病风险不存在统计学意义的关联(P=0.928,P=0.974)。结论本研究发现rs671在吸烟和饮酒人群中其多态性与胃癌的发病风险有关,rs1800875多态性与胃癌的发病风险无关。 | 赵芸 陈凤 杨淑娟 田智 温圆圆 谢瑶 潘雄飞 Marie Loh 黄荷 兰慧 温莹 赵志梅 Richie Soong 常虹 李思齐 薛清萍 杨春霞 | 2014 | 现代预防医学2014，41，21： | 4 |
| 8 | 玻璃体内注射曲安奈德治疗继发于IRVAN的黄斑水肿(英文)显示文摘目的:报告玻璃体内注射曲安奈德对特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎(IRVAN)所致的黄斑水肿的治疗效果。方法:病例报告。结果:患者诊断为特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎导致的伴有视力丧失的继发性黄斑水肿。玻璃体内注射曲安奈德后黄斑水肿减轻,视力显著改善。结论:以前的报告建议采取全视网膜光凝,玻璃体切除术及全身和眼部类固醇治疗。对于继发于IRVAN的黄斑水肿和血管炎,玻璃体内注射曲安奈德是一种安全有效的治疗方法。 | Terrence Kwong-Weng Soong Visvaraja Subrayan Choo May May | 2010 | 国际眼科杂志2010，10，11： | 4 |
| 9 | 上海保税区企业人群体质指数、腰臀比与血脂异常的关系显示文摘目的探讨上海保税区企业人群体质指数、腰臀比(WHR)与血脂异常的关系。方法从2006年1月至2007年8月上海外高桥保税区企业员工的体检资料中选取有人体成分、血脂及肝脏超声波检查项目者350名,根据体质指数分为超重肥胖组(177例)及正常组(173例),比较两组的体质指数、WHR、体脂比率(FAT%)及血脂状况、脂肪肝及血脂异常患病率。结果超重肥胖组的WHR、FAT%、血清甘油三酯(TG)和胆固醇(TC)的水平明显高于正常组,高密度脂蛋白胆固醇的水平明显低于正常组,两组间的差别均有统计学意义(P=0.000)。超重肥胖组中心性肥胖、脂肪肝和高TG血症、高TC血症、低HDL-C血症的患病率分别为88.70%,72.32%,49.7%,33.89%,40.68%,与正常组比较,差别有统计学意义(P=0.000)。结论通过人体成分测定可以早期识别、早期干预高危人群,对预测和降低心血管疾病的发生有重要意义。 | 施荣香 Paul Soong | 2008 | 中国慢性病预防与控制2008，16，1： | 3 |
| 10 | Feasibility of Split Liver Transplantation for 2 Adults in the Model of End-Stage Liver Disease Era显示文摘 | Wei-Chen Lee Kun-Ming Chan Hong-Shiue Chou Ting-Jung Wu Chen-Fang Lee Ruey-Shyang Soong Tsung-Han Wu Ching-Song Lee | 2013 | Annals of Surgery2013，，2： | 3 |
| 11 | An analysis of pulse control for simple mechanical system显示文摘 | Prucz Z Soong T T Reinhorm A M | 1985 | Journal of Dynamic Systems Measurement Control1985，107，： | 2 |
| 12 | The Roles of Personality Traits and Negative Life Events on the Episodes of Depressive Symptoms in Nonreferred Adolescents: A 1-Year Follow-Up Study显示文摘 | Hao-Jan Yang Yu-Ju Chiu Wei-Tsuen Soong Wei J. Chen | 2008 | Journal of Adolescent Health2008，，4： | 2 |
| 13 | Antioxidant activity and phenolic content of selected fruit seeds显示文摘 | Yean-Yean Soong Philip J Barlow | 2004 | Food Chemistry2004，，3： | 2 |
| 14 | Flow Structure and Heat Transfer Between Two Disks Rotating Independently显示文摘In the present paper,fluid flow and convective heat transfer between two co-axial disks rotating independently are dealt with mainly based on the author's recent research on that topic.Three rotational modes,i.e.co-rotation,rotor-stator,and counter-rotation,are considered.Theory of rotating non-isothermal fluids with the presence of disk rotation and thermal effects is addressed.Rotational buoyancy effects on the flow structure development are highlighted.Results of flow visualization and heat transfer measurements are discussed to explore the thermal flow mechanisms involved in the two-disk flow at various rotational and geometric conditions.Potential issues open to the future investigation are also proposed. | Chyi-Yeou Soong | 2003 | Journal of Thermal Science2003，12，1： | 2 |
| 15 | Meta-analysis of genetic polymorphisms and gastric cancer risk: Variability in associations according to race显示文摘 | Marie Loh King Xin Koh Boon Huat Yeo Chun Meng Song Kee Seng Chia Feng Zhu Khay Guan Yeoh Jeffrey Hill Barry Iacopetta Richie Soong | 2009 | European Journal of Cancer2009，，14： | 2 |
| 16 | Xenografting of human umbilical mesenchymal stem cells from Wharton’s jelly ameliorates mouse spinocerebellar ataxia type 1显示文摘Background:Spinocerebellar ataxia type 1(SCA1)is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 protein.Unfortunately,there has yet been any effective treatment so far for SCA1.This study investigated the feasibility of transplanting human umbilical mesenchymal stem cells(HUMSCs)into transgenic SCA1 mice containing an expanded uninterrupted allele with 82 repeats in the ATXN1-coding region.Methods:106 human umbilical mesenchymal stem cells were transplanted into the cerebella at 1 month of age.Results:HUMSCs displayed significant ameliorating effects in SCA1 mice in terms of motor behaviors in balance beam test and open field test as compared with the untransplanted SCA1 mice.HUMSCs transplantation effectively reduced the cerebellar atrophy,salvaged Purkinje cell death,and alleviated molecular layer shrinkage.Electrophysiological studies showed higher amplitudes of compound motor action potentials as indicated by increasing neuronal-muscular response strength to stimuli after stem cell transplantation.At 5 months after transplantation,HUMSCs scattering in the mice cerebella remained viable and secreted cytokines without differentiating into neuronal or glia cells.Conclusions:Our findings provide hope for a new therapeutic direction for the treatment of SCA1. | Pei-Jiun Tsai Chang-Ching Yeh Wan-Jhen Huang Ming-Yuan Min Tzu-Hao Huang Tsui-Ling Ko Pei-Yu Huang Tien-Hua Chen Sanford P.C.Hsu Bing-Wen Soong Yu-Show Fu | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 17 | Herpes simplex encephalitis显示文摘 | Whitley R J Soong S J Linneman C Jr | 1982 | JAMA1982，247，31： | 2 |
| 18 | 飞秒激光辅助后部板层角膜移植术:眼库保存眼手术方法的初步研究 | Soong H.K. Mian S. Abbasi O. Juhasz T. 张鹏 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，5： | 2 |
| 19 | 上海市保税区企业职员运动生活方式与慢性病患病的关系显示文摘目的了解上海市保税区企业职员运动生活方式与慢性病患病的关系,探讨运动生活方式对控制慢性病的有效性,为开展慢性病的行为干预和健康教育提供科学依据。方法以2006年1月至2007年12月在上海外高桥保税区医疗保健中心参加健康体检的保税区企业职员为研究对象,根据生活方式和身体活动问卷,将其分为多量运动组、少量运动组及静坐生活组,比较3组调查对象的体检指标和慢性病患病情况,分析不同运动生活组患慢性病的相对风险。结果共调查企业职员526人,其中多量运动组170人,少量运动组177人,静坐生活组179人。与静坐生活组比较,多量运动组和少量运动组的体质指数、腰臀比、血压、空腹血糖、血脂水平均较低,差异具有统计学意义(P<0.05)。多量运动组、少量运动组和静坐生活组慢性病患病率分别为58.8%、80.2%和87.7%。与静坐生活组比较,多量运动组和少量运动组慢性病患病率均较低(P<0.01),多种慢性病共患的比例较低(P<0.05)。与静坐生活组比较,多量运动组发生超重/肥胖、高血压、糖尿病和血脂异常的OR值分别为0.209(0.134~0.325),0.261(0.160~0.370),0.229(0.071~0.744),0.248(0.160~0.384),少量运动组则分别为0.572(0.373~0.876),0.566(0.366~0.875),0.371(0.134~0.975),0.583(0.380~0.895)。结论运动生活方式是慢性病的一项显著的保护因素,应加强健康教育,促进科学运动生活方式的形成,预防和控制慢性病。 | 施荣香 Paul Soong 张嘉瑞 | 2009 | 中国健康教育2009，25，1： | 2 |
| 20 | Photoelectrochemical evaluation of SILAR-deposited nanoporous BiVO4 photoanodes for solar-driven water splitting显示文摘We report a photoelectrochemical investigation of BiVO4 photoanodes prepared by successive ionic layer adsorption and reaction(SILAR),a facile method that yields uniform nanoporous films.After characterization of the phase,morphology,composition,and optical properties of the prepared films,the efficiencies of charge separation(ηsep)and water oxidation(ηox)in solar water splitting cells employing these photoanodes were estimated following a previously reported procedure.Unexpected wavelength and illumination direction dependencies were discovered in the derived efficiencies,casting doubt on the validity of the analysis.An alternative approach using a diffusion–reaction model that explicitly considers the efficiency of electron collection resolved the discrepancies and explained the illumination direction dependence of the photocurrent.Electron diffusion lengths(Ln)of 0.45μm and 0.55μm were derived for pristine and cobalt phosphate(Co-Pi)modified BiVO4,respectively,which are much shorter than the film thickness of^2.1μm.The Co-Pi treatment also increasedηoxfrom 0.86 to^1,which is the main reason for the overall performance enhancement caused by adding Co-Pi.These findings suggest that there is little scope for improving the performance of SILAR-deposited BiVO4 photoanodes by further catalyzing water oxidation,but enhanced performance is achievable if electron transport can be improved. | Siti Nur'ain Haji Yassin Adrian Soong Leong Sim James Robert Jennings | 2020 | Nano Materials Science2020，2，3： | 2 |
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