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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Targeting key alteration minerals in epithermal deposits in Patagonia,Argentina,using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza C R Azevedo F | 2003 | International Journal of Remote Sensing2003，24，21： | 1 |
| 3 | Maternal complications and perinatal mortality : findings of the World Health Organization Muhieountry Survey on Maternal and Newborn Health 显示文摘 | VOGEL J P SOUZA J P MORI R | 2014 | B JOG2014，1211，： | 1 |
| 4 | Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension 显示文摘 | Perros F Dorfmuller P Souza R l | 2007 | Eur Respir J2007，29，5： | 1 |
| 5 | Ionic liquid(molten salt) phase organometallic catalysis显示文摘 | Dupont J Souza R F D Suarez P A Z | 2002 | Chem Rev2002，102，： | 1 |
| 6 | Trypsin-like enzyme from intestine and pyloric caeca of spotted goaffish ( Pseudupeneus maeulatus ) 显示文摘 | Souza A A G Amaral I P G Santo A R E | 2007 | Food Chem2007，100，4： | 1 |
| 7 | Ionic liquid (molten salt)phase organometallic catalysis显示文摘 | DUPONT J SOUZA R SUAREZ P | 2002 | Chem Rev2002，102，10： | 1 |
| 8 | Ionic liquid (molten salt) phase organometallic catalysis 显示文摘 | Dupont J Souza R F Suarez P A Z | 2002 | Chem Rev2002，102，： | 1 |
| 9 | Targeting key alteration minerals in epithermal deposits in Patagonia, Argentina, using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza Filho C R D E | 2003 | INT J Remote Sensing2003，24，21： | 1 |
| 10 | 显示文摘 | Dupont J Souza R F D Suarez P A Z | 2002 | Chem Rev2002，，102： | 1 |
| 11 | Targeting key alteration minerals in epithermal deposits in Patagonia,Argentina,using ASTER imagery and principal component analysis显示文摘 | Crosta A P Souza Filho C R Azevedo F Brodie C | | 0，，21： | 1 |
| 12 | 查看详情显示文摘 | Dupont J Souza R F Suarez P A | | 0，，10： | 1 |
| 13 | ICP OES simultaneous determination of Ca, Cu, Fe, Mg, Mn, Na, and P inbiodiesel by axial and radial inductively coupled plasma-optical emission spectrometry显示文摘 | de SOUZA R M LEOCADIO L G da SILVEIRA C L P | 2008 | Analytical Letter2008，41，9： | 1 |
| 14 | Selective linear dimerization of 1,3-butadiene by palladium compounds immobilized into 1-nbutyl-3-methyl imidazolium ionic liquids显示文摘 | Suarez P A Z de Souza R F | 1998 | Polym Bull1998，40，： | 1 |
| 15 | Ionic liquids(molten salt) phase organometallic catalysis显示文摘 | Dupont J De Souza R F Suarez P A Z | 2002 | Chem Rev2002，102，10： | 1 |
| 16 | Robust H∞ filtering design for uncertain linear systems with multiple time-varying state delays显示文摘 | De Souza C E Palhares R M Peres P L D | 2001 | IEEE Trans on Signal Processing2001，49，3： | 1 |
| 17 | Claudin-3 and Claudin-4 expres- sion in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity 显示文摘 | Agarwal R D' Souza T Morin P J | 2005 | Cancer Res2005，65，16： | 1 |
| 18 | Powder properties and system behavior during spray drying of Bauhinia fomicata link extract显示文摘 | Souza C R F Oliveira W P | 2006 | Drying Technology2006，24，46： | 1 |
| 19 | Photosynthetic gas exchange,chlorophyll fluorescence and some associated metabolic changes in cowpea (Vigna unguiculata) during water stress and recovery显示文摘 | Souza R P Machado E C Silva J A B | 2004 | Environ Exp Bot2004，51，： | 1 |
| 20 | Photosynthetic gas exchange, chlorophyll fluorescence and some associated rectabolic changes in cowpea (Vigna unguiculata) during water stress and recoyery显示文摘 | Souza R P Machado E C Silva J A B | 2004 | Environmental and Experimental Botany2004，51，1： | 1 |
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