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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Surgical technique and algorithm for the treatment of closed and displaced intra-articular calcaneal fractures by the sinus tarsi approach and plate fixation显示文摘 | Fuentes E M Staub R F Cataldo M M | 2014 | Techniques in Foot&Ankle Surgery2014，13，3： | 1 |
| 3 | Human pS2/trefoil factor 1: Production and characterization in Pichia pastoris 显示文摘 | Kannan R Tomasetto C Staub A | 2001 | Protein Expr Purif2001，21，1： | 1 |
| 4 | Identification and comparative analysis of quantitative trait loci associated with parthenocarpy in processing cucumber 显示文摘 | Sun Z Lower R Staub J E | 2006 | Plant Breeding2006，125，3： | 1 |
| 5 | Best duplex-sonographic criteria for the assessment of renal artery stenosis--correlation with intra-arterial pressure gradient 显示文摘 | Staub D Canevascini R Huegli RW | 2007 | Ultraschall Med2007，28，1： | 1 |
| 6 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 7 | Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts 显示文摘 | Goicoechea SM Garcia-Mata R Staub J | 2014 | Oncogene2014，33，10： | 1 |
| 8 | Trust: the taproot of innovation显示文摘 | Staub R | 1994 | Executive Excellence1994，11，11： | 1 |
| 9 | Best duplexsonographic criteria for the assessment of renal artery stenosis-correlation with intra-arterial pressure gradient显示文摘 | Canevascini R Huegli RW | 2007 | Ultraschall Med2007，28，1： | 1 |
| 10 | Multiple interstitial substances measured by microdialysis in patients with subarachnoid hemorrhage显示文摘 | Staub F Graf R Gabel P | 2000 | Neurosurgery2000，47，5： | 1 |
| 11 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S W Li R Q Zhang Z H Li L Gu X F Fan W Lucas W J Wang X W Xie B Y Ni P X Ren Y Zhu H M Li J Lin K Jin W W Fei Z J Li G C Staub J B Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Q Ren Y Tian G Lu Y Ruan J Qian W Wang M W Huang Q F Li B Xuan Z L | | 0，，12： | 1 |
| 12 | The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders 显示文摘 | Staub E Perez-Tur J Siebert R | 2002 | Trends Biochem Sci2002，27，9： | 1 |
| 13 | Multipl e interstitial substances measured by microdialysis in patients with subarachnoi d hemorrhage显示文摘 | Graf R Gabel P | 2000 | Neurosurgery2000，47，5： | 1 |
| 14 | Flux of COS,DMS and CS2 from various soils in Germany显示文摘 | STAUBES R GEORGII H W OCKELMANN G | 1989 | Tellus1989，41，： | 1 |
| 15 | Linkage analysis of potyvirus resistance alleles in cucumber显示文摘 | Wai T Staub J E Grumet R | 1997 | J Hered1997，88，： | 1 |
| 16 | Evolution of bank efficiency in Brazil:a DEA approach显示文摘 | Staub R B Souza G S Tabak B M | 2010 | European Journal of Operational Research2010，202，1： | 1 |
| 17 | Best duplexsonographic criteria for the assessment of renal arterystenosis-correlation with intra-arterial pressure gradient显示文摘 | Staub D Canevascini R Huegli RW | 2007 | Ultraschall Med2007，28，1： | 1 |
| 18 | Evolution of bank efficiency in brazil: a DEA approach显示文摘 | STAUB R B SOUZA G D S E TABAK B M | 2010 | European Journal of Op- erational Research2010，202，1： | 1 |
| 19 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S Li R Zhang Z Li L Gu X Fan W Lucas WJ Wang X Xie B Ni P Ren Y Zhu H Li J Lin K Jin W Fei Z Li G Staub J Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Ren Y Tian G Lu Y Ruan J Qian W Wang M Huang Q Li B Xuan Z Cao J Asan Wu Z Zhang J Cai Q Ba | | 0，，12： | 1 |
| 20 | Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts显示文摘 | Goicoechea SM Garcia-Mata R Staub J | 2014 | Oncogene2014，33，10： | 1 |
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