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| 1 | 四种心肌克隆钾通道的表达和电生理记录显示文摘为建立一种研究离子通道的有效模型 ,笔者应用分子生物学技术 ,将包含有Kv1.4、Kv1.5、Herg和KvLQT1等几种心肌克隆钾离子 (K+ )通道cDNA的质粒经扩增 ,提取 ,以及纯化后转录为mRNA。经微注射技术分别将它们注射入克隆离子通道表达系统———非洲爪蟾卵母细胞内 ,然后应用膜片钳技术记录上述克隆离子通道电流。结果 :获得了四种克隆通道的电流 时间关系曲线 (I/t)和电流 电压关系曲线 (I/V)。结论 :本实验结果证明所采用的技术稳定可靠 ,并为今后开展克隆离子通道结构和功能的关系以及抗心律失常药物与离子通道相互作用的研究提供了坚实的基础。 | 徐林 黄从新 蒋学俊 李晓艳 吴钢 唐哨勇 Duffey M Strauss HC Rasmusson RL 王世敏 | 2004 | 中国心脏起搏与心电生理杂志2004，18，2： | 6 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Aging and the occurrence of dmentia:findingsfroma population based cohort with a large sample of nonagenarians显示文摘 | Von strauss E Viitanen M deRonchi d | 1999 | Arch Neurol1999，56，5： | 2 |
| 4 | The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis 显示文摘 | Herwig S Strauss M | 1999 | Biochem1999，246，3： | 1 |
| 5 | The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis 显示文摘 | STRAUSS E JAFFE E S PUCK J M | 2001 | Blood2001，98，1： | 1 |
| 6 | Coexistent carcinoma of thethyroid gland and Hashimoto's thyroiditis显示文摘 | STRAUSS M LAURIAN N ANTELI E | 1983 | Surg Gynecol Obstet1983，157，3： | 1 |
| 7 | Role of ultrasound - guidedfine - needle aspiration biopsy in evaluation of nonpalpable thyroidnodules显示文摘 | HAGAG P STRAUSS S WEISS M | 1998 | Thyroid1998，8，11： | 1 |
| 8 | An investi- gation of personality similarity effects (relational and perceived) on peer and supervisor ratings and the role of familiarity and liking 显示文摘 | Strauss J P Barrick M R Connerley M L | 2001 | Journal of Occupational and Organizational Psychology2001，74，5： | 1 |
| 9 | Thrombocytopenia in patients in the medical intensive care unit:bleeding prevalence,transfusion requirements,and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，： | 1 |
| 10 | The participation of interleukin-fi, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease显示文摘 | Hull M Strauss S Berger M | 1996 | Behav Brain Res1996，78，1： | 1 |
| 11 | A new wafer level coating technique to reduce the color distribution of LEDs显示文摘 | Braune B Petersen K Strauss J Kromotis P Kaempf M | | 0，，： | 1 |
| 12 | Pressure Drop Reduction In Cyclone显示文摘 | J M Browne W Strauss | 1978 | Atmospheric Environment1978，，12： | 1 |
| 13 | Blisters associated with lower-extremity fracture:results of a prospective treatment protocol显示文摘 | Strauss EJ Petrucelli G Bong M | 2006 | J Orthop Trauma2006，20，9： | 1 |
| 14 | C3 nephritic factor and hypocomplementaemia in a clinically healthy individual显示文摘 | Gewurz A T Imherr S M Strauss S | 1983 | Clin Exp Immunol1983，54，1： | 1 |
| 15 | Influence line-model correction approach for the assessment of engineering structures using novel monitoring techniques显示文摘 | Strauss A Wender R Frangopol D M Bergmeister K | 2012 | Smart Structures and Systems2012，9，1： | 1 |
| 16 | Plant phenolics as cross-linkers of gel- atin gels and gelatin-based coacervates for use as food ingredients显示文摘 | STRAUSS G GIBSON S M | 2004 | Food Hydrocolloids2004，18，1： | 1 |
| 17 | Blood Cleatance of 99Tcm-N2S2-AnnexinⅤ in Human Subjects显示文摘 | Strauss HW Kown M Hunt S | 2000 | J Nucl Med2000，41，： | 1 |
| 18 | Oncogenic alterations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control 显示文摘 | Lukas J Aagaard L Strauss M | 1996 | Cancer Res1996，55，21： | 1 |
| 19 | A unique subset of CD4+ CD25highFoxp3+ T cells secreting interleu- kin-10 and transforming growthfactor-betal mediates sup- pression in the tumor microenvironment 显示文摘 | Strauss L Bergmann C Szczepanski M | 2007 | Clin Can- cerRes2007，13，151： | 1 |
| 20 | Thrombocytopenia in pa- tients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome 显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
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