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| 1 | PtrHB7, a class III HD-Zip Gene, Plays a Critical Role in Regulation of Vascular Cambium Differentiation in Populus显示文摘在树的第二等的生长的一个关键问题是脉管的形成层房间的区别怎么被指导到 concurrentlyform 二不同纸巾:木部或韧皮部。类 III homeodomain 白氨酸拉链(HD 压缩 III ) 基因被知道在主要、第二等的 growth.However 的进程在脉管的系统的开始, patterning,和区别玩 criticalroles,这些基因怎么控制第二等的脉管的区别的机制是未知的。这里,我们显示出那 Populus 类 III HD 压缩基因, PtrHB7,优先地在 cambial 被表示地区。压制 PtrHB7 的植物在木部与减小在脉管的纸巾显示了重要变化但是韧皮部的增加。Transcriptionalanalysis 表明调整木部区别的基因是下面调整的,而基因调整韧皮部 differentiationwere 起来调整。相应地, PtrHB7 overexpression 向木部房间提高了 cambial 房间的区别,但是禁止了韧皮部区别。cambial 房间区别上的 PtrHB7 规定与它的抄本丰富被联系。一起,结果 demonstratedthat PtrHB7 在在剂量依赖者 manner.Key 在 processof Populus 第二等的生长控制在第二等的木部和韧皮部纸巾之间的平衡区别起一个关键作用词: | Yingying Zhu Dongliang Song Jiayan Sun Xingfen Wang Laigeng Li | 2013 | Molecular Plant2013，6，4： | 13 |
| 2 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 3 | Isolation and characterization of a novel lectin with antifungal and antiproliferative activities from Sophora alopecuroides seeds显示文摘Sophora alopecuroides lectin (柳安) ,从 Sophora alopecuroides 的种子的新奇 lectin,被离子交换层析在 diethylaminoethyl (DEAE ) 上净化 - 并且 carboxymethyl (厘米)-Sepharose 列,在 Sephadex 75 10/300 GL 列上由胶化过滤列在后面。柳安被发现是 39916.3 Da 的单体,由 tricine 钠 dodecyl sulphate-polyacrylamide 胶化电气泳动和高效的液体层析决定了 HPLC ) 。柳安的 N 终端 10-amino 酸顺序, KPWALSFSFG,另外的荚 lectins 类似于那些。对在 11.9 g/ml 的兔子红血球的柳安展览 hemagglutinating 活动。它的 hemagglutinating 活动在 pH 范围是稳定的 711 并且在温度范围 3090 吗? | Tingting Li Xiaoli Yin Dongliang Liu Xiaojin Ma Hui Lv Surong Sun | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 4 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 5 | Implementation of an efficient segregated algorithm-IDEAL on 3D collocated grid system显示文摘The segregated algorithm-IDEAL (inner doubly-iterative efficient algorithm for linked-equations) is an efficient and stable algorithm. In this algorithm, there exist inner doubly-iterative processes for pres-sure equation, which almost completely overcome two approximations in SIMPLE algorithm. Thus the coupling between velocity and pressure is fully guaranteed, greatly enhancing the convergence rate and stability of iteration process. In this paper, implementation of the IDEAL algorithm on a 3D collo-cated grid system is conducted. The interface velocity is calculated by the modified momentum inter-polation method (MMIM), by which the converged result is independent of the under-relaxation factor. Finally, five three-dimensional incompressible fluid flow and heat transfer problems are provided to compare the convergence rate and robustness between the IDEAL and three other most widely-used algorithms (SIMPLER, SIMPLEC and PISO). By the comparison it can be concluded that the IDEAL al-gorithm is more robust and efficient than the three other algorithms. | SUN DongLiang QU ZhiGuo HE YaLing Tao WenQuan | 2009 | Chinese Science Bulletin2009，54，6： | 5 |
| 6 | Numerical study of flow pattern modulation in a vertical phase separation condenser tube显示文摘The passive phase separation concept was proposed to modulate flow patterns for heat transfer enhancement. By the flow pattern modulation, the gas tends to be near the wall and the liquid tends to be in the tube core. Experiment has been performed to verify the fresh idea and the flow pattern modulation mechanism was analyzed qualitatively. This paper focuses on the numerical simulation of the bubble dynamics for a single bubble in the vertical phase separation condenser tube to quantitatively explore the flow pattern mechanism, based on a multiscale grid system and the volume-of-fluid (VOF) method. It is found that: (1) the modulated liquid film thickness can be decreased by 70% compared to that in the bare tube region; (2) the modulated bubble traveling velocity can be doubled, causing the increased liquid velocity and velocity gradient in the annular region to weaken the fluid boundary layer; (3) the significantly increased bubble traveling velocity in the annular region promotes the mass and momentum exchange between the annular region and the core region, and yields the self-sustained pulsating flow in the core region. The above three factors are benefit for the performance improvement of the heat transfer facilities. | SUN DongLiang XU JinLiang CHEN QiCheng CAO Zhen | 2013 | Chinese Science Bulletin2013，58，13： | 4 |
| 7 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 8 | Condensation heat transfer enhancement mechanism for vertical upflows by the phase separation concept at small gravity显示文摘In the field of aerospace, minimum and seal of equipments cause the increase in the thermal loading sharply. Due to the lack of driving force, the performance of conventional condenser deteriorates greatly under the small gravity environment, which leads to reduction in the service life of equipments. In this study, a passive condenser, developed on basis of the phase separation concept,is utilized to improve the performance of the condensation heat transfer under the small gravity environment. As a result of the limitation of experiments, the mechanisms of heat transfer enhancement of the phase separation condenser tube are revealed through numerical simulation based on the volume-of-fluid(VOF) method. The following conclusions could be obtained:(1) A novel phase distribution of ‘‘gas near the tube wall and liquid in the tube core'' is formed. The thin liquid film is indeed created after the flow pattern modulation by inserting mesh cylinder.(2)The condensation quantity for single bubble in the annular region increases about 16 times greater than that in the bare tube region in the case of Jl= 0.0574 m/s and Jg= 0.0229 m/s.(3) Gas volume fraction affects the parameters of liquid film thickness, bubble length and liquid bridge length. The increase in the gas volume fraction results in the decrease in the evaluation index from21.56 to 12.82. The evaluation index is defined as the ratio of the condensation quantities per unit tube length of the annular region and the bare tube region. | Qicheng Chen Dongliang Sun | 2015 | Science Bulletin2015，60，20： | 2 |
| 9 | The bubble leakage mechanism for vertical upflows by the phase separation concept显示文摘Recently,our research group proposed the phase separation condenser tube,in which a mesh cylinder was inserted to form the flow structure of‘‘gas near the tube wall and liquid in the tube core’’,significantly enhance the condensation heat transfer.But the bubble leakage towards the core region may worsen the heat transfer enhancement.In order to prevent the bubble leakage,the critical criterion was proposed based on the Young–Laplace equation,considering the inertia force,viscous force and pulsating flow.It was found that the critical criterion depends on the dimensionless parameter G*,the We number and a coefficient C.The numerical model was developed in terms of the volume of fluid method to predict the two-phase laminar flow in the phase separation condenser tube.The results show that the bubble leakage takes place at the bubble tip,which is agreed with the experimental observations.The critical curve distinguishing the non-bubble-breaking and bubble-breaking was obtained by comparing the bubble dynamics at different G*and We.The coefficient C was determined.The critical criterion for the bubble leakage is given as G We0:22We0:99349 G4:7 103 We0:00651t196:39We0:006514cosa DHW,providing the design and operation guidance for the phase separation condenser tube. | Qicheng Chen Jinliang Xu Dongliang Sun | 2014 | Chinese Science Bulletin2014，59，21： | 2 |
| 10 | Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation显示文摘Reduced cellular immune function in patients after liver transplantation easily results in many types of viral infections,such as Epstein-Barr virus.Epstein-Barr virus is a γ-herpesvirus and is related to many malignant diseases,especially epithelial and lymph tumors.The abnormal interaction of cluster of differentiation 40 with cluster of differentiation 40 ligand and expression of cluster of differentiation 40 ligand are considered closely related to the development of myeloma cells.This study explored the influence and mechanism of Epstein-Barr virus infection on the phenotype and biological behavior of myeloma cells after liver transplantation.Flow cytometry was used to detect coexpression of cluster of differentiation 40 and cluster of differentiation 40 ligand in 10 samples of freshly isolated multiple myeloma cells.Cluster of differentiation 40 and cluster of differentiation 40 ligand were coexpressed in sample Nos.5,8,9,and 10,particularly in sample No.5.Western blot analysis was used to detect the expression of the Epstein-Barr virus antigens latent membrane protein 1 and Epstein-Barr virus nuclear antigen 2 in the multiple myeloma cell line RPMI 8226 infected with Epstein-Barr virus.The antigen expression indicated that Epstein-Barr virus can infect multiple myeloma virus cells in vitro.Reverse transcription-polymerase chain reaction revealed upregulated expression of cluster of differentiation 40 ligand on the infected RPMI 8226 cells,which may be involved in the anti-apoptosis activity of the infected cells.Confocal microscopy showed that pairs of molecules of cluster of differentiation 40,cluster of differentiation 40 ligand,and latent membrane protein 1 were colocalized on the surface of the infected cells.CXC chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus infection.The migratory ability of the infected cells improved in the presence of the chemokine stromal cell-derived factor-1α.Anti-apoptosis and migration are known important biological characteristics of malignant cells.Our results indicate the involvement of Epstein-Barr virus in the origin and development of multiple myeloma.The risk of multiple myeloma increases when Epstein-Barr virus infects B cells in the germinal center,which may result in an anti-apoptosis effect of B cells and an improved ability to migrate from the germinal center to peripheral blood. | ZHANG YeWei ZHAO HeWei HE Xia ZHENG SuWen WANG TaiHong YAN DongLiang SUN JingFeng LU Xiang WEN JianFei LAU Wan Yee | 2012 | Science China(Life Sciences)2012，55，8： | 2 |
| 11 | Purification and characterization of a novel antifungal protein with antiproliferation and anti-HIV-1 reverse transcriptase activities from Peganum harmala seeds显示文摘新奇抗真菌的蛋白质,指定了为 PHP,从 Peganum harmala 的种子被孤立,由资源 S 列上的 cationic 交换层析和 Sephadex 75 10/300 GL 上的胶化过滤列。PHP 被发现形成大约 16 kDa 的 homodimer。等电位的集中 polyacrylamide 胶化电气泳动分析证明 PHP 的等电位的点是 8.4。PHP 的 N 终端 20-amino 酸顺序, ITCPQVTQSLAPCVPYLISG,在某些植物类似于非特定的类脂化合物转移蛋白质。PHP 展出了类脂化合物绑定活动。而且, PHP 对 Alternaria 替换物,毛丛 degitatum, Rhizopus stuolonifer,和 Magnaporthe grisea 施加了抗真菌的活动,并且它的抗真菌的活动在温度范围是稳定的 460 瑮晩湵慧 ? 牰瑯楥? 楷桴愠瑮灩潲楬敦慲楴湯愠摮愠瑮 ???? 敲敶獲? 牴湡 ' 諛 L 瑰獡 ? 捡楴楶楴獥映潲 ? 敐慧畮 ? 慨浲污 ?敳摥 s 瑮吗?? | Xiaojin Ma Dongliang Liu Haishu Tang Yan Wang Ting Wu Yang Li Jie Yang Jianhua Yang Surong Sun Fuchun Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 1 |
| 12 | Superplasticity in a large-grained TiAI alloy 显示文摘 | Lin Dongliang Sun Feng | 2004 | Intermetallics2004，12，79： | 1 |
| 13 | Superplastic pheno-menon in a large-grained TiAl alloy显示文摘 | Feng Sun lin Dongliang | 2001 | Scripta Mater2001，4，4： | 1 |
| 14 | Influence of the source size on domino effect risk caused by fragments 显示文摘 | Dongliang Sun Juneheng Jiang Mingguang Zhang | 2015 | Journal of loss prevention in the process industries2015，35，3： | 1 |
| 15 | Ballistic experiments on the mechanism of protective layer against domino effect caused by projectiles显示文摘 | Dongliang Sun Juneheng Jiang Mingguang Zhang | 2016 | Journal of loss prevention in the process industries2016，40，： | 1 |
| 16 | Complete genome sequence of Lactobacillus casei Zhang,a new probiotic strain isolated from traditional home-made koumiss in Inner Mongolia of China显示文摘 | Zhang Wenyi Yu Dongliang Sun Zhihong | 2010 | Journal of Bacteriology2010，192，19： | 1 |
| 17 | An Improved S-Random Interleaver Design for Turbo Code Based on Chaos Model显示文摘A new method to design interleaver based on Henon chaos model is presented. The designed interleaver is with rather random behavior. Experimental results show that the proposed S-henon interleaver make a magnitude of improvement in bit error rate (BER) performance by 0.4 dB compared with the S-random interleaver for AWGN channel respectively. The S-henon interleaver may be adapted to 3G mobile communication systems. | XIAO Dongliang SHI Hongling SUN Hong JIAO Bingli | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 1 |
| 18 | Genome-wide identification and analysis of late embryogenesis abundant (LEA) genes in Prunus mume显示文摘 | Dongliang Du Qixiang Zhang Tangren Cheng Huitang Pan Weiru Yang Lidan Sun | 2013 | Molecular Biology Reports2013，，2： | 1 |
| 19 | Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang 显示文摘 | Wenyi Zhang Dongliang Yu Zhihong Sun | 2008 | Plasmid2008，60，2： | 1 |
| 20 | Diversity of Culturable Bacteria Isolated from Root Domains of Moso Bamboo (Phyllostachys edulis)显示文摘 | Jigang Han Dongliang Xia Lubin Li Lei Sun Kai Yang Liping Zhang | 2009 | Microbial Ecology2009，，2： | 1 |
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