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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy显示文摘A copper-bearing Ti-6AI-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure,antibacterial performance,and cytocompatibility.Characterization of microstructure revealed that the solution treated alloy consisted of α phase,α' phase and(3 phase,while besides these phases,the aged alloy also contained the precipitations of intermetallic Ti_2Cu compound.The solution treated alloy showed better antibacterial performance with increasing the solution temperature.The Cu ions released from Ti—6AI—4V—5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy,and do not induce any cytotoxicity.The optimal heat treatment for Ti-6Al-4V-5Cu alloy was solution treated at 930 C,at which it could exhibit both promising antibacterial performance and no cytotoxicity. | Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra | 2015 | Journal of Materials Science & Technology2015，31，7： | 10 |
| 3 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 4 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 5 | Recycled Nd-Fe-B sintered magnets prepared from sludges by calcium reduction-diffusion process显示文摘Environmental friendly recycling process for Nd-Fe-B sintered magnet sludges generated in the manufacturing process, which contain large amount of rare earth, including Nd, Pr and Dy, is badly needed so far. In present study, we have developed an effective route to obtain recycled sintered magnets from Nd-Fe-B sintered magnet sludges by calcium reduction-diffusion(RD) process. Compared to conventional recycling process, our research is focused on recovering most of the useful elements, including Nd, Pr, Dy, Co, and Fe together instead of just rare earth elements. To improve the recycling efficiency and reduce pollution, the co-precipitating parameters were simulated and calculated using MATLAB software. Most of useful elements were recovered by a co-precipitation method, and the obtained composite powders were then directly fabricated as recycled Nd-Fe-B powders by a calcium reduction-diffusion(RD) method. The recovery rates are 98%, 99%, 99%, 93%, and 99%, for Nd, Pr, Dy, Co, and Fe, respectively. The amount of useful elements contained in the recovered composite powders is greater than99.71 wt%. The process of RD for synthesizing Nd_2 Fe_(14)B and subsequently removing CaO was thoroughly investigated. Furthermore, the recycled Nd-Fe-B magnet exhibits a remanence of 1.1 T, a coercivity of1053 kA/m, and an energy product of 235.6 kJ/m^3, respectively, indicating that recycled Nd-Fe-B sintered magnet was successfully recovered from the severely contaminated sludges via an effective recycling route. | Xiaowen Yin Min Liu Baicen Wan Yu Zhang Weiqiang Liu Yufeng Wu Dongtao Zhang Ming Yue | 2018 | Journal of Rare Earths2018，36，12： | 6 |
| 6 | Antibacterial Properties of Ti-6Al-4V-xCu Alloys显示文摘Surgical implant-associated bacterial infection is becoming a serious clinical problem.A series of copper-bearing titanium alloy,Ti—6AI—4V—xCu(x = 1,3,5 wt%),were fabricated in the present study in order to reduce the hazard of the bacterial infection problem by means of the strong antibacterial ability of Cu element.The metallography,X-ray diffraction,antibacterial ability,corrosion resistance and cytotoxicity of Ti—6AI—4V—xCu alloys were preliminarily studied with comparison to the commercial medical Ti—6AI—4V alloy.The Ti—6AI—4V—xCu alloys showed obvious antibacterial abilities with good corrosion resistance and cytocompatibility,and the antibacterial role was enhanced with increasing Cu content,which has significant potential for clinical applications as surgical implant materials. | Ling Ren Zheng Ma Mei Li Yu Zhang Weiqiang Liu Zhenhua Liao Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，7： | 5 |
| 7 | Synthesis of W-Y2O3 alloys by freeze-drying and subsequent low temperature sintering:Microstructure refinement and second phase particles regulation显示文摘In this work,W-Y2 O3 alloys are prepared by freeze-drying and subsequent low temperature sintering.The average size of reduced W-Y2 O3 composite powders prepared by freeze-drying method is only 18.1 nm.After low temperature sintering of these composite nanopowders,the formed W-Y2 O3 alloys possess a smaller grain size of 510 nm while maintaining a comparatively higher density of 97.8%.Besides a few submicron Y2 O3 particles(about 100-300 nm)with a W-Y-O phase diffusion layer on their surface distribute at W grain boundaries,lots of nano Y2 WO6 particles(<20 nm)exist in W matrix.Moreover,many Y6 WO12(<10 nm)particles exist within submicron Y2 O3 particles.The formation of these ternary phases indicates that some oxygen impurities in the W matrix can be adsorbed by ternary phases,resulting in the purification of W matrix and the strengthening of phase boundaries.The combined action of the above factors makes the hardness of the sintered W-Y2 O3 alloys in our work as high as 656.6±39.0 HV0.2.Our work indicates that freeze-drying and subsequent low temperature sintering is a promising method for preparing high performance W-Y2 O3 alloys. | Weiqiang Hu Zhi Dong Liming Yu Zongqing Ma Yongchang Liu | 2020 | Journal of Materials Science & Technology2020，36，1： | 3 |
| 8 | True random coded photon counting Lidar显示文摘A true random coded photon counting Lidar system is proposed in this paper,in which a single photon detector acts as the true random sequence signal generator instead of the traditional function generator.Compared with the traditional pseudo-random coded method,the true random coded method not only improves the anti-crosstalk capability of the system,but more importantly,it effectively overcomes the adverse effect of the detector’s dead time on the ranging performance.The experiment results show that the ranging performance of the true random coded method is obviously better than that of the pseudo-random coded method.As a result,a three-dimensional scanning imaging of a model car is completed by the true random coded method. | Bo Liu Yang Yu Zhen Chen Weiqiang Han | 2020 | Opto-Electronic Advances2020，3，2： | 3 |
| 9 | An off-line simulation of land surface processes over the northern Tibetan Plateau显示文摘In order to further understand the land surface processes over the northern Tibetan Plateau, this study produced an off-line simulated examination at the Bujiao site on the northern Tibetan Plateau from June 2002 to April 2004, using the Noah Land Surface Model(Noah LSM) and observed data from the CAMP/Tibet experiment. The observed data were necessarily corrected and the number of soil layers in the Noah LSM was changed from 4 to 10 to enable this off-line simulation and analysis. The main conclusions are as follows: the Noah LSM performed well on the northern Tibetan Plateau. The simulated net radiation, upward longwave radiation, and upward shortwave radiation demonstrated the same remarkable annual and seasonal variation as the observed data, especially the upward longwave radiation. The simulated soil temperatures were acceptably close to the observed temperatures, especially in the shallow soil layers. The simulated freezing and melting processes were shown to start from the surface soil layer and spread down to the deep soil layers, but they took longer than the observed processes. However, Noah LSM did not adequately simulate the soil moisture. Therefore, additional high-quality, long-term observations of land surface–atmosphere processes over the Tibetan Plateau will be a key factor in proper adjustments of the model parameters in the future. | MinHong Song YaoMing Ma Yu Zhang WeiQiang Ma SiQiong Luo | 2014 | Research in Cold and Arid Regions2014，6，3： | 2 |
| 10 | Prototype of multi-filament electron curtain accelerator显示文摘 | LI Guohua TANG Huaping LIU Jinsheng ZHANG Huayi LIU Yaohong ZHANG Dongsheng HE Yu LI Jian GUAN Weiqiang | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 11 | Fast screening compositions of PM2.5 by ATR-FTIR: Comparison with results from IC and OC/EC analyzers显示文摘Chemical speciation of fine particles or PM_(2.5) collected on filters is still a costly and timeconsuming task. In this study, filter-based PM_(2.5) samples were collected during November–December 2013 at four sites in Guangzhou, and the major components were fast screened(~7 min per filter sample) by Attenuated Total Reflectance(ATR)-Fourier Transform Infrared Spectroscopic(FTIR) in comparison with that measured by Organic carbon/Element carbon(OC/EC) analyzer and Ion Chromatography(IC). The concentrations of nitrate, ammonium, sulfate,primary organic carbon(POC) and secondary organic carbon(SOC) measured by OC/EC and IC analyzers were better correlated with their infrared absorption peak heights at 1320 cm^(-1) for nitrate, 1435, 3045 and 3215 cm^(-1) for ammonium, 615 cm^(-1) for sulfate, 690, 760 and 890 cm^(-1) for POC and 1640 and 1660 cm^(-1) for SOC respectively, during polluted days(PM_(2.5)> 75 μg/m^3) than during clean days(PM_(2.5)≤ 75 μg/m^3). With the evolution of a haze episode during our field campaign, the concentrations of the major PM_(2.5) components displayed consistent variations with their infrared absorption peak heights, suggesting ATR-FTIR could be a fast and useful technique to characterize filter-based PM_(2.5) compositions particularly during pollution events although cautions should be taken when PM_(2.5) levels are low. Notably, elevated PM_(2.5) mass concentrations occurred with enhanced ratios of [NO_(-3)]/[SO_4^(2-)] and [NH^(+4)]/[SO_4^(2-)], implying that nitrogenous components play vital roles in the PM_(2.5) pollution events in the study region. | Xu Yu Wei Song Qingqing Yu Sheng Li Ming Zhu Yanli Zhang Wei Deng Weiqiang Yang Zhonghui Huang Xinhui Bi Xinming Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 2 |
| 12 | Refined microstructure and enhanced mechanical properties in Mo-Y_(2)O_(3)alloys prepared by freeze-drying method and subsequent low temperature sintering显示文摘The ultrafine Mo-Y_(2)O_(3)composite powders were successfully synthesized by innovative freeze-drying method.Consequently,the freeze-dried Mo-Y_(2)O_(3)composite powders with high sintering activities possess an average grain size of 54 nm.After low temperature sintering at 1600°C,the Mo-Y_(2)O_(3)alloys maintaining a high density(99.6%)have the finest grain size(620 nm)comparing with available literature about oxide dispersion strengthened molybdenum alloy(ODS-Mo).The oxide particles remain their small size(mainly<50 nm)within Mo grains and at Mo grain boundaries.Furthermore,the Y_(5)MO_(2)O_(12)particles were firstly observed within Mo matrix,and its formation can absorb nearby oxygen impurities,which involves the purification of Mo matrix.The mechanical properties show that Mo-Y_(2)O_(3)alloy possess a high hardness of 487±28 HV_(0.2),a high yield strength of 902 MPa,a high compressive strength of1110 MPa,respectively.Our work suggests that freeze-drying and subsequent low temperature sintering can shed light on the preparation of ultrafine ODS-Mo alloys with high performance. | Weiqiang Hu Tao Sun Chenxi Liu Liming Yu Tansir Ahamad Zongqing Ma | 2021 | Journal of Materials Science & Technology2021，，29： | 2 |
| 13 | The effect of Chinese herbal medicine on non-biliogenic severe acute pancreatitis: A systematic review and meta-analysis显示文摘 | Xiaoguang Lu Weiqiang Xiao Xin Kang Jie Yu Zhiwei Fan | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 14 | Spin-liquid state for two-dimensional Heisenberg antiferromagnets on a Kagomé lattice显示文摘 | Feng Shiping | 2000 | Eur Phys J2000，13，： | 1 |
| 15 | Synthesis and Structural Characterization of (CH2)n-Bridged Indenyl-Pyrazoles and Their Cyclopentadienyl Nickel (II) Complexes显示文摘 | Tan Weiqiang Yu Zhengkun Liu Bing | 2009 | J Organomet Chem2009，694，： | 1 |
| 16 | Cathode infiltration with enhanced catalytic activity and durability for intermediate-temperature solid oxide fuel cells显示文摘To lower the operation temperature and increase the durability of solid oxide fuel cells(SOFCs), increasing attentions have been paid on developing cathode materials with good oxygen reduction reaction(ORR)activity at intermediate-temperature(IT, 500-750 ℃) range. However, most cathode materials exhibit poor catalytic activity, or they thermally mismatch with SOFC electrolytes and undergo severe degeneration. Infiltrating catalysts on existing backbone materials has been proved to be an efficient method to construct highly active and durable cathodes. In this mini-review, the advantages of infiltration-based cathode compared with new material-based cathodes are summarized. The merits and drawbacks of different backbones are illustrated. Different types of catalysts for infiltration are depicted in detail. Suggestions on the material/structure optimization of the infiltrated cathodes of IT-SOFC are provided. | Yinghua Niu Weirong Huo Yuandong Yu Wenjun Li Yulin Chen Weiqiang Lv | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 17 | Anomalous c-axis charge dynamics in copper oxide materials显示文摘 | Feng Shiping Yuan Feng Yu Weiqiang | 1999 | Phys Rev1999，60，： | 1 |
| 18 | Effects of monsoon onset vortex on heat budget in the mixed layer of the Bay of Bengal显示文摘We investigated the effects of monsoon onset vortex(MOV)on the mixed layer heat budget in the Bay of Bengal(BOB)in spring 2003 using the reanalysis datasets.The results suggest that the solar radiation flux penetrating the mixed layer and the existence of barrier layer are both able to modulate the effects of MOV on the evolution of sea surface temperature(SST)in the BOB.Prior to the formation of BOB MOV,the local SST raised quickly due to mass of solar radiation reaching the sea surface under the clear-sky condition.Meanwhile,since the mixed layer was shallow before the onset of the Asian summer monsoon(ASM),some solar radiation flux could penetrate to directly heat the deeper water,which partly offset the warming effect of shortwave radiation.On the other hand,the in-situ SST started to cool due to the upwelling of cold water when the MOV generated over the BOB,along with the rapidly increased surface wind speed and its resultant deeper mixed layer.As the MOV developed and moved northward,the SST tended to decrease remarkably because of the strong upward surface latent heat flux over the BOB ascribed to the wind-evaporation mechanism.However,the MOV-related precipitation brought more fresh water into the upper ocean to produce a thicker barrier layer,whose thermal barrier effect damped the cooling effect of entrainment upwelling on the decrease tendency of the BOB SST.In other words,the thermal barrier effect could slow down the decreasing trend of the BOB SST even after the onset of ASM,which facilitated the further enhancement of the MOV. | Effects of monsoon onset vortex on heat budget in the mixed layer of the Bay of BengalXU Kang LIU Boqi LIU Yu WANG Weiqiang HE Zhuoqi | 2020 | Journal of Oceanology and Limnology2020，38，6： | 1 |
| 19 | Ni/NaX=A Bi- functional Efficient Catalyst for Selective Hydrogenolysis of Glycerol显示文摘 | Zhao Jing Yu Weiqiang Chen Chen | 2010 | Catal Lett2010，134，12： | 1 |
| 20 | Flexible,anti-damage,and non-contact sensing electronic skin implanted with MWCNT to block public pathogens contact infection显示文摘If a person comes into contact with pathogens on public facilities,there is a threat of contact(skin/wound)infections.More urgently,there are also reports about COVID-19 coronavirus contact infection,which once again reminds that contact infection is a very easily overlooked disease exposure route.Herein,we propose an innovative implantation strategy to fabricate a multi-walled carbon nanotube/polyvinyl alcohol(MWCNT/PVA,MCP)interpenetrating interface to achieve flexibility,anti-damage,and non-contact sensing electronic skin(E-skin).Interestingly,the MCP E-skin had a fascinating non-contact sensing function,which can respond to the finger approaching 0−20 mm through the spatial weak field.This non-contact sensing can be applied urgently to human–machine interactions in public facilities to block pathogen.The scratches of the fruit knife did not damage the MCP E-skin,and can resist chemical corrosion after hydrophobic treatment.In addition,the MCP E-skin was developed to real-time monitor the respiratory and cough for exercise detection and disease diagnosis.Notably,the MCP E-skin has great potential for emergency applications in times of infectious disease pandemics. | Duan-Chao Wang Hou-Yong Yu Lurong Jiang Dongming Qi Xinxing Zhang Lumin Chen Wentao Lv Weiqiang Xu Kam Chiu Tam | 2022 | Nano Research2022，15，3： | 1 |
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