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| 1 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 2 | Carotenoid Metabolism in Plants: The Role ol Plastids显示文摘 | Tianhu Sun Hui Yuan Hongbo Cao Mohammad Yazdani Yaakov Tadmor Li Li | 2018 | Molecular Plant2018，11，1： | 33 |
| 3 | Ubiquitin signaling in immune responses显示文摘 | Hongbo Hu Shao-Cong Sun | 2016 | Cell Research2016，26，4： | 27 |
| 4 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 5 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 6 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 7 | High speed interpolation for micro-line trajectory and adaptive real-time look-ahead scheme in CNC machining显示文摘CNC machining plays an important role in mechanical manufacturing.A key issue is to improve the machining feedrate while keeping the machining precision and satisfying the acceleration constraints of the CNC machine.For the consecutive micro-line segments interpolation,the velocities at the junction of two segments are the bottlenecks for the machining efficiency.This paper proposes a multi-period turning method to improve the feedrate at the junctions using the linear acceleration and deceleration mode,which utilizes the maximal acceleration capabilities of the NC machine while satisfying the machining precision.A new and more efficient look-ahead method and a feedrate override method are also proposed to boast the global machining speed.The proposed algorithm has been implemented on Blue Sky NC System,and experimented in real material manufacturing.Compared with several existing algorithms,the current algorithm can improve the manufacturing time ranging from 50% to 180%,depending on the machining parameters,and also results in better machining quality.In addition,the algorithm also satisfies the need of real-time interpolation. | ZHANG LiXian SUN RuiYong GAO XiaoShan LI HongBo | 2011 | Science China(Technological Sciences)2011，54，6： | 17 |
| 8 | Bio-leaching effects of Leptospirillum ferriphilum on the surface chemical properties of pyrite显示文摘Leptospirillum ferriphilum cultured using different energy sources(either soluble ferrous ion or pyrite) changed the surface properties of pyrite.Cell adsorption,zeta-potential,hydrophobicty,FT-IR spectra and surface morphology were investigated.Adhesion of bacterial cells to the pyrite surface is a fast process.Furthermore,the adsorption of cells grown in pyrite is greater than of cells grown in soluble ferrous ion.The Iso-Electric Point(IEP) of pyrite treated with L.ferriphilum approaches that of the cells themselves.The contact angle of the pyrite surface was observed to decrease due to the surface formation of some hydrophilic substances during bio-leaching.Changes in pyrite surface properties after bacterial treatment support the idea that ferric ion plays an important role and that indirect bio-oxidation is the principal mechanism of pyrite bio-leaching. | GU, Guohua SU, Lijun CHEN, Minglian SUN, Xiaojun ZHOU, Hongbo | 2010 | Mining Science and Technology2010，20，2： | 14 |
| 9 | CPSF30-L-mediated recognition of mRNA m^(6)A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis显示文摘N6-methyladenosine(m^(6)A),a ubiquitous internal modification of eukaryotic mRNAs,plays a vital role in almost every aspect of mRNA metabolism.However,there is little evidence documenting the role of m^(6)A in regulating alternative polyadenylation(APA)in plants.APA is controlled by a large protein-RNA complex with many components,including CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30(CPSF30).In Arabidopsis,CPSF30 has two isoforms and the longer isoform(CPSF30-L)contains a YT512-B Homology(YTH)domain,which is unique to plants.In this study,we showed that CPSF30-L YTH domain binds to m^(6)A in v itro.In the cpsf30-2 mutant,the transcripts of many genes including several important nitrate signaling-related genes had shifts in polyadenylation sites that were correlated with m^(6)A peaks,indicating that these gene transcripts carrying m^(6)A tend to be regulated by APA.Wild-type CPSF30-L could rescue the defects in APA and nitrate metabolism in cpsf30-2,but m^(6)A-binding-defective mutants of CPSF30-L could not.Taken together,our results demonstrated that m^(6)A modification regulates APA in Arabidops is and revealed that the m^(6)A reader CPSF30-L affects nitrate signaling by controlling APA,shedding new light on the roles of the m^(6)A modification during RNA 3-end processing in nitrate metabolism. | Yiteng Hou Jing Sun Baixing Wu Yangyang Gao Hongbo Nie Zhentian Nie Shuxuan Quan Yong Wang Xiaofeng Cao Sisi Li | 2021 | Molecular Plant2021，14，4： | 12 |
| 10 | Fuzzy dynamic characteristic modeling and adaptive control of nonlinear systems and its application to hypersonic vehicles显示文摘In this paper, a fuzzy dynamic characteristic modeling and adaptive control method is proposed for a class of nonlinear systems. By employing fuzzy dynamic characteristic model, the controlled plant is described as a slowly time-varying fuzzy system, wherein the parameters are estimated online by using recursive Least-Squares algorithm. Under this framework, a fuzzy adaptive controller is constructed, and the stability condition of the closed-loop system is also derived. The main advantage of the proposed method lies in no requirement for the prior knowledge of system model and less parameters to tune, which allows engineers to operate it in a simple, straightforward manner. The proposed method is applied to the control of hypersonic vehicle, and simulation results are given to demonstrate the effectiveness of the obtained results. | LI HongBo SUN ZengQi MIN HaiBo DENG JianQiu | 2011 | Science China(Information Sciences)2011，54，3： | 10 |
| 11 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 12 | Enhanced Vitamin C Production Mediated by an ABA-Induced PTP-like Nucleotidase Improves Plant Drought Tolerance in Arabidopsis and Maize显示文摘Abscisic acid(ABA)is a key phytohormone that mediates environmental stress responses.Vitamin C,or L-ascorbic acid(AsA),is the most abundant antioxidant protecting against stress damage in plants.How the ABA and AsA signaling pathways interact in stress responses remains elusive.In this study,we characterized the role of a previously unidentified gene,PTPN(PTP-like Nucleotidase)in plant drought tolerance.In Arabidopsis,(AtPTPN was expressed in multiple tissues and upregulated by ABA and drought treatments.Loss-of-function mutants oiAtPTPN were hyposensitive to ABA but hypersensitive to drought stresses,whereas plants with enhanced expression AtPTPN showed opposite phenotypes to.Overexpression of maize PTPN(ZmPTPN)promoted,while knockdown oiZmPTPN inhibited plant drought tolerance,indicating conserved and positive roles of PTPN in plant drought tolerance.We found that both AtPTPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP,and that AtPTPN positively regulated AsA production via endogenous Pi content control.Consistently,overexpression of VTC2,the rate-limiting synthetic enzyme in AsA biosynthesis,promoted AsA production and plant drought tolerance,and these effects were largely dependent on AtPTPN activity.Furthermore,we demonstrated that the heat shock transcription factor HSFA6a directly binds the AtPTPN promoter and activates AtPTPN expression.Genetic analyses showed that AtPTPN is required for HSFA6a to regulate ABA and drought responses.Taken together,our data indicate that PTPN-mediated crosstalk between the ABA signaling and AsA biosynthesis pathways positively controls plant drought tolerance. | Hui Zhang Yanli Xiang Neng He Xiangguo Liu Hongbo Liu Liping Fang Fei Zhang Xiaopeng Sun Delin Zhang Xingwang Li William Terzaghi Jianbing Yan Mingqiu Dai | 2020 | Molecular Plant2020，13，5： | 7 |
| 13 | Polymer assisted deposition of high-quality CsPbI2Br film with enhanced film thickness and stability显示文摘Inorganic halide perovskites such as cesium lead iodide(CsPbI3)have drawn tremendous attention,as their tunable band gaps are desirable for solar cells as well as light emitting diodes.However,due to their low Goldschmidt tolerance factor,the cubic phase of bulk CsPbX3-the variant with desirable band gap-is not stable in ambient,especially in humid air.Besides,the low solubility of CsX in precursor makes it difficult to control the film thickness and morphology of CsPbX3,which becomes another obstacle for the practical application of inorganic perovskite.Here,we report a polymer assisted deposition of high-quality CsPbI2Br film by spin-coating a polymer-blended CsPbI2Br precursor.The long-chained polymer increases the viscosity of the solution,which enables us to achieve a ca.700-nm thick film with a low solution concentration of CsPbI2Br.Moreover,the polymer network helps to regulate the crystallization process and provides more crystallization sites for perovskite film,reducing grain size and thus improving the film coverage.Perovskite solar cells with the polymer network exhibit improved efficiency and reproducibility(0.72%standard deviation).Moreover,the device demonstrates excellent robustness against moisture and oxygen,and maintains 90%of its initial power conversion efficiency(PCEs)after aging 4 months in ambient conditions.The conception of polymer incorporation into inorganic perovskite films paves a way to further increase the performance,stability and reproducibility of inorganic perovskite devices. | Jing Wei Xi Wang Xiangyu Sun Zhaofeng Yang Iwan Moreels Kun Xu Hongbo Li | 2020 | Nano Research2020，13，3： | 6 |
| 14 | A hybrid LES (Large Eddy Simulation)/assumed sub-grid PDF (Probability Density Function) model for supersonic turbulent combustion显示文摘A hybrid LES (Large Eddy Simulation)/assumed sub-grid PDF (Probability Density Function) closure model has been devel-oped for supersonic turbulent combustion. Scalar transport equations for all species in a given chemical kinetic mechanism were solved, which are necessary in the supersonic combustion where the non-equilibrium chemistry is essentially involved. The clipped Gaussian PDF of temperature and multivariate ? PDF of composition were used to close the sub-grid chemical sources that appear in the conservation equations. The sub-grid variances of temperature and composition were constructed based on scale similarity approach. A semi-implicit approach based on the PDF model was proposed to tackle the resulting numerical stiffness associated with finite rate chemistry. The model was applied to simulate a supersonic, coaxial H2-air burner, where both the mean and rms (root mean square) results were compared with the experimental data. In general, good agree-ments were achieved, which indicated that the present sub-grid PDF method could work well in simulating supersonic turbu-lent combustion. Moreover, the calculation showed that the sub-grid fluctuations of temperature and major species in the combustion region were of the order of 10%-20% of their rms, while the sub-grid fluctuation of hydroxyl might be as high as 40%-50% of its rms. | WANG HongBo QIN Ning SUN MingBo WU HaiYan WANG ZhenGuo | 2011 | Science China(Technological Sciences)2011，54，10： | 6 |
| 15 | A Fusion Based Particle Filter TBD Algorithm for Dim Targets显示文摘A Fusion based particle filter track-beforedetect algorithm(FPF-TBD) is proposed for dealing with dim targets, in which the importance density function of the Particle filter(PF) is generated by means of a fusion algorithm. In order to construct an accurate approximation to the true proposal distribution, the state at each time scan is predicted according to the Extended Kalman filter algorithm(EKF) and the Unscented Kalman filter(UKF) simultaneously. The information, based on the recursion of the weights, is gathered over multiple scans, and the detection decision is made based on tracking results at the end of the processing chain. By making best use of the recent measurements, this new proposed method can obtain an accurate approximation to the system and as a result, improve the track accuracy and detection performance. Simulation results illustrate the effectiveness of this approach. | YU Hongbo WANG Guohong CAO Qian SUN Yun | 2015 | Chinese Journal of Electronics2015，24，3： | 6 |
| 16 | Vegetation evolution on the central Chinese Loess Plateau since late Quaternary evidenced by elemental carbon isotopic composition显示文摘There are many controversial issues in loess studies such as natural vegetation types on the Chinese Loess Plateau during the historical periods and the spatial and temporal evolution of C3/C4 plants. Elemental carbon isotopic composition (δ13Cec) in the loess section may offer new evidence for these problems. Elemental carbon (EC) is produced by incomplete combustion of vegetation, and its carbon isotopic composition has a very small difference from that of the formal vegetation, then δ13Cec can be used as a record to recover the changes of vegetation. Elemental carbon was extracted by applying the oxidation method from the loess-paleosol sequence in the central Chinese Loess Plateau, and its carbon isotope composition was analyzed by the isotope mass spectrometer. The results showed that the vegetation in this region was a mixed type of C3 and C4 plants, dominated with C3 plants in most of the time. Since late Quaternary, C3/C4 plants may not follow a simple glacial-interglacial cycle mode on the Chinese Loess Plateau, but showing fluctuations. C3 plants increased gradually in L4 period, and more C3 plants occurred during S3 period, and C4 plants increased again during L3―L2 periods, after that, C3 plants dominated again during S1―S0 periods. During periods of paleosol development, C3 plants were abundant in S3 and S1, and there were more C4 plants in S2 and S0. During periods of loess sedimen- tation, there were more C3 plants in L4 and L1, and there were more C4 plants in L3 and L2. On the or- bital timescale, the vegetation variations revealed by δ13Cec record are consistent with the results of pollen data and also similar to the results obtained by organic carbon isotopic composition since the last glacial period. | ZHOU Bin SHEN ChengDe ZHENG HongBo ZHAO MeiXun SUN YanMin | 2009 | Chinese Science Bulletin2009，54，12： | 6 |
| 17 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 18 | Nonlinear analysis of combustion oscillations in a cavity-based supersonic combustor显示文摘Combustion oscillations in a supersonic combustor with hydrogen injection upstream of a cavity flameholder are investigated using nonlinear analysis based on experimental measurements.Time series of both flamefront and wall pressure are acquired,and the state space reconstruction approach is adopted to characterize the nonlinear behavior of the combustion oscillations.Three overall equivalence ratios,0.038,0.076 and 0.11,are considered.The existence of a chaotic source in the present combustion system is demonstrated.The correlation dimension and the largest Lyapunov exponent tend to become larger with the increasing equivalence ratio,indicating a more complicated and unstable combustion system.In particular,it is found that the correlation dimension for the highest equivalence ratio is much greater than those of the two lower equivalence ratios.Two possible reasons responsible for the observed nonlinear behaviors are identified.One is the shock-related instabilities and the other is the transition of combustion stabilization mode between the cavity and jet-wake stabilized mode. | WANG HongBo WANG ZhenGuo SUN MingBo WU HaiYan | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 19 | Operation and Force Analysis of the Guide Wire in a Minimally Invasive Vascular Interventional Surgery Robot System显示文摘To develop a robot system for minimally invasive surgery is significant,however the existing minimally invasive surgery robots are not applicable in practical operations,due to their limited functioning and weaker perception.A novel wire feeder is proposed for minimally invasive vascular interventional surgery.It is used for assisting surgeons in delivering a guide wire,balloon and stenting into a specific lesion location.By contrasting those existing wire feeders,the motion methods for delivering and rotating the guide wire in blood vessel are described,and their mechanical realization is presented.A new resistant force detecting method is given in details.The change of the resistance force can help the operator feel the block or embolism existing in front of the guide wire.The driving torque for rotating the guide wire is developed at different positions.Using the CT reconstruction image and extracted vessel paths,the path equation of the blood vessel is obtained.Combining the shapes of the guide wire outside the blood vessel,the whole bending equation of the guide wire is obtained.That is a risk criterion in the delivering process.This process can make operations safer and man-machine interaction more reliable.A novel surgery robot for feeding guide wire is designed,and a risk criterion for the system is given. | YANG Xue WANG Hongbo SUN Li YU Hongnian | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 5 |
| 20 | Mechanically Strong Proteinaceous Fibers:Engineered Fabrication by Microfluidics显示文摘Lightweight and mechanically strong natural silk fibers have been extensively investigated over the past decades.Inspired by this research,many artificial spinning techniques(wet spinning,dry spinning,electrospinning,etc.)have been developed to fabricate robust protein fibers.As the traditional spinning methods provide poor control over the as-spun fibers,microfluidics has been integrated with these techniques to allow the fabrication of biological fibers in a well-designed manner,with simplicity and cost efficiency.The mechanical behavior of the developed fibers can be precisely modulated by controlling the type iop and size of microfluidic channel,flow rate,and shear force.This technique has been successfully used to manufacture a broad range of protein fibers,and can accelerate the production and application of protein fibers in various fields.This review outlines recent progress in the design and fabrication of protein-based fibers based on microfluidics.We first briefly discuss the natural spider silk-spinning process and the microfluidics spinning process.Next,the fabrication and mechanical properties of regenerated protein fibers via microfluidics are discussed,followed by a discussion of recombinant protein fibers.Other sourced protein fibers are also reviewed in detail.Finally,a brief outlook on the development of microfluidic technology for producing protein fibers is presented. | Jing Sun Jingsi Chen Kai Liu Hongbo Zeng | 2021 | Engineering2021，7，5： | 5 |
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