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| 1 | Metallomics in environmental and health related research:Current status and perspectives显示文摘Metals and metalloids play distinct roles in human health,either beneficial or toxic,depending on their concentrations and species.There is an increasing interest in metals uptake,trafficking,function,and exertion in microorganisms to maintain and advance human health.Metallomics,an emerging research area,focuses on elucidation of metals/metalloids location,distribution,speciation,and behavior in living organisms.This paper briefly summarized the recent progress on the methodology development of metallomics including various techniques,i.e.multiple dimensional liquid chromatography-inductively coupled plasma mass spectrometry(LC-ICPMS),gel electrophoresis-laser ablation-inductively coupled plasma mass spectrometry(GE-LA-ICPMS),synchrotron X-ray fluorescent spectroscopy(XFS),and the applications of metallomics in environmental and health care. | HU LiGang HE Bin WANG YuChuan JIANG GuiBin SUN HongZhe | 2013 | Chinese Science Bulletin2013，58，2： | 2 |
| 2 | Bioinorganic chemistry of bismuth and an- timony : target sites of metallodrugs 显示文摘 | GE RuiGang SUN HongZhe | 2007 | Acc Chem Res2007，40，4： | 1 |
| 3 | Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells显示文摘 | Ruiguang Ge Xuesong Sun Dongxian Wang Qinglu Zhou Hongzhe Sun | 2011 | BBA - Molecular Cell Research2011，，8： | 1 |
| 4 | Adsorption and heterogeneous Fenton degradation of 17α-methyltestosterone on nano Fe 3 O 4 /MWCNTs in aqueous solution显示文摘 | Xiaobin Hu Benzhi Liu Yuehua Deng Hongzhe Chen Si Luo Cheng Sun Po Yang Shaogui Yang | 2011 | Applied Catalysis B, Environmental2011，，3： | 1 |
| 5 | Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma显示文摘 | Hongzhe Sun Ka Yee Szeto | 2002 | Journal of Inorganic Biochemistry2002，，1： | 1 |
| 6 | Polymeric architectures of bismuth citrate based on dimeric building blocks显示文摘Four bismuth complexes, (H2En)[Bi2(cit)2(H2O)4/3]·(H2O)x (1), (H2En)3[Bi2(cit)2Cl4]·(H2O)x (2), (HPy)2[Bi2(cit)2(H2O)8/5]·(H2O)x (3) and (H2En)[Bi2(cit)2](H2O)x (4) [cit = citrate4-; En = ethylenediamine; Py = pyridine] have been synthesized and crystallized. The crystal structures reveal that the basic building blocks in all of these complexes are bismuth citrate dimeric units which combine to form polymeric architectures. The embedded protonated ethylenediamine and pyridine moieties in the polymeric frameworks have been identified by X-ray crystallography and solid-state cross polarization/magic angle spinning (CP/MAS) 13C NMR. Based on the framework of complex 1, a structural model of a clinically used antiulcer drug, ranitidine bismuth citrate (RBC) was generated. The behavior of the protonated amine-bismuth citrate complexes in acidic aqueous solution has been studied by electrospray ionization-mass spectrometry (ESI-MS). | YANG Nan AN Yan CAI JiWen HU LiHong ZENG YiBo MAO ZongWan CHEN GuanHua SUN HongZhe | 2010 | Science China Chemistry2010，53，10： | 1 |
| 7 | Behavioral methods for the functional assessment of hair cells in zebrafish显示文摘Zebrafish 是为听觉的系统上的研究的一个新兴的动物模型。这个模型与人,到听见的机关的好可接近性,和高产量能力介绍高相似性。为了更好利用这个动物模型,,方法论需要被用来听力确定 zebrafish 的功能。Zebrafish 显示与它的听觉的功能有关的一系列天生、柔韧的行为。这里,我们考察了在听觉的研究使用 zebrafish 的优点然后如下介绍了三行为的测试:startle 反应,门厅眼睛的反射,和走流性。这些测试以他们的生理的特征,新技术发展,和仪器描述被讨论。测试限制和区域也被介绍改善。最后,我们在 zebrafish 揭示了这些应用的可行性在在听觉相关的基因和药上的高产量的屏蔽的行为的评价和他们的潜力。 | Qin Yang Peng sun Shi Chen Hongzhe Li Fangyi Chen | 2017 | Frontiers of Medicine2017，11，2： | 1 |
| 8 | Bismuth subcarbonate nanoparticles fabricated by water-in-oil microemulsion-assisted hydrothermal process exhibit anti- Helicobacter pylori properties显示文摘 | Rong Chen Gang Cheng Man Ho So Jiliang Wu Zhong Lu Chi-Ming Che Hongzhe Sun | 2010 | Materials Research Bulletin2010，，5： | 1 |
| 9 | Bioinorganic chemistry of bismuth and antimony:target sites of metallodrugs显示文摘 | GE Ruigang SUN Hongzhe | 2007 | Accounts of Chemical Research2007，40，： | 1 |
| 10 | Silver nanoparticles: partial oxidation and antibacterial activities显示文摘 | Chun-Nam Lok Chi-Ming Ho Rong Chen Qing-Yu He Wing-Yiu Yu Hongzhe Sun Paul Kwong-Hang Tam Jen-Fu Chiu Chi-Ming Che | 2007 | JBIC Journal of Biological Inorganic Chemistry2007，，4： | 1 |
| 11 | Biocoordination chemistry of bismuth: Recent advances显示文摘 | Nan Yang Hongzhe Sun | 2007 | Coordination Chemistry Reviews2007，，17： | 1 |
| 12 | Silver nanoparticles: partial oxidation and antibacterial activities显示文摘 | Chun-Nam Lok Chi-Ming Ho Rong Chen Qing-Yu He Wing-Yiu Yu Hongzhe Sun Paul Kwong-Hang Tam Jen-Fu Chiu Chi-Ming Che | 2007 | JBIC Journal of Biological Inorganic Chemistry2007，，4： | 1 |
| 13 | Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway显示文摘 | Qian Zhongming Li Hongyan Sun Hongzhe | 2002 | Pharmacol Rev2002，54，： | 1 |
| 14 | Silver nanoparticles: partial oxidation and antibacterial activities显示文摘 | Chun-Nam Lok Chi-Ming Ho Rong Chen Qing-Yu He Wing-Yiu Yu Hongzhe Sun Paul Kwong-Hang Tam Jen-Fu Chiu Chi-Ming Che | 2007 | JBIC Journal of Biological Inorganic Chemistry2007，，4： | 1 |
| 15 | Binding of Ni2+ to a histidine- and glutamine-rich protein, Hpn-like显示文摘 | Yi-Bo Zeng Dong-Mei Zhang Hongyan Li Hongzhe Sun | 2008 | JBIC Journal of Biological Inorganic Chemistry2008，，7： | 1 |
| 16 | A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori显示文摘 | Ruiguang Ge Xuesong Sun Qing Gu Rory M. Watt Julian A. Tanner Benjamin Chun Yu Wong Harry Huaxiang Xia Jian-Dong Huang Qing-Yu He Hongzhe Sun | 2007 | JBIC Journal of Biological Inorganic Chemistry2007，，6： | 1 |
| 17 | Inhibition of urease by bismuth(III): Implications for the mechanism of action of bismuth drugs显示文摘 | Li Zhang Scott B. Mulrooney Andy F. K. Leung Yibo Zeng Ben B. C. Ko Robert P. Hausinger Hongzhe Sun | 2006 | BioMetals2006，，5： | 1 |
| 18 | Systematic exploration of the applicability of the idiomatic vapor balance rule to distillation column consolidation显示文摘For N-component distillation(N≥3),consolidation between different column sections is an inevitable manipulation when synthesizing complex distillation configurations.In the consolidation,the idiomatic vapor balance(IVB)rule,in which the larger vapor flowrate in the two columns before consolidation will be chosen as the balanced vapor flowrate at the consolidation point,has been widely used.However,the applicability of the IVB rule has not been verified,which is of essential importance to the accuracy of the distillation configuration synthesis.In the present study,the applicability of the IVB rule to distillation column consolidation was systematically explored by rigorous method for the first time.First,the separation of ideal and non-ideal three-component mixtures with variable compositions was studied,and the optimized configurations before and after consolidation were determined by a rigorous method.The results indicated that for the separation of an ideal mixture,the IVB rule was applicable for the whole composition range,while for the separation of a non-ideal mixture,the IVB rule was only applicable for very limited composition range.Finally,two cases of synthesizing distillation configurations for the separation of non-ideal mixtures were studied to verify the remarkable deviations the IVB rule may cause.The results indicated that the applicability of the shortcut method using the IVB rule to the distillation configuration synthesis depended on the composition of the non-ideal mixture,and a remarkable error might result and the truly optimal configuration might be missed if the IVB rule is applied to a non-ideal mixture. | Shuo Zhang Yifan Sun Yiqing Luo Hongzhe Hou Xigang Yuan | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 1 |
| 19 | Urease inactivation by an unusual GroES chaperonin显示文摘It remains uncovered yet how the common gastric pathogen,Helicobacter pylori,survives through the acidic barrier and the immune response simultaneously in the stomach.Herein we report a unique GroES chaperonin that effectively inactivates Helicobacter pylori urease in Escherichia coli model.Such a function depends on the quaternary structure as well as the metal binding at the C terminus.Surprisingly,the C-terminal metal capacity seems not closely relevant to the apparent urease inactivation.Our findings have possibly revealed a survival strategy of Helicobacter pylori after its gastric localization. | CUN ShuJian SUN HongZhe | 2014 | Science China Chemistry2014，57，6： | 0 |
| 20 | Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase显示文摘Staphylococcus aureus produces staphyloxanthin,a C30 carotenoid with golden color,as an antioxidant to promote bacterial resistance to reactive oxygen species.The biosynthesis pathway of staphyloxanthin involves a series of catalytic enzymes.Aldehyde dehydrogenase(AldH)is a dehydrogenase recently identified to convert 4,4’-diaponeurosporenaldehyde into 4,4’-diaponeurosporenoic acid during staphyloxanthin biosynthesis.Here,we present the crystallographic structures of apo-and holo-forms of S.aureus AldH.The dimeric enzyme contains a unique C-terminal helix,which resembles a“gatekeeper”helix found in human membrane-bound fatty aldehyde dehydrogenase(FALDH).Particularly,the helix adopts“open”and“closed”conformations in apo-and holo-AldH,respectively,to control the access of the substrate tunnel.Mutagenesis in combination with in vitro and in vivo activity assays identifies several residues essential for S.aureus AldH substrate recognition and enzyme catalytic turnover.Our results provide insights into substrate recognition of S.aureus AldH toward polyunsaturated long-chain aldehydes at atomic resolution. | Xuan Tao Zhemin Zhang Xiao Zhang Hongyan Li Hongzhe Sun Zong-Wan Mao Wei Xia | 2020 | CCS Chemistry2020，2，5： | 0 |
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