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| 1 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 2 | Influences of Cu or Cd on the neurotoxicity induced by petroleum hydrocarbons in ragworm Perinereis aibuhitensis显示文摘破布蠕虫上的重金属和石油烃(PHC ) 的 ecotoxicological 效果仍然是含糊的。在毒物学的索引(死亡和乙酰胆碱酯酶(疼痛) 活动) 和有毒物(Cu, Cd,和 PHC ) 的集中之间的关系处于实验室条件在河口重点种类 Perinereis aibuhitensis 被检验。单个有毒物的结果显示三有毒物有潜在地生理的毒性到 P。aibuhitensis。为 Cu, Cd,和 PHC 的估计的 4-d 和 10-d LC50 从在死亡和有毒物集中之间的关系被导出。在 P 的词法症状的著名变化。暴露于 PHC 的 aibuhitensis 被观察。P 的疼痛活动。aibuhitensis 比其它对 PHC 的毒性更敏感。联合有毒物的结果暗示到 P 的 Cu 或 Cd 和 PHC 的联合毒性。aibuhitensis 与有毒物的集中联合有关。比较了挑选 PHC 治疗, Cu 或 Cd 的增加显著地在 P 减轻了 PHC 的 neurotoxicity 到疼痛活动。aibuhitensis,它显示出对抗效果。 | ZHANG Qianru ZHOU Qixing WANG Jing SUN Shulan HUA Tao REN Liping | 2008 | Journal of Environmental Sciences2008，20，3： | 12 |
| 3 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 4 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | Characterization of a new mutant allele of the Arabidopsis Flowering Locus D (FLD) gene that controls theflowering time by repressing FLC显示文摘Flowering in higher plants is controlled by both the internal and environmental cues. In Arabidopsis, several major genetic loci have been defined as the key switches to control flowering. The Flowering Locus C (FLC) gene has been shown in the autonomous pathway to inhibit the vege-tative-to-reproductive transition. FLC appears to be re-pressed by Flowering Locus D (FLD), which encodes a com-ponent of the histone deacetylase complex. Here we report the identification and characterization of a new mutant allele fld-5. Genetic analysis indicates that fld-5 (in the Was-silewskija background) is allelic to the previously character-ized fld-3 and fld-4 (in the Colombia-0 background). Genetic and molecular analyses reveal that fld-5 carries a frame-shift mutation, resulting in a premature termination of the FLD open reading frame. The FLC expression is remarkably in-creased in fld-5, which presumably attributes to the ex-tremely delayed flowering phenotype of the mutant. | CHEN Ruiqiang ZHANG Suzhi SUN Shulan CHANG Jianhong ZUO Jianru | 2005 | Chinese Science Bulletin2005，50，23： | 6 |
| 6 | Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer显示文摘Background:Increasing studies have reported that oncogenes regulate components of the immune system,suggesting that this is a mechanism for tumorigenesis.Aurora kinase A(AURKA),a serine/threonine kinase,is involved in cell mitosis and is essential for tumor cell proliferation,metastasis,and drug resistance.However,the mechanism by which AURKA is involved in immune response regulation is unclear.Therefore,this study aimed to investigate the role of AURKA in immune regulation in triple-negative breast cancer(TNBC).Methods:Peripheral blood mononuclear cells(PBMCs)were co-cultured with TNBC cells.The xCELLigence Real-Time Cell Analyzer-MP system was used to detect the killing efficiency of immune cells on TNBC cells.The expression of immune effector molecules was tested by quantitative real-time polymerase chain reaction(qRT-PCR)to evaluate immune function.Furthermore,to validate AURKA-regulated immune response in vivo,4T1 murine breast cancer cell line with AURKA overexpression or downregulation was engrafted into BALB/c mice.The distribution and proportion of immune cells in tumors were further evaluated by immunohistochemistry and flow cytometry.Results:Downregulation of AURKA in TNBC cells increased immune response by activating CD8^(+)T cell proliferation and activity.Nuclear rather than cytoplasmic AURKA-derived programmed death-ligand 1(PD-L1)expression was independent of its kinase activity.Mechanistic investigations showed that nuclear AURKA increased PD-L1 expression via an MYC-dependent pathway.PD-L1 overexpression mostly reversed AURKA silencing-induced expression of immune effector molecules,including interleukin-(IL-2),interferon-γ(IFN-γ),and perforin.Moreover,AURKA expression was negatively correlated with the enrichment and activity of tumor-infiltrating CD8^(+)T cells in 4T1 engrafted BALB/c mouse model.Conclusions:Nuclear AURKA elevated PD-L1 expression via an MYCdependent pathway and contributed to immune evasion in TNBC.Therapies targeting nuclear AURKA may restore immune responses against tumors. | Shulan Sun Wei Zhou Xiaoxi Li Fei Peng Min Yan Yajing Zhan Fan An Xiaoyan Li Yunyong Liu Quentin Liu Haozhe Piao | 2021 | Cancer Communications2021，41，9： | 2 |
| 7 | Effects of contrasting soil management regimes on total and labile soil organic carbon fractions in a loess soil in China显示文摘 | Xueyun Yang Weidong Ren Benhua Sun Shulan Zhang | 2012 | Geoderma2012，，： | 1 |
| 8 | Grain refinement in steels and the application trials in China显示文摘 | DONG Han SUN Xingjun ZHANG Shulan | 2008 | ISIJ International2008，48，8： | 1 |
| 9 | Culture and Sustainable Utilization of Hirudos显示文摘In this paper,the resource distribution,pharmacological action and culture status of hirudos were reviewed.Hirudo resources are widely distributed and have a variety of pharmacological effects,but culture is difficult,so the scientific development of hirudos culture and solving the problem of hirudos breeding can alleviate the contradiction in the medicine market and contribute to the sustainable development of hirudo medicine. | Jinhua LIU Shuang PAN Qiaoqiao SUN Shulan CUI Jinbo ZHANG | 2022 | Medicinal Plant2022，13，5： | 0 |
| 10 | Effects of the structure of the branches on the two-photon absorption properties for the multi-branched molecules with nitrogen (N) as coupling center显示文摘In order to investigate the effects of the structure of branches on the TPA properties for multi-branched molecules, the TPA cross section is calculated by using ZINDO/SOS method. The investigated mole- cules have different branches (chomorfores based on stilbene, dithienothiophene and flourene) with nitrogen(N) as coupling center. The results show that the cooperative enhancement in multi-branched molecules depends on the structures of the branches and the structures of branches play an important role in the enhancement of the TPA cross section. The designed molecules with stilbene and dithie- nothiophene as branched possess relatively larger two-photon absorption cross sections. | SUN XueQin ZHAO Xian ZHOU ShuLan LI BaiDong CHENG XiuFeng | 2008 | Science China Chemistry2008，51，1： | 0 |
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