|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 2 | Ultrathin Co(Ni)-doped MoS2 nanosheets as catalytic promoters enabling efficient solar hydrogen production显示文摘收获太阳能经由水减小驾驶氢进化反应的有效人工的光合的系统的设计从两个是很重要的理论、实际的观点。与吸收材料的大光集成适当合作催化剂倡导者代表理想的策略在氢生产提高太阳能的变换效率。此处,第一次,我们报导由 ultrathin 公司(Ni ) 组成的唯一的混合结构的一个班的合成做了瞬间 2 nanosheets (合作催化剂倡导者) 在半导体 CdS nanorods (轻吸收器) 上亲密地成年。同样综合的一个维的 CdS@doped 瞬间 2 heterostructures 展出了很高的 photocatalytic 活动(与 17.3% 的量收益) 并且向从水的光致还原的 H 2 进化的稳定性。理论计算表明做的 Ni 能在瞬间 2 nanosheets 的边地点增加不协调的原子的数字越过 CdS/MoS 2 接口以及氢减小支持电子转移,导致有效 H 2 进化反应。 | Xiaoyan Ma Jinquan Li Changhua An Juan Feng Yuhua Chi Junxue Liu Jun Zhang Yugang Sun | 2016 | Nano Research2016，9，8： | 7 |
| 3 | Interfaced heterogeneous nanodimers显示文摘Dimerization of diferent nanocomponents in single nanoparticles becomes interesting due to not only inheritance of properties of both components but also generation of new properties associated with strong coupling of the two components. As a class of emerging nanomaterials, interfaced heterogeneous nanodimers(IHNDs) are atracting more atentions in the ield of materials research, in particular,nanoscience and nanotechnology. his review provides a timely and comprehensive overview on the general principles for the synthesis of IHNDs and typical examples of IHNDs made of various compositional combinations. he current challenges related to the synthesis and characterization of IHNDs are summarized at the end of the review and future research directions are also discussed. | Yugang Sun | 2015 | National Science Review2015，2，3： | 6 |
| 4 | Facile Tuning of Superhydrophobic States with Ag Nanoplates显示文摘GaAs wafers have been decorated with Ag nanoplates through direct galvanic reaction between aqueous AgNO_(3) solutions and GaAs,resulting in Ag nanoplate/GaAs composite surfaces with varying hydrophobocity after the Ag nanoplates were coated with self-assembled monolayers of alkyl thiol molecules.By carefully controlling the reaction conditions,such as growth time and concentration of the AgNO_(3) solution,the size,thickness,and surface roughness of the individual Ag nanoplates can be tuned in order to produce different topographic structures and roughness of the composite surfaces,which in turn infl uences the hydrophobicity of the surfaces.The as-synthesized composite surfaces have been found to exhibit various levels of hydrophobicity and different wetting states such as the Wenzel wetting state,Cassie impregnating wetting state,and Cassie nonwetting state.The relationship between surface structure and hydrophobic state is also discussed. | Yugang Sun Rui Qiao | 2008 | Nano Research2008，1，4： | 4 |
| 5 | Thermal transformation of δ-MnO_2 nanoflowers studied by in-situ TEM显示文摘在原处,在有一个加热阶段的联合的传播电子显微镜学在直到 665 的在提高的温度的热退火之上以他们的形态学和水晶的结构被采用了到阶段 MnO2 nanoflowers | SUN YuGang LIU YuZi TRUONG Tu T REN Yang | 2012 | Science China Chemistry2012，55，11： | 3 |
| 6 | PROTACs: great opportunities for academia and industry显示文摘Although many kinds of therapies are applied in the clinic,drug-resistance is a major and unavoidable problem.Another disturbing statistic is the limited number of drug targets,which are presently only 20–25%of all protein targets that are currently being studied.Moreover,the focus of current explorations of targets are their enzymatic functions,which ignores the functions from their scaffold moiety.As a promising and appealing technology,PROteolysis TArgeting Chimeras(PROTACs)have attracted great attention both from academia and industry for finding available approaches to solve the above problems.PROTACs regulate protein function by degrading target proteins instead of inhibiting them,providing more sensitivity to drug-resistant targets and a greater chance to affect the nonenzymatic functions.PROTACs have been proven to show better selectivity compared to classic inhibitors.PROTACs can be described as a chemical knockdown approach with rapidity and reversibility,which presents new and different biology compared to other gene editing tools by avoiding misinterpretations that arise from potential genetic compensation and/or spontaneous mutations.PRTOACs have been widely explored throughout the world and have outperformed not only in cancer diseases,but also in immune disorders,viral infections and neurodegenerative diseases.Although PROTACs present a very promising and powerful approach for crossing the hurdles of present drug discovery and tool development in biology,more efforts are needed to gain to get deeper insight into the efficacy and safety of PROTACs in the clinic.More target binders and more E3 ligases applicable for developing PROTACs are waiting for exploration. | Xiuyun Sun Hongying Gao Yiqing Yang Ming He Yue Wu Yugang Song Yan Tong Yu Rao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 3 |
| 7 | Combined torsional buckling of double-walled carbon nanotubes with axial load in the multi-field coupled condition显示文摘The present study has theoretically investigated the combined torsional buckling of double-walled carbon nanotubes (DWCNTs) with axial load in the multi-field coupled condition. The effects of torsion, axial load, thermal-electrical change, surrounding elastic medium and the Van der Waals forces are all taken into consideration. The governing equation of buckling for CNTs subjected to thermo-electro-mechanical loadings has been established based on an elastic shell model of continuum mechanics. Reasonable simplifications are made to get the explicit expression of the critical buckling shear stress of DWCNTs, and numerical experiments are conducted for further research. It is shown that under certain electric and temperature field the critical buckling shear stress of DWCNTs only depends on the wave number of buckling modes. On the other hand, all the related impact factors have enormous influence on the critical buckling shear stress under a certain buckling mode. The critical buckling shear stress changes linearly with the axial-to-shear stress ratio, as well as the thermal and electric change. Axial compression tends to make DWCNTs unstable, while axial tension benefits the buckling stability. The critical buckling shear stress is directly proportional to the applied voltage. At room or lower temperature, the critical shear stress for infinitesimal buckling increases as the temperature change increases, while it decreases at a higher temperature. The conclusions are useful for the design of nano-structures related to the buckling stability of DWCNTs. | SUN YuGang YAO XiaoHu HAN Qiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，9： | 2 |
| 8 | Shaped gold and silver nanoparticles显示文摘在用黄金和银做的塑造的 nanoparticles 的合成的进展在这篇文章被考察。这评论由分析在 nanoparticle 形状和它的内部水晶的结构的几何对称之间的关系以一个新角度开始。根据关系,有明确的形状的 nanoparticles 被分类进三个范畴:有单个 crystallinity,有尖双胞胎的 nanoparticles,和有平行双胞胎的 nanoparticles 的 nanoparticles。为在每个范畴的塑造的 nanoparticles 的合成的古典方法的讨论和分析也被包括,在塑造的金属 nanoparticles 的合成的未来研究方向上的个人观点简短被总结。这评论被期望在为塑造的 nanoparticles 的合成设计策略并且分析相应生长机制提供一个指南。 | Yugang SUN Changhua AN | 2011 | Frontiers of Materials Science2011，5，1： | 2 |
| 9 | Silica-coating-assisted nitridation of TiO_(2) nanoparticles and their photothermal property显示文摘Nanoparticles of refractory compounds represent a class of stable materials showing a great promise to support localized surface plasmon resonances(LSPRs)in both visible and near infrared(NIR)spectral regions.It is still challenging to rationally tune the LSPR band because of the difficulty to control the density of charge carriers in individual refractory nanoparticles and maintain the dispersity of nanoparticles in the processes of synthesis and applications.In this work,controlled chemical transformation of titanium dioxide(TiO_(2))nanoparticles encapsulated with mesoporous silica(SiO_(2))shells to titanium nitride(TiN)via nitridation reaction at elevated temperatures is developed to tune the density of free electrons in the resulting titanium-oxide-nitride(TiO_(x)N_(y))nanoparticles.Such tunability enables a flexibility to support LSPR-based optical absorption in the synthesized TiO_(x)N_(y)@SiO_(2) core-shell nanoparticles across both the visible and NIR regions.The silica shells play a crucial role in preventing the sintering of TiO_(x)N_(y) nanoparticles in the nitridation reaction and maintaining the stability of TiOxNy nanoparticles in applications.The LSPR-based broadband absorption of light in the TiO_(x)N_(y)@SiO_(2) nanoparticles exhibits strong photothermal effect with photo-to-thermal conversion efficiency as high as〜76%. | Qilin Wei Danielle L.Kuhn Zachary Zander Brendan G.DeLacy Hai-Lung Dai Yugang Sun | 2021 | Nano Research2021，14，9： | 2 |
| 10 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 11 | Polymer imprint lithography with molecular-scale resolution显示文摘 | Hua Feng Sun Yugang Gaur Anshu | 2004 | Nano Letters2004，4，12： | 1 |
| 12 | One -dimensional nanostructures : Synthesis, characterization, and applications显示文摘 | XIA YOUNAN YANG PEIDONG SUN YUGANG | 2003 | Adv Mater2003，15，5： | 1 |
| 13 | Gold and silver nanoparticles:a class of chromophores with colors tunable in the range from 400 to 750 nm显示文摘 | Yugang Sun Younan Xia | 2003 | The Analyst2003，128，6： | 1 |
| 14 | A self-templated approach to TiO2 microcapsules 显示文摘 | HU Yongxing GE Jianping SUN Yugang | 2007 | Nano Lett2007，6，7： | 1 |
| 15 | Polyol synthesis of silver nanoparticles: use of chloride and oxygen to pro mote the formation of single-crystal, truncated cubes and tetrahedrons显示文摘 | Wiley B Herricks T Sun Yugang | 2004 | Nano Lett2004，4，： | 1 |
| 16 | Triangular nanoplates of silver:synthesis,characterization,and use as sacrificial templates for generating triangular nanorings of gold显示文摘 | Yugang Sun Younan Xia | 2003 | Advanced Materials2003，15，9： | 1 |
| 17 | Transformation of silver nanospheres into nanobelts and triangular nanoplates through a thermal process显示文摘 | Yugang Sun Brian Mayers Younan Xia | 2003 | Nano Letters2003，3，5： | 1 |
| 18 | Determining multiple steady-state ZCS operating points of a switch-mode eontaetless power transfer system显示文摘 | Tang Chunsen Sun Yue Su Yugang | 2009 | IEEE Transactions on Power Electronics2009，24，2： | 1 |
| 19 | Multiple-welled nanotubes made of metal显示文摘 | Yugang Sun Younan Xia | 2004 | Advanced Materials2004，16，3： | 1 |
| 20 | 显示文摘 | Wiley B Sun Yugang Mayers B | 2005 | Chem Eur J2005，11，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员