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| 1 | NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer显示文摘 | Couturier-Maillard Aurélie Secher Thomas Rehman Ateequr Normand Sylvain De Arcangelis Adéle Haesler Robert Huot Ludovic Grandjean Teddy Bressenot Aude Delanoye-Crespin Anne Gaillot Olivier Schreiber Stefan Lemoine Yves Ryffel Bernhard Hot D | 2013 | Journal of Clinical Investigation2013，，2： | 5 |
| 2 | Value of liver computed tomography with iodixanol 270, 80 kVp and iterative reconstruction显示文摘AIM: To evaluate the image quality of hepatic multidetector computed tomography(MDCT) with dynamic contrast enhancement. METHODS: It uses iodixanol 270 mg/m L(Visipaque 270) and 80 kVp acquisitions reconstructed with sinogram affirmed iterative reconstruction(SAFIRE?) in comparison with a standard MDCT protocol. Fiftythree consecutive patients with known or suspected hepatocellular carcinoma underwent 55 CT examinations, with two different four-phase CT protocols. The first group of 30 patients underwent a standard 120 kVp acquisition after injection of Iohexol 350 mg/m L(Accupaque 350~?) and reconstructed with filtered back projection. The second group of 25 patients underwent a dual-energy CT at 80-140 kVp with iodixanol 270. The 80 kVp component of the second group was reconstructed iteratively(SAFIRE?-Siemens). All hyperdense and hypodense hepatic lesions ≥ 5 mm were identified with both protocols. Aorta and portal vessels/liver parenchyma contrast to noise ratio(CNR) in arterial phase, hypervascular lesion/liver parenchyma CNR in arterial phase, hypodense lesion/liver parenchyma CNR in portal and late phase were calculated in both groups.RESULTS: Aorta/liver and focal lesions altogether/liver CNR were higher for the second protocol(P = 0.0078 and 0.0346). Hypervascular lesions/liver CNR was not statistically different(P = 0.86). Hypodense lesion/liver CNR in the portal phase was significantly higher for the second group(P = 0.0107). Hypodense lesion/liver CNR in the late phase was the same for both groups(P = 0.9926).CONCLUSION: MDCT imaging with 80 kVp with iterative reconstruction and iodixanol 270 yields equal or even better image quality. | Diomidis Botsikas Isabelle Barnaure Sylvain Terraz Christoph D Becker Anastasia Kalovidouri Xavier Montet | 2016 | World Journal of Radiology2016，8，7： | 5 |
| 3 | Characterisation and seasonal variations of particles in the atmosphere of rural, urban and industrial areas:Organic compounds显示文摘Atmospheric aerosol samples(PM_(2.5–0.3), i.e., atmospheric particles ranging from 0.3 to2.5 μm) were collected during two periods: spring–summer 2008 and autumn–winter 2008–2009, using high volume samplers equipped with cascade impactors. Two sites located in the Northern France were compared in this study: a highly industrialised city(Dunkirk) and a rural site(Rubrouck). Physicochemical analysis of particulate matter(PM) was undertaken to propose parameters that could be used to distinguish the various sources and to exhibit seasonal variations but also to provide knowledge of chemical element composition for the interpretation of future toxicological studies. The study showed that PM2.5–0.3concentration in the atmosphere of the rural area remains stable along the year and was significantly lower than in the urban or industrial ones, for which concentrations increase during winter.High concentrations of polycyclic aromatic hydrocarbons(PAHs), dioxins, furans and dioxin like polychlorinated biphenyls(DL-PCBs), generated by industrial activities, traffic and municipal wastes incineration were detected in the samples. Specific criteria like Carbon Preference Index(CPI) and Combustion PAHs/Total PAHs ratio(CPAHs/TPAHs) were used to identify the possible sources of atmospheric pollution. They revealed that paraffins are mainly emitted by biogenic sources in spring–summer whereas as in the case of PAHs, they have numerous anthropogenic emission sources in autumn-winter(mainly from traffic and domestic heating). | Fabrice Cazier Paul Genevray Dorothée Dewaele Habiba Nouali Anthony Verdin Frédéric Ledoux Adam Hachimi Lucie Courcot Sylvain Billet Saad Bouhsina Pirouz Shirali Guillaume Garcon Dominique Courcot | 2016 | Journal of Environmental Sciences2016，28，6： | 4 |
| 4 | Transient elastography: a new noninvasive method for assessment of hepatic fibrosis显示文摘 | Laurent Sandrin Bertrand Fourquet Jean-Michel Hasquenoph Sylvain Yon Céline Fournier Frédéric Mal Christos Christidis Marianne Ziol Bruno Poulet Farad Kazemi Michel Beaugrand Robert Palau | 2003 | Ultrasound in Medicine & Biology2003，，12： | 3 |
| 5 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 6 | Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test显示文摘 | Denis Heresbach Sylvain Manfredi Pierre N. D?Halluin Jean-Fran?ois Bretagne Bernard Branger | 2006 | European Journal of Gastroenterology & Hepatology2006，，4： | 2 |
| 7 | A behavioral multi-agent model for road traffic simulation 显示文摘 | Arnaud D Rene M Sylvain P | 2008 | Engineering Applications of Artificial Intelligence (S0952-1976)2008，21，8： | 1 |
| 8 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 9 | Niche separation in com- munity analysis: A new method 显示文摘 | Sylvain D Daniel C Clementine G C | 2000 | Ecology2000，81，10： | 1 |
| 10 | High-resolution 1D moire s as counterfeit security features显示文摘A moireis an interference pattern that appears when two different periodic structures are overlaid.The image created is extremely sensitive to small variations in the original layers and is thus very interesting for anti-counterfeit protection.We present a microfabricated 1D moire enabling complex high-resolution patterns as a significantly improved security feature that cannot be reproduced using standard printing methods.Furthermore,we demonstrate,theoretically and experimentally,that a microscopic deviation from the original design results in a macroscopic variation in the moire that is clearly visible to the naked eye.The record resolution achieved in the elements fabricated and the increased design freedom,make these high-resolution moires excellent candidates for a variety of visually appealing security applications. | Victor J Cadarso Sylvain Chosson Katrin Sidler Roger D Hersch Jurgen Brugger | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 11 | Influence of surface finish and re- sidual stresses on the ageingsensitivity of biomedical grade zirconia 显示文摘 | Sylvain D Jerome C Laurent G | 2006 | Biomaterials2006，27，10： | 1 |
| 12 | A MYB Transcription Factor Regulates Very-Long-Chain Fatty Acid Biosynthesis for Activation of the Hypersensitive Cell Death Response in Arabidopsis(W)(OA)显示文摘 | Raffaele Sylvain Vailleau Fabienne Léger Amandine Joubès Jér?me Miersch Otto Huard Carine Blée Elisabeth Mongrand Sébastien Domergue Frédéric Roby Dominique | 2008 | Plant Cell2008，，3： | 1 |
| 13 | Vancomycin-resistant enterococci:a road map on how to prevent the emergence and transmission of anti- microbial resistance显示文摘 | Sylvain D Ttish MP | 2003 | Chest2003，123，5： | 1 |
| 14 | Niche separation in community analysis: a new method显示文摘 | SYLVAIN D DANIEL C CLEMENTINE G C | 2000 | Ecology2000，81，： | 1 |
| 15 | Caseinomacropeptides specifically stimulates exocrine pancreatic secretion in the anesthetized rat显示文摘 | Nathalie L R Claire N D Sylvain M | 2000 | Science Direct-Peptides2000，21，10： | 1 |
| 16 | Cancer-associated hypercalcemia treated with intravenous diphosphonates: a survival and prognostic factor analysis 显示文摘 | Nicolas P Sylvain D Philippe D | 2008 | Support Care Cancer2008，16，4： | 1 |
| 17 | Implementation of an urban canopy parameterization in a mesoscale meteorological model显示文摘 | Tanya L O Avraham L Sylvain D | 2004 | Journal of Applied Meteorology2004，43，： | 1 |
| 18 | Vancomycin-resistant enterococci:a road map on how to prevent the emergence and transmission of antimicrobial resistance显示文摘 | Sylvain D Trish MP | 2003 | Chest2003，123，5： | 1 |
| 19 | Fabrication and squeeze casting infiltration of graphite/alumina performs显示文摘 | Coupard D Goni J Sylvain J F | 1999 | Journal of Materials Science1999，34，21： | 1 |
| 20 | Knee Derangement Assessed with 3 - minute Threedimensional Isovoxel True FISP MR Sequence: Preliminary Study显示文摘 | Sylvain R D Christian W A Peter P K | 2008 | Radiology2008，2，： | 1 |
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