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| 1 | Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells显示文摘 | Marie-José Blivet-Van Eggelpo?l Hamza Chettouh Laetitia Fartoux Lynda Aoudjehane Véronique Barbu Colette Rey Sabrina Priam Chantal Housset Olivier Rosmorduc Christèle Desbois-Mouthon | 2012 | Journal of Hepatology2012，，1： | 2 |
| 2 | Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective显示文摘Until very recently, treatment for chronic hepatitis C virus(HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011(Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first timesince the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples. | Karina Salvatierra Sabrina Fareleski Alicia Forcada F Xavier López-Labrador | 2013 | World Journal of Virology2013，2，1： | 2 |
| 3 | Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry显示文摘BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to sepsis.The validated caerulein-(CAE)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for study.AIM To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in CAE-pancreatitis.METHODS Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAE(50μg/kg),3 d a week for 6 wk in male C57BL/6J mice.Starting in week 4,mice received either vehicle or ALC until experiment’s end.Mechanical hypersensitivity was assessed with von Frey filaments.Heat hypersensitivity was determined with the hotplate test.Anxiety-like behavior was tested in week 6 using elevated plus maze and open field tests.Microglial activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).RESULTS Mice with CAE-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing pain.Treatment with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections persisted.Animals with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to controls.Treatment with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not changed.After all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous healing.Post mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast Green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAE-induced pancreatitis that was not rescued by treatment with ALC.Microglial Iba1 immunostaining was significantly increased in hippocampus,thalamus(intralaminar nuclei),hypothalamus,and amygdala of mice with CAE-induced pancreatitis compared to naïve controls but unchanged in the primary somatosensory cortex compared to naïves.CONCLUSION CAE-induced pancreatitis caused increased pain-related behaviors,pancreatic fibrosis,and brain microglial changes.ALC alleviated CAE-induced mechanical and heat hypersensitivity but not abdominal wall injury-induced hypersensitivity caused by the repeated injections. | Sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito Karin N Westlund | 2021 | World Journal of Gastroenterology2021，27，9： | 2 |
| 4 | Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats显示文摘AIM:To characterize an alcohol and high fat diet induced chronic pancreatitis rat model that mimics poor human dietary choices.METHODS:Experimental rats were fed a modified Lieber-De Carli alcohol(6%) and high-fat(65%) diet(AHF) for 10 wk while control animals received a regular rodent chow diet.Weekly behavioral tests determinedmechanical and heat sensitivity.In week 10 a fasting glucose tolerance test was performed,measuring blood glucose levels before and after a 2 g/kg bodyweight intraperitoneal(i.p.) injection of glucose.Post mortem histological analysis was performed by staining pancreas and liver tissue sections with hematoxylin and eosin.Pancreas sections were also stained with Sirius red and fast green to quantify collagen content.Insulinexpressing cells were identified immunohistochemically in separate sections.Tissue staining density was quantified using Image J software.After mechanical and heat sensitivity became stable(weeks 6-10) in the AHF-fed animals,three different drugs were tested for their efficacy in attenuating pancreatitis associated hypersensitivity:a Group Ⅱ metabotropic glutamate receptor specific agonist(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate(APDC,3 mg/kg,ip; Tocris,Bristol,United Kingdom),nociceptin(20,60,200 nmol/kg,ip; Tocris),and morphine sulfate(3 mg/kg,μ-opioid receptor agonist; Baxter Healthcare,Deerfield,IL,United States).RESULTS:Histological analysis of pancreas and liver determined that unlike control rats,AHF fed animals had pancreatic fibrosis,acinar and beta cell atrophy,with steatosis in both organs.Fat vacuolization was significantly increased in AHF fed rats(6.4% ± 1.1% in controls vs 23.8% ± 4.2%,P < 0.05).Rats fed the AHF diet had reduced fasting glucose tolerance in week 10 when peak blood glucose levels reached significantly higher concentrations than controls(127.4 ± 9.2 mg/d L in controls vs 161.0 ± 8.6 mg/d L,P < 0.05).This concurred with a 3.5 fold higher incidence of single and small 2-10 cell insulin-positive cell clusters(P < 0.05).Insulin expressing islet of Langerhans cells appeared hypertrophied while islet number and area measurements were not different from controls.Weekly behavioral tests determined that mechanical and heat sensitivities were significantly increased by 4 wk on AHF diet compared to controls.Hypersensitivitywas attenuated with efficacy similar to morphine with single dose treatment of either metabotropic glutamate receptor 2/3 agonist APDC,or nociceptin,the endogenous ligand for opioid-receptor-like 1 receptor.CONCLUSION:The AHF diet induces a chronic alcoholic pancreatitis in rats with measurable features resembling clinical patients with chronic pancreatitis and type 3c diabetes mellitus. | Sabrina L McIlwrath Karin N Westlund | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 5 | Explaining IT-Based Knowledge Sharing Behavior with IS Continuance Model and Social Factors显示文摘 | Sabrina F S S Matthew L K O | 2006 | PACIS 2006 Proceedings2006，，： | 1 |
| 6 | Properties of thick sputtered Ta used for protective gun tube coatings 显示文摘 | Mastson Dean W McClanahan Edwin D Lee Sabrina L | 2001 | Surface and Coatings Technology2001，，： | 1 |
| 7 | A comparison of diagnostic assays for the detection of type A swine influenza virus from nasal swabs and lung显示文摘 | Sabrina L S Lani L V Brandi M L | 2001 | J Vet Diagn Invest2001，13，： | 1 |
| 8 | Torsade de points: the clinical considerations显示文摘 | Gowda RM Khan IA Sabrina L | 2004 | Int J Cardiol2004，96，1： | 1 |
| 9 | Properties of thick sputtered Ta used for protective gun tube coat- ings显示文摘 | Dean W Matson Edwin D McClanahan Sabrina L Lee | 2001 | Surface and Coating Technology2001，146，34： | 1 |
| 10 | A Hybrid Approach to Semantic Web Services Matchmaking显示文摘 | Giuseppe F Vincenzo L Sabrina S | 2008 | International Journal of Approximate Reasoning2008，48，3： | 1 |
| 11 | A new microbial screening method for the detection of antimicrobial residues in slaughter animals: The Nouws antibiotic test (NAT-screening)显示文摘 | Mari?l G. Pikkemaat Sabrina Oostra-van Dijk Jan Schouten Michel Rapallini Harry J. van Egmond | 2007 | Food Control2007，，8： | 1 |
| 12 | Adenosine as an an-tiarrhythmic agent显示文摘 | Sabrina L Wilbur M D Francis E | 1997 | Am J Cardiol1997，79，79： | 1 |
| 13 | Barrett's esophagus:an update显示文摘 | Massimo C Gabriella L Sabrina B | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 14 | Membrane-parti- cle interactions in an asymmetric flow field flow fractionation channel studied with titanium dioxide nanopartieles 显示文摘 | NINA B SABRINA L CHRISTIAN A | 2014 | J Chro- matogrA2014，1334，： | 1 |
| 15 | The K121Q polymorphism of the ENPP1/PC - 1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction 显示文摘 | Simonetta B Ornella L Sabrina P | 2005 | Diabetes2005，54，10： | 1 |
| 16 | The effects of face eooling during hyperthermic exercise in man:evidence for an integrated thermal, neuroendocrine and behavioural response显示文摘 | TOBY MUNDEL SABRINA J BUNN PAULA L HOOPER | 2007 | Exp Physiol2007，92，： | 1 |
| 17 | Neonatal endosurgical congenital diaphragmatic hernia repair a systematic review and meta-analysis显示文摘 | Nick L Sabrina A Paul DL | 2010 | Ann Surg2010，252，1： | 1 |
| 18 | Deletion of a 5 - cM rgion at chromosome 8p23 is associated with a spectrum of congenital heart defects显示文摘 | Sabrina G Sharon L G Giorgio G | 2000 | Circulation2000，102，： | 1 |
| 19 | Evaluation of serological tests for the detection of pseudorabies gE antibodies during early infection显示文摘 | David K Sabrina L S Lie-Ling W | 1997 | Vet Micro1997，55，： | 1 |
| 20 | Application of Laser Pulse Heating to Simulate Thermomechanical Damage at Gun Bore Surfaces显示文摘 | P J Cote Sabrina L Lee M E Todaro | 2003 | Journal of Pressure Vessel Technology2003，125，： | 1 |
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