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| 1 | Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents显示文摘AIM To establish a threshold value for liver fat content between healthy children and those with nonalcoholic fatty liver disease(NAFLD) by using magnetic resonance imaging(MRI), with liver biopsy serving as a reference standard. METHODS The study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis. The assessment of liver fat fraction was performed using MRI, with a high field magnet and 2D gradient-echo and multiple-echo T1-weighted sequence with low flip angle and single-voxel pointresolved 1H MR-Spectroscopy(1H-MRS), corrected for T1 and T2* decays. Receiver operating characteristic curve analysis was used to determine the best cutoff value. Lin coefficient test was used to evaluate thecorrelation between histology, MRS and MRI-PDFF. A Mann-Whitney U-test and multivariate analysis were performed to analyze the continuous variables. RESULTS According to MRS, the threshold value between healthy children and those with NAFLD is 6%; using MRI-PDFF, a cut-off value of 3.5% is suggested. The Lin analysis revealed a good fit between the histology and MRS as well as MRI-PDFF.CONCLUSION MRS is an accurate and precise method for detecting NAFLD in children. | Michele Di Martino Lucia Pacifico Mario Bezzi Rossella Di Miscio Beatrice Sacconi Claudio Chiesa Carlo Catalano | 2016 | World Journal of Gastroenterology2016，22，39： | 16 |
| 2 | MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies显示文摘 | Federico Cappuzzo Andrea Sacconi Lorenza Landi Vienna Ludovini Francesca Biagioni Armida D’Incecco Alessandra Capodanno Jessica Salvini Enrichetta Corgna Samanta Cupini Cecilia Barbara Gabriella Fontanini Lucio Crinò Giovanni Blandino | 2013 | Clinical Colorectal Cancer2013，，： | 3 |
| 3 | An international comparision of roundness measurement between ten-europen national standards laboratories 显示文摘 | Sacconi A Pasin W | 1994 | Measurement1994，13，2： | 2 |
| 4 | International comparison of high-accuracy roundness measurements 显示文摘 | Frennberg M Sacconi A | 1996 | Metrologia1996，33，6： | 2 |
| 5 | The indeterminable resilience of the fascial system显示文摘The most recent information on fascial tissue indicates that there are not fascial layers, but polyhedral microvacuoles of connective tissue, which connect the body systems and, by hosting specialized cells, permit several functions, such as motor, nervous, vascular and visceral. These microvacuoles(a repetition of polyhedral units of connective fibrils) under internal or external tension change shape and can manage the movement variations, regulating different body functions and ensuring the maintenance of efficiency of the body systems. Their plasticity is based on perfect functional chaos: it is not possible to determine the motion vectors of the different fibrils, which differ in behavior and orientation; this strategy confers to the fascial continuum the maximum level of adaptability in response to the changing internal and external conditions of the cell. The present commentary deals with this concept, providing clinical examples of different disease patterns, providing contrary examples in which this adaptability does not occur, and lastly suggesting considerations for the approach to manipulative therapy of the fascial tissue. The fascial continuum is like a flock of birds flying together without a predetermined logic and maintaining their individuality at the same time. | Bruno Bordoni Fabiola Marelli Bruno Morabito Beatrice Sacconi | 2017 | Journal of Integrative Medicine2017，15，5： | 2 |
| 6 | A functionally dominant mitochondrial DNA mutation显示文摘 | Sacconi S Salviati L Nishigaki Y | 2008 | Hum Mol Genet2008，17，： | 1 |
| 7 | Multiphoton muhifocal microscopy exploiting a diffractive optical element 显示文摘 | SACCONI L FRONTER E ANTOLINI R | 2003 | OptLett2003，28，20： | 1 |
| 8 | A novel CRYAB mutation resulting in muhisystemic disease 显示文摘 | Sacconi S Fasson L Antoine JC | 2012 | Neuromuscul Disord2012，22，： | 1 |
| 9 | MR appearance of parathy roid adenomas at 3T in patients with primary hyperparathyroid ism : what radiologists need to know/or pre operative localization 显示文摘 | Sacconi B Argiro R Diacinti D | 2016 | Eur Radiol2016，26，3： | 1 |
| 10 | Spontaneous and piezoelectric polarization effects on the oput characteristics of AlGaN/GaN heterojunction modulation doped FETs显示文摘 | Fabio Sacconi Aldo Di Carlo P Lugli | 2001 | IEEE Trans Electron Device2001，48，3： | 1 |
| 11 | Electronic andtransport Properties of silicon nanowire显示文摘 | Sacconi F Persson M P Povolotskyi M | 2007 | Journal of ComputationalElectronics2007，6，1： | 1 |
| 12 | The IMGC Calibration Setup for Micro- displacement Actuators显示文摘 | Attilio Sacconi Gian Bartolo Picotto Walter Pasin | 1999 | IEEE Transactions on Instrumentation and Measurement1999，48，2： | 1 |
| 13 | The IMGC calibration setup for micro- displacement actuators 显示文摘 | Sacconi A Picotto G B Pasin W | 1999 | IEEE Trans on Instrum and Meas1999，48，2： | 1 |
| 14 | miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer显示文摘 | Sacconi A Biagioni F Canu V | 2012 | Cell Death Dis2012，3，： | 1 |
| 15 | Optical recording of fast neuronal membrane potential transients in acute mammalian brain slices by second-harmonic generation microscopy显示文摘 | Dombeck D A Sacconi L Blanchard-Desce M | 2005 | Neurophysiol2005，94，： | 1 |
| 16 | The IMGC calibration setup for micro- displacement actuators显示文摘 | Attilio SACCONI Gian Bartolo PICOTTO Walter PASIN | 1999 | IEEE Transactions on Instrumentation and Measurement1999，48，2： | 1 |
| 17 | Novel SURF1 mutation in a child with subacute encephalopathy and without the radiological features of Leigh syndrome显示文摘 | Salviati L Freehauf C Sacconi S | | 0，，02： | 1 |
| 18 | Fundus autofluorescence changes after ranibizumab treatment for subfoveal choroidal neovascularization sec- ondary to pathologic myopia显示文摘 | PARODI MB IACONO P SACCONI R IULIANO L BANDEL- LO F | 2015 | Am J Ophthalmol2015，160，2： | 1 |
| 19 | Decrease of brain acetylcholine release in aging freely moving rats detected by microdialysis显示文摘 | Wu CF Bertorelli R Sacconi M | 1988 | Neurobiol Aging1988，9，4： | 1 |
| 20 | The IMGC calibration setup for micro-displacement actuators 显示文摘 | Attilio Sacconi Gian Bartolo Picotto Walter Pasin | 1999 | IEEE Transactions on Instrumentation and Measurement1999，48，2： | 1 |
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