|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy显示文摘AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after PD.Computed tomography(CT)images were evaluated every 6 mo after PD for follow-up.Hepatic steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield units.Liver biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo biopsies.To compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver biopsy.Double-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy specimens.RESULTS:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after PD.Those patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin resistance.Liver biopsy was performed in four patients with NAFLD after PD.All four patients showed moderate-to-severe steatosis and NASH was diagnosed in two.Numbers of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy specimens.The number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with metabolic syndrome specimens,which indicated the presence of significantly more Kupffer cells in NAFLD after PD than in NAFLD associated with metabolic syndrome.Similarly,more CD14+ cells,namely,LPS-sensitized Kupffer cells,were observed in NAFLD after PD than in NAFLD associated with metabolic syndrome.Regarding NASH,more CD68+ cells and CD14+ cells were observed in NASH after PD specimens than in NASH associated with metabolic syndrome.This showed that more Kupffer cells and more LPS-sensitized Kupffer cells were present in NASH after PD than in NASH associated with metabolic syndrome.These observations suggest that after PD,Kupffer cells and LPS-sensitized Kupffer cells were significantly upregulated,not only in NASH,but also in simple fatty liver.CONCLUSION:NAFLD after PD is characterized by both malnutrition and the up-regulation of CD14 on Kupffer cells.Gut-derived endotoxin appears central to the development of NAFLD after PD. | Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 2 | Annexin V assay-proven anti-apoptotic effect of ascorbic acid 2-glucoslde after cold ischemia/reperfusion injury in rat liver transplantation显示文摘 | Liu J Yagi T Sadamori H | 2003 | Acta Med Okayama2003，57，5： | 1 |
| 3 | Application concepts and evaluation of small-scale catalytic combustors for natural gas显示文摘 | SADAMORI H | 1999 | Catal Today1999，47，14： | 1 |
| 4 | Radiofrequency Ablation for Hepatocellular Carcinoma显示文摘 | Inagki M Yagi T Sadamori H | 2002 | Gan To Kagaku Ryoho2002，29，12： | 1 |
| 5 | Application concepts and evaluation of smallscale catalytic combustors for natural gas 显示文摘 | Hiroki | 1999 | Catalysis Today1999，47，： | 1 |
| 6 | Intractable bile leakage after hepatectomy for hepatocellular carcinoma in 359 recent cases显示文摘 | Sadamori H Yagi T Matsuda H | 2012 | Digestive Surgery2012，29，2： | 1 |
| 7 | Effects of Prophylactic Splenic Artery Modulation on Portal Overperfusion and Liver Regeneration in Small-for-Size Graft显示文摘 | Yuzo Umeda Takahito Yagi Hiroshi Sadamori Hiroyoshi Matsukawa Hiroaki Matsuda Susumu Shinoura Kenji Mizuno Ryuichi Yoshida Takayuki Iwamoto Daisuke Satoh Noriaki Tanaka | 2008 | Transplantation2008，，5： | 1 |
| 8 | Application concept and evaluation of smallscale catalytic combustors for natural gas 显示文摘 | Sadamori H | 1999 | Catalysis Today1999，47，： | 1 |
| 9 | Primary-adrenal lymphoma with chromosomal abnormalities 显示文摘 | Sasagawa L Sadamori N hoyama T | 1995 | Acta Haematol1995，94，： | 1 |
| 10 | Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft显示文摘 | Umeda Y Yagi T Sadamori H | 2008 | Transplantation2008，86，5： | 1 |
| 11 | A Convenient one-pot preparation of benzol b ] -tellurophenes, selenophenes, and - thiophenes from o-bromoethynyl- benzenes显示文摘 | Sashida H Sadamori K Tsuchiya T | 1998 | SYNTHETIC COMMUNICATIONS1998，28，4： | 1 |
| 12 | Resection of metachronous lymph node metastases from hepatocellular carcinoma after hepatectomy:report of four cases显示文摘 | Utsumi M Matsuda H Sadamori H | | 0，，02： | 1 |
| 13 | Bitterness of phenylalanine-and tyrosine-containing peptides (Food & Nutrition ) 显示文摘 | Ishibashi N Sadamori K Yamamoto O | 1987 | Agricultural and Biological Chemistry1987，51，12： | 1 |
| 14 | High-flow-rate haemodiafiltration as a brain-support therapy proceeding to liver transplantation for hyperacute fulminant hepatic failure 显示文摘 | Sadamori H Yagi T Inagaki M | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
| 15 | The sonohystero- graphic difference in submueosal uterine fibroids and endometrial polyps treated by hysteroscopic surgery 显示文摘 | Tamura - Sadamori R Emoto M Naganuma Y | 2007 | J Ultrasound Med2007，26，7： | 1 |
| 16 | Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation显示文摘 | Yoshida R Yagi T Sadamori H | 2012 | J Hepatobiliary Pancreat Sci2012，19，4： | 1 |
| 17 | Bitterness ofPhenylalanine - and Tyrosine - containing peptides ( Food & Nutrition ) 显示文摘 | Ishibashi N Sadamori K Yamamoto O | 1987 | Agricultural and Biological Chemistry1987，，12： | 1 |
| 18 | Risk factors for major morbidity after liver resection for hepatocellular carcinoma显示文摘 | Sadamori H Yagi T Shinoura S | 2013 | Br J Surg2013，100，1： | 1 |
| 19 | Risk factors for organ/space surgical site infection after hepatectomy for hepatocellular carcinoma in 359 recent cases显示文摘 | Hiroshi Sadamori Takahito Yagi Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Daisuke Satoh Daisuke Nobuoka Masashi Utsumi Kazuhiro Yoshida Toshiyoshi Fujiwara | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，2： | 1 |
| 20 | High-flow-rate haemodiafiltration as a brain-support therapy proceeding to liver transplantation for hyperacute fulminant hepatic failure 显示文摘 | Yagi T Inagaki M | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员