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| 1 | CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy显示文摘AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after PD.Computed tomography(CT)images were evaluated every 6 mo after PD for follow-up.Hepatic steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield units.Liver biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo biopsies.To compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver biopsy.Double-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy specimens.RESULTS:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after PD.Those patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin resistance.Liver biopsy was performed in four patients with NAFLD after PD.All four patients showed moderate-to-severe steatosis and NASH was diagnosed in two.Numbers of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy specimens.The number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with metabolic syndrome specimens,which indicated the presence of significantly more Kupffer cells in NAFLD after PD than in NAFLD associated with metabolic syndrome.Similarly,more CD14+ cells,namely,LPS-sensitized Kupffer cells,were observed in NAFLD after PD than in NAFLD associated with metabolic syndrome.Regarding NASH,more CD68+ cells and CD14+ cells were observed in NASH after PD specimens than in NASH associated with metabolic syndrome.This showed that more Kupffer cells and more LPS-sensitized Kupffer cells were present in NASH after PD than in NASH associated with metabolic syndrome.These observations suggest that after PD,Kupffer cells and LPS-sensitized Kupffer cells were significantly upregulated,not only in NASH,but also in simple fatty liver.CONCLUSION:NAFLD after PD is characterized by both malnutrition and the up-regulation of CD14 on Kupffer cells.Gut-derived endotoxin appears central to the development of NAFLD after PD. | Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 2 | Co-transduction of Apaf-1 and easpase-9 highly enhances p53-mediated apoptosis in gliomas显示文摘 | Shinoura N Sakurai S Shibasaki F | 2002 | Br J Cancer2002，86，4： | 1 |
| 3 | Protein and messenger RNA expression of connexin43 in astrocytomas:implications in brain tumor gene therapy显示文摘 | Shinoura N Chen L Wani MA | 1996 | J Neurosurg1996，84，5： | 1 |
| 4 | Relative level of expression of Bax and Bcl-xl determines the cellular rate of apoptosis/necrosis inducing by the overexpression of Bax显示文摘 | Shinoura N Yoshida Y Asai A | 1999 | Oncogene1999，18，41： | 1 |
| 5 | Risk factors for major mor- bidity after liver resection for hepatocellular carcinoma 显示文摘 | Sadamofi H Yagi T Shinoura S | 2013 | Br J Surg2013，100，1： | 1 |
| 6 | Adenovirus mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas 显示文摘 | Shinoura N Muramatsu Y Nishimura M | 1999 | Cancer Res1999，59，21： | 1 |
| 7 | Adenovirus-mediated transfer of p33^ING1 with p53 drastically augments apoptosis in gliomas 显示文摘 | Shinoura N Muramatsu Y Nishimura M | 1999 | Cancer Res1999，59，21： | 1 |
| 8 | Effects of Prophylactic Splenic Artery Modulation on Portal Overperfusion and Liver Regeneration in Small-for-Size Graft显示文摘 | Yuzo Umeda Takahito Yagi Hiroshi Sadamori Hiroyoshi Matsukawa Hiroaki Matsuda Susumu Shinoura Kenji Mizuno Ryuichi Yoshida Takayuki Iwamoto Daisuke Satoh Noriaki Tanaka | 2008 | Transplantation2008，，5： | 1 |
| 9 | The a1D-adrenergie receptor directly regulates arterial blood pressure via vasoconstriction显示文摘 | Tauoue A Nasa Y Koshimizu T Shinoura H Ooshikawa S Kawai T | 2002 | J Clin Invest2002，109，： | 1 |
| 10 | Adenovirus mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas显示文摘 | SHINOURA N MURAMATSU Y NISHIMURA M | 1999 | Cancer Res1999，59，： | 1 |
| 11 | Adenovirus - mediated overexpression of Fas induces apoptosis of gliomas显示文摘 | Shinoura N Ohashi M Yoshida Y | 2000 | Cancer Gene Therapy2000，7，2： | 1 |
| 12 | Adenovirus--me- diated transfer of p331NG1 with p53 drastically augments apoptosis in gliomas显示文摘 | Shinoura N Muramatsu Y Nishimura M | 1999 | Cancer Reseach1999，59，21： | 1 |
| 13 | Adenovims-mediated transfer of p33ING1 with 1753 drastically augments apoptosis in gliomas显示文摘 | Shinoura N Muramatsu Y Nishimura M | 1999 | Cancer Res1999，69，9： | 1 |
| 14 | PET Imaging of Brain Tumor With choline显示文摘 | Hara T Kosaka N Shinoura N | 1997 | J Nucl Med1997，38，6： | 1 |
| 15 | Mirror therapy activates outside of cerebellum and ipsilateral M 1 显示文摘 | Shinoura N Suzuki N Watanabe Y | 2008 | Neuro Rehabilitation2008，23，： | 1 |
| 16 | Expression level of Bcl 2 determines anti or proapoptotic function显示文摘 | Shinoura N Yoshida Y Nis~imura M Muramatsu Y Asai A Kirino T | 1999 | Cancer Res1999，59，： | 1 |
| 17 | Mirror therapy activates outside of cerebellum and ipsilateral M1显示文摘 | Nobusada Shinoura Yuichi Suzuki Yasuko Watanabe Ryozi Yamada Yusuke Tabei Kuniaki Saito Kazuo Yagi | 2008 | Neurorehabilitation2008，，3： | 1 |
| 18 | Restored activation of primary motor area from motor reorganization and improved motor function after brain tumor resection 显示文摘 | Shinoura N Suzuki Y Yamada R | 2006 | Am J Neuroradiol2006，27，6： | 1 |
| 19 | Quantification of alpha1-adrenoceptor subtypes by real-time RT-PCR and correlation with age and prostate volume in benign prostatic hyperplasia patients显示文摘 | Kojima Y Sasaki S Shinoura H | 2006 | Prostate2006，66，7： | 1 |
| 20 | Protein and Messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy显示文摘 | Chen L Wani MA | 1996 | J Neurosurg1996，84，5： | 1 |
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