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| 1 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 2 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 3 | POEMS sydrome with vascular lesions:a role forinterleukin-1beta and interleukin-6 increase-a case report显示文摘 | Bova G,Pasqui AL,Saletti M | 1998 | Angiology1998，，： | 1 |
| 4 | Nutritional status and a 3-year follow-up in elderly receiving support at home 显示文摘 | A Saletti Johansson L Yifter-Lindgren E | 2005 | Gerontology2005，51，3： | 1 |
| 5 | Differing Deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant显示文摘 | Molinari F Martin V Saletti P | 2009 | Br J Cancer2009，100，7： | 1 |
| 6 | POEMS syndrome with vascu- lar lesions : a role for interleukin - 1 beta and interleukin - 6 in- crease : a ease report显示文摘 | Bova G Pasqui AL Saletti M | 1998 | Angio[ogy1998，49，11： | 1 |
| 7 | Mass spectrometry in food proteomics: a tutorial显示文摘 | Ctmsolo V Muccilli V Saletti R | 2014 | J Mass Spectrom2014，49，9： | 1 |
| 8 | POEMS syndrome with vascular lesions: a role for interleukin 1 beta and interleukin-6 increase - a case report 显示文摘 | Bova G Pasqui AL Saletti M | 1998 | Angiology1998，49，11： | 1 |
| 9 | POEMS syndrome with vascular lesions and renal carcinoma-possible role of cytokines 显示文摘 | Pasqui AL Bova G Saletti M | 1998 | Eur J Med Res1998，3，6： | 1 |
| 10 | Induction of antigon- specific antibodies in vaginal sectetions by using a nontoxic mutant of heat labile enterotoxin as a mucosal adjuvant显示文摘 | Di Tommaso A Saletti G Pizza M | 1996 | Infect Immun1996，64，： | 1 |
| 11 | Assessment of acute spontaneous intracerebral hematoma by CT perfusion imaging 显示文摘 | Fainardi E Borrelli M Saletti A | 2005 | J Neuroradial2005，32，： | 1 |
| 12 | Nutri- tional status and a 3-year follow-up in elderly receiving support at home 显示文摘 | Saletti A Johansson L Yifter-Lindgren E | 2005 | Gerontology2005，51，3： | 1 |
| 13 | CT perfusion map ping of hemodynamic disturbances associated to acute sponta neous intracerebral hemorrhage 显示文摘 | Fainardi E Borrelli M Saletti A | 2008 | Neuroradiology2008，50，： | 1 |
| 14 | Characterization of B and C-type low molecular weight glutenin subunits by electrospray ionization mass spectrometry and matrix assisted laser desorption/ionization mass spectrometry显示文摘 | MUCCILLI V CUNSOLO V SALETTI R | 2005 | Proteomics2005，5，： | 1 |
| 15 | PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients显示文摘 | Frattini M Saletti O Romagnani E | 2007 | Br J Cancer2007，97，8： | 1 |
| 16 | Mass spectrometry in food proteomics: a tutorial显示文摘 | Cunsolo V Muccilli V Saletti R | 2014 | Journal of Mass Spectometry2014，49，9： | 1 |
| 17 | Immunogeni ceorrelation between cross-reacting material (CRMI97) produced by a mutant of 2orynebacterium diphtheriaand diphtheria toxoid 显示文摘 | Porro M Saletti M Neneioni L | 1980 | J Infect Dis1980，142，5： | 1 |
| 18 | PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients显示文摘 | Frattini M Saletti P Romagnani E | | 0，，08： | 1 |
| 19 | Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine:a multicenter,phase II trial of the Swiss Group for Clinical Cancer Research显示文摘 | Koeberle D Saletti P Borner M | 2008 | J Clin Oncol2008，26，22： | 1 |
| 20 | PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients 显示文摘 | Frattini M Saletti P Romagnani E | 2007 | BrJCancer2007，97，8： | 1 |
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