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| 1 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 2 | 1100kV/1200kV断路器大功率试验(英文)显示文摘特高压(UHV)断路器试验本身就是一项挑战,当前,KEMA已开发了用于超高压和特高压开关设备大功率测试装置。鉴于特高压断路器一般至少由双断口灭弧室组成,需要做验证其正常电流(或故障电流)开断能力的局部试验,可以只针对断路器单断口(即断路器的1/2或1/4)来进行。例如,装有均压电容的瓷柱式断路器的情形就是这样。然而,为满足对金属封闭式开关设备的试验要求(见IEC61633),在带电部件和外壳之间以及在分闸过程应具备正确的电介质应力,不做断路器整极试验在技术上是不正确的。这就要求开发新的UHV断路器试验电路。关键之处在于使用一种双级合成电路,其中一级电路放置在测试对象的附近。这种做法的好处是,测试对象的外壳可以保持地电位。各种800kV以及1100或1200kV断路器整极全面试验均证明这种方法是有效可行的。文章中展示了试验的例子。 | René Peter Paul Smeets Sander Kuivenhoven Piet Knol Adriaan Hofstee | 2009 | 南方电网技术2009，3，6： | 4 |
| 3 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 4 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 5 | The Montreal Definition and Classification of Gastroesophageal Reflux Disease:A Global Evidence Based Cosensus显示文摘 | Nimish Vakil Sander Vvan Zanten Peter Kahrilas | 2006 | Am J Gastroenterol2006，101，： | 1 |
| 6 | Newborn Screening for Congenital Adrenal Hyperplasia: additional steroid profile using liquid chromatography- tandem mass spectrometry 显示文摘 | Janzen N Peter M Sander S | 2007 | J Clin Endocrinol Metab2007，24，： | 1 |
| 7 | Singularities of principal Direction Fields from 3-D Images 显示文摘 | Sander Peter T Zucker Steven W | 1992 | IEEE Trans1992，14，3： | 1 |
| 8 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 9 | Newborn screening for congenital adrenal hyperplasia: additional steroid profile using liquid chromatography-tandem mass spectrometry显示文摘 | Janzen N Peter M Sander S | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 10 | Scalable Content-aware Request Distribution in Cluster-based Network Servers显示文摘 | Darren Sanders Peter Druschel Willy Zwaenepoel | 2000 | In Proceedings of the USENIX 2000 Annual Technical Conference San Diego CA June2000，2000，： | 1 |
| 11 | Ash transformation during cofiring coal and straw显示文摘 | Yuanjing Zheng Peter Arendt Jensen Anker Degn Jensen Bo Sander Helle Junker | 2007 | Fuel2007，86，： | 1 |
| 12 | Gas solubility calculations I, UNIFAC 显示文摘 | Bo Sander Steen Skjold Peter Rasmussen | 1983 | Fluid Phase Equilibria1983，11，2： | 1 |
| 13 | An experimental study exploring the relationship between the size of bacterial inoculum and bacterial adherence to prosthetic mesh显示文摘 | David L. Sanders Andrew N. Kingsnorth Jaynnie Lambie Peter Bond Roy Moate Jane A. Steer | 2013 | Surgical Endoscopy2013，，3： | 1 |
| 14 | Energy-efficient sorting using solid state disks显示文摘 | Andreas Beckmann Ulrich Meyer Peter Sanders Johannes Singler | 2011 | Sustainable Computing: Informatics and Systems2011，，2： | 1 |
| 15 | Comparison of Cranial Facet Joint Violation Rates Between Open and Percutaneous Pedicle Screw Placement Using Intraoperative 3-D CT (O-arm) Computer Navigation显示文摘 | Sharon C. Yson Jonathan N. Sembrano Peter C. Sanders Edward Rainier G. Santos Charles Gerald T. Ledonio David W. Polly | 2013 | Spine2013，，： | 1 |
| 16 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 17 | Complement Inhibition as a Proposed Neuroprotective Strategy following Cardiac Arrest显示文摘 | Brad E. Zacharia Zachary L. Hickman Bartosz T. Grobelny Peter A. DeRosa Andrew F. Ducruet E. Sander Connolly Fulvio D’Acquisto | 2010 | Mediators of Inflammation2010，，： | 1 |
| 18 | Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm显示文摘 | Han S. Lim Scott R. Willoughby Carlee Schultz Cheryl Gan Muayad Alasady Dennis H. Lau Darryl P. Leong Anthony G. Brooks Glenn D. Young Peter M. Kistler Jonathan M. Kalman Matthew I. Worthley Prashanthan Sanders | 2013 | Journal of the American College of Cardiology2013，，8： | 1 |
| 19 | The Montreal definition and classification of gastroesophageal Reflux disease: A global evidence-based Consensus 显示文摘 | Nimish Vakil Sander V van Zanten Peter Kahrilas et M | 2006 | Am J Gastroenterol2006，101，： | 1 |
| 20 | Mycorrhizal fungal diversity determines plant biodiversity, ecosystem variability and productivity 显示文摘 | Heiden M G A Klironomos J N Margot U Peter M Ruth S E Thomas B Andres W Sanders I | 1998 | Nature1998，396，： | 1 |
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